scholarly journals The incidence ofHerpesvirus hominisantibody in the population

1967 ◽  
Vol 65 (3) ◽  
pp. 395-408 ◽  
Author(s):  
Isabel W. Smith ◽  
J. F. Peutherer ◽  
F. O. MacCallum

Sera from 1029 individuals, 864 from Edinburgh and 165 from Oxford, have been examined for the presence of antibodies toHerpesvirus hominis. The results of the smaller Oxford survey did not reveal a higher incidence of antibody where direct comparison was possible with those from Edinburgh.The incidence of both complement-fixing and neutralizing antibodies in the sera from 710 people in Edinburgh with ages varying from 1 month to 92 years was compared with the more complete of the earlier surveys, and in particular with that of Holzelet al.(1953) in Manchester, England. This comparison revealed a lower incidence of antibody in people under 25 in Edinburgh in 1965.Results obtained with sera from medical students in Oxford and Edinburgh and from nurses in Edinburgh were in agreement with those of previous surveys. The low incidence of antibody in these young people emphasized the possible occupational risk of infection from patients and that primary herpetic infection might be encountered more frequently than before in teenagers and young adults.

BMJ Open ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. e038471
Author(s):  
Rachel M Taylor ◽  
Lorna A Fern ◽  
Julie Barber ◽  
Javier Alvarez-Galvez ◽  
Richard Feltbower ◽  
...  

ObjectivesIn England, healthcare policy advocates specialised age-appropriate services for teenagers and young adults (TYA), those aged 13 to 24 years at diagnosis. Specialist Principal Treatment Centres (PTC) provide enhanced TYA age-specific care, although many still receive care in adult or children’s cancer services. We present the first prospective structured analysis of quality of life (QOL) associated with the amount of care received in a TYA-PTCDesignLongitudinal cohort study.SettingHospitals delivering inpatient cancer care in England.Participants1114 young people aged 13 to 24 years newly diagnosed with cancer.InterventionExposure to the TYA-PTC defined as patients receiving NO-TYA-PTC care with those receiving ALL-TYA-PTC and SOME-TYA-PTC care.Primary outcomeQuality of life measured at five time points: 6, 12, 18, 24 and 36 months after diagnosis.ResultsGroup mean total QOL improved over time for all patients, but for those receiving NO-TYA-PTC was an average of 5.63 points higher (95% CI 2.77 to 8.49) than in young people receiving SOME-TYA-PTC care, and 4·17 points higher (95% CI 1.07 to 7.28) compared with ALL-TYA-PTC care. Differences were greatest 6 months after diagnosis, reduced over time and did not meet the 8-point level that is proposed to be clinically significant. Young people receiving NO-TYA-PTC care were more likely to have been offered a choice of place of care, be older, from more deprived areas, in work and have less severe disease. However, analyses adjusting for confounding factors did not explain the differences between TYA groups.ConclusionsReceipt of some or all care in a TYA-PTC was associated with lower QOL shortly after cancer diagnosis. The NO-TYA-PTC group had higher QOL 3 years after diagnosis, however those receiving all or some care in a TYA-PTC experienced more rapid QOL improvements. Receipt of some care in a TYA-PTC requires further study.


2020 ◽  
Vol 3 (5) ◽  
pp. 131-136
Author(s):  
Anna V. Semyonova ◽  

This paper presents a theoretical analysis of a study of the problem of predisposition to risk in teenagers and young adults. The article describes the features of the manifestation of risky behavior, considers the constructive and destructive types of manifestation of risk in adolescence. The theoretical study examines the biological basis of the need for predisposition to risk in adolescence, as well as characterological fea-tures that indicate varying degrees of risk predisposition and change throughout a per-son's life. The presented work will be useful for students of pedagogical and psychological areas of education, teachers of secondary specialized and higher educational institutions, teachers, parents of teenagers, educational psychologists, practicing psychologists in the area of family counseling, as well as individual counseling for.


Author(s):  
Tom Boterberg ◽  
Karin Dieckmann ◽  
Mark Gaze

Chapter 1 introduces the topic of cancer in children, teenagers, and young adults. Cancer in children and young people is rare: less than 1% of total cancer incidence. There is a wide variety of tumour types, and these are often different from the common adult cancers. Leukaemia, brain tumours, and malignancies of embryonal origin are most common in younger children. Genetic predisposition is important. Environmental causes are less common than in adults. Treatments have improved significantly and, currently, about three out of four children and young people are cured of their cancer. Multimodality protocols including chemotherapy, surgery, and, more frequently now, biological treatment, in addition to selective use of more sophisticated radiotherapy techniques, is the norm. Increasing personalization of treatment based on risk stratification has allowed for improved cure rates with a reduction in treatment-related morbidity.


2020 ◽  
Vol 23 (2) ◽  
pp. 133-152
Author(s):  
Kamil Janowicz

Although it is generally assumed that experiences related to being in a romantic relationship are important for forming attitudes toward being a parent, yet there has been no reliable empirical evidence for that. Two empirical studies have been conducted to examine relations between status and length of romantic relationship and vision of own parenting (VOP). The first of them was conducted on 178 teenagers and young adults aged from 18 to 32 with the use of a survey related to predictions about being a parent in the future. In the second study, conducted on 413 young people aged from 17 to 29, the Vision of Own Parenting Questionnaire (VOPQ) was used. The structure and the content of the vision of own parenting of singles and people involved in a romantic relationship were compared. Relations between time spent in this relationship and extension of the VOP were also subject to examination. The results of both studies revealed that people involved in a romantic relationship value parenthood higher than singles, have a more extended vision of their own parenting, and have a greater desire to participate in different forms of preparation for being a parent. They also predicted more positive changes in the relationship with a life partner after childbirth, and had fewer doubts about being a parent in the future. These findings support the common thought and some theoretical concepts that being in a romantic relationship is related to forming attitudes toward being a parent in the future.


2007 ◽  
Vol 12 (6) ◽  
pp. 7-8 ◽  
Author(s):  
Marta Pires de Miranda ◽  
M Carmo Gomes ◽  
H Rebelo de Andrade

The last case of poliomyelitis in Portugal caused by indigenous wild poliovirus occurred in 1986 and the country was declared polio-free in 2002. High levels of immunity must be maintained to prevent the importation of wild poliovirus. In this study, we determined the immunity against poliomyelitis of the Portuguese population in order to identify possible immunity gaps. A representative sample of 1,133 individuals older than two years residing in mainland Portugal was studied. Logistical difficulties regarding quick sample transportation precluded the Portuguese islands (Madeira and the Azores) from this study. Sera were collected in 2002 from individuals attending health clinics throughout the 18 districts of Portugal. Levels of neutralizing antibodies against poliovirus types 1, 2 and 3 were determined and a titre of >= 1:8 was defined as indicative of protected immunity. Results were expressed in international units. The antibody prevalence and the geometric mean antibody concentration (GMAC) was 91.6% (GMAC: 2.96 IU/ml), 94.2% (GMAC: 5.03 IU/ml) and 75% (GMAC: 0.53 IU/ml) for poliovirus types 1, 2 and 3, respectively. For poliovirus types 1 and 2, antibody prevalence was close to or above 90% in the majority of age groups. For poliovirus type 3, antibody prevalence was below 80% in teenagers and young adults. Our study shows that the Portuguese are well protected against poliovirus types 1 and 2. For poliovirus type 3, the suboptimal antibody levels observed in teenagers and young adults suggest the need for a booster dose to minimise the risk of wild poliovirus importation.


2018 ◽  
Vol 133 (1_suppl) ◽  
pp. 54S-64S ◽  
Author(s):  
Tamar Mendelson ◽  
Kristin Mmari ◽  
Robert W. Blum ◽  
Richard F. Catalano ◽  
Claire D. Brindis

Approximately 1 in 9 teenagers and young adults aged 16-24 in the United States is currently disconnected from school and employment. These disconnected young people (ie, opportunity youth) are not only at high risk for long-term emotional, behavioral, and health problems, but they also represent a loss of human capital, with high social and economic costs. In this article, we offer a public health perspective on opportunity youth by describing their distribution in the population and consequences of their disconnection; proposing a conceptual model of the issue based on epidemiological principles, life course development concepts, and ecological theory; and recommending multisector strategies for preventing disconnection of young people and reengaging opportunity youth. A public health approach to the problem of opportunity youth would involve developing and investing in youth monitoring data systems that can be coordinated across multiple sectors, consolidating both the delivery and funding of services for opportunity youth, developing policies and programs that encourage engagement of young people, and fostering systematic approaches to the testing and scaling up of preventive and reengagement interventions.


2000 ◽  
Vol 90 (1) ◽  
pp. 121-122 ◽  
Author(s):  
Richard Pollard

The incidence of left-handed writing among 590 young Bulgarian adults was 6.4%, significantly lower than that reported in two studies of students in the United States. Of those writing with the right hand, 10.8% stated that they had been forced to change their preferred hand for writing. The parents of the Bulgarian sample had a similar low incidence of left-handed writing (5.9%). Left-handed writing was almost three times more likely if one or both of the parents wrote with the left hand.


Author(s):  
I.S. Lisecka ◽  
◽  
M.M. Rozhko ◽  

Numerous studies in recent years have shown that the prevalence of dental disease, periodontal tissue and dental anomalies remains high among children, despite the development and implementation of new prevention and treatment regimens. Thus, the prevalence of dental caries in children in the period of temporary occlusion reaches 80–90%, in the period of permanent occlusion — 70–80%. The prevalence of chronic catarrhal gingivitis in children 12–15 years of age is 70–80%, reaching 95–98% in some regions, and localized and generalized periodontitis – 4.1–16.4%. It is known that the pathogenesis of dental diseases is closely related to the presence of a bad habit — smoking, mostly there is a strict correlation between the intensity and experience of smoking and the emergence and development of pathological changes in various organs and systems, including the oral cavity. Maintaining proper oral hygiene is an important factor influencing the occurrence of periodontal disease. It is known that the formation of oral care skills is formed in childhood, so the study of oral hygiene and the level of hygienic knowledge in adolescents with healthy periodontitis and catarrhal gingivitis in order to further develop a scheme of preventive measures remains one of the most important areas of pediatric dentistry. Purpose — to study the level of hygienic oral care and knowledge in teenagers and young adults who smoke. Materials and methods. The level of knowledge on the observance of individual oral hygiene in 87 people aged 15 to 24 years was studied. The main group included 40 adolescents and young people who smoked, in the comparison group we included 47 people of the same age without a bad habit of smoking. Results. It was found that the majority of all respondents have information on how to properly care for the hygiene of RP, respectively 67.54±3.75% — in the main group, 72.78±4.81% — in the comparison group. However, not all respondents have the full amount of information, as indicated by 23.43±7.51% of adolescents and young people in the main group and 17.86±6.42%. In addition, the individual assessment of their own oral care skills according to the respondents revealed that not all respondents regularly oral care. In the main group only 59.56±4.61% indicated regular oral care, which was 1.4 times less than in the comparison group 81.42±5.73% (p<0.001). Conclusions. It is necessary to conduct additional hygienic training, mandatory reinformation on the risks of dental diseases, in order to form a system of sustainable understanding and awareness of the need for adolescents and young people to observe individual oral hygiene. Particular attention should be paid to aspects of the emergence and rooting of bad habits, namely the bad habit of smoking, both traditional and alternative types of smoking, which adversely affects somatic and dental health, because it is known that without smoking it is impossible to achieve sustainable and long-term results of treatment and prevention measures. The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local Ethics Committee of all participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key words: teenager, young adult, oral hygiene, smoking.


Blood ◽  
2013 ◽  
Vol 122 (21) ◽  
pp. 57-57 ◽  
Author(s):  
Clare Rowntree ◽  
Rachael E Hough ◽  
Rachel Wade ◽  
Nicholas Goulden ◽  
Chris Mitchell ◽  
...  

Abstract Background Outcomes for adults with acute lymphoblastic leukaemia (ALL) have traditionally been inferior to outcomes for children, with differences in survival being noted from adolescence onwards. The reasons for the declining cure rates with increasing age are likely to be multi factorial but the choice of treatment protocol has been shown to play an important role in outcomes for teenagers and young adults (TYAs) with ALL. Over the past decade there has been increasing evidence of better outcomes for TYAs treated on paediatric regimens compared to adult regimens. Historically, 15-17 year olds treated on the adult UKALL XII trial had about 15% lower 5-year probability of both overall survival (OS) and event-free survival (EFS) compared to those treated on the corresponding paediatric ALL 97/99 trial during the same period, with the EFS difference not accounted for by age, gender, WBC or Ph status. (Ramanujachar et al. Pediatr Blood Cancer. 2007 Mar;48(3):254-61). UKALL 2003 was a randomised controlled trial investigating treatment modification according to Minimal Residual Disease (MRD) status at the end of induction and week 11, in consecutively diagnosed children and young people with Philadelphia negative ALL recruited from the UK and Republic of Ireland between October 2003 and June 2011. The trial was initially open to children up to the age of 18 years but the upper age limit was increased to 20th birthday in 2006 and 25th birthday in 2007. Here we report the outcomes for the 16 – 24 year old teenage and young adult (TYA) patients recruited to the trial from 2003-2011. Results A total of 229 out of 3126 patients entered were aged 16-24 years (7.3%), although only 56 patients were over 20 years of age at diagnosis. With follow up to October 2012, the 5-year EFS for the 16-24 year old cohort was 72% (95% CI: 66-79%) compared to an EFS for 1-10 year olds and 10-15 year olds of 90% (88-91%) and 84% (80-87%) respectively, p(trend)<0.0001. At the last analysis, 37 TYA patients had relapsed with a 5-year cumulative risk of relapse of 21% (14-27%), compared to 11% (8-14%) for the 10-15 year olds and 7% (6-9%) for the 1-10 year olds, p(trend)<0.0001. Within UKALL 2003 there was no significant increase in reported toxicities in the 16-24 year age group compared to the 10-15 year age group. The induction death rate was 2.2% for 16-24 year olds, 2.1% for 10-15 year olds and 1.2% for under 10 year olds. 53% of TYA patients had one or more serious adverse event (SAE) reported compared to 56% for 10-15 year olds and 31% for under 10 years. The SAEs reported were primarily infections and expected toxicities related to steroids, pegylated asparaginase and methotrexate. There was a trend (p=0.05) towards an increase in deaths in remission in the TYA age group at 6.1% compared to 3.1% in the 10-15 year olds. Outcomes in TYAs were analysed by MRD status as previously described (Vora et al. Lancet Oncol. 2013 Mar;14(3):199-209). There was an increase in the proportion of TYA patients with persistent MRD positivity compared to the younger patient groups; 49% were MRD high risk, 24% were MRD low risk and 27% MRD indeterminate compared to 32%, 36% and 32% respectively for patients under 16 years, p<0.0001. MRD was highly predictive of outcome in the TYA age group, as in the trial overall. Five-year EFS for those aged 16-24 was 64% (95% CI: 54-74%) for MRD high risk patients, 71% (58-84%) for MRD indeterminate and 93% (86-100%) for MRD low risk; MRD high risk vs low risk, p=0.0003. The TYA EFS compares favourably with the 10-15 year old cohort with EFS of 74% (68-81%), 83% (77-88%) and 95% (91-99%) respectively. Conclusion This large randomised study provides evidence that TYAs with ALL can be treated on a national paediatric trial with toxicities similar to those seen in younger teenagers. Outcomes are significantly improved using this approach in TYAs compared to the historical, transplant focused adult ALL regimens. MRD based risk stratification in this age group remains a valid approach with low risk patients having an unprecedented 93% EFS at 5 years. Further intensification of therapy for MRD high risk patients, possibly including transplantation may be required for the MRD high risk TYA patients and this question is being examined in the next national trial, UKALL 2011. Disclosures: No relevant conflicts of interest to declare.


2016 ◽  
Vol 04 (01) ◽  
pp. 4-10

AbstractImmunosuppression permits graft survival after transplantation and consequently a longer and better life. On the other hand, it increases the risk of infection, for instance with cytomegalovirus (CMV). However, the various available immunosuppressive therapies differ in this regard. One of the first clinical trials using de novo everolimus after kidney transplantation [1] already revealed a considerably lower incidence of CMV infection in the everolimus arms than in the mycophenolate mofetil (MMF) arm. This result was repeatedly confirmed in later studies [2–4]. Everolimus is now considered a substance with antiviral properties. This article is based on the expert meeting “Posttransplant CMV infection and the role of immunosuppression”. The expert panel called for a paradigm shift: In a CMV prevention strategy the targeted selection of the immunosuppressive therapy is also a key element. For patients with elevated risk of CMV, mTOR inhibitor-based immunosuppression is advantageous as it is associated with a significantly lower incidence of CMV events.


Sign in / Sign up

Export Citation Format

Share Document