scholarly journals Interplay of early-life nutritional programming on obesity, inflammation and epigenetic outcomes

2012 ◽  
Vol 71 (2) ◽  
pp. 276-283 ◽  
Author(s):  
J. Alfredo Martínez ◽  
Paúl Cordero ◽  
Javier Campión ◽  
Fermín I. Milagro
Keyword(s):  
Nutritional Interventions ◽  
Nutritional Programming ◽  
Diagnosis And Prognosis ◽  
Metabolic Functions ◽  
Epigenetic Biomarkers ◽  
Non Coding Rna ◽  
Pregnancy And Lactation ◽  
Covalent Modifications ◽  
Dietary Treatments ◽  
Methylation Patterns

The huge health burden accompanying obesity is not only attributable to inadequate dietary and sedentary lifestyle habits, since a predisposing genetic make-up and other putative determinants concerning easier weight gain and fat deposition have been reported. Thus, several investigations aiming to understand energy metabolism and body composition maintenance have been performed considering the participation of perinatal nutritional programming and epigenetic processes as well as inflammation phenomena. The Developmental Origins of Health and Disease hypothesis and inheritance-oriented investigations concerning gene–nutrient interactions on energy homoeostasis and metabolic functions have suggested that inflammation could be not only a comorbidity of obesity but also a cause. There are several examples about the role of nutritional interventions in pregnancy and lactation, such as energetic deprivation, protein restriction and excess fat, which determine a cluster of disorders affecting energy efficiency in the offspring as well as different metabolic pathways, which are mediated by epigenetics encompassing the chromatin information encrypted by DNA methylation patterns, histone covalent modifications and non-coding RNA or microRNA. Epigenetic mechanisms may be boosted or impaired by dietary and environmental factors in the mother, intergenerationally or transiently transmitted, and could be involved in the obesity and inflammation susceptibility in the offspring. The aims currently pursued are the early identification of epigenetic biomarkers concerned in individual's disease susceptibility and the description of protocols for tailored dietary treatments/advice to counterbalance adverse epigenomic events. These approaches will allow diagnosis and prognosis implementation and facilitate therapeutic strategies in a personalised ‘epigenomically modelled’ manner to combat obesity and inflammation.

scholarly journals Epigenetic Biomarkers in Head and Neck Cancer

2018 ◽  
Vol 1 (2) ◽  
pp. 41-50 ◽  
Author(s):  
Shilpi Gupta ◽  
Prabhat Kumar ◽  
Jayant Maini ◽  
Harsimrut Kaur
Keyword(s):  
Risk Factors ◽  
Dna Methylation ◽  
Head And Neck ◽  
Current Knowledge ◽  
Human Papillomaviruses ◽  
Epigenetic Mechanisms ◽  
Definite Diagnosis ◽  
Diagnosis And Prognosis ◽  
Epigenetic Biomarkers ◽  
Non Coding Rna

Head and neck cancers (HNCs) are the most prevalent and aggressive type of cancers. Genetic, epigenetic, environmental and viral risk-factors are associated with HNC carcinogenesis. Persistent infection of oncogenic human papillomaviruses (HR-HPVs) represent distinct biological, molecular and epigenetic entities in HNCs. There are three main epigenetic mechanisms that regulate transcription, these are DNA methylation, histone modifications and alteration in non-coding RNA networks, which can dissected to identify innovative and accurate epigenetic biomarkers for diagnosis and prognosis of HNC patients. Due to the lacunae of accurate distinctive biomarkers for the definite diagnosis of HNC, the identification of predictive epigenetic markers is necessary that might modify or increase HNC patient’s survival. In this mini review, we briefly summarize the current knowledge of different epigenetic biomarkers in HNC.

scholarly journals Epigenetic Biomarkers for the Diagnosis and Treatment of Liver Disease

Cancers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1265
Author(s):  
María Arechederra ◽  
Miriam Recalde ◽  
María Gárate-Rascón ◽  
Maite G. Fernández-Barrena ◽  
Matías A. Ávila ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Liver Disease ◽  
Therapeutic Strategy ◽  
Therapeutic Strategies ◽  
Epigenetic Alterations ◽  
Post Translational Modifications ◽  
Epigenetic Marks ◽  
Diagnosis And Prognosis ◽  
Epigenetic Biomarkers ◽  
Non Coding Rna

Research in the last decades has demonstrated the relevance of epigenetics in controlling gene expression to maintain cell homeostasis, and the important role played by epigenome alterations in disease development. Moreover, the reversibility of epigenetic marks can be harnessed as a therapeutic strategy, and epigenetic marks can be used as diagnosis biomarkers. Epigenetic alterations in DNA methylation, histone post-translational modifications (PTMs), and non-coding RNA (ncRNA) expression have been associated with the process of hepatocarcinogenesis. Here, we summarize epigenetic alterations involved in the pathogenesis of chronic liver disease (CLD), particularly focusing on DNA methylation. We also discuss their utility as epigenetic biomarkers in liquid biopsy for the diagnosis and prognosis of hepatocellular carcinoma (HCC). Finally, we discuss the potential of epigenetic therapeutic strategies for HCC treatment.

scholarly journals Small Non-Coding-RNA in Gynecological Malignancies

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1085
Author(s):  
Shailendra Kumar Dhar Dwivedi ◽  
Geeta Rao ◽  
Anindya Dey ◽  
Priyabrata Mukherjee ◽  
Jonathan D. Wren ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Noncoding Rna ◽  
Molecular Mechanisms ◽  
P Element ◽  
Gynecologic Malignancies ◽  
Diagnosis And Prognosis ◽  
Gynecological Malignancies ◽  
Non Coding Rna ◽  
Therapeutic Research ◽  
Regulatory Functions

Gynecologic malignancies, which include cancers of the cervix, ovary, uterus, vulva, vagina, and fallopian tube, are among the leading causes of female mortality worldwide, with the most prevalent being endometrial, ovarian, and cervical cancer. Gynecologic malignancies are complex, heterogeneous diseases, and despite extensive research efforts, the molecular mechanisms underlying their development and pathology remain largely unclear. Currently, mechanistic and therapeutic research in cancer is largely focused on protein targets that are encoded by about 1% of the human genome. Our current understanding of 99% of the genome, which includes noncoding RNA, is limited. The discovery of tens of thousands of noncoding RNAs (ncRNAs), possessing either structural or regulatory functions, has fundamentally altered our understanding of genetics, physiology, pathophysiology, and disease treatment as they relate to gynecologic malignancies. In recent years, it has become clear that ncRNAs are relatively stable, and can serve as biomarkers for cancer diagnosis and prognosis, as well as guide therapy choices. Here we discuss the role of small non-coding RNAs, i.e., microRNAs (miRs), P-Element induced wimpy testis interacting (PIWI) RNAs (piRNAs), and tRNA-derived small RNAs in gynecological malignancies, specifically focusing on ovarian, endometrial, and cervical cancer.

scholarly journals Analysis of Both Lipid Metabolism and Endocannabinoid Signaling Reveals a New Role for Hypothalamic Astrocytes in Maternal Caloric Restriction-Induced Perinatal Programming

2021 ◽  
Vol 22 (12) ◽  
pp. 6292
Author(s):  
Rubén Tovar ◽  
Antonio Vargas ◽  
Jesús Aranda ◽  
Lourdes Sánchez-Salido ◽  
Laura González-González ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Caloric Restriction ◽  
Energy Homeostasis ◽  
Caloric Intake ◽  
Endocannabinoid System ◽  
Critical Periods ◽  
Nutritional Programming ◽  
Metabolic Functions ◽  
Gene And Protein Expression ◽  
Induced Changes

Maternal malnutrition in critical periods of development increases the risk of developing short- and long-term diseases in the offspring. The alterations induced by this nutritional programming in the hypothalamus of the offspring are of special relevance due to its role in energy homeostasis, especially in the endocannabinoid system (ECS), which is involved in metabolic functions. Since astrocytes are essential for neuronal energy efficiency and are implicated in brain endocannabinoid signaling, here we have used a rat model to investigate whether a moderate caloric restriction (R) spanning from two weeks prior to the start of gestation to its end induced changes in offspring hypothalamic (a) ECS, (b) lipid metabolism (LM) and/or (c) hypothalamic astrocytes. Monitorization was performed by analyzing both the gene and protein expression of proteins involved in LM and ECS signaling. Offspring born from caloric-restricted mothers presented hypothalamic alterations in both the main enzymes involved in LM and endocannabinoids synthesis/degradation. Furthermore, most of these changes were similar to those observed in hypothalamic offspring astrocytes in culture. In conclusion, a maternal low caloric intake altered LM and ECS in both the hypothalamus and its astrocytes, pointing to these glial cells as responsible for a large part of the alterations seen in the total hypothalamus and suggesting a high degree of involvement of astrocytes in nutritional programming.

scholarly journals Reproduction Differentially Affects Trabecular Bone Depending on Its Mechanical Versus Metabolic Role

2017 ◽  
Vol 139 (11) ◽  
Author(s):  
Chantal M. J. de Bakker ◽  
Wei-Ju Tseng ◽  
Yihan Li ◽  
Hongbo Zhao ◽  
Allison R. Altman-Singles ◽  
...  
Keyword(s):  
Bone Loss ◽  
Bearing Capacity ◽  
Trabecular Bone ◽  
Bone Structure ◽  
Lumbar Vertebra ◽  
Load Bearing Capacity ◽  
Load Bearing ◽  
Metabolic Functions ◽  
Metabolic Role ◽  
Pregnancy And Lactation

During pregnancy and lactation, the maternal skeleton provides calcium for fetal/infant growth, resulting in substantial bone loss, which partially recovers after weaning. However, the amount of bone that is lost and the extent of post-weaning recovery are highly variable among different skeletal sites, and, despite persistent alterations in bone structure at some locations, reproductive history does not increase postmenopausal fracture risk. To explain this phenomenon, we hypothesized that the degree of reproductive bone loss/recovery at trabecular sites may vary depending on the extent to which the trabecular compartment is involved in the bone’s load-bearing function. Using a rat model, we quantified the proportion of the load carried by the trabeculae, as well as the extent of reproductive bone loss and recovery, at two distinct skeletal sites: the tibia and lumbar vertebra. Both sites underwent significant bone loss during pregnancy and lactation, which was partially recovered post-weaning. However, the extent of the deterioration and the resumption of trabecular load-bearing capacity after weaning varied substantially. Tibial trabecular bone, which bore a low proportion of the total applied load, underwent dramatic and irreversible microstructural deterioration during reproduction. Meanwhile, vertebral trabecular bone bore a greater fraction of the load, underwent minimal deterioration in microarchitecture, and resumed its full load-bearing capacity after weaning. Because pregnancy and lactation are physiological processes, the distinctive responses to these natural events among different skeletal sites may help to elucidate the extent of the trabecular bone’s structural versus metabolic functions.

scholarly journals Energy partitioning of pregnant and lactating rabbit fed combination of concentrate and stylosanthes hamata hay

2020 ◽  
Vol 46 (1) ◽  
pp. 94-100
Author(s):  
D. T. Tsavkar ◽  
M. Y. Latu ◽  
D. T. Tsavkar ◽  
A. K. Olutunmogun ◽  
P. P. Barje ◽  
...  
Keyword(s):  
New Zealand ◽  
Reference Data ◽  
Energy Partitioning ◽  
Nutritional Requirement ◽  
Digestible Energy ◽  
Stylosanthes Hamata ◽  
Pregnancy And Lactation ◽  
Dietary Treatments

The study was carried out to examine energy partitioning of pregnant and lactating rabbit offered levels of concentrate and Stylosanthes hamata hay to ascertain whether it meets their high reproductive and nutritional requirement. Forty-eight nulliparous crossbred does (New Zealand White x California and California x Chinchilla breeds) of eight months old were allocated to four dietary treatments in a completely randomised design. During gestation, 150 g/doe/day concentrate and Stylosanthes hamata hay combinations (30:120g, 60:90g, 90:60g and 120:30g) was offered while 350 g/doe/day concentrate and Stylosanthes hamata hay combinations (70:280g, 140:210g, 210:140g and 280:70g) was offered during lactation. Estimations of digestible energy during pregnancy and lactation were carried out and reference data were used to calculate forDE DE DE DE BalanceDE and DE /LW0.75. req, m, fg, macc, req Results obtained showed non-significant (P>0.05) difference among 90:60 and 120:30% concentrate and Stylosanthes hamata hay combinations in terms of DM DE DE DE intake, intake, req, fg, DE BalanceDE and DE /LW0.75, but were significantly (P<0.05) higher than 30:120 and macc, req 60:90% concentrate and Stylosanthes hamata hay combinations. Rabbit in the 4th week of pregnancy had significantly (P<0.05) higher DE DE DE DE BalanceDE and intake, req, fg, macc, DE /LW0.75 than does in the 2nd week of pregnancy. During lactation, all parameters showed req non-significant (P>0.05) difference. Therefore, the diet combinations were sufficient to provide adequate digestible energy for the physiological needs of does during pregnancy and lactation.

scholarly journals Long Non-Coding RNA-DUXAP8 Regulates TOP2A in the Growth and Metastasis of Osteosarcoma via MicroRNA-635

2020 ◽  
Author(s):  
Ting Yang ◽  
Jian Ping Quo ◽  
Fan Li ◽  
Chao Xiu ◽  
Hua Wang ◽  
...  
Keyword(s):  
Cancer Progression ◽  
Human Cancer ◽  
Luciferase Reporter ◽  
Migration And Invasion ◽  
High Morbidity ◽  
Real Time Quantitative Pcr ◽  
Diagnosis And Prognosis ◽  
Non Coding Rna ◽  
Cell Progression ◽  
And Migration

Abstract Purpose: Osteosarcoma (OS) is a malignant tumor disease with high morbidity and mortality in children and adolescents. Evidence indicates that long non-coding RNAs (lncRNAs) may be important players in human cancer progression, including OS. In this study, we identified the role of lnc-DUXAP8 in the development of OS.Materials and Methods: Expression of lncRNA DUXAP8 was determined by real-time quantitative PCR and Western blotting in OS tissues. Cell proliferation was evaluated using CCK8 and colony formation assay; Transwell assay was conducted to measure cell invasion. Cell migration was evaluated using Wound Healing assay. The binding site between the lnc-DUXAP8 and miR-635 RNAs was evaluated using a luciferase reporter assay. Results: The expression of the lnc-DUXAP8 was significantly upregulated in OS samples and OS cell lines compared to normal tissue. High expression of lncRNA DUXAP8 was associated with shorter overall survival. Knockdown of lncRNA DUXAP8 inhibited proliferation and migration, and invasion in OS cells. More importantly, mechanism investigation revealed that lncRNA DUXAP8 was predominantly acted as a competing endogenous RNA (ceRNA) in OS by regulating miR-635/ TOP2A axis. Conclusion: LncRNA DUXAP8 is upregulated in OS, and LncRNA DUXAP8 knockdown plays a vital anti-tumor role in OS cell progression through a miR-635/ TOP2A axis. Our study suggests that LncRNA DUXAP8 may be a novel, promising biomarker for diagnosis and prognosis of OS.

scholarly journals The Good, the Bad, and the Ugly of Pregnancy Nutrients and Developmental Programming of Adult Disease

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 894 ◽  
Author(s):  
Hsu ◽  
Tain
Keyword(s):  
Animal Models ◽  
Maternal Nutrition ◽  
Decisive Role ◽  
Developmental Programming ◽  
Adult Onset ◽  
Epidemiological Evidence ◽  
Nutritional Interventions ◽  
Adult Disease ◽  
Nutritional Programming ◽  
The Common

Maternal nutrition plays a decisive role in developmental programming of many non-communicable diseases (NCDs). A variety of nutritional insults during gestation can cause programming and contribute to the development of adult-onset diseases. Nutritional interventions during pregnancy may serve as reprogramming strategies to reverse programming processes and prevent NCDs. In this review, firstly we summarize epidemiological evidence for nutritional programming of human disease. It will also discuss evidence from animal models, for the common mechanisms underlying nutritional programming, and potential nutritional interventions used as reprogramming strategies.

FEEDING HIGH LEVELS OF RAPESEED MEAL TO PREGNANT GILTS

1971 ◽  
Vol 51 (3) ◽  
pp. 715-719 ◽  
Author(s):  
J. DEVILAT ◽  
A. SKOKNIĆ
Keyword(s):  
Sodium Chloride ◽  
Brassica Napus ◽  
Iodine Deficiency ◽  
Fish Meal ◽  
Rapeseed Meal ◽  
Deficiency Syndrome ◽  
Thyroid Glands ◽  
Pregnancy And Lactation ◽  
Dietary Treatments ◽  
Supplemental Protein

Eleven crossbred gilts were allotted at random to two dietary treatments containing either 0% or 12% solvent-extracted rapeseed meal (RSM) of Chilean origin as the main source of supplemental protein in the diet. The RSM, of Brassica napus type, contained 4.1 mg isothiocyanates per g meal. The experiment, which covered the periods of pregnancy and lactation, was started immediately after mating and terminated 3 weeks after birth. Results indicated that gilts fed 12% RSM during pregnancy gained significantly less with the same feed allowance (2 kg per day) than the fish meal (FM) group. Total litter size and weight at birth were similar for both treatments. However, only 49% of the piglets were born alive from the gilts fed the 12% RSM diet; thyroid glands of live and stillborn piglets were markedly enlarged and symptoms of iodine deficiency were clearly manifested. Most pigs died within 72 hours after birth and four of the seven gilts lost their whole litter during this period. Of total pigs born to RSM-fed gilts only 13.4% survived to 3 weeks, although these individual pigs attained weaning weights similar to those of FM-fed gilts. It is concluded that RSM of the type fed when used as the main source of supplemental protein for gilts may result in a severe iodine deficiency syndrome in litters when non-iodized sodium chloride is used in the diet.

Sign in / Sign up

Export Citation Format

Share Document