This chapter examines the illness profile of a disaster-prone village Char Majhira at Sariakandi Upazilla of Bogra district in Bangladesh which frequently affect various communicable and non-communicable illness. The researcher had administered participant observation, a thick description of villagers, an in-depth interview and FGD for data collection by using purposive sampling of the 250 households during November 2010 to June 2011. The salient health hazards of Char Majhira were rickets and vision problems, and the leading causes of death were asthma, neoplasm, respiratory infections, senility, stroke, various conditions during the neonatal period, accidents, cardiovascular illness other than stroke and diarrheal diseases, hepatitis and hypertension. As this is a chapter about illness profile of a disaster-prone village, it obviously will be helpful for development planners and policy makers to take essential steps for the prevention of illness in the disadvantage people in Bangladesh, as well as rest of the world.