scholarly journals Genetic diversity of Bartonella species in small mammals in the Qaidam Basin, western China

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Huaxiang Rao ◽  
Shoujiang Li ◽  
Liang Lu ◽  
Rong Wang ◽  
Xiuping Song ◽  
...  
Keyword(s):  
Infection Rate ◽  
Small Mammals ◽  
Statistical Difference ◽  
Qaidam Basin ◽  
Polymerase Chain Reaction Amplification ◽  
Scientific Basis ◽  
Control Measures ◽  
Western China ◽  
Polymerase Beta ◽  
And Gender

AbstractInvestigation of the prevalence and diversity of Bartonella infections in small mammals in the Qaidam Basin, western China, could provide a scientific basis for the control and prevention of Bartonella infections in humans. Accordingly, in this study, small mammals were captured using snap traps in Wulan County and Ge’ermu City, Qaidam Basin, China. Spleen and brain tissues were collected and cultured to isolate Bartonella strains. The suspected positive colonies were detected with polymerase chain reaction amplification and sequencing of gltA, ftsZ, RNA polymerase beta subunit (rpoB) and ribC genes. Among 101 small mammals, 39 were positive for Bartonella, with the infection rate of 38.61%. The infection rate in different tissues (spleens and brains) (χ2 = 0.112, P = 0.738) and gender (χ2 = 1.927, P = 0.165) of small mammals did not have statistical difference, but that in different habitats had statistical difference (χ2 = 10.361, P = 0.016). Through genetic evolution analysis, 40 Bartonella strains were identified (two different Bartonella species were detected in one small mammal), including B. grahamii (30), B. jaculi (3), B. krasnovii (3) and Candidatus B. gerbillinarum (4), which showed rodent-specific characteristics. B. grahamii was the dominant epidemic strain (accounted for 75.0%). Furthermore, phylogenetic analysis showed that B. grahamii in the Qaidam Basin, might be close to the strains isolated from Japan and China. Overall, we observed a high prevalence of Bartonella infection in small mammals in the Qaidam Basin. B. grahamii may cause human disease, and the pathogenicity of the others Bartonella species needs further study, the corresponding prevention and control measures should be taken into consideration.

scholarly journals Eastern Cape Healthcare Workers Acquisition of SARS-CoV-2 (ECHAS): Cross-Sectional (Nested Cohort) Study Protocol

2021 ◽  
Vol 18 (1) ◽  
pp. 323
Author(s):  
Oladele Vincent Adeniyi ◽  
David Stead ◽  
Mandisa Singata-Madliki ◽  
Joanne Batting ◽  
Leo Hyera ◽  
...  
Keyword(s):  
Cohort Study ◽  
Infection Rate ◽  
Healthcare Workers ◽  
Health Facilities ◽  
Control Measures ◽  
Infection Prevention And Control ◽  
Eastern Cape ◽  
Rt Pcr ◽  
Cross Sectional ◽  
Increased Risk

Healthcare workers (HCWs) are at increased risk of infection by the virulent severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Though data exist on the positivity rate of the SARS-CoV-2 reverse transcription polymerase chain reaction (RT-PCR) test as well as COVID-19-related deaths amongst HCWs in South Africa, the overall infection rate remains underestimated by these indicators. It is also unclear whether the humoral immune response after SARS-CoV-2 infection offers durable protection against reinfection. This study will assess the SARS-CoV-2 seroprevalence amongst HCWs in the Eastern Cape (EC) and examine the longitudinal changes (rate of decay) in the antibody levels after infection in this cohort. Using a multi-stage cluster sampling of healthcare workers in selected health facilities in the EC, a cross-sectional study of 2250 participants will be recruited. In order to assess the community infection rate, 750 antenatal women in the same settings will be recruited. Relevant demographic and clinical characteristics will be obtained by a self-administered questionnaire. A chemiluminescent microparticle immunoassay (CMIA) will be used for the qualitative detection of IgG antibodies against SARS-CoV-2 nucleocapsid protein. A nested cohort study will be conducted by performing eight-weekly antibody assays (X2) from 201 participants who tested positive for both SARS-CoV-2 RT-PCR and serology. Logistic regression models will be fitted to identify the independent risk factors for SARS-CoV-2 infection. The cumulative SARS-CoV-2 infection rate and infection fatality rate among the frontline HCWs will be estimated. In addition, the study will highlight the overall effectiveness of infection prevention and control measures (IPC) per exposure sites/wards at the selected health facilities. Findings will inform the South African Department of Health’s policies on how to protect HCWs better as the country prepares for the second wave of the SARS-CoV pandemic.

Joint inversion of HRDL and HRDI with site applications at the Qaidam Basin of western China

2012 ◽  
Vol 94-95 ◽  
pp. 73-78
Author(s):  
Zhenhua Liu ◽  
Zhigang Cheng ◽  
Jie Wu ◽  
Jianhua Zhang
Keyword(s):  
Qaidam Basin ◽  
Joint Inversion ◽  
Western China

Jurassic evolution of the Qaidam Basin in western China: Constrained by stratigraphic succession, detrital zircon U-Pb geochronology and Hf isotope analysis

2021 ◽  
Author(s):  
Tao Qian ◽  
Zongxiu Wang ◽  
Yu Wang ◽  
Shaofeng Liu ◽  
Wanli Gao ◽  
...  
Keyword(s):  
Late Jurassic ◽  
Qaidam Basin ◽  
Isotope Analysis ◽  
Lower Jurassic ◽  
Early Jurassic ◽  
Hf Isotope ◽  
Western China ◽  
Small Scale ◽  
Altyn Tagh ◽  
Stratigraphic Succession

The formation and evolution of an intracontinental basin triggered via the subduction or collision of plates at continental margins can record intracontinental tectonic processes. As a typical intracontinental basin during the Jurassic, the Qaidam Basin in western China records how this extensional basin formed and evolved in response to distant subduction or collisional processes and tectonism caused by stresses transmitted from distant convergent plate margins. The Jurassic evolution of the Qaidam Basin, in terms of basin-filling architecture, sediment dispersal pattern and basin properties, remains speculative; hence, these uncertainties need to be revisited. An integrated study of the stratigraphic succession, conglomerates, U-Pb geochronology, and Hf isotopes of detrital zircons was adopted to elucidate the Jurassic evolutionary process of the Qaidam Basin. The results show that a discrete Jurassic terrestrial succession characterized by alluvial fan, braided stream, braided river delta, and lacustrine deposits developed on the western and northern margins of the Qaidam Basin. The stratigraphic succession, U-Pb age dating, and Hf isotope analysis, along with the reconstructed provenance results, suggest small-scale distribution of Lower Jurassic sediments deposited via autochthonous sedimentation on the western margin of the basin, with material mainly originating from the Altyn Tagh Range. Lower Jurassic sediments in the western segment of the northern basin were shed from the Qilian Range (especially the South Qilian) and Eastern Kunlun Range. And coeval sediments in the eastern segment of the northern basin were originated from the Quanji massif. During the Middle-Late Jurassic, the primary source areas were the Qilian Range and Eastern Kunlun Range, which fed material to the whole basin. The Jurassic sedimentary environment in the Qaidam Basin evolved from a series of small-scale, scattered, and rift-related depressions distributed on the western and northern margins during the Early Jurassic to a larger, extensive, and unified depression occupying the whole basin in the Middle Jurassic. The Altyn Tagh Range rose to a certain extent during the Early Jurassic but lacked large-scale strike-slip tectonism throughout the Jurassic. At that time, the North Qaidam tectonic belt had not yet been uplifted and did not shed material into the basin during the Jurassic. The Qaidam Basin experienced intracontinental extensional tectonism with a northeast-southwest trend throughout the Jurassic in response to far-field effects driven by the sequential northward or northeastward amalgamation of blocks to the southern margin of the Qaidam Block and successive accretion of the Qiangtang Block and Lhasa Block onto the southern Eurasian margin during the Late Triassic−Early Jurassic and Late Jurassic−Early Cretaceous, respectively.

Hong Kong’s response to COVID-19: a glance to the control measures and their enforcement

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Ka Ki Lawrence Ho ◽  
Ying-Tung Chan
Keyword(s):  
Hong Kong ◽  
Infection Rate ◽  
Government Policy ◽  
Design Methodology ◽  
Control Measures ◽  
Content Type ◽  
The Government ◽  
And Control ◽  
Viral Outbreak

Purpose This study aims to examine Hong Kong’s responses to COVID-19, arguing that Hong Kong’s relatively low infection rate is due to self-discipline of citizens together with the enforcement measures introduced by the government. Design/methodology/approach This study reviewed the government policy announcements and the prevailing scholarly analyses on Hong Kong society during COVID-19. Findings It starts by examining the partial lockdown and control measures since mid-January, and the roles of different government units in enforcement were examined and assessed. Suppression of viral outbreak in Hong Kong should primarily be attributed to the appropriate lockdown and quarantine actions of the government. Originality/value However, outperformance of the frontline professionals and the highly aware, self-disciplined and mutually aided citizens in the community are also the key to the “interim success” by June 2020 in the highly accessible and densely populated city.

Perspective on control options forEchinococcus multiloculariswith particular reference to Japan

Parasitology ◽  
2003 ◽  
Vol 127 (S1) ◽  
pp. S159-S172 ◽  
Author(s):  
A. ITO ◽  
T. ROMIG ◽  
K. TAKAHASHI
Keyword(s):  
Close Contact ◽  
Integrated Control ◽  
Risk Behaviour ◽  
Control Measures ◽  
Domestic Dogs ◽  
Western China ◽  
Preventive Strategies ◽  
Preventive Chemotherapy ◽  
Information Campaigns ◽  
Control Options

Following a brief introduction of recent advances in molecular and immunological technology for detection of persons and animals infected withEchinococcus multilocularisand an overview of the current situation of alveolar echinococcosis (AE) in Japan, perspectives on control options are discussed with reference to different epidemiological situations. AE is considered the most serious parasitic zoonosis in temperate and arctic regions of the northern hemisphere. The number of human cases differs drastically among regions. While high numbers of patients are apparently associated with highE. multilocularisprevalence in domestic dogs, e.g. in parts of Alaska and western China, the number of cases is moderate or low in areas where the parasite is mainly transmitted by wild canid species (e.g. in central Europe or temperate North America). However, the severity of the disease, the absence of curative treatment for most cases, the high cost of long-term chemotherapy and the anxiety caused for the population in highly endemic areas call for the development of preventive strategies even in regions where human AE is rare. Furthermore, in view of (1) drastically increasing numbers and infection rates of foxes involved in transmission ofE. multilocularis, and (2) increasingly close contact between humans and foxes e.g. in Europe and Japan, there is considerable concern that AE incidences may in future increase in these regions. Control options depend on a variety of factors including the species of canid principally responsible for transmission and the socio-economic situation in the region. Where domestic dogs (stray or owned) are the principal hosts forE. multilocularis, control options can include those applicable toE. granulosus, i.e. reduction of the number of stray dogs, registration and regular preventive chemotherapy of owned dogs, and information campaigns for the population promoting low-risk behaviour for man and dogs. WhereE. multilocularisis mainly transmitted by wild canids, the situation is far more difficult with preventive strategies still being in trial stage. Integrated control measures could include prevention information campaigns, restricting access of pet animals (dogs and cats) to rodents, chemotherapy of foxes on local or regional scales, and strategies to minimize contacts between people and foxes.

scholarly journals Examining and investigating the impact of demographic characteristics and chronic diseases on mortality of COVID-19: Retrospective study

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0257131
Author(s):  
Abbas Al Mutair ◽  
Alya Al Mutairi ◽  
Saad Alhumaid ◽  
Syed Maaz Abdullah ◽  
Abdul Rehman Zia Zaidi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Saudi Arabia ◽  
Binary Logistic Regression ◽  
Demographic Characteristics ◽  
Control Measures ◽  
Effective Control ◽  
Diabetic Patients ◽  
History Of ◽  
And Gender ◽  
The Impact

Background Epidemiological features characterization of COVID-19 is highly important for developing and implementing effective control measures. In Saudi Arabia mortality rate varies between 0.6% to 1.26%. The purpose of the study was to investigate whether demographic characteristics (age and gender) and non-communicable diseases (Hypertension and Diabetes mellitus) have a significant association with mortality in COVID-19 patients. Methods Prior to data collection, an expedite approval was obtained from Institutional Review Board (IRB Log No: RC. RC20.09.10) in Al Habib Research Center at Dr. Sulaiman Al-Habib Medical Group, Riyadh, Saudi Arabia. This is a retrospective design where we used descriptive and inferential analysis to analyse the data. Binary logistic regression was done to study the association between comorbidities and mortality of COVID-19. Results 43 (86%) of the male patients were non-survivors while 7 (14%) of the female patients were survivors. The odds of non-survivors among hypertensive patients are 3.56 times higher than those who are not having a history of Hypertension (HTN). The odds of non-survivors among diabetic patients are 5.17 times higher than those who are not having a history of Diabetes mellitus (DM). The odds of non-survivors are 2.77 times higher among those who have a history of HTN and DM as compared to those who did not have a history of HTN and DM. Conclusions Those patients that had a history of Hypertension and Diabetes had a higher probability of non-survival in contrast to those who did not have a history of Diabetes and hypertension. Further studies are required to study the association of comorbidities with COVID-19 and mortality.

scholarly journals Impact of the Inflow Population From Outbreak Areas on the COVID-19 Epidemic in Yunnan Province and the Recommended Control Measures: A Preliminary Study

2020 ◽  
Vol 8 ◽  
Author(s):  
Zhong Sun ◽  
Guozhong He ◽  
Ninghao Huang ◽  
Hongyu Chen ◽  
Shuwei Zhang ◽  
...  
Keyword(s):  
Prevention And Control ◽  
Yunnan Province ◽  
Clinical Manifestations ◽  
Control Measures ◽  
Proper Management ◽  
Outbreak Areas ◽  
Prevention And Control Measures ◽  
And Gender ◽  
And Control ◽  
The Impact

Background: COVID-19 developed into a global pandemic in 2020 and poses challenges regarding the prevention and control capabilities of countries. A large number of inbound travelers from other regions could lead to a renewed outbreak of COVID-19 in the local regions. Globally, as a result of the imbalance in the control of the epidemic, all countries are facing the risk of a renewed COVID-19 outbreak brought about by travelers from epidemic areas. Therefore, studies on a proper management of the inbound travelers are urgent.Methods: We collected a total of 4,733,414 inbound travelers and 174 COVID-19 diagnosed patients in Yunnan province from 21 January 2020 to 20 February 2020. Data on place of origin, travel history, age, and gender, as well as whether they had suspected clinical manifestations for inbound travelers in Yunnan were collected. The impact of inbound travelers on the local epidemic was analyzed with a collinear statistical analysis and the effect of the control measures on the epidemic was evaluated with a sophisticated modeling approach.Results: Of the 174 COVID-19 patients, 60.9% were not from Yunnan, and 76.4% had a history of travel in Hubei. The amount of new daily cases in Yunnan was significant correlated with the number of inbound travelers from Hubei and suspected cases among them. Using Susceptible–Exposed–Infectious–Recovered (SEIR) model analysis, we found that the prevention and control measures dropped the local R0 down to 1.07 in Yunnan province.Conclusions: Our preliminary analysis showed that the proper management of inbound travelers from outbreak areas has a significantly positive effect on the prevention and control of the virus. In the process of resettlement, some effective measures taken by Yunnan province may provide an important reference for preventing the renewed COVID-19 outbreak in other regions.

scholarly journals Association of meteorological factors with seasonal activity of influenza A subtypes and B lineages in subtropical western China

2019 ◽  
Vol 147 ◽  
Author(s):  
M. Pan ◽  
H. P. Yang ◽  
J. Jian ◽  
Y. Kuang ◽  
J. N. Xu ◽  
...  
Keyword(s):  
Annual Cycle ◽  
Influenza A ◽  
Meteorological Factors ◽  
Temporal Distribution ◽  
Absolute Humidity ◽  
Influenza Viruses ◽  
Control Measures ◽  
Western China ◽  
The Tropics ◽  
The Impact

AbstractThe seasonality of individual influenza subtypes/lineages and the association of influenza epidemics with meteorological factors in the tropics/subtropics have not been well understood. The impact of the 2009 H1N1 pandemic on the prevalence of seasonal influenza virus remains to be explored. Using wavelet analysis, the periodicities of A/H3N2, seasonal A/H1N1, A/H1N1pdm09, Victoria and Yamagata were identified, respectively, in Panzhihua during 2006–2015. As a subtropical city in southwestern China, Panzhihua is the first industrial city in the upper reaches of the Yangtze River. The relationship between influenza epidemics and local climatic variables was examined based on regression models. The temporal distribution of influenza subtypes/lineages during the pre-pandemic (2006–2009), pandemic (2009) and post-pandemic (2010–2015) years was described and compared. A total of 6892 respiratory specimens were collected and 737 influenza viruses were isolated. A/H3N2 showed an annual cycle with a peak in summer–autumn, while A/H1N1pdm09, Victoria and Yamagata exhibited an annual cycle with a peak in winter–spring. Regression analyses demonstrated that relative humidity was positively associated with A/H3N2 activity while negatively associated with Victoria activity. Higher prevalence of A/H1N1pdm09 and Yamagata was driven by lower absolute humidity. The role of weather conditions in regulating influenza epidemics could be complicated since the diverse viral transmission modes and mechanism. Differences in seasonality and different associations with meteorological factors by influenza subtypes/lineages should be considered in epidemiological studies in the tropics/subtropics. The development of subtype- and lineage-specific prevention and control measures is of significant importance.

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