scholarly journals Value of perfusion parameters histogram analysis of triphasic CT in differentiating intrahepatic mass forming cholangiocarcinoma from hepatocellular carcinoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Fang Zhao ◽  
Guodong Pang ◽  
Xuejing Li ◽  
Shuo Yang ◽  
Hai Zhong
Keyword(s):  
Characteristic Curve ◽  
Liver Perfusion ◽  
Normal Liver ◽  
Mean Value ◽  
Ct Scans ◽  
Arterial Blood ◽  
Specificity And Sensitivity ◽  
The Mean ◽  
The Difference ◽  
Triphasic Ct

AbstractWe aim to gain further insight into identifying differential perfusion parameters and corresponding histogram parameters of intrahepatic mass-forming cholangiocarcinoma (IMCC) from hepatocellular carcinomas (HCCs) on triphasic computed tomography (CT) scans. 90 patients with pathologically confirmed HCCs (n = 54) and IMCCs (n = 36) who underwent triple-phase enhanced CT imaging were included. Quantitative analysis of CT images derived from triphasic CT scans were evaluated to generate liver perfusion and histogram parameters. The differential performances, including the area under the receiver operating characteristic curve (AUC), specificity, and sensitivity were assessed. The mean value, and all thepercentiles of the arterial enhancement fraction (AEF) were significantly higher in HCCs than in IMCCs. The difference in hepatic arterial blood supply perfusion (HAP) and AEF (ΔHAP = HAPtumor − HAPliver, ΔAEF = AEFtumor − AEFliver) for the mean perfusion parameters and all percentile parameters between tumor and peripheral normal liver were significantly higher in HCCs than in IMCCs. The relative AEF (rAEF = ΔAEF/AEFliver), including the mean value and all corresponding percentile parameters were statistically significant between HCCs and IMCCs. The 10th percentiles of the ΔAEF and rAEF had the highest AUC of 0.788 for differentiating IMCC from HCC, with sensitivities and specificities of 87.0%, 83.3%, and 61.8%, 64.7%, respectively. Among all parameters, the mean value of ∆AEF, the 75th percentiles of ∆AEF and rAEF, and the 25th percentile of HFtumor exhibited the highest sensitivities of 94.4%, while the 50th percentile of rAEF had the highest specificity of 82.4%. AEF (including ΔAEF and rAEF) and the corresponding histogram parameters derived from triphasic CT scans provided useful value and facilitated the accurate discrimination between IMCCs and HCCs.

Seasonal trends in the stable isotopic composition of snow and meltwater runoff in a subarctic catchment at Okstindan, Norway

2004 ◽  
Vol 35 (2) ◽  
pp. 119-137 ◽  
Author(s):  
S.D. Gurney ◽  
D.S.L. Lawrence
Keyword(s):  
Isotopic Composition ◽  
Mean Value ◽  
Mean Values ◽  
Stable Isotopic Composition ◽  
Meltwater Runoff ◽  
Stable Isotopic ◽  
The Mean ◽  
The Difference ◽  
Δ18o And Δd

Seasonal variations in the stable isotopic composition of snow and meltwater were investigated in a sub-arctic, mountainous, but non-glacial, catchment at Okstindan in northern Norway based on analyses of δ18O and δD. Samples were collected during four field periods (August 1998; April 1999; June 1999 and August 1999) at three sites lying on an altitudinal transect (740–970 m a.s.l.). Snowpack data display an increase in the mean values of δ18O (increasing from a mean value of −13.51 to −11.49‰ between April and August), as well as a decrease in variability through the melt period. Comparison with a regional meteoric water line indicates that the slope of the δ18O–δD line for the snowpacks decreases over the same period, dropping from 7.49 to approximately 6.2.This change points to the role of evaporation in snowpack ablation and is confirmed by the vertical profile of deuterium excess. Snowpack seepage data, although limited, also suggest reduced values of δD, as might be associated with local evaporation during meltwater generation. In general, meltwaters were depleted in δ18O relative to the source snowpack at the peak of the melt (June), but later in the year (August) the difference between the two was not statistically significant. The diurnal pattern of isotopic composition indicates that the most depleted meltwaters coincide with the peak in temperature and, hence, meltwater production.

scholarly journals Lateral Antebrachial Cutaneous Nerve as a Donor Source for Digital Nerve Grafting: A Concept Revisited

2017 ◽  
Vol 11 (1) ◽  
pp. 1041-1048 ◽  
Author(s):  
Mehmet Bekir Unal ◽  
Kemal Gokkus ◽  
Evrim Sirin ◽  
Eren Cansü
Keyword(s):  
Pearson Correlation ◽  
Mean Value ◽  
Cutaneous Nerve ◽  
Digital Nerve ◽  
Mean Values ◽  
Nerve Grafts ◽  
The Mean ◽  
The Difference ◽  
Mean Time

Objective: The main objective of this study is to evaluate the availability of lateral antebrachial cutaneous nerve (LACN) autograft for acute or delayed repair of segmented digital nerve injuries. Patients and Methods: 13 digital nerve defects of 11 patients; treated with interposition of LACN graft that harvested from ipsilateral extremity were included in the study. Mean follow up period was 35, 7 months. The mean time from injury to grafting is 53, 3 days. The results of the mean 2PDT and SWMT values of injured /uninjured finger at the end of follow up period were evaluated with Paired T test. The correlation between the defect length and the difference of 2PDT, SWMT values between the uninjured and injured finger at the end of follow up period; were evaluated with Pearson - correlation analysis. Results: The mean value of our 2PDT and SWMT results are ~5,923, ~3, 52, respectively in which can be interpreted between the normal and diminished light touch. The defect length and difference percentage of SWMT values is positively and significantly correlated statistically. Mean length of interposed nerve grafts was 18.5 mm. The age of the patient and the mean values of 2PDT and SWMT with the difference % of 2PDT and % of SWMT are not statistically correlated. Conclusion: Based on results regarding sensory regaining at recipient side and negligible sensory deficit at harvesting side, we suggest that lateral antebrachial cutaneous nerve might be a valuable graft option for digital nerve defects.

scholarly journals True and Pseudo Cholinesterase levels in short and long-term of pesticides exposures

2020 ◽  
pp. 9-12
Author(s):  
Mohammed Abdul Rahman ◽  
Raghunatha Rao D ◽  
Vasantha L
Keyword(s):  
Whole Blood ◽  
Acute Poisoning ◽  
Mean Value ◽  
Serum Cholinesterase ◽  
Control Group ◽  
Study Group ◽  
Chronic Poisoning ◽  
The Mean ◽  
The Difference ◽  
And Control

The present study is aimed to study and analyze the true and pseudo Cholinesterase levels in the subjects exposed to pesticides during short term by intentional or accidental intake and long term exposure due to their occupation were studied at Department of Biochemistry, SVS medical college and hospital mahbubnagar district. Whole blood cholinesterase levels and Pseudo cholinesterase levels were estimated. 150 people were taken as controls who had no medical illness and a total number of 300 cases of pesticide poisoning were selected, aged between 20 to 55 years, which consist of 150 acute poisoning and 150 chronic poisoning subjects in Mahbubnagar district, were taken as case study, the detailed case history and the type of organophosphorus pesticide taken were recorded. Mean and standard deviation (S.D) of all variables were calculated and compared with those of controls. Statistical significance was assessed and P-value <0.05 were considered significant.           During acute poisoning the mean value of Whole blood cholinesterase/True cholinesterase (U / L) in acute poisoning cases on first day was 1.267± 0.612 on 3th day was 1.651±0.647, on 7th day was 2.221±0.684 and at the end of 6 months was 3.970±0.404.The difference between the study group and control group (4.0 ± 0.39) was found to be statistically significant in1st, 3rd, 7th day but not significant at the end of 6 months. The mean value of serum cholinesterase/pseudo cholinesterase (U/L) in acute poisoning cases on first day was 2213.05 ± 1749.81, on 3th day was 2862.3 ± 2025.6, on 7th day was 4008.4 ± 2355.9 and at the end of 6 months was 7708.34 ± 880.72.The difference between the study group and control group (7991.97 ± 1276.5) was found to be statistically significant in1st, 3rd, 7th day but not significant at the end of 6 months. During chronic poisoning (exposure) the mean value of Whole blood cholinesterase (U/L) in controls is 4.0 ± 0.39 as compared to 3.019 ± 0.848 in cases of chronic poisoning. The difference between the study group and control group was found to be statistically significant. The mean value of serum cholinesterase/pseudo cholinesterase (U/L) in controls was 7991.97 ± 1276.5 as compared to 6214 ± 1189 in cases of chronic poisoning. The difference between the study group and control group was found to be statistically significant.

scholarly journals Urine CA-2 as a biomarker for diagnosis urinary stone and prediction of its complications

2020 ◽  
Author(s):  
Yuan-jing Leng ◽  
Hai-bin Zhou ◽  
Jiang-ling Fu ◽  
Wen-juan Wang
Keyword(s):  
Healthy Subjects ◽  
Characteristic Curve ◽  
Urinary Stone ◽  
Urinary Stones ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Healthy Control ◽  
The Mean ◽  
The Difference ◽  
The Relationship

Abstract PURPOSECarbonic anhydrase-2 (CA-2) plays a role in mineralization and calcification in organism. Strong evidence suggests that CA-2 is associated with urolithiasis. However, the relationship between CA-2 and urinary stone remains unclear. The study aimed to assess the association of urine CA-2 (uCA-2) level and the potential risk of urinary stone.METHODSFrom March 2017 to November 2019, a prospective cohort study was conducted on patients with urinary stones and healthy subjects to determine the pretreatment uCA-2 level detection by Enzyme linked immunosorbent assay (ELISA). The difference of uCA-2 level between patients with urinary stones and healthy subjects was compared. Then comparison between stone patients with complications and without complications was carried out as well as correlation analysis to detect factors associated with biomarker expression.RESULTS118 patients with urinary stones were into urinary stones group and 42 healthy subjects were into healthy control group. The mean pretreatment uCA-2 level was significantly higher in patients with urinary stones group than healthy controls group (P=0.028). Furthermore, The uCA-2 level was positive correlation with urinary stones complications (R=0.379, P=0.000), especially pain complications (R=0.524, P=0.000) and hematuria complications (R=0.374, P=0.000). Receiver operating characteristic curve (ROC) analysis that a uCA-2 level threshold of 10.94 ng/mL had 83.67% sensitivity and 68.12% specificity for predicting urinary stones complications. CONCLUSIONSExcessive uCA-2 excretion is a major risk factor for urinary stone. Our findings suggested that uCA-2 may be used as an unappreciated biomarker for the diagnosis urinary stone in patients and to predict its complications.

scholarly journals CORRELATION BETWEEN BODY MASS INDEX AND MICROALBUMINURIA IN ESSENTIAL HYPERTENSIVE ADULTS

2020 ◽  
pp. 54-56
Author(s):  
IRENGBAM SUSUPRIYA DEVI ◽  
GLADYS RAI ◽  
V. P. S PUNIA ◽  
MANOJ KUMAR NANDKEOLIAR
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Early Morning ◽  
Mean Value ◽  
Control Group ◽  
Inclusion Criteria ◽  
Hypertensive Patients ◽  
Positive Correlation ◽  
Arterial Blood ◽  
The Mean

Objective: This study aimed to find the correlation between body mass index (BMI) and microalbuminuria (MA) in essential hypertensive adults. Methods: This study included 35 essential hypertensive patients in the 18–65 years of age group, who satisfied the inclusion criteria. Arterial blood pressure was measured by a sphygmomanometer and the first voided early morning urine sample was collected for the estimation of microalbumin. Results: The mean age of the population studied was 49±11.08 in essential hypertensive patients and 46.89±11.10 in the control group. The mean value of BMI in the hypertensive group was found to be 27.59±5.45. In the present study, the mean value of microalbumin in essential hypertensive patients was 20.95±16.96. A significant positive correlation between BMI and MA was observed in the study with p<0.001. Conclusion: Our study shows a positive correlation between BMI and MA. Therefore, this study will help in the early detection of renal injury and prevents its progression to renal failure by lifestyle and diet modifications.

scholarly journals III. On the uneliminated instrumental error in the observations of magnetic dip

1869 ◽  
Vol 17 ◽  
pp. 427-429
Keyword(s):  
Mean Value ◽  
Usual Method ◽  
Centre Of Gravity ◽  
Single Reading ◽  
The Mean ◽  
The Difference ◽  
The One ◽  
Number Of Passes ◽  
Source Of Error ◽  
Complete Observation

A single reading of one end of a dipping-needle placed in a dip-circle provided with microscopes for observing is liable to a variety of instrumental errors, which are eliminated by taking the mean of the sixteen readings of the two ends in the eight different positions included in a complete observation. Nevertheless it is found that with the best modern instruments a mean value results from these sixteen observations different for each different needle, and that the difference between the results obtained with two different needles is not the same at all times. The irregularities in the values of the dip observed at Bombay with two needles of excellent character made by Barrow of London, led the author to investigate the effect of a hypothetical irregularity in the shape of the axle of the needle, such that a section of the axle by a plane perpendicular to its axis would be elliptical instead of circular in form. Another source of error, which was brought to the notice of the Royal Society many years ago in a paper published in the Proceedings, is the displacement of the centre of gravity of the needle from the centre of the axle, combined with inequality in the magnetization of the needle when the poles are direct and reversed. Experience has led the author to the conclusion that the usual method of magnetization, by a definite number of passes of the same pair of bar-magnets, communicates magnetism to the needle very unequally when the one end of the needle is made north and when the other end is made north. Consequently it is advisable to investigate the effects of ellipticity of the axle and of displacement of the centre of gravity at the same time, which the author proceeds to do.

STUDIES ON THE INFLUENCE OF AGE ON OESTROGENS IN POST-MENOPAUSAL WOMEN WITH ATROPHIC ENDOMETRIUM AND NORMAL LIVER FUNCTION

1969 ◽  
Vol 62 (3) ◽  
pp. 461-467 ◽  
Author(s):  
B.-J. Procopé ◽  
H. Adlercreutz
Keyword(s):  
Age Groups ◽  
Normal Liver ◽  
Time Lapse ◽  
Mean Value ◽  
Vaginal Smear ◽  
Normal Liver Function ◽  
Menopausal Women ◽  
The Mean ◽  
Post Menopausal ◽  
Considerable Individual Variation

ABSTRACT A group of 104 post-menopausal women, who were at least 50 years old and with a time lapse of at least 2 years since the last menstruation, were investigated for their urinary oestrogen content. All the women had an atrophic endometrium as judged by histological investigation of a biopsy specimen. In 66 of the subjects the mean value of the karyopyknotic and eosinophilic indices in the vaginal smear was also calculated. The women, whose ages ranged from 50 to 79 years, were divided into 6 age groups. The median values for the excretion of oestrone, oestradiol, oestriol and total oestrogens and the mean karyopyknotic and eosinophilic indices for all age groups were very constant though there was considerable individual variation. It was also shown that the median values for all subjects were practically identical with those of 57 ovariectomized women reported in a previous study. It is concluded that in the majority of post-menopausal women with atrophic endometrium the ovarian contribution to the production of oestrogens is insignificant. It can also be concluded that with increasing age the normal liver does not significantly change the metabolism of oestrogens in post-menopausal women, as judged by the excretion of oestrone, oestradiol and oestriol, and the oestrogenic effect on the vaginal smear.

Effect of Erythropoietin on Platelet Function and Glycoprotein Expression in Patients with MDS.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 3993-3993
Author(s):  
Fotis F.I. Girtovitis ◽  
Dimitrios D. Bougiouklis ◽  
Michel M.P. Makris ◽  
Elefteria E. Pithara ◽  
Pantelis P.E. Makris
Keyword(s):  
Flow Cytometry ◽  
Platelet Function ◽  
Normal Subjects ◽  
Mean Value ◽  
Special Treatment ◽  
Recombinant Erythropoietin ◽  
Mean Values ◽  
Human Recombinant Erythropoietin ◽  
The Mean ◽  
The Difference

Abstract Aim: We decide to study the effect of erythropoietin on the platelet function and glycoproteins expression in patients (pts) with myelodysplastic syndrome (MDS). All patients suffered from primary MDS but none of them received any special treatment. From our study pts that suffered from diseases or they were receiving medication that affect the function of platelets were excluded. Furthermore pts with platelet count&lt;50,000/μl were excluded also because we were unable to check the aggregation of platelets. Material: 41 subjects were studied, 15 normal subject (10 men and 5 women mean age 66,6±14 years old)and 26 pts (17 men and 9 women with mean age70,9±7,4 years old) suffered from all types of MDS according to FAB criteria (9 with RA, 3 with RARS, 7 RAEB, 4 with CMML and 3 with RAEB-t). We divided them in 2 groups: 1st - 7 Pts receiving human recombinant erythropoietin (rEPO) with mean dose 30.000 iu subcutaneous weekly and 2nd - 19 without rEPO. Methods. 1- The platelet function was studied in Platelet Ionized Calcium Aggregometer (PICA) using Ristocetin, ADP, Collagen and Adrenalin as stimulators. 2- The expression of platelet glycoproteins (GPIb, IX, IIb, IIIa and P-selectin) was studied using the flow cytometry and special monoclonal antibodies. This way the percentage of glycoprotein expressed in platelet membrane and MFI were estimated. We performed the statistical analysis of our results using the t-test with common standard deviation.. Results: our results concerning the aggregation test and flow cytometry are presented in tables 1,2 and 3. From the study of our results we can see that while the decrease of aggregation between the patients under EPO and normal subjects is statistically non significant (p&lt;0.1)the decrease of the corresponding values between the pts that did not received EPO and normal subjects was statistically very significant for all stimulators (p &lt;0,001). pts under EPO show an important increase of platelet expressing GPIIb percentage grater than the expressed percentage of patients without EPO (60% vs. 46,1% correspondingly, p&lt;0.001). The difference of expressed MFI was not statistically significant. Conclusion: The findings of our study show us that erythropoietin improves the function of platelets in patients with MDS, probably through the increase of platelet percentage which express glycoproteins. Table 1 Comparison of the mean value of aggregation between the groups Table 2 Comparison of the mean values of the platelets expressing corresponding glycoproteins percentage between the groups Table 3 Comparison of the mean value of MFI between the groups

Comparison of the genetic diversity in two species of cycads

2005 ◽  
Vol 53 (3) ◽  
pp. 219 ◽  
Author(s):  
Longqian Xiao ◽  
Xun Gong ◽  
Gang Hao ◽  
Xuejun Ge ◽  
Bo Tian ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Simple Sequence Repeat ◽  
Inter Simple Sequence Repeat ◽  
Issr Markers ◽  
Mean Value ◽  
The Mean ◽  
The Difference ◽  
General Opinion ◽  
Simple Sequence ◽  
Striking Contrast

Inter-simple sequence repeat (ISSR) markers were used to examine the level and distribution of genetic diversity in two cycad species: Cycas parvula S.L.Yang and C. balansae Warburg. The former is found in only two adjacent populations and the latter in a relatively wider distribution. Although genetic diversity in C. balansae (He = 0.1301) is higher than that in C. parvula (He = 0.0538), both are still low in comparison with the mean value (He = 0.169) in gymnosperms. This confirms the general opinion that cycads are genetic relics. The genetic differentiation in both species, however, presents a striking contrast: Gst is 0.0978 in C. parvula, but 0.4003 in C. balansae, which may be ascribed to the difference in distances between their populations.

scholarly journals PERBANDINGAN STATUS KEBERSIHAN GIGI DAN MULUTPADA ANAK BERKEBUTUHAN KHUSUS SLB-B DAN SLB-C KOTA TOMOHON

e-GIGI ◽  
2015 ◽  
Vol 3 (2) ◽  
Author(s):  
Vivie Indahwati ◽  
Max F. J. Mantik ◽  
Paulina N. Gunawan
Keyword(s):  
Oral Hygiene ◽  
Mean Value ◽  
T Test ◽  
P Value ◽  
Special Needs Children ◽  
Normal Children ◽  
Children With Disability ◽  
The Mean ◽  
The Difference ◽  
Better Than

Abstract: Special need children is children with disability mental, physical, and emotion which different with the normal children, thus their more needed parents help in keeping hygene especially oral hygene. Every disability they have influenced the behaviour of special need children in keeping their oral hygiene. This study aimed to obtain the difference of oral hygiene between special needs children in SLB-B and SLB-C in Tomohon.This was a descriptive analytical study. Samples were obtained by total sampling method. This study was conducted at SLB-B GMIM Damai Tomohon and SLB-C Katolik Santa Anna Tomohon. There were 101 children in this study. The results of independent t test showed that there were significant differences between the mean value of OHI-S status at SLB-B (1.86) and the mean value OHI-S status at SLB-B ( 2.50) with a P value of <0,05. Conclusion: Oral hygiene of SLB-B children was significantly better than of SLB-C children.Keywords: oral hygiene, special need childrenAbstrak: Anak berkebutuhan khusus merupakan anak yang memiliki keterbatasan mental, fisik dan emosi yang berbeda dengan anak normal, sehingga mereka memerlukan bantuan dalam menjaga kebersihan diri khusunya kebersihan gigi dan mulut. Perbedaan keterbatasan yang mereka miliki, memengaruhi perilaku anak berkebutuhan khusus dalam menjaga kebersihan gigi dan mulut. Penelitian ini bertujuan untuk melihat bagaimana perbedaan status kebersihan gigi dan mulut pada anak berkebutuhan khusus di SLB-B dan SLB-C kota Tomohon, Jenis penelitian yang digunakan adalah deskriptif analitik. Pengambilan sampel penelitian ini secara total sampling. Pengambilan data dilaksanakan di SLB-B GMIM Damai Tomohon dan SLB-C Katolik Santa Anna Tomohon. Jumlah anak dalam penelitian sebanyak 101 anak. Hasil penelitian diolah dengan uji statistik t tidak berpasangan (independent t test).Dari uji statistik diperoleh bahwa terdapat perbedaan rerata yang bermakna, antara status OHI-S SLB-B dengan nilai rata-rata 1,86 dibandingkan status OHI-S SLB-C dengan nilai rata-rata 2,50 dan nilai p<0,05. Simpulan: Rerata status kebersihan gigi dan mulut SLB-B lebih baik secara bermakna dibandingkan dengan SLB-C.Kata kunci: kebersihan gigi dan mulut, anak berkebutuhan khusus

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