This chapter explores the idea of generative businesses that focus on goals of vitality at multiple levels, with operations based on principles of renewal, restoration, and resilience. Key is shifting the core understanding of the role(s) of businesses in society and how we—and they—view the world. To do that, we need to fundamentally change the memes—the core cultural artifacts—that surround the idea of business. This chapter uses a shamanic rationale—the idea of according dignity to all people, other living beings, and Earth itself in all its manifestations—to argue for a radically different business system that works in harmony and balance with the planet—a form of planetary stewardship on the part of businesses. Generative businesses serve the communities in which they operate, creating vitality in the form of connections and community, stable and decent employment opportunities, and a holistic approach to doing business.