scholarly journals Anti-hyperglycemic effects of aqueous Lenzites betulina extracts from the Philippines on the blood glucose levels of the ICR mice ( Mus musculus )

2016 ◽  
Vol 6 (2) ◽  
pp. 155-158 ◽  
Author(s):  
Faizal Rajeeb Mangudadatu Hussin ◽  
Rodel Jonathan Santos Vitor ◽  
Julie Ann Oraa Joaquin ◽  
Melody Mendoza Clerigo ◽  
Anamy Ma. Caterial Paano
Keyword(s):  
Blood Glucose ◽  
Mus Musculus ◽  
The Philippines ◽  
Glucose Levels ◽  
Icr Mice ◽  
Blood Glucose Levels ◽  
Lenzites Betulina

scholarly journals PEMANFAATAN INFUSA DAUN SIRIH MERAH (Piper crocatum) SEBAGAI ANTI-OBESITAS PADA MENCIT (Mus musculus)

2020 ◽  
Vol 10 ◽  
pp. 50-57
Author(s):  
Desty Apritya ◽  
Miarsono Sigit ◽  
Retina Yunani ◽  
Fuji Lestari
Keyword(s):  
Blood Glucose ◽  
Mus Musculus ◽  
Experimental Animals ◽  
Betel Leaf ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Randomized Design ◽  
Obesity In Mice ◽  
Sugar Levels ◽  
The Relationship

The purpose of this research is to know the effectiveness of red betel leaf infusion (Piper crocatum) as anti-obesity in mice (Mus musculus). Other parameters of this study to know the relationship between changes in blood glucose levels to obesity in experimental animals. Experimental animals used were 24 male mice. The design of this research is completely randomized design (CRD) with 4 treatments 6 repetitions. There are four treatmens P0 (Control), P1 (6 mice by giving a betel leaf infusion with a concentration of 5%), P2 (6 mice by giving a betel leaf infusion with a concentration of 10%), and P3 (6 mice by giving a betel leaf infusion with a concentration of red 15%). The treatment is carried out once every day for 21 days. Before treatment, initial weight was weighed and blood glucose level examination continued on the 7th day, on the 14th day, and on the 21st day. Data obtained from the results of weighing and checking blood sugar levels were further analyzed using the ANOVA test which statistically showed no significant changes (P> 0.05) of body weight and blood glucose levels in mice (Mus musculus) given infusion red betel leaf (Piper crocatum).

scholarly journals PENGARUH EKSTRAK BAWANG HITAM TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA MENCIT

2021 ◽  
Vol 4 (1) ◽  
pp. 49
Author(s):  
Pipit Festi W
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Mus Musculus ◽  
T Test ◽  
Control Group ◽  
Control Group Design ◽  
Significance Level ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Reduce Blood Glucose

 Administration of oral hypoglycemic drugs and insulin is one of the most common pharmacological treatments given to people with diabetes mellitus. This treatment is carried out in the long term so that it causes side effects and is carried out continuously so that it will affect the financial condition of the diabetes mellitus patient. The purpose of this study was to determine the effect of black garlic extract on decreasing blood glucose levels in mice (mus musculus). This study uses the design of True Experimental design (pretest-posttest with control group design). The population is mice in Pusvetma Surabaya. Sampling method uses Non Probability Sampling Purposive Sampling type. Samples taken were 30 mice consisting of 15 intervention groups and 15 control groups. Data was collected using observation sheets, then analyzed using Independent sample t test and Dependent sample t test with a significance level of 5 0.05. The results showed: Using the test Independent sample T test obtained a significance value ρ = 0,000  It can be concluded that there is an effect of black onion extract to reduce blood glucose levels in mice. In the paired t-test test in the treatment group showed ρ = 0,000  that there were differences in blood glucose levels before being given extracts of garlic and after being given intervention. It is expected that black garlic can be used as an alternative medicine to reduce blood glucose levels.Keyword : Ekstrak of black garlic, Blood sugar levels, mus musculus

scholarly journals BLOOD GLUCOSE LEVEL AND PANCREAS HISTOLOGICAL SECTION OF MICE ( Mus musculus L.) INDUCED BY ALLOXAN AFTER TREATMENT OF Curcuma mangga Val. RHIZOME EXTRACT

2016 ◽  
Vol 20 (2) ◽  
pp. 64 ◽  
Author(s):  
Madihah Madihah ◽  
Fitriani Alfina ◽  
Yetti Yusri Gani
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Mus Musculus ◽  
Fasting Blood Glucose ◽  
Histological Section ◽  
Tolerance Test ◽  
Endocrine Gland ◽  
Synthetic Drugs ◽  
Glucose Levels ◽  
Blood Glucose Levels

Herbal-based drug development for diabetes mellitus continues to grow in order to find alternatives of theuse of synthetic drugs which is relatively expensive. The present study examined the potency of temu mangga(Curcuma mangga Val.) rhizome extract in decreasing blood glucose levels and repairing histological damage ofpancreas endocrine gland in male mice (Mus musculus L.) Swiss-Webster that has been induced by alloxan. Theexperimental method with 5 treatments and 5 replications were used. The dose of alloxan was 200 mg/kg bw,while the dose of temu mangga extract were 100, 200, 400 and 800 mg/kg bw. The measured parameters werethe body weight, fasting blood glucose levels by using blood glucose tolerance test, and the percentage of pancreatic? cells that undergo necrosis. Data were analyzed by ANOVA with 95% confidence level and continued withDuncan’s multiple range tests. The results showed no difference on body weight of test animals in all treatments.The reduction percentage of fasting blood glucose levels from temu mangga rhizome extract by dosage of 400mg/kg bw (48.712%) was significantly different from the treatment of alloxan (0.588%) (p<0.05). The percentageof ? cells that undergo necrosis from temu mangga rhizome by dosages of 200, 400, and 800 mg/kg bw weresignificantly different with alloxan (22.75±3.68 %) (p<0.05). In conclusion, temu mangga rhizome extract bydosage of 400 mg/kg was optimum to decrease blood glucose levels and repair the pancreas histological damagein mice that were induced by alloxan.

scholarly journals Uji Efek Antidiabetik Ekstrak Daun Trembesi (Albizia saman (Jacq.) Merr) Terhadap Mencit (Mus musculus L)

WARTA FARMASI ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 43-52
Author(s):  
Muhammad Azdar Setiawan ◽  
Muhammad Syaiful Saehu ◽  
Kartini Kartini
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Mus Musculus ◽  
Leaf Extract ◽  
Positive Control ◽  
Negative Control ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Reduce Blood Glucose ◽  
Albizia Saman

ABSTRAK Daun trembesi (Albizia saman (Jacq.) Merr) adalah salah satu tanaman berkhasiat menurunkan kadar glukosa darah dimana kandungan kimianya berpotensi menurunkan kadar glukosa darah antara lain flavonoid yang bekerja dengan cara menstimulasi sel- sel beta dari pulau langerhans, sehingga sekresi insulin ditingkatkan.Penelitian ini bertujuan untuk mengetahui efek antidiabetes ekstrak daun trembesi (Albizia saman (Jacq.) Merr) pada mencit (Mus musculus). Metode Penelitian ini merupakan penelitian Eksperimen dimana sebanyak 20 ekor mencit dibuat diabetes dengan menggunakan Streptozotosin 150 mg/kgBB secara Intraperitonial. Kemudian dibagi menjadi 5 kelompok perlakuan, yaitu: Ekstrak dosis 25 mg/kgBB, 50 mg/kgBB, 100  mg/kgBB, sebagai kontrol positif Glibenclamid 5 mg dan kontrol negatif suspensi Na.CMC 0,5%. Data yang diperoleh dianalisis dengan uji ANOVA. Hasil analisa statistik menunjukan pada konsentrasi ekstrak 100 mg/kgBB memberikan efek yang optimum dengan perlakuan kontrol positif Glibenklamid.  Kata Kunci  : Ekstrak Daun Trembesi, Antidiabetik.  ABSTRACT Trembesi leaf (Albizia saman (Jacq.) Merr) is one of the efficacious plants to reduce blood glucose levels where the chemical content has the potential to reduce blood glucose levels, among others, flavonoids that work by stimulating beta cells of the island langerhans, so that insulin secretion is increased. It aims to determine the antidiabetic effect of trembesi leaf extract (Albizia saman (Jacq.) Merr) in mice (Mus musculus). This research method is an experimental study in which as many as 20 mice were made diabetic using Streptozotosin 150 mg / kgBW intraperitonially. Then divided into 5 treatment groups, namely: Extract dose 25 mg / kg body weight, 50 mg / kg body weight, 100 mg / kg body weight, as positive control Glibenclamid 5 mg and negative control suspension Na.CMC 0.5%. The data obtained were analyzed by ANOVA test. The results of statistical analysis showed that the extract concentration of 100 mg / kgBB gave the optimum effect with the positive control of Glibenclamide. Keywords: Trembesi Leaf Extract, Antidiabetic.

scholarly journals KADAR GLUKOSA DARAH MENCIT (MUS MUSCULUS) DIABETES MELLITUS PASKA PEMBERIAN MODEL LATIHAN ISOMETRIK

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Sonia Hardiyanti ◽  
Harmayetty Harmayetty ◽  
Ika Yuni Widyawati
Keyword(s):  
Blood Glucose ◽  
Mus Musculus ◽  
Isometric Exercise ◽  
Exercise Group ◽  
Diabetic Mice ◽  
Glucose Levels ◽  
The Third ◽  
Blood Glucose Levels ◽  
Decrease Blood Glucose ◽  
Kolmogorov Smirnov

Introduction: Based on the latest research, exercise had significant effect to decrease blood glucose. The aimed of this study was to investigate the effect of isometric exercise model on blood glucose in Diabetic Mice (Mus musculus).Methodes: This research was used a true experimental study with randomize post-test only control group design. The sample was male mice (Mus musculus) in 20-27 grams weight. 27 male mice were divided into three groups; the first group was normal group (control) that injected by NaCl as placebo, the second group was diabetic mice and the third group was diabetic mice with exercise. Both second group and third group were injected by streptozotocin (STZ) to induce Diabetes Mellitus. After 2x24 hours injected, all groups were given oral glucose (Dextrose-40% or D40). One hour after they given by D40, the third group was treated by isometric exercise used treadmill for 23.31 minutes with 21 cm/second speed and 0° elevation angle. Then the blood samples of all groups were taken to measure the blood glucose level. Data were analyzed by One Kolmogorov-Smirnov test, ANOVA test, and Least Significance Difference (LSD) with significance level of α<0.05.Result: The result of One Kolmogorov-Smirnov test showed that there was p=0.94 in normal group, p=0.50 in diabetic group, and p=0.19 in diabetic with exercise group. The result of ANOVA test was p=0.08. The result of LSD for blood glucose revealed was p=0.23 for diabetic group and diabetic with exercise group. The researcher had an assumption that probably it happened because of in second group there were two mice that had normal blood glucose levels and in the third group the initial blood glucose levels were unknown, hence they probably could had normal blood glucose levels too. Discussion: It can be concluded that there is no effect of isometric exercise to decrease blood glucose. Further research should investigate more about the frequency and intensity of isometric exercise that could has effect to decrease blood glucose.

scholarly journals Pengaruh Ekstrak Kulit Buah Manggis (Garcinia mangostana L.) terhadap Histologis Pankreas Mencit (Mus musculus L. Swiss Webster) yang Diinduksi Sukrosa

2018 ◽  
Vol 19 (1) ◽  
pp. 100-112
Author(s):  
Ramadhan Sumarmin
Keyword(s):  
Blood Glucose ◽  
Alternative Medicine ◽  
Mus Musculus ◽  
Islet Cells ◽  
Negative Control ◽  
Garcinia Mangostana ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Mangosteen Peel ◽  
Peel Extract

Diabetes Mellitus (DM) is a metabolic disorder caused by lack of insulin which islet cells of Langerhans in the pancreas were damaged or decreased. DM treatment is quite expensive so it takes the alternative medicine. Ones of alternative medicine using Mangosteen Fruit pod. The pod of the mangosteen fruit have xanton flavonoid compounds, which function as antioxidants that can lower blood glucose levels and improve pancreatic cells. The study aimed to determine the effect of mangosteen rind extract (Garcinia mangostana L.) to display the pancreatic histology of mice (Mus musculus L. Swiss Webster) induced male sucrose. This study used Completely Randomized Design (CRD) with 5 treatments and 5 replications. treatments is P1 (positive control), sucrose 0.8 g/kg (negative control / P2), sucrose + 200 mg/kg of mangosteen peel extract (P3), sucrose + 400 g/kg of mangosteen peel extract ( P4), sucrose + 600 mg/kg of mangosteen peel extract (P5). Observations quantitatively to determine blood glucose levels and the number of Langerhans islet cells after 5 days and 4 days inducing the extract. Data were analyzed by ANOVA, if there is a difference will be continued with Duncan test at the 0.05 significance level. The results showed the average number of Langerhans islet cells 205.6 (P1), 134.0 cells (P2), 114.2 cells (P3), 193.0 cell (P4), and 181.8 cells (P5). From the results obtained in the analysis of data obtained Fhitung<Ftabel significant at 0.05, so it can be concluded that the mangosteen rind extract has no effect on pancreatic histological induced male mice sucrose.

scholarly journals Pengaruh Pemberian Infusa Daun Kersen (Muntingia calabura L.) terhadap Kadar Glukosa Darah Mencit Putih (Mus musculus) yang Diberi Beban Glukosa

2019 ◽  
Vol 8 (2) ◽  
pp. 60-66
Author(s):  
Mira Febrina
Keyword(s):  
Blood Glucose ◽  
Mus Musculus ◽  
Animal Experiments ◽  
Negative Control ◽  
Control Group ◽  
Oral Glucose ◽  
Glucose Load ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Muntingia Calabura

A study on the effect of cherry leaf infusion (Muntingia calabura L.) on glucose levels of male white mice (Mus musculus) given glucose load. This study aims to see the effect of cherry leaf infusion (Muntingia calabura L.) to blood glucose levels of male white mice (Mus musculus) given glucose load as much as 0.65ml / 20gBB. This research used Oral Glucose Tolerance Test (TTGO) method. Animal experiments were divided into 6 groups. The negative control group was given only aquadest, the positive group was given metformin with the dosage of 1.3mg / 20gBB, the comparison group was given 0.65ml / 20gBB glucose solution, the treatment group was given cesen leaves infusion (Muntingia calabura L.) with concentration 5, 10 and 20 %. After each test animal was given 30 minutes treatment then given glucose 0.65ml / 20gBB orally. Then measured blood glucose levels of mice at minute 30-180. Based on the results of testing the infusion of kersen leaf (Muntingia calabura L.) showed that the concentrations of 5, 10 and 20% had decreased levels of white mice blood glucose (Mus musculus) with normal control. However, the results of the two-way ANOVA assay continued with the Post Hoc Tukey test showed that the concentration of 20% differed significantly with the concentrations of 5 and 10%. And the results obtained also indicate that the duration of administration may affect the decrease in blood glucose levels of mice (p <0.05).

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