SIRT7 is a deacetylase of N4-acetylcytidine on ribosomal RNA
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AbstractN-acetyltransferase 10 catalyzes RNA N4-acetylcytidine (ac4C) modifications and thus regulates RNA stability and translation efficiency. However, the deacetylase for ac4C is unknown. SIRT7 was initially identified as an NAD+-dependent protein deacetylase and plays essential roles in genome stability, circadian rhythms, metabolism, and aging. In this study, we identified SIRT7 as a deacetylase of the ac4C of ribosomal (r)RNA for the first time and found it to be NAD+-independent. Our data highlight the important role of SIRT7 in rRNA ac4C modification and suggest an additional epitranscriptional regulation of aging.
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2015 ◽
Vol 13
(02)
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pp. 1550002
Seasonality and role of SCN in entrainment of lizard circadian rhythms to daily melatonin injections
1998 ◽
Vol 274
(4)
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pp. R1004-R1014
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2019 ◽
Vol 20
(19)
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pp. 4945
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