scholarly journals Gender Variation in Octogenarians and Nonagenarian Patients Undergoing PCI

2017 ◽  
Vol 02 (01) ◽  
pp. 047-051
Author(s):  
E. Kumar ◽  
K. Prasad ◽  
A. Prasad
Keyword(s):  
Age Distribution ◽  
Chronic Stable Angina ◽  
P Value ◽  
Male Population ◽  
Female Population ◽  
Female Patients ◽  
Vessel Disease ◽  
Minimum Age ◽  
Male Patients ◽  
Distribution Type

AbstractBackground: The aging of the population worldwide will result in increasing numbers of elderly patients, among whom heart disease is the leading cause of death. Changes in cardiovascular physiology with normal aging and prevalence of comorbidities are different between both sex. This results in differences in the effects of common cardiac problems as well as the response to their treatments. Clinical trials in octogenarians and nonagenarians PCI results are limited. The present study aims to analyze the gender variations in respect to the success of PCI in this elderly population.Methods: This is a retrospective observational study of patients aged ≥ 80 yrs. with cardiovascular disease undergoing PCI. The prevalence of variables like age distribution, type of presentation, and pattern of angiographic profile, requirement of pre-dilation before stenting and success of PCI has been compared between male and female population. Student “t” test is used for comparison.Results: The study population consists of 174 patients with female to male ratio of 1:3.7. The mean age is 82.4 ± 2.9 yrs in males and 82.2±2.9 yrs. in females. The minimum age is 80 and maximum is 99 yrs. 74(54%) male patients and 20 (54.1%)) female patients presented with chronic stable angina. Incidence of single vessel disease among male population is 97 (70.8%) and female population is 23 (62.1%) (p value=0.3). Rest of them are multi vessel disease. Pre-dilatation is required in 89% male patients and 86% female patients (95% CI = 0.09 to 0.14, P-Value = 0.7). LAD, LCX and RCA angioplasties are comparable between the both groups. Three LMCA PCI in females and 3 SVG PCI in males were done. Successful PCI done in 132 (96.4%) male patients and 35 (94.6%) female patients (p=0.7; CI-0.09 to 0.06).Conclusion: Clinical and demographic features including success of PCI are similar in both female and males in octogenarians and nonagenarians who are undergoing PCI for CAD.

scholarly journals To Establish A Normal Range of Inter-Incisal Opening - A Study of 756 Subjects of Age Group 20-50 Years in Yamunanagar City, Haryana.

2013 ◽  
Vol 01 (01) ◽  
pp. 001-003
Author(s):  
Aruna Singh ◽  
Nymphea Pandit ◽  
Monica Sharma
Keyword(s):  
Pearson Correlation ◽  
Mouth Opening ◽  
Clinical History ◽  
P Value ◽  
Age Group ◽  
Male Population ◽  
Female Population ◽  
Odontogenic Infections ◽  
Anterior Teeth ◽  
Average Maximum

Abstract Aim- 1. The aim of this study was to investigate the average maximum range of inter-incisal mouth opening in a representative sample of the adult subjects of Haryana. 2. To see any correlation between maximal inter-incisal opening with age. Methods- Maximum mouth opening was studied in 756 adult subjects with age range of 20-50 years in Yamunanagar, Haryana. Age limit was further divided into three groups (20-30, 31-40, 41-50). Those with clinical history of TMJ involvement, OSMF, any trauma, odontogenic and non-odontogenic infections, dental prosthesis on the anterior teeth, congenital anomalies in the maxillofacial region were excluded from this study. The measurements were recorded twice and mean of the two values were taken. Statistical Analysis- Independent sample t-test was calculated to compare age and mouth opening in both male and females respectively. Bivariate pearson correlation was used to see any relationship between age and mouth opening. P-value ≤ 0.05 and CI (confidence interval) at 95% were considered statistically significant. The Results- The average mouth opening of males (45.36±6.70 mm) subjects was higher as compared to female (41.27 ± 6.75 mm) with significant, p-value 0.000. The mean mouth opening ± SD for both sexes combined was 43.39 ± 7.02 mm. The corresponding values for mean inter-incisal opening in male population aged 20-30, 31-40, 41-50 were 45.52 ± 7.15, 46.16 ± 5.47, 42.96 ± 6.82 mm and in female population aged 20-30, 31-40, 41-50 were 41.40 ± 7.08, 41.60 ± 6.29 and 40.03 ± 6.38 mm respectively. Conclusion- Maximal mouth opening differ significantly with gender. There is a decrease in MMO with older age group.

scholarly journals LUNG CANCER - STATISTICAL ANALYSIS DATA IN A 5 YEAR PERIOD IN BITOLA, REPUBLIC OF NORTH MACEDONIA

2020 ◽  
Vol 8 (2) ◽  
pp. 108-117
Author(s):  
Jihe Zhu ◽  
Blagica Arsovska ◽  
Kristina Kozovska
Keyword(s):  
Public Health ◽  
Lung Cancer ◽  
Analysis Data ◽  
Malignant Cells ◽  
Female Population ◽  
Female Patients ◽  
The World ◽  
Pulmonary Parenchyma ◽  
Male Patients ◽  
The Republic

Lung cancer is one of the most common and deadly malignancies in the world, which is characterized by uncontrolled division and growth of malignant cells in the pulmonary parenchyma. For the purposes of this paper was used data from the clinical hospital “Dr. Trifun Panovski'' in the Municipality of Bitola, Republic of North Macedonia  in the period of 2015-2019. The results show that the most of the cases are male with the leading age of about 55-64 years. However, the disease is becoming more common in the female population at a later age. Regarding the number of male patients treated in the Municipality of Bitola, it can be noted that the highest number of male patients was in 2018, and the lowest in 2017. Most female patients were treated in 2016 and the least in 2018. From the analysis of the Institute of Public Health, the highest number of male deaths in Bitola occurred in 2014 and the lowest in 2015 and 2018, among female patients, the highest number of deaths was in 2014, but the lowest in 2018. Death outcomes in Bitola represent about 6-7% of total number of deaths in the Republic of North Macedonia.

scholarly journals EVALUATION OF FACTORS ASSOCIATED WITH ASYMPTOMATIC AIRFLOW OBSTRUCTION

2019 ◽  
Vol 3 (8) ◽  
Author(s):  
Dr. Deepali Kamdar
Keyword(s):  
Smoking Habit ◽  
Airflow Obstruction ◽  
Study Participant ◽  
Airway Disease ◽  
Obstructive Airway Disease ◽  
P Value ◽  
Male Population ◽  
Female Population ◽  
Asymptomatic Patients ◽  
Significant Difference

Background: Obstructive Airway Disease also imposes economic burden and increase the out of pocket expenditure of the patient and the country.(1)  In previous researches it was found that obstructive Airway Disease were reported frequently and often present with complications. The most commonly seen obstructive airway diseases are COPD, Asthma, Bronchitis, Bronchiolitis and Bronchiectasis. Material & Methods: In the present study100 Asymptomatic Patients with not previously diagnosed Obstructive Airway disease and patients with no evidence of any physical disease were included in the study. Clearance from Institutional Ethics Committee was taken before start of study. Written informed consent was taken from each study participant. Results: Out of the total, 15 (20.3%) of the male population and 3 (11.5%) of the female population had asymptomatic airflow obstruction with statistically significant difference (P value <0.05). Out of the total on the basis of distribution according to BMI (Kg/m2), 7 (15.5%) patients had airflow obstruction among lower BMI population and 11 (20%) patients had airflow obstruction among higher BMI population with statistically non-significant difference (P value >0.05). ). Out of the total on the basis of distribution according to weight, 4 (11.1%) patients had airflow obstruction among age <50 years population and 14 (21.8%) patients had airflow obstruction among age >50 years population with statistically significant difference (P value <0.05). Conclusion: There was high burden of undiagnosed asymptomatic obstructive airway disease reported among patients who were males, higher age and had higher BMI. Patients who were current smokers had maximum airflow obstruction in compared to patients who never had smoking habit and patients who were ex-smokers. Key words: Obstructive Airway Disease, COPD, Spirometry.

scholarly journals Male Gender is A Risk Factor For Sever Form of COVID-19 Illness and Worse Outcome in The Middle East

2020 ◽  
Author(s):  
Ibrahim Y Hachim ◽  
Mahmood Y Hachim ◽  
Kashif Bin Naeem ◽  
Haifa Hannawi ◽  
Issa Al Salmi ◽  
...  
Keyword(s):  
Middle East ◽  
Liver Function Tests ◽  
P Value ◽  
Icu Admission ◽  
Female Patients ◽  
Wide Range ◽  
Significant Impairment ◽  
History Of ◽  
Male Patients ◽  
Novel Coronavirus

Abstract The identification of risk-factors, predicting the disease severity and outcome in novel coronavirus-disease-19 (COVID-19) patients, is essential to improve responsiveness to this pandemic. The association between gender and wide-range of clinical, pathological, and epidemiological factors was studied in 200-patients recruited during March-April 2020. A higher prevalence of COVID-19 infection in male (72%) compared to females (28%). Age and history of previous comorbidities were nearly comparable between genders (P value 0.75 and 0.97, respectively), male-patients had higher incidence of sever-critical form of the disease (44.67%) compared to only 23.22% in female-patients (P < 0.001). A 26.39% and 1.79% of male and female patients needed Intensive-care-unit (ICU) admission(P < 0.001), respectively. Male-patients developed a significant higher rate of lung injury presented as bilateral airspace consolidation in the plain chest X-ray at admission (38.89%) compared to 23.21% in female patient (P = 0.036%). A significant impairment of the renal-function (P = 0.031) and liver-function tests with higher level of lactate-dehydrogenase (LDH) (P < 0.001), serum bilirubin (P < 0.001), alanine-transferase; ALT (P = 0.036), and aspartate-aminotransferase, AST (P = 0.022) in male patients compared to female patients. In conclusion, this is the first detailed analysis in the middle east that thoroughly investigate the role of gender in determining the clinical course and severity of COVID-19 infection. Males compared to their age matched females, with same prevalence of comorbidities were more vulnerable to the sever COVID-19 illness with higher probability for ICU admission.

scholarly journals Evaluation of Cardiac Repolarization Indices in Epilepsy Patients Treated with Carbamazepine and Valproic Acid

Medicina ◽  
2020 ◽  
Vol 56 (1) ◽  
pp. 20
Author(s):  
Ramazan Asoğlu ◽  
Mahmut Özdemir ◽  
Nesim Aladağ ◽  
Emin Asoğlu
Keyword(s):  
Valproic Acid ◽  
Qt Interval ◽  
Qt Dispersion ◽  
Clonic Seizure ◽  
Control Group ◽  
Cardiac Repolarization ◽  
Healthy Controls ◽  
Male Population ◽  
Female Patients ◽  
Male Patients

Background and Objectives: Epilepsy patients have a higher risk of sudden unexplained death compared to the rest of the population. Cardiac repolarization abnormalities might be seen in epilepsy during interictal periods. We aimed to evaluate the changes in electrocardiography (ECG) parameters in generalized tonic-clonic seizure patients treated with carbamazepine or valproic acid (VPA) drug. Materials and Methods: A totally of 129 subjects (66 epilepsy patients, 63 healthy subjects) were enrolled in the study. Of the patients, 36 were on carbamazepine and 30 were on VPA. There were 12-lead ECGs obtained from all participants. RR interval (time between consecutive R peaks), QT interval (defines the period of ventricular repolarization), corrected QT (QT interval corrected for heart rate; QTc), QTc-maximum (QTc-max), QTc-minimum (QTc-min), QTc dispersion (QTcd), P (atrial depolarization )-maximum (P-max), P-minimum (P-min) and P dispersion (Pd) were measured. Results: QTd (QT dispersion), QTcd, and Pd values were significantly higher in the patients compared to the controls (p < 0.01). QTcd, Pd, and P-max values were statistically higher in male patients compared to healthy male controls. QTcd values were significantly higher in female patients using carbamazepine compared to the female patients on VPA and healthy controls (p = 0.01). Male patients using VPA had significantly higher QTcd values against the male population in carbamazepine and control groups. Conclusions: This study demonstrated that QTd, QTcd, and Pd values were significantly higher in epilepsy patients than in healthy controls. In addition, female patients using carbamazepine and male patients using VPA were prone to ventricular arrhythmia compared to the control group.

scholarly journals Aspects of the life history of the Atlantic poacher, Leptagonus decagonus, in Svalbard waters

2015 ◽  
Vol 36 (1) ◽  
pp. 79-87
Author(s):  
Kristin Heggland ◽  
Camilla A. Meyer Ottesen ◽  
Jørgen Berge
Keyword(s):  
Life History ◽  
Reproductive Strategies ◽  
Age Distribution ◽  
Gut Content ◽  
Sex Distribution ◽  
Male Population ◽  
Female Population ◽  
Significant Difference ◽  
History Of ◽  
Age Range

Abstract The aim of the study is to describe aspects of the life history of the Atlantic poacher (Leptagonus decagonus) obtained during early October 2010 and late September 2011 from the Hinlopen Strait, located between Nordaustlandet and the Spitsbergen Archipelago. Length was measured for 142 individuals, and 82 out of these were weighed, sexed and the age in years determined. The sex distribution in the population was 45% females and 55% males. Gut content examination revealed the domination of the mesopelagic and hyper−benthic calanoid Bradyidius similis that was recorded in 87% of the stomachs analysed. Overall there was a significant difference in size (length and weight) between the sexes, and a difference in length and weight at age between the sexes. There was no difference in age distribution between the sexes, but there was a larger age range within the male population than in the female population. The sexual dimorphism in size is likely linked to different reproductive strategies. This study represents the first data on the life history of the Atlantic poacher in Svalbard waters.

scholarly journals Characteristics of pulmonary tuberculosis patients in Moses Kotane region North West Province, South Africa

2017 ◽  
Vol 59 (2) ◽  
pp. 32
Author(s):  
Jean Louis Yoko ◽  
John Tumbo ◽  
Benjamin A Mills ◽  
Cila Dominic Kabongo
Keyword(s):  
Pulmonary Tuberculosis ◽  
Health Care Facilities ◽  
P Value ◽  
North West ◽  
Female Patients ◽  
Sputum Microscopy ◽  
Significant Difference ◽  
North West Province ◽  
Directly Observed Treatment ◽  
Male Patients

Aim: To determine the characteristics of patients with pulmonary tuberculosis registered in primary health care facilities in Moses Kotane region North West Province. Method: A retrospective record review of pulmonary TB patients registered in five community health centres (CHCs) in 2010 was conducted. Results: Of the 229 new patients diagnosed using sputum microscopy or culture, 176 were cured and 53 were not cured. The mean age for cured patients was 36.4 years and 34.0 years for not cured patients with standard deviations of 13.5 and 11.4 respectively (p-value 0.195). In total, 97 (55.1%) female patients and 79 (44.9%) male patients were cured while 24 (45.3%) female patients and 29 (54.7%) male patients were not cured (p-value 0.214). Among the 169 unemployed patients, 120 (68.2%) were cured and 40 (75.5%) were not cured. Of the 69 patients with employment, 56 (31.8%) were cured and 13 (24.5%) failed to cure (p-value 0.394). Of 176 cured patients, 130 had directly observed treatment (DOT) support while 31 of 53 not cured patients did not have DOT support (p-value 0.00002). Some 154 (67.2%) patients were HIV positive and among them 119 (67.6%) were cured and 35 (66.0%) were not cured while of the 75 who were HIV negative 57 (32.4%) were cured and 18 (33.9%) were not cured (p-value 0.8680). Conclusion: DOT support was a strong predictive characteristic for the outcomes of these TB patients during their treatment with a statistically significant difference between cured and not cured patients; the majority of not cured patients did not have DOT support. Other characteristics like gender, age, HIV status, employment or other medical conditions did not show any statistically significant difference between cured and not cured patients. (Full text of the research articles are available online at www.medpharm.tandfonline.com/ojfp) S Afr Fam Pract 2017; DOI: 10.1080/20786190.2016.1272249

scholarly journals Epidemiology of human brucellosis in Nahavand county, Hamadan Province, western Iran: an 8-year (2010–2017) registry-based analysis

2020 ◽  
Vol 14 (4) ◽  
pp. 151-158
Author(s):  
Salman Khazaei ◽  
Manoochehr Solgi ◽  
Shahram Goodarzi ◽  
Leila Khazaei ◽  
Iraj Salehi ◽  
...  
Keyword(s):  
Rural Areas ◽  
Human Brucellosis ◽  
Male Population ◽  
Female Population ◽  
Western Iran ◽  
History Of ◽  
Male Patients ◽  
The Mean ◽  
Rural Dwellers ◽  
Epidemiological Characteristics

AbstractBackgroundBrucellosis is an infectious zoonosis, which greatly afflicts human health and animal productivity.ObjectivesTo describe the trends and epidemiological characteristics of human brucellosis in Nahavand county, Hamadan Province, western Iran over 8 years (2010–2017).MethodsIn this registry-based longitudinal study, we analyzed all reported cases of human brucellosis, including 1,130 patients from 2010 to 2017. A checklist including demographic and clinical characteristics of patients with reported cases of brucellosis had been used to gather data. We calculated annual percent changes (APCs) and average annual percent changes (AAPCs) using Joinpoint software to determine the trend of brucellosis using a segmented regression model.ResultsAmong the patients, 60.9% were male and 87.3% lived in rural areas. The mean age of the patients was 35.9 ± 18.34 years. Compared with male patients, female patients were more affected when they were elderly (15.6% men vs. 24.2% women for those aged ≥55 years) (P = 0.001). Of patients with brucellosis, 65.2% had consumed unpasteurized dairy products and 82.3% had a history of contact with animals. The incidence of human brucellosis in Nahavand county increased between 2010 and 2014, then decreased in 2015, and thereafter remained steady. Per 100,000 population, the AAPC pertaining to the incidence was 17.4 in the male population (95% CI: 4.4, 31.9), 13.8 in the female population (95% CI: 0.2, 29.3), and 16.1 in rural dwellers (95% CI: 2.2, 31.8) indicating an increasing trend from 2010 to 2017 (P < 0.05).ConclusionThe incidence of brucellosis in the western part of Iran is high and remains a challenging health problem. In the present study, age, job, sex, and seasonal changes are important risk factors for human brucellosis.

scholarly journals Parkinson’s Disease Is Associated With Dysregulation of Circulatory Levels of lncRNAs

2021 ◽  
Vol 12 ◽  
Author(s):  
Kasra Honarmand Tamizkar ◽  
Pooneh Gorji ◽  
Mahdi Gholipour ◽  
Bashdar Mahmud Hussen ◽  
Mehrdokht Mazdeh ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Stage ◽  
P Value ◽  
Roc Curve Analysis ◽  
Expression Ratio ◽  
Male And Female ◽  
Female Patients ◽  
Male Patients ◽  
Non Coding Rnas

Long non-coding RNAs (lncRNAs) have been recently reported to be involved in the pathoetiology of Parkinson’s disease (PD). Circulatory levels of lncRNAs might be used as markers for PD. In the present work, we measured expression levels of HULC, PVT1, MEG3, SPRY4-IT1, LINC-ROR and DSCAM-AS1 lncRNAs in the circulation of patients with PD versus healthy controls. Expression of HULC was lower in total patients compared with total controls (Expression ratio (ER)=0.19, adjusted P value&lt;0.0001) as well as in female patients compared with female controls (ER=0.071, adjusted P value=0.0004). Expression of PVT1 was lower in total patients compared with total controls (ER=0.55, adjusted P value=0.0124). Expression of DSCAM-AS1 was higher in total patients compared with total controls (ER=5.67, P value=0.0029) and in male patients compared with male controls (ER=9.526, adjusted P value=0.0024). Expression of SPRY4-IT was higher in total patients compared with total controls (ER=2.64, adjusted P value&lt;0.02) and in male patients compared with male controls (ER=3.43, P value&lt;0.03). Expression of LINC-ROR was higher in total patients compared with total controls (ER=10.36, adjusted P value&lt;0.0001) and in both male and female patients compared with sex-matched controls (ER=4.57, adjusted P value=0.03 and ER=23.47, adjusted P value=0.0019, respectively). Finally, expression of MEG3 was higher in total patients compared with total controls (ER=13.94, adjusted P value&lt;0.0001) and in both male and female patients compared with sex-matched controls (ER=8.60, adjusted P value&lt;0.004 and ER=22.58, adjusted P value&lt;0.0085, respectively). ROC curve analysis revealed that MEG3 and LINC-ROR have diagnostic power of 0.77 and 0.73, respectively. Other lncRNAs had AUC values less than 0.7. Expression of none of lncRNAs was correlated with age of patients, disease duration, disease stage, MMSE or UPDRS. The current study provides further evidence for dysregulation of lncRNAs in the circulation of PD patients.

scholarly journals CHARACTERISTICS OF PATIENTS WITH ORGANOPHOSPHORUS POISONING AND ITS MANAGEMENT: PHARMACOEPIDEMIOLOGICAL EVALUATION

2019 ◽  
pp. 86-88
Author(s):  
MADHURI KULKARNI ◽  
ANANT PATIL
Keyword(s):  
Total Dose ◽  
Clinical Outcomes ◽  
Female Population ◽  
Male And Female ◽  
Female Patients ◽  
Organophosphorus Poisoning ◽  
Male Patients ◽  
The Mean ◽  
Gastric Irritation ◽  
Acute Organophosphorus Poisoning

Objective: The objective of this study was to analyze demographics, management pattern, and clinical outcomes in patients with organophosphorus poisoning. Methods: In this subgroup analysis of retrospective data of patients admitted in intensive care unit (ICU) with a diagnosis of acute organophosphorus poisoning, demographic details, pattern of use of medicines, dose of atropine and pralidoxime (PRAM), duration of ICU stay, and clinical outcomes were analyzed. Results: A total of 92 patients with organophosphorus poisoning (mean age 34.7 years; male 69 [75%]) were included. The age of male patients was more than female patients (36.2 vs. 30.0 years; p=0.047). Atropine and PRAM were given to all patients. Ondansetron was used in all patients, whereas ranitidine was used in 91 (98.9%) patients. The mean total dose of atropine in male and female population was 99.5 mg and 89.0 mg, respectively (p=0.298). The mean total dose of PRAM in male and female population was 12.2 mg and 12.0 mg, respectively (p=0.772). There was no difference in the mean (standard deviation) duration of stay in ICU between male patients and female patients (7.6 [4.5] vs. 6.4 [3.9] days; p=0.249). A total of 61 (66.3%) patients were transferred to the ward, whereas 30 (32.6%) died. Conclusion: Atropine and PRAM are the primary drugs for the treatment of organophosphorus poisoning. Ondansetron and ranitidine are useful drugs for the treatment of vomiting and gastric irritation, respectively, in these patients.

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