Inhibition of muscle growth in foetal sheep

1973 ◽  
Vol 80 (3) ◽  
pp. 503-509 ◽  
Author(s):  
H. J. Swatland ◽  
R. G. Cassens
Keyword(s):  
Maternal Nutrition ◽  
Muscle Growth ◽  
Dry Weight ◽  
Linear Size ◽  
Morphological Evidence ◽  
Longissimus Dorsi ◽  
Allometric Growth ◽  
Inhibition Of Growth ◽  
Muscle Histology ◽  
The Relationship

SummaryEighteen foetal sheep were used to study the relationship between suboptimal growth and linear size of skeletal units, dry weights of representative muscles and muscle histology. Foetuses with suboptimal growth caused by inadequate maternal nutrition and competition with other foetuses showed a decrease in skeletomuscular growth although allometric growth was not affected. A slight correlation (r =0·14, P < 0·005) existed between dry weight of the longissimus dorsi and mean minimum myofibre diameter. On morphological evidence, myofibre hyperplasia was thought to be complete by approximately 80 days gestation in all foetuses. Increases in the number of myofibres crossing mid-length transverse sections of the sartorius occurred after this time but were thought to be due to intrafascicularly terminating myofibres growing in length. Suboptimal muscle growth of foetuses in the latter third of gestation was thought to be associated with an inhibition of growth in length of intrafascicularly terminating myofibres.

0697 Effects of poor maternal nutrition during gestation on offspring prenatal muscle growth

2016 ◽  
Vol 94 (suppl_5) ◽  
pp. 333-334
Author(s):  
S. M. Pillai ◽  
A. K. Jones ◽  
M. L. Hoffman ◽  
K. K. McFadden ◽  
S. A. Zinn ◽  
...  
Keyword(s):  
Maternal Nutrition ◽  
Muscle Growth

scholarly journals PSIX-29 JAK2-STAT3 Pathway Mediated Satellite Cell Apoptosis to Govern Skeletal Muscle Growth with Lysine

2020 ◽  
Vol 98 (Supplement_4) ◽  
pp. 334-334
Author(s):  
Zhi-wen Song ◽  
Cheng-long Jin ◽  
Mao Ye ◽  
Chun-qi Gao ◽  
Hui-chao Yan ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Growth ◽  
Longissimus Dorsi ◽  
Control Group ◽  
Stat3 Pathway ◽  
Skeletal Muscle Growth ◽  
Longissimus Dorsi Muscle ◽  
Dorsi Muscle ◽  
Pathway Inhibition ◽  
Induced Apoptosis

Abstract Apoptosis is programmed cell death that can be stimulated by external stress or nutrition restrictions. Lysine (Lys) is an essential amino acid for pig growth, and the relationship between Lys deficiency caused apoptosis and inhibition of skeletal muscle growth remains unknown. The objective of this study was to investigate whether apoptosis could be regulated by Lys supplementation and the potential mechanism. In current work, 30 male Duroc × Landrace × Large weaned piglets were divided randomly into 3 groups: control group (Lys 1.30%), Lys deficiency group (Lys 0.86%), and Lys rescue group (Lys 0.86%, 0-14d; 1.30%,15–28 d). The experiment lasted for 28 days, and on the morning of 29 d, piglets were slaughtered to collect samples. Isobaric tag for relative and absolute quantification (iTRAQ) proteomics analysis of the longissimus dorsi muscle showed that Janus family tyrosine kinase (JAK)-signal transducer and activator of transcription (STAT) pathway was involved in Lys deficiency-induced apoptosis and inhibited skeletal muscle growth. Meanwhile, western blotting results of the longissimus dorsi muscle demonstrated that Lys deficiency caused apoptosis (P &lt; 0.05) with the JAK2-STAT3 pathway inhibition (P &lt; 0.05). Interestingly, apoptosis was suppressed (P &lt; 0.05), and the JAK2-STAT3 pathway was reactivated (P &lt; 0.05) after Lys re-supplementation in longissimus dorsi muscle. In addition, results of satellite cells (SCs) isolated from the longissimus dorsi muscle of 5-day-old Landrace piglets showed that Lys deficiency-induced apoptosis (P &lt; 0.05) was mediated by the JAK2-STAT3 pathway inhibition (P &lt; 0.05). Moreover, the JAK2-STAT3 pathway was reactivated (P &lt; 0.05) by Lys re-supplementation and suppressed apoptosis in SCs (P &lt; 0.05), and this effect was blocked (P &lt; 0.05) after SCs treated with AG-490 (a specific inhibitor of JAK2). Collectively, Lys inhibited apoptosis in SCs to govern skeletal muscle growth via the JAK2-STAT3 pathway.

scholarly journals Morphological Evidence of Telocytes in Skeletal Muscle Interstitium of Exercised and Sedentary Rodents

Biomedicines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 807
Author(s):  
Silvia Ravalli ◽  
Concetta Federico ◽  
Giovanni Lauretta ◽  
Salvatore Saccone ◽  
Elisabetta Pricoco ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Atrophy ◽  
Stromal Cells ◽  
Tibialis Anterior Muscle ◽  
Skeletal Muscle Atrophy ◽  
Morphological Evidence ◽  
Double Positive ◽  
Functional Changes ◽  
Cell Niche ◽  
The Relationship

Skeletal muscle atrophy, resulting from states of hypokinesis or immobilization, leads to morphological, metabolic, and functional changes within the muscle tissue, a large variety of which are supported by the stromal cells populating the interstitium. Telocytes represent a recently discovered population of stromal cells, which has been increasingly identified in several human organs and appears to participate in sustaining cross-talk, promoting regenerative mechanisms and supporting differentiation of local stem cell niche. The aim of this morphologic study was to investigate the presence of Telocytes in the tibialis anterior muscle of healthy rats undergoing an endurance training protocol for either 4 weeks or 16 weeks compared to sedentary rats. Histomorphometric analysis of muscle fibers diameter revealed muscle atrophy in sedentary rats. Telocytes were identified by double-positive immunofluorescence staining for CD34/CD117 and CD34/vimentin. The results showed that Telocytes were significantly reduced in sedentary rats at 16 weeks, while rats subjected to regular exercise maintained a stable Telocytes population after 16 weeks. Understanding of the relationship between Telocytes and exercise offers new chances in the field of regenerative medicine, suggesting possible triggers for Telocytes in sarcopenia and other musculoskeletal disorders, promoting adapted physical activity and rehabilitation programmes in clinical practice.

Cold tolerance of the Antarctic springtail Gomphiocephalus hodgsoni (Collembola, Hypogastruridae)

2001 ◽  
Vol 13 (3) ◽  
pp. 271-279 ◽  
Author(s):  
Brent J. Sinclair ◽  
Heidi Sjursen
Keyword(s):  
Cold Tolerance ◽  
Thermal Environment ◽  
Strong Relationship ◽  
Dry Weight ◽  
Glycerol Content ◽  
Recrystallization Inhibition ◽  
Low Levels ◽  
Inhibition Studies ◽  
The Antarctic ◽  
The Relationship

Cold tolerance of the springtail Gomphiocephalus hodgsoni Carpenter (Collembola: Hypogastruridae) was studied at Cape Bird, Ross Island, Antarctica (77°13′S, 166°26′E). Microclimate temperatures indicate a highly seasonal thermal environment, with winter minima <–39°C. Snow cover significantly buffers both minimum temperatures and cooling rates. Gomphiocephalus hodgsoni survives low temperatures by avoiding freezing. Mean low group supercooling points (SCPs) ranged from –35.4°C in October to –28.3°C in January. The lowest SCP measured was –38.0°C. The high SCP group was very small, making up only 18% of the population in January. In October, G. hodgsoni had a very high glycerol content (>80 μg mg−1 dry weight), although this declined rapidly to low levels (c. 7–10 μg mg−1 dry weight) in January. Quantities of glucose and trehalose were low during October, but steadily increased throughout the summer. Haemolymph osmolality was exceptionally high (up to 1755 mOsm kg−1) at the end of November, but this rapidly declined to c. 500 mOsm kg−1 by late December. The presence of thermal hystersis proteins was indicated by both osmometry on haemolymph samples and recrystallization inhibition studies of springtail homogenates. There was a strong relationship between glycerol content and SCP, but the relationship between haemolymph osmolality, SCP and carbohydrates is uncertain.

scholarly journals Circulating levels of IGF1 are associated with muscle strength in middle-aged- and oldest-old women

2011 ◽  
Vol 164 (2) ◽  
pp. 189-196 ◽  
Author(s):  
Diana G Taekema ◽  
Carolina H Y Ling ◽  
Gerard Jan Blauw ◽  
Carel G Meskers ◽  
Rudi G J Westendorp ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Physical Performance ◽  
Handgrip Strength ◽  
Oldest Old ◽  
Muscle Growth ◽  
Serum Levels ◽  
Middle Aged ◽  
Cross Sectional ◽  
The Relationship ◽  
Circulating Levels

ObjectiveIn aging populations, poor handgrip strength has been associated with physical disability and mortality. IGF1 is an important mediator of muscle growth and regeneration affecting muscle function. We studied the relationship between circulating levels of IGF1, its binding protein 3 (IGFBP3), and handgrip strength and physical performance in middle-aged- and oldest-old subjects.DesignCross-sectional analysis in two different cohorts composed of middle-aged- (n=672, mean 63.9±6.7 years) and oldest-old subjects (n=272, all 89 years).MethodsHandgrip strength, functional performance and ability, and serum levels of IGF1 and IGFBP3 were measured in all subjects and analyzed by linear regression for men and women separately.ResultsIGF1 and IGFBP3 levels declined with chronological age and were positively associated with handgrip strength in middle-aged- and oldest-old women (both, P<0.05), but not in men of either age group. Furthermore, higher serum levels of IGF1 were associated with slower walking speed in oldest-old men (P=0.012), and serum levels of IGFBP3 were positively associated with activities of daily living in the oldest-old women (P=0.002).ConclusionThe significant relationship between IGF1 levels and muscle strength found in women but not in men suggests a gender-specific influence of IGF1 on muscle strength. Further studies are necessary to test the relationship with physical performance.

Seborrheic Dermatitis of Infants: Treatment with Biotin Injections for the Nursing Mother

PEDIATRICS ◽  
1969 ◽  
Vol 44 (6) ◽  
pp. 1014-1016
Author(s):  
Aaron Nisenson
Keyword(s):  
Breast Milk ◽  
Maternal Nutrition ◽  
Seborrheic Dermatitis ◽  
Cow’S Milk ◽  
Blood Levels ◽  
Biotin Deficiency ◽  
Nursing Mother ◽  
Limited Experience ◽  
The Relationship ◽  
Breast Fed

Four cases of extensive seborrheic dermatitis or Leiner's disease are presented which dramatically improved after the nursing mother was given injections of biotin. The relationship between seborrheic dermatitis in infants and biotin deficiency is discussed and the literature reviewed. From this review it appears that breast milk is deficient in biotin in comparison to cow's milk. The deficiency is further aggravated by poor maternal nutrition. Infection and diarrhea in the infant may also contribute to low blood levels of biotin. On the basis of this limited experience, injections of biotin to the nursing mother appear to be a useful treatment for the breast-fed infant with extensive seborrheic dermatitis.

scholarly journals Allometric equation of local bamboo for estimating carbon sequestration of bamboo riparian forest

2021 ◽  
Vol 905 (1) ◽  
pp. 012002
Author(s):  
C Prayogo ◽  
C Muthahar ◽  
R M Ishaq
Keyword(s):  
Land Use ◽  
Carbon Sequestration ◽  
Riparian Forest ◽  
Dry Weight ◽  
Allometric Equation ◽  
Total Carbon ◽  
Destructive Sampling ◽  
Industrial Activities ◽  
Bamboo Stem ◽  
The Relationship

Abstract The cause of global warming is the increasing carbon concentration arising from industrial activities, burning of fossils, and land-use change. The purpose of this research was to find out the allometric equation to calculate the local bamboo biomass and then to be able to calculate how much carbon sequestration at bamboo riparian forest since this area was rarely being explored. The parameters observed were the height and diameter of the bamboo stem at 1.3 m height of 6 types of local bamboo using destructive sampling, along with the measurement of bamboo weight. The carbon content of the bamboo biomass, litter, and soil was measured to complement the estimation of total carbon sequestration. The results showed that the allometric equation for estimating local bamboo biomass is Y=0.6396 X1.6162 with R2=0.77, obtained from the relationship equations between dry weight and the diameter. Total carbon sequestration of this system ranged between 81 to 215 tons C ha−1.

scholarly journals Relación entre el peso freco y el peso seco del rastrojo de maíz en diferentes estados fenológicos del cultivo.

2016 ◽  
Vol 8 (1) ◽  
pp. 20 ◽  
Author(s):  
M. Bänziger ◽  
G. O. Edmeades ◽  
J. Bolaños
Keyword(s):  
Dry Matter ◽  
Dry Weight ◽  
Important Variable ◽  
Growth Stages ◽  
Simple Method ◽  
Plant Parts ◽  
Maturity Period ◽  
Area Unit ◽  
Drying Conditions ◽  
The Relationship

The amount of dry matter produced during various stages of corn growth is a important variable to be taken into consideration. However, the lack of drying facilities makes its measurement a difficult task in the fields. A simple method to convert the fresh weight of a crop in the field into dry weight, could be an answer to that problem. In this study, we calculated the relationship between fresh and dry weight of corn stovers, over several, growth, stages of eight corn cultivars of different vigour and maturity period, at two Mexican locations. The differences between cultivars were for percent stover dry weight (%SDW) most evident in the second half of the grain growth stage, when late cultivars showed less humidity than the early ones. The % SDW was regressed against the phenological developmental stage and expressed as a ratio against antesis (R, days to sampling /days to 50% antesis). The equations (R2 = 0.97 - 0.99) with best results were: Early maturing cultivars: %SDW = 12.6 + 0.94R2 + 1.68R4; Late: %SDW = 16.1 - 4.00 R2 + 3.36R4. There were no consistant differences among cultivars with different vigour levels, even though certain differences were noted among the locations and they were attributed to differences in relative humidity. We describe a protocol for determining the dry weight of corn stover by area unit (t/ha) when drying conditions are not available, by utilizing only a scale and a ruler.We also suggest a method to calculate percent dry matter for a real plant parts (including grain).

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