Serum Levels of Some Micronutrients and Congenital Malformations: A Prospective Cohort Study in Healthy Saudi-Arabian First-Trimester Pregnant Women

2013 ◽  
Vol 83 (6) ◽  
pp. 346-354 ◽  
Author(s):  
Sahar A. Ibrahim Hammouda ◽  
Om Alsaad Farouk Abd Al-Halim ◽  
Ahmed M. Mohamadin
Keyword(s):  
Pregnant Women ◽  
Congenital Malformations ◽  
Saudi Arabian ◽  
Serum Levels ◽  
First Trimester ◽  
Serum Concentrations ◽  
Vitamin Deficiencies ◽  
The Relationship ◽  
The City ◽  
Health Care Centers

Background/Objectives: Various studies have linked vitamin deficiencies in early pregnancy with birth defects. The objective of this study was to identify the relationship between micronutrient deficiency and congenital malformations (CM). Subjects and Methods: There were 1,180 healthy, first-trimester pregnant Saudi-Arabian females selected from the antenatal care clinics of two hospitals and 21 health care centers located all over the city. Their full medical history, clinical examination, anthropometry, and various laboratory analyses were completed. Results: Forty-eight infants were born with CM. The serum concentrations of the analyzed nutrients (selenium, zinc, magnesium, and vitamins A, E, B12, and folic acid) were significantly lower in mothers of infants with CM compared to the mothers of infants without CM. In comparison, the serum totals of homocysteine (tHcy) levels were significantly higher among the CM group. Conclusion: This study highlights the association of CM with the deficiency of certain vitamins and minerals among pregnant women.

Dietary and serum vitamin D and preeclampsia risk in Chinese pregnant women: a matched case–control study

2021 ◽  
pp. 1-26
Author(s):  
Xue-min Huang ◽  
Yan-hua Liu ◽  
Han Zhang ◽  
Yuan Cao ◽  
Wei-feng Dou ◽  
...  
Keyword(s):  
Vitamin D ◽  
Dietary Intake ◽  
Pregnant Women ◽  
Case Control Study ◽  
Serum Levels ◽  
Case Control ◽  
Serum Concentrations ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

Abstract The effect of vitamin D (VD) on the risk of preeclampsia (PE) is uncertain. Few of previous studies focused on the relationship between dietary VD intake and PE risk. Therefore, we conducted this 1:1 matched case-control study to explore the association of dietary VD intake and serum VD concentrations with PE risk in Chinese pregnant women. A total of 440 pairs of participants were recruited during March 2016 to June 2019. Dietary information was obtained using a 78-item semi-quantitative food frequency questionnaire. Serum concentrations of 25(OH)D2 and 25(OH)D3 were measured by liquid chromatography–tandem mass spectrometry. Multivariate conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic splines (RCS) were plotted to evaluate the dose-response relationship of dietary VD intake and serum VD concentrations with PE risk. Compared with the lowest quartile, the ORs of the highest quartile were 0.45 (95%CI: 0.29-0.71, Ptrend = 0.001) for VD dietary intake and 0.26 (95%CI: 0.11-0.60, Ptrend = 0.003) for serum levels after adjusting for confounders. In addition, the RCS analysis suggested a reverse J-shaped relationship between dietary VD intake and PE risk (P-nonlinearity = 0.02). A similar association was also found between serum concentrations of total 25(OH)D and PE risk (P-nonlinearity = 0.02). In conclusion, this study provides evidence that higher dietary intake and serum levels of VD are associated with the lower risk of PE in Chinese pregnant women.

scholarly journals Osteocalcin Serum Levels in Gestational Diabetes Mellitus and Their Intrinsic and Extrinsic Determinants: Systematic Review and Meta-Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-15 ◽  
Author(s):  
Raigam J. Martinez-Portilla ◽  
Jose R. Villafan-Bernal ◽  
Diana L. Lip-Sosa ◽  
Eva Meler ◽  
Jordi Clotet ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Meta Analysis ◽  
Serum Levels ◽  
Mean Difference ◽  
Undercarboxylated Osteocalcin ◽  
Serum Concentrations ◽  
Potential Marker

Background. Undercarboxylated osteocalcin (ucOC) increases insulin release and insulin resistance in mice. In humans, evidence is scarce but a correlation of ucOC and total osteocalcin (tOC) with glycemic status markers has been demonstrated. The relationship of ucOC and tOC with gestational diabetes mellitus (GDM) has been even less characterized. Objective. To assess the mean difference of tOC and ucOC serum concentrations among nondiabetic pregnant women and women diagnosed as GDM in the second trimester of pregnancy and to determine the possible intrinsic and extrinsic contributors to this difference. Methods. A systematic search was performed to identify relevant studies published in English and Spanish using PubMed, SCOPUS, ISI Web of Knowledge, and PROSPERO database for meta-analysis. Observational studies measuring mean serum levels of osteocalcin among GDM, with at least 10 subjects analyzed in each group were selected. Mean difference (MD) by random effects model was used. Heterogeneity between studies was assessed using Cochran’s Q, H, and I2 statistics. Results. From 38 selected studies, 5 were retained for analysis for a total of 1119 pregnant women. Serum concentrations of tOC were not significantly different among women with GDM and nondiabetic pregnant controls (MD: 1.56; 95% CI: −0.70 to 3.82; p=0.175). Meanwhile, ucOC serum levels were significantly higher among women with GDM (MD: 1.17; 95% CI: 0.24 to 2.11; p=0.013). The only factor influencing tOC was the UV index, showing a reduction in mean difference between GDM and controls when exposed to higher concentrations of UV rays. Conclusions. This meta-analysis provides evidence to support the use of ucOC as a potential marker for GDM rather than tOC, yielding very little variability among studies and no difference among methods or brands used for its analysis.

Decreased parathyroid hormone serum levels in pregnant women with first-trimester vaginal bleeding

1997 ◽  
Vol 76 (8) ◽  
pp. 807-808
Author(s):  
Frunco Bugnoli ◽  
Cluictlio De Felice ◽  
Cvsimo Mussafra ◽  
Lorenx Pecciarini ◽  
Stejania Bencini ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Pregnant Women ◽  
Vaginal Bleeding ◽  
Serum Levels ◽  
First Trimester

Serum concentrations of 3,5,3',5'-tetraiodothyroacetate (T4A) in subjects with hypo-, hyper- and euthyroidism

1986 ◽  
Vol 112 (2) ◽  
pp. 192-196 ◽  
Author(s):  
D. B. Ramsden ◽  
D. N. Crossley
Keyword(s):  
Human Subjects ◽  
Serum Levels ◽  
Free Thyroxine ◽  
Serum Concentrations ◽  
Normal Range ◽  
Thyroxine Binding Globulin ◽  
Factors Influencing ◽  
The Relationship ◽  
Peripheral Metabolism

Abstract. Some factors influencing serum 3,5,3',5'-tetradiodothyroacetate (T4A) concentrations were examined in hypothyroid, euthyroid and hyperthyroid human subjects. Serum T4A concentration was shown to be correlated with parameters such as serum, total and free thyroxine (T4) concentrations and thyroxine: thyroxine binding globulin ratio, which are indicative of the availability of T4 for peripheral metabolism. The relationship between T4A and these parameters was not a simple linear one; serum levels of T4A tended to show less variation from the normal range than did serum total T4 in hyperthyroid subjects.

scholarly journals Interleukin-1 Receptor Antagonist Gene Polymorphism, Vaginal Interleukin-1 Receptor Antagonist Concentrations, and Vaginal Ureaplasma urealyticum Colonization in Pregnant Women

2003 ◽  
Vol 71 (1) ◽  
pp. 271-274 ◽  
Author(s):  
Parrin T. Barton ◽  
Stefan Gerber ◽  
Daniel W. Skupski ◽  
Steven S. Witkin
Keyword(s):  
Pregnant Women ◽  
Receptor Antagonist ◽  
Ureaplasma Urealyticum ◽  
Interleukin 1 ◽  
First Trimester ◽  
Enzyme Linked Immunosorbent Assay ◽  
Interleukin 1 Receptor Antagonist ◽  
First Trimester Of Pregnancy ◽  
The Relationship ◽  
Uneventful Pregnancy

ABSTRACT Ureaplasma urealyticum is the microorganism most frequently isolated from amniotic fluids of women in preterm labor. The relationship between vaginal colonization with U. urealyticum, vaginal interleukin-1 receptor antagonist (IL-1ra) levels, and the IL-1ra genotype in pregnant women was examined. Vaginal specimens, obtained with a cotton swab from 207 women in their first trimester of pregnancy, were tested for IL-1ra concentrations by enzyme-linked immunosorbent assay and for U. urealyticum and IL-1ra genotypes by PCR. U. urealyticum was detected in 85 (41.1%) women. The median IL-1ra level was 450 ng/ml in women positive for U. urealyticum, as opposed to 225 ng/ml in women negative for this microorganism (P < 0.0001). Sixty-two percent of the 16 women who were homozygous for allele 2 of the IL-1ra gene (IL-1RN*2) were colonized with U. urealyticum, as opposed to 47% of the 49 women who were IL-1RN*1/IL-1RN*2 heterozygotes and 34% of the 133 women who were IL-1RN*1 homozygotes (P < 0.05). Median IL-1ra levels were 750 ng/ml in IL-1RN*2 homozygotes, 300 ng/ml in IL-1RN*1/IL-1RN*2 heterozygotes, and 250 ng/ml in IL-1RN*1 homozygotes (P = 0.02). The vast majority of subjects had an uneventful pregnancy and delivered a healthy infant at term. The IL-1ra genotype or U. urealyticum colonization was unrelated to birth weight. Pregnant women who are colonized with U. urealyticum during the first trimester have elevated vaginal IL-1ra concentrations and a higher prevalence of the IL-1RN*2 homozygote genotype than do noncolonized women.

scholarly journals KORELASI ASUPAN ZAT BESI, PROTEIN, VITAMIN C DAN MUAL MUNTAH TERHADAP KEJADIAN ANEMIA PADA IBU HAMIL TRIMESTER I (PERTAMA)

2019 ◽  
Vol 9 (4) ◽  
pp. 301
Author(s):  
Karwati Karwati ◽  
Damay Yanti
Keyword(s):  
Vitamin C ◽  
Pregnant Women ◽  
First Trimester ◽  
Nausea And Vomiting ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Iron Protein ◽  
Food Records ◽  
The Relationship

Anemia is one of the many problems that occur in pregnant women in developing countries. First trimester pregnant women often experience nausea and vomiting that can affect the pattern of eating that is received. The purpose of this study was to determine whether nutritional intake and nausea and vomiting disorders in first trimester pregnant women were associated with anemia. The sample of this study was all first trimester pregnant women, selected by quota sampling technique. The research design used in this study was cross sectional, which aims to examine the correlation between nutrient intake (iron, protein, and vitamin C) and nausea and vomiting disorders with anemia. The instrument used to determine the intake of iron, protein, vitamin C was food records that were filled by respondents for 3 days. To test the hypothesis of the relationship used the chi square test and Fisher's exact test. From the results of the analysis of the relationship between iron intake, Vitamin C and nausea and vomiting with anemia, p-value = 0.003, p-value = 0.001 and p-value 0.001, it can be concluded that there is a relationship between iron intake, vitamin C and vomiting nausea with the incidence of anemia in first trimester pregnant women (first). While the results of the analysis of the relationship of protein intake with anemia obtained p-value = 0.806, it can be concluded that there is no relationship between protein intake and the incidence of anemia in first trimester pregnant women (first). The mean intake of iron, protein, and vitamin C in first trimester pregnant women both in the anemic and non-anemic groups had a daily intake that was still far from the nutritional adequacy standard set by the government that the RDA of iron was 26 g / dL / day Protein was 76 mg / day and Vit C is 70-85 mg / day. Keywords: food intake; nausea and vomiting; anemia ABSTRAK Anemia merupakan salah satu masalah yang banyak terjadi pada ibu hamil di negara berkembang. Ibu hamil trimester I sering mengalami gangguan mual muntah yang dapat berpengaruh pada pola ragam makan yang diterima. Tujuan dari penelitian ini adalah mengetahui apakah asupan nutrisi dan gangguan mual muntah pada ibu hamil trimester I berhubungan dengan kejadian anemia. Sampel penelitian ini adalah seluruh ibu hamil trimester I diambil dengan teknik Non Probability sampling yaitu Sampling Kuota. Desain penelitian yang digunakan dalam penelitian ini adalah epidemiologi analitik observasional dengan desain cross sectional, yang bertujuan menguji hipotesi dalam mencari korelasi asupan nutrisi (zat besi, protein, dan vitamin C) dan gangguan mual muntah dengan kejadian anemia. Instrumen yang digunakan untuk mengetahui kecukupan asupan zat besi, protein,vitamin C adalah food records yang di isi oleh responden selama 3 hari. Untuk melihat hubungan karakteristik dengan variabel dependen digunakan uji chi square dengan alternative uji exact fisher. Dari hasil analisis hubungan antara asupan zat besi, Vitamin C dan mual muntah dengan anemia didapatkan nilai p-value= 0,003, p-value = 0,001 dan p-value 0,001 maka dapat disimpulkan bahwa ada hubungan antara asupan Zat Besi, Vitamin C dan Mual Muntah dengan kejadian Anemia pada ibu hamil trimester 1 (pertama). Sedangkan hasil analisis hubungan asupan protein dengan anemia didaparkan p-value= 0,806 maka dapat disimpulkan bahwa tidak ada hubungan antara asupan protein dengan kejadian anemia pada ibu hamil trimester 1 (pertama). Rerata asupan zat besi, protein, dan vitamin C pada ibu hamil trimester I baik pada kelompok anemia maupun tidak anemia memiliki jumlah asupan harian yang masih jauh dari standar kecukupan gizi yang ditetapkan oleh pemerintah bahwa AKG zat besi adalah 26 g/dL/hari Protein adalah 76 mg/hari dan Vit C adalah 70-85 mg/hari. Kata kunci: asupan makanan; mual dan muntah; anemia

scholarly journals Asupan Energi, Zat Gizi Makro dan Pertambahan Berat Badan Ibu Hamil

2021 ◽  
Vol 12 (2) ◽  
pp. 156
Author(s):  
Nurmela Setia Ningsih ◽  
Betty Yosephin Simanjuntak ◽  
Miratul Haya
Keyword(s):  
Weight Gain ◽  
Pregnant Women ◽  
Protein Intake ◽  
Total Sample ◽  
Cross Sectional Study ◽  
Vulnerable Groups ◽  
P Value ◽  
Cross Sectional ◽  
The Relationship ◽  
The City

<p>Pregnant women are one of the vulnerable groups. During pregnancy, there is an increase in the need for nutrients to meet the needs of the mother and fetus as well as preparation for labor. It is very important to pay attention to the recommended weight gain during pregnancy to prevent the occurrence of low birth weight. The purpose of this study was to determine the relationship between energy, carbohydrate, fat, and protein intake on weight gain of pregnant women in the city of Bengkulu. The design of this study was a cross-sectional study with a total sample of 47 pregnant women who had received an education of the first thousand days of life when registering to become a prospective bride at the Religious Affairs Office. As many as 53.2% of mothers had good weight gain and had a relationship between energy intake (p-value 0,032), carbohydrate intake (p-value 0,024), protein intake (p-value 0,039), and fat intake (p-value 0,023). Energy and macronutrients have a relationship with the weight gain of pregnant women in the group of preconception couples who have received education about the first 1000 days of life. It is hoped that pregnant women will be able to control their weight during pregnancy and apply the knowledge that has been obtained through education while preconception age.<strong></strong></p>

scholarly journals .Assessment of Renal Functions among Saudi Arabian Pregnant Women in Jazan Region

2015 ◽  
Vol 1 (1) ◽  
Author(s):  
Akram Hamed Awad All Elsukar - Ahmed Mohammed Ahmed
Keyword(s):  
Glomerular Filtration Rate ◽  
Pregnant Women ◽  
Glomerular Filtration ◽  
Plasma Flow ◽  
Filtration Rate ◽  
Renal Plasma Flow ◽  
Saudi Arabian ◽  
Serum Levels ◽  
Control Group ◽  
Renal Functions

Marked renal hemodynamic changes are apparent by the end of the first trimester. Both the Glomerular filtration rate and effective renal plasma flow increase by 50% of pregnant women. Effective renal plasma flow probably increases to a greater extent, and thus, the filtration fraction is decreased during early and mid-pregnancy. Objectives: To assess the serum levels of renal functions among Saudi Arabian Pregnant women in Jazan region. Materials and Methods: a prospective, case- control hospital based study conducted in Jazan region from March 2014– June 2015.30 pregnant women selected in Jazan General Hospital and assessed for renal function tests. 30 healthy subjects selected as control group who were age, and socioeconomic matched to the pregnancy group. SPSS was used for data analysis using student’s ‟t” test and Pearson's correlation for assessment of correlation between different variables. Results: There was a significant difference in the mean of the serum levels of urea and creatinine in test group (p<0.05) when compared to control group with a significant moderate positive correlation between serum levels of creatinine with the period of gestation. Conclusion: Serum levels of urea and creatinine significantly reduced in Saudi Arabian pregnant women. The progressive decrease in the levels of urea and creatinine through the 3 trimesters of pregnancy suggests an increase in Glomerular filtration rate, probably due to increased cardiac output, renal blood flow and changes in fluid distribution.

scholarly journals Study of the relationship between the parameters of complex prenatal screening of the first trimester of pregnancy with a risk of the most common aneuploidies

2020 ◽  
Vol 5 ◽  
pp. 33-36
Author(s):  
V. I. Oshovskyy
Keyword(s):  
Blood Pressure ◽  
Growth Factor ◽  
Pregnant Women ◽  
Prenatal Screening ◽  
First Trimester ◽  
Placental Growth Factor ◽  
Type I ◽  
Uterine Arteries ◽  
Increased Risk ◽  
The Relationship

Complex prenatal screening of the first trimester remains the most accessible and effective way of stratifying the risks of fetal chromosomal abnormalities in the general population, which has satisfactory sensitivity and specificity. Over the last decade, due to including additional parameters (average pulsation index of blood flow in the uterine arteries, average blood pressure, placental growth factor concentration, obstetric and somatic anamnesis data), it has also become a tool for determining obstetric risks. The objective: to study the effect of these additional parameters on the accuracy of predicting the most common aneuploidies was made. Materials and methods. The cohort included 2164 pregnant women at 11+0 – 13+6 weeks of gestation, who underwent extended complex screening of the first trimester, which aimed to determine the risk of trisomy on the 21st, 13th and 18th chromosomes in the fetus and calculation risk of perinatal complications, namely: premature birth, preeclampsia and fetal growth retardation. Results. It was found that the history of miscarriage at 13–22 weeks of pregnancy (P=0,0006), increased resistance in the uterine arteries (P=0,0307), decreased concentration of placental growth factor (P=<0,0001) and increased mean blood pressure (P=0,0125) correlate with a high risk of trisomy of chromosome 21. Type I diabetes mellitus in pregnant women (P=0,0477) correlates with an increased risk of trisomy on chromosome 18. The concentration of placental growth factor (P=<0,0001) correlates with an increased risk of trisomy on chromosome 13. Conclusions. The data obtained require detailed analysis in the context of the possibility of optimizing mathematical models for predicting aneuploidy, as well as studying the relationship between markers of trophoblast invasion and chromosomal pathology of the fetus to better understand the mechanisms of first trimester fetal loss and placental dysfunction in the second half of pregnancy.

scholarly journals HUBUNGAN ASAP ROKOK TERHADAP TERJADINYA HIPERTENSI PADA IBU HAMIL DI DESA BRANGKAL BOJONEGORO

IKESMA ◽  
2019 ◽  
Vol 15 (1) ◽  
pp. 43
Author(s):  
Astri Meidah Setiawati
Keyword(s):  
Pregnant Women ◽  
Cigarette Smoke ◽  
P Value ◽  
Increase Blood Pressure ◽  
Chi Square ◽  
Cross Sectional ◽  
Chi Square Test ◽  
Relationship Of ◽  
The Relationship ◽  
The City

Cigarette exposure is one factor in the occurrence of hypertension and can increase blood pressure both for pregnant women and not. Hypertension is a fairly high disease problem in Indonesia. The purpose of this study was to determine the relationship of cigarette smoke to the occurrence of hypertension in pregnant women in Brangkal Village, Kepohbaru District, Bojonegoro City. This study is an observational analytic study and uses a quantitative approach. The design of this study uses cross sectional. The location of this study was conducted in Brangkal Village, Kepohbaru District, Bojonegoro City, from July to August 2018. The sample in this study used a total sampling of the population of all pregnant women in Brangkal Village, namely 10 pregnant women. The results of the study here are from the calculation of the chi-square test above indicating that the root problem of cigarette smoke in hypertension has P Value <α so that the results obtained are Ho accepted or not significant (p = 0.857). The conclusion of this study is that there is no significant relationship to exposure to cigarette smoke in the incidence of hypertension in pregnant women. This occurs due to several factors such as a husband who is working outside the city so that exposure to cigarette smoke is not as often as possible. Supporting factors are such as diet, knowledge and the amount of parity can affect hypertension in pregnant women.

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