Use of novel cystine analogs to decrease oxidative stress and control product quality

As technology advances at this time, players in business are aware of the importance of product quality in the increasingly fierce competition in the industrial world due to the emergence of many similar companies. Therefore, companies must be able to compete to meet customer desires and try to retain customers. To maintain customers and their marketing areas, companies must have high competitiveness in order to survive by prioritizing quality improvement, increasing efficiency and increasing productivity to improve quality because by increasing quality, products can be accepted among consumers so that company goals can be fulfilled. Therefore, the company must carry out effective quality control which will result in high productivity, lower overall cost of making goods and the factors that cause production failure to be minimized. To improve quality, use the six sigma method, DMAIC and seven tools so that it can be known the cause of the damage and what actions are taken so that there needs to be a controversy to stabilize the processes of the production process so that we can know what percentage of damage and what factors cause damage, therefore there must be measurements and recommendations for improvement and control to reduce the causes From the analysis, it was found that the dent cup was 20.36%, the lid was 21.36% less dense, the lid was damaged in the finished product 18.72%, the cup was 19.28% less thick, the packaging was flexible 20.55%Seiring kemajuan teknologi pada saat ini pelaku di bisnis menyadari akan pentingnya kualitas produk dalam persaingan dunia industri yang semakin ketat karena banyak bermunculan perusahaan-perusahaan sejenis. Oleh sebab itu perusahaan harus dapat bersaing untuk memenuhi keinginan pelanggan dan berusaha dapat mempertahankan pelanggan. Untuk mempertahankan pelangan dan wilayah pemasaranya perusahaan-perusahaan harus mempunyai daya saing yang tinggi untuk dapat bertahan dengan mengutamakan peningkatan mutu, peningkatan efisiensi dan peningkatan produktivitas untuk meningkatkan kualitas karena dengan peningkatan kualitas, produk dapat diterima di kalangan konsumen sehingga tujuan perusahaan dapat terpenuhi. Maka dari itu perusahaan harus melakukan pengendalian kualitas yang efektif akan menghasilkan produktivitas yang tinggi, biaya pembuatan barang keseluruhan yang lebih rendah serta faktor-faktor yang menyebabkan kegagalan produksi akan dapat ditekan sekecil mungkin. Untuk meningkatkan kualitas mengunakan metode six sigma, DMAIC dan seven tools agar dapat diketahui penyebab kerusakan dan tindakan apa saja yang dilakukan sehingga perlu ada kontror untuk menstabilkan peoses proses produksi sehinga dapat di ketahui berapa persen kerusakan dan faktor-faktor apa saja yang menyebabkan kerusakan maka dari itu harus ada pengukuran dan rekomendasi perbaikan serta melakukan kontrol untuk mengurangi penyebab kerusakan. Dari hasil analisis di ketahui cup penyok 20,36%, lid kurang rapat 21,36%, lid rusak pada produk jadi 18,72%,cup kurang tebal 19,28 %kemasan lentur 20,55%

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Association Between Magnesium and Oxidative Stress in Patients with Obesity

Current Nutrition & Food Science ◽

10.2174/1573401315666190730123842 ◽

2020 ◽

Vol 16 (5) ◽

pp. 743-748

Author(s):

Ana R.S. de Oliveira ◽

Kyria J.C. Cruz ◽

Jennifer B.S. Morais ◽

Juliana S. Severo ◽

Jéssica B. Beserra ◽

...

Keyword(s):

Oxidative Stress ◽

Thiobarbituric Acid ◽

Magnesium Concentration ◽

Control Group ◽

Compensatory Mechanism ◽

Thiobarbituric Acid Reactive Substances ◽

Magnesium Intake ◽

Significant Difference ◽

Dietary Magnesium ◽

And Control

Background: The role of minerals in preventing the generation of oxidative stress in obese individuals has been evaluated. Magnesium is an antioxidant nutrient and a cofactor of enzymes involved in the cell membrane stabilization, attenuating the effects of oxidative stress. Objective: To evaluate the association between magnesium and concentrations of thiobarbituric acid reactive substances (TBARS) in patients with obesity and eutrophic women. Methods: A cross-sectional study was conducted with 73 women, divided into two groups: case group (patients with obesity, n=27) and control group (eutrophic women, n=46). Measurements of body mass index and waist circumference were performed. Dietary magnesium intake was assessed by the three-day food record using the NutWin software. Urinary magnesium concentration was measured by atomic absorption spectrophotometry method. Plasma concentrations of thiobarbituric acid reactive substances (TBARS) were also determined. Results: Mean values of dietary magnesium intake were 161.59 ± 60.04 and 158.73 ± 31.96 for patients with obesity and control group, respectively, with no significant difference between the groups studied (p >0.05). The value of urinary excretion of magnesium was lower than the reference values in both groups, with no significant difference between the groups studied (p >0.05). The plasma concentration of thiobarbituric acid reactive substances was significantly higher in patients with obesity compared to the control group (p <0.001). There was no correlation between levels of magnesium biomarkers and the concentration of TBARS (p >0.05). Conclusion: Patients with obesity showed a reduced dietary magnesium intake which seems to induce hypomagnesuria as a compensatory mechanism. The marker of oxidative stress evaluated in this study was not influenced by magnesium.

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The Formation and Control of Ice Crystal and Its Impact on the Quality of Frozen Aquatic Products: A Review

Crystals ◽

10.3390/cryst11010068 ◽

2021 ◽

Vol 11 (1) ◽

pp. 68

Author(s):

Mingtang Tan ◽

Jun Mei ◽

Jing Xie

Keyword(s):

Product Quality ◽

Freezing Point ◽

Ice Crystals ◽

Affecting Factors ◽

Frozen Food ◽

Aquatic Products ◽

Size Number ◽

Underlying Mechanisms ◽

And Control ◽

Ice Crystallization

Although freezing has been used to delay the deterioration of product quality and extend its shelf life, the formation of ice crystals inevitably destroys product quality. This comprehensive review describes detailed information on the effects of ice crystals on aquatic products during freezing storage. The affecting factors (including nucleation temperature, freezing point, freezing rate, and temperature fluctuation) on the size, number, distribution, and shape of ice crystals are also elaborated in detail. Meanwhile, the corresponding technologies to control ice crystals have been developed based on these affecting factors to control the formation of ice crystals by inhibiting or inducing ice crystallization. In addition, the effects of ice crystals on the water, texture, and protein of aquatic products are comprehensively discussed, and the paper tries to describe their underlying mechanisms. This review can provide an understanding of ice crystallization in the aquatic products during freezing and contribute more clues for maintaining frozen food quality.

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Oxygen Is Instrumental for Biological Signaling: An Overview

Oxygen ◽

10.3390/oxygen1010002 ◽

2021 ◽

Vol 1 (1) ◽

pp. 3-15

Author(s):

John T. Hancock

Keyword(s):

Oxidative Stress ◽

Superoxide Anion ◽

Nitrosative Stress ◽

Redox Status ◽

Complex Interplay ◽

Wide Range ◽

Form Part ◽

High Concentrations ◽

And Control ◽

Signaling Components

Control of cellular function is extremely complex, being reliant on a wide range of components. Several of these are small oxygen-based molecules. Although reactive compounds containing oxygen are usually harmful to cells when accumulated to relatively high concentrations, they are also instrumental in the control of the activity of a myriad of proteins, and control both the upregulation and downregulation of gene expression. The formation of one oxygen-based molecule, such as the superoxide anion, can lead to a cascade of downstream generation of others, such as hydrogen peroxide (H2O2) and the hydroxyl radical (∙OH), each with their own reactivity and effect. Nitrogen-based signaling molecules also contain oxygen, and include nitric oxide (NO) and peroxynitrite, both instrumental among the suite of cell signaling components. These molecules do not act alone, but form part of a complex interplay of reactions, including with several sulfur-based compounds, such as glutathione and hydrogen sulfide (H2S). Overaccumulation of oxygen-based reactive compounds may alter the redox status of the cell and lead to programmed cell death, in processes referred to as oxidative stress, or nitrosative stress (for nitrogen-based molecules). Here, an overview of the main oxygen-based molecules involved, and the ramifications of their production, is given.

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Proanthocyanidins against Oxidative Stress: From Molecular Mechanisms to Clinical Applications

BioMed Research International ◽

10.1155/2018/8584136 ◽

2018 ◽

Vol 2018 ◽

pp. 1-11 ◽

Cited By ~ 12

Author(s):

Lingyu Yang ◽

Dehai Xian ◽

Xia Xiong ◽

Rui Lai ◽

Jing Song ◽

...

Keyword(s):

Oxidative Stress ◽

Signaling Pathways ◽

Molecular Mechanisms ◽

Metabolic Diseases ◽

Low Cost ◽

Natural Agents ◽

Molecular Damage ◽

And Control

Proanthocyanidins (PCs) are naturally occurring polyphenolic compounds abundant in many vegetables, plant skins (rind/bark), seeds, flowers, fruits, and nuts. Numerousin vitroandin vivostudies have demonstrated myriad effects potentially beneficial to human health, such as antioxidation, anti-inflammation, immunomodulation, DNA repair, and antitumor activity. Accumulation of prooxidants such as reactive oxygen species (ROS) exceeding cellular antioxidant capacity results in oxidative stress (OS), which can damage macromolecules (DNA, lipids, and proteins), organelles (membranes and mitochondria), and whole tissues. OS is implicated in the pathogenesis and exacerbation of many cardiovascular, neurodegenerative, dermatological, and metabolic diseases, both through direct molecular damage and secondary activation of stress-associated signaling pathways. PCs are promising natural agents to safely prevent acute damage and control chronic diseases at relatively low cost. In this review, we summarize the molecules and signaling pathways involved in OS and the corresponding therapeutic mechanisms of PCs.

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Biomarkers of oxidative stress in schizophrenic and control subjects

Prostaglandins Leukotrienes and Essential Fatty Acids ◽

10.1016/j.plefa.2006.11.003 ◽

2007 ◽

Vol 76 (2) ◽

pp. 73-85 ◽

Cited By ~ 48

Author(s):

J. Young ◽

S.B. McKinney ◽

B.M. Ross ◽

K.W.J. Wahle ◽

S.P. Boyle

Keyword(s):

Oxidative Stress ◽

Control Subjects ◽

And Control ◽

Biomarkers Of Oxidative Stress

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Product-Quality Based Scheduling of Automated Food Processing

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.1018.563 ◽

2014 ◽

Vol 1018 ◽

pp. 563-570

Author(s):

Marcel Wagner ◽

Tim Schleimer ◽

Tobias Seeberger ◽

Gunther Reinhart

Keyword(s):

Product Quality ◽

Production Planning ◽

Food Processing ◽

Crucial Role ◽

Classical Field ◽

Shop Floor ◽

Production Planning And Control ◽

Optimization Criteria ◽

Planning And Control ◽

And Control

Production Planning and Control (PPC) does not only play an important role in the classical field of production. Concerning a trend to more customer related products and a so called buyers market, also the not yet strongly automated businesses have to think about topics like PPC. By forming a new automated shop floor in a commercial kitchen for example, new optimization criteria in the PPC play a crucial role. Especially in the manner of scheduling jobs different constraints concerning the handled products come up. This paper demonstrates a possibility to extend the criteria of PPC with the subjective parameter of product quality. This approach allows influencing an oven-control to reach the best product quality in its processing.

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The Effect of an Encapsulated Nutrient Mixture on Food Intake and Satiety: A Double-Blind Randomized Cross-Over Proof of Concept Study

Nutrients ◽

10.3390/nu10111787 ◽

2018 ◽

Vol 10 (11) ◽

pp. 1787 ◽

Cited By ~ 5

Author(s):

Annick Alleleyn ◽

Mark van Avesaat ◽

Dina Ripken ◽

Sinéad Bleiel ◽

Daniel Keszthelyi ◽

...

Keyword(s):

Small Intestine ◽

Food Intake ◽

Area Under The Curve ◽

Double Blind ◽

Distal Small Intestine ◽

Active Product ◽

Non Invasive ◽

Control Product ◽

Scale Scores ◽

And Control

Activation of the intestinal brake by infusing nutrients into the distal small intestine with catheters inhibits food intake and enhances satiety. Encapsulation of macronutrients, which protects against digestion in the proximal gastrointestinal tract, can be a non-invasive alternative to activate this brake. In this study, we investigate the effect of oral ingestion of an encapsulated casein and sucrose mixture (active) targeting the distal small intestine versus a control product designed to be released in the stomach on food intake, satiety, and plasma glucose concentrations. Fifty-nine volunteers received the active and control product on two separate test days. Food intake was determined during an ad libitum meal 90 min after ingestion of the test product. Visual analogue scale scores for satiety and blood samples for glucose analysis were collected at regular intervals. Ingestion of the active product decreased food intake compared to the control product (655 kcal compared with 699 kcal, respectively, p < 0.05). The area under the curve (AUC) for hunger was decreased (p < 0.05) and AUC for satiety was increased (p < 0.01) after ingestion of the active product compared to the control product. Ingestion of an encapsulated protein-carbohydrate mixture resulted in inhibition of food intake compared to a non-encapsulated control product.

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Blood Exosomes Have Neuroprotective Effects in a Mouse Model of Parkinson’s Disease

Oxidative Medicine and Cellular Longevity ◽

10.1155/2020/3807476 ◽

2020 ◽

Vol 2020 ◽

pp. 1-14

Author(s):

Ting Sun ◽

Zhe-Xu Ding ◽

Xin Luo ◽

Qing-Shan Liu ◽

Yong Cheng

Keyword(s):

Oxidative Stress ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Amino Acid ◽

Dopaminergic Neurons ◽

Motor Coordination ◽

Oxidized Lipids ◽

Metabolomic Analysis ◽

Neuroprotective Effects ◽

And Control

Parkinson’s disease (PD) is a common and complex neurodegenerative disease; the pathogenesis of which is still uncertain. Exosomes, nanosized extracellular vesicles, have been suggested to participate in the pathogenesis of PD, but their role is unknown. Here, a metabolomic analysis of serum and brain exosomes showed differentially expressed metabolites between 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine hydrochloride- (MPTP-) induced PD mice and control mice, such as oxidized lipids, vitamins, and cholesterol. These metabolites were enriched in coenzyme, nicotinamide, and amino acid pathways related to PD, and they could be served as preclinical biomarkers. We further found that blood-derived exosomes from healthy volunteers alleviated impaired motor coordination in MPTP-treated mice. Results from immunohistochemistry and western blotting indicated that the loss of dopaminergic neurons in substantia nigra and striatum of PD model mice was rescued by the exosome treatment. The exosome treatment also restored the homeostasis of oxidative stress, neuroinflammation, and cell apoptosis in the model mice. These results suggest that exosomes are important mediators for PD pathogenesis, and exosomes are promising targets for the diagnosis and treatment of PD.

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