scholarly journals UJI EFEK EKSTRAK GEDI MERAH (Abelmoschus manihot L. Medik) TERHADAP KADAR GULA DARAH TIKUS PUTIH JANTAN GALUR WISTAR (Rattus novergicus) YANG DIINDUKSI ALOKSAN

2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Friska Adeline ◽  
Jane Wuisan ◽  
Henoch Awaloei
Keyword(s):  
Blood Sugar ◽  
Blood Sugar Level ◽  
Leaf Extract ◽  
White Male ◽  
Male Rats ◽  
Male Rat ◽  
The People ◽  
Wistar Strain ◽  
Medicinal Substances ◽  
Sugar Levels

Abstract: Epidemiological study in Manado indicated that the prevalence of Diabetes Melitus (DM) was 6.1%. It is necessary to do scientific assessment of the various species of plants which are thought containing medicinal substances (phytopharmaca). Based on the information from the people living in the subdistrict Pineleng Minahasa red gedi leaves (Abelmoschus manihot L.Medik ) can be used as herbal treatment for lowering blood sugar level. This study aimed to evaluate the effect of red gedi leaves extract in lowering blood sugar level on white male rat induced by aloksan. This study used 15 white male rats of Wistar strain with diabetic induced by 200 mg/kg BW aloksan intraperitoneal. The rats were randomly divided into 5 groups; each group were given aquadest 2,5 ml/ 200 g BW, insulin Novomix 0,9 U/Kg BW, red gedi leaf extract 1.25 mg/200 g BW, 2.5 mg/200 g BW, and 3.75 mg/200 g BW, once daily for 24 hours. Blood sugar levels were measured at 6th, 12th, 18th, and 24 th hours after treatment by using glucometer. The result showed that red gedi leaf extract can lower blood level in diabetic white male rat induced by aloksan.Keywords: red gedi leaf extract, blood glucose, aloksan, diabeticAbstrak: Pada penelitian epidemiologis di kota Manado didapatkan prevalensi penderita DM 6,1 %. Untuk itu perlu dilakukan pengkajian ilmiah terhadap berbagai spesies tumbuhan yang diduga mengandung zat berkhasiat obat (fitofarmaka). Berdasarkan informasi masyarakat di daerah kecamatan Pineleng kabupaten Minahasa daun Gedi Merah (Abelmoschus manihot L.Medik) dapat dimanfaatkan sebagai penanganan herbal untuk menurunkan kadar gula darah. Penelitian ini bertujuan menguji efektivitas ekstrak daun Gedi Merah (Abelmoschus manihot L. Medik) dalam menurunkan kadar gula darah tikus putih jantan galur Wistar (Rattus norvegicus) yang diinduksi aloksan. Tikus galur Wistar sejumlah 15 dinduksi dengan aloksan intraperitoneal 200 mg/kg BB dan dibagi secara acak dalam 5 kelompok penelitian yaitu kelompok perlakuan dengan aquadest 2,5 ml/200 g BB, insulin Novomix 0,9 U / Kg BB, ekstrak daun gedi merah 1,25 mg/ 200 g BB, 2,5 mg/ 200 g BB dan 3,75 mg/ 200 g BB. Perlakuan diberikan satu kali sehari selama 6 hari. Pengukuran kadar glukosa darah dilakukan pada hari ke 2, 4 dan 6 setelah perlakuan menggunakan glukometer. Hasil penelitian menunjukkan bahwa ekstrak daun gedi merah dapat menurunkan kadar glukosa darah tikus putih jantan diabetes yang diinduksi dengan aloksan.Kata kunci: ekstrak daun gedi merah, glukosa darah, aloksan, diabetes

scholarly journals THE EFFECT OF ADMINISTERING MANGOSTEEN RIND EXTRACT (Garnicia mangostana l) COMPARED WITH GLIMEPIRIDE TO THE BLOOD SUGAR LEVELS OF WHITE MALE RAT (Rattus norwegicus l) INDUCED BY STREPTOZOTOCIN

2017 ◽  
Vol 52 (4) ◽  
pp. 241
Author(s):  
Hasyim As’ari ◽  
Dewi Mutmainnah Mahartini
Keyword(s):  
Treatment Group ◽  
Blood Sugar ◽  
White Male ◽  
Data Distribution ◽  
Male Rats ◽  
Male Rat ◽  
Control Group ◽  
Control Group Design ◽  
Significant Difference ◽  
Sugar Levels

The purpose of this study is to prove the differential effect of administering the mangosteen Rind extract due to lowering the blood sugar levels of Winstar white male rats induced by streptozotosin (STZ). This study used a randomized design of the ramdomized posttest only control group design. The sample consisted of 4 groups with a sample size of 7 animals each group of rats. All samples were prepared STZ induction of diabetes with a single dose of 50 mg/Kg BW through intraperitoneal (IP). K0 (control group; given 1% CMC 1 cc/day), K1 (treatment group 1; given 0,054 mg glimepiride/200 grBW, K2 (treatment group 2; given mangosteen Rind extract 50 mg/Kg BW), K3 (treatment group 3; given the mangosteen Rind extract 100 mg/Kg BW). Timing of therapy in each group was for 7 days. Shapiro-Wilk normality test (a=0.05) in the BW D variable data, pre-post STZ GDP and D GDP. Testing homogeneity used Levene's test. When data distribution was normal and homogenous, it used an ANOVA deferential test. When data distribution was normal and inhomogeneous, it proceed to apply T-test with 2 free samples. The results: 1) There were significant differences between K0 D GDP with K1 (p=0.015), K0 to K2 (p=0.003) and group K0 to K3 (p=0.002), 2) Whereas no difference was shown in the K1 with K2 (p=0.442), K1 to K3 (p=0,401) and K2 to K3 (p=0.878). Conclusion: The administration of mangosteen Rind extract doses of 50 and 100 mg/kg bw/day did not differ in lowering blood sugar levels compared with glimepiride administration of a dose of 0.054 mg/200 grBW rat/day. Mangosteen Rind extract dose of 100 mg/kg bw/day and 50 mg/kg bw/day did not provide a significant difference in lowering blood sugar levels.

scholarly journals Mechanism of Pancreatic Islet Number Improvement on Hyperglycemic Wistar Rats (Rattus norvegicus) After Golden Sea Cucumber (Stichopus hermanii) Extract Administration

2020 ◽  
Vol 9 (3S) ◽  
pp. 320-324
Keyword(s):  
Blood Sugar ◽  
Pancreatic Islet ◽  
Blood Sugar Level ◽  
Sea Cucumber ◽  
Histopathological Examination ◽  
Ethanol Extract ◽  
Male Rats ◽  
Laboratory Research ◽  
Control Group ◽  
Sugar Levels

Diabetes mellitus constitutes a metabolic disorder indicated by a decrease in insulin secretion, insulin insensitivity, or a combination of both. Golden sea cucumber (Stichopus hermanii) is a natural resource of Indonesian waters with benefit for reducing blood sugar levels. This research aimed to determine the anti-hyperglycemic mechanism of golden sea cucumber.This study used a experimental laboratory research with Post-test Only Control Group. The sample of this study consisted of 25 male rats aged 60-70 days, divided into 5 groups: K(-), K(+), P1, P2, and P3 randomly. Rats from K(+), P1, P2, and P3 groups were injected with streptozotocin (STZ) with a dose of 50 mg/kg BW. Treatment was administered for 21 days. K(-) and K(+) groups were fed normally while P1, P2 and P3 groups were given golden sea cucumber 80% ethanol extract with a dose of 4,25 mg/kgBW/day, 8,50 mg/kgBW/day and 12,75 mg/kgBW/day respectively. On the 22nd day, fasting blood sugar level was measured and the number of pancreatic islet was counted with histopathological examination. The administration of golden sea cucumber (Stichopus hermanii) extract on rats with hyperglycemia does not reduce blood sugar level, but the extract administration increases the number of pancreatic islet. Golden sea cucumber (Stichopus hermanni) extract may improve the number of pancreatic islet and prevent the progressive damage of pancreatic islet.C

scholarly journals THE EFFECTIVENESS OF CORIANDER (Coriandrum sativum L.) EXTRACTS ON REDUCING THE BLOOD SUGAR LEVELS OF ALLOXAN INDUCED WISTAR MALE RATS (Rattus norvegicus L.)

2020 ◽  
Vol 6 (1) ◽  
pp. 36-44
Author(s):  
Kalvin Dersing
Keyword(s):  
Blood Sugar ◽  
Rattus Norvegicus ◽  
Water Extract ◽  
Coriandrum Sativum ◽  
Male Rats ◽  
Control Group ◽  
Control Group Design ◽  
White Rats ◽  
Wistar Strain ◽  
Sugar Levels

AbstractBackground : Diabetes mellitus is the most common metabolic syndrome in the whole world with an incidence of 1-8%. This disease arises when insufficient insulin is produced or insulin cannot function properly.The ability of coriander juice water extract is expected to reduce blood glucose levels because the action is similar to insulin and can stimulate insulin release. Purpose : Knowing effectiveness coriander extract (Coriandrum sativum L.)to decline blood sugar levels in male white rats (Rattus norvegicus L.) wistar strain induced by alloxan. Method : This is a pure experimental study (true-experiment) using a pre and post test design with control group design using subjects namely white rats (Rattus norvegicus L.) male Wistar strain aged 10-12 weeks with a weight of 150-200 grams. By looking at changes in blood sugar levels during administration of alloxan and administration of coriander extract. Results : There were significant changes in some groups induced alloxan (p <0.05), but the effect of coriander extract was not very significant (p> 0.05). Conclusion : Coriander extract can control blood sugar levels to be stable or normal, but it takes longer and more research.  Keywords : coriander extract, blood sugar levels, alloxan

scholarly journals Effect of Giving Extract of Lannea Coromandelica (Lannea coromandelica (Houttuyn) Merrill) Leaf to Decrease the Blood Sugar Level of Mice (Mus musculus)

2019 ◽  
Vol 8 (4) ◽  
pp. 223-229
Author(s):  
Moh. Husaini ◽  
Supriadi Supriadi ◽  
Minarni R. Jura
Keyword(s):  
Blood Glucose ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Leaf Extract ◽  
Negative Control ◽  
Animal Testing ◽  
Leaf Sample ◽  
Lannea Coromandelica ◽  
Sugar Levels ◽  
Tree Leaf

The Indian ash tree leaf (Lannea coromandelica (Houttuyn) Merrill) contains natural ingredients that can reduce blood glucose levels. This study aimed to determine the concentration of the Indian ash tree leaf extract which is the most effective to reduce blood sugar levels of mice. The leaf sample of the Indian ash tree plant was obtained from Talise sub-district, Mantikulore district, Palu, Central Sulawesi. The preparation of the extract was conducted by the maceration method. The animal testing used were 20 male mice that were induced by EDTA (ethylene diamine tetraacetic acid). Mice were divided into 5 groups as random with different treatments. Treatments I, II, and III were given an extract of 10, 20, and 40%, respectively, treatment IV was given Na-CMC as a negative control (-), and treatment V was given glibenclamide suspension as a positive control (+). The data obtained were analyzed by statistical analysis of variance analysis (ANOVA) and were continued by the Duncan test. The results showed that the Indian ash tree leaf extract can reduce the blood sugar levels of mice. The mean decreased blood glucose level at treatment I was 40.00 mg/dL, treatment II was 47.75 mg/dL, treatment III was 54.75 mg/dL, treatment IV was 1.75 mg/dL, and treatment V was 49.00 mg/dL. The conclusion of this research was that the Indian ash tree leaf extract could reduce the blood sugar level of mice with an effective concentration of 20% with α = 0.05.

scholarly journals 12. The Effect Of Neem Leaves (Azadirachta Indica) Extract To The Blood Profile Of Male Rat (Rattus Norvegicus) Infected With Trypanosoma Evansi Of Krueng Raya Isolat

2018 ◽  
Vol 12 (1) ◽  
pp. 70-76
Author(s):  
Atika Agusty ◽  
Yudha Fahrimal ◽  
Triva Murtina Lubis ◽  
Muhammad Hambal ◽  
Zuhrawaty NA ◽  
...  
Keyword(s):  
Rattus Norvegicus ◽  
Leaf Extract ◽  
White Male ◽  
Positive Control ◽  
Trypanosoma Evansi ◽  
Male Rats ◽  
Male Rat ◽  
Blood Profile ◽  
White Rats ◽  
Neem Leaf Extract

This study aimed to determine the ability of neem leaf extract to maintain the normal blood profile of white male rat (Rattus norvegicus) infected with Trypanosoma evansi. A total of 24 male white rats were divided into 6 groups. The K0 group as the negative control received no T. evansi infection and no neem leaf extract. Furthermore, K1  group (positive control) only infected with T. evansi,  K2 and K3 were given neem leaf extract 50mg/kg BW and 100mg/kgBW, while K4 and K5 were given neem leaf extract 400mg/KgBW and  K5 800mg/kgBW. The neem leaf extract was administered for 3 consecutive days after infection established. The blood of the rats was collected to determine the amount of erythrocyte and leukocyte, hemoglobin level and hematocrit value. The data were analyzed using Analysis of Variance (ANOVA) through SPSS for Windows 16.0. The averages (+SD) of erythrocyte of K0, K1, K2, K3, K4, and K5 were 5,64±0,57; 2,31±1; 1,93±0; 0; 2,55±0,33; and 2,56±0,48. The amount of leukocyte were 4,46±1,09; 4,45±1,91; 5,25±0; 0; 8,42±1,66; and 8,14± 5,17. The value of hemoglobin were 12,00±0,47; 10,50±0,57; 4,30±0; 0; 5,60±0,20; and 9,03±0,66. The level of hematocrit 38,00±1,83; 25,00±9,90; 15±0; 0; 18,00±2,65, and 20,75±1,71. The result showed that the administration of neem leaf extract with doses 400mg/kgBW and 800mg/kgBW were difference significantly (P0.05) compare to the positive control of rats, but could not equalize blood profile of uninfected white male rats

Effects of Myrtus communis leaf extracts on CdCl2-induced metabolic disturbance in male wistar rats

2020 ◽  
Vol 9 (5) ◽  
pp. 185-192
Author(s):  
Hafsa Dellaoui ◽  
Abdelkrim Berroukche ◽  
Bakhta Bouzouira ◽  
Narimen Taibi ◽  
Mohamed Zouidi ◽  
...  
Keyword(s):  
Blood Sugar ◽  
Methanol Extract ◽  
Cadmium Accumulation ◽  
Male Rats ◽  
Myrtus Communis ◽  
Leaf Extracts ◽  
Male Wistar Rats ◽  
Sugar Levels ◽  
Induced Changes ◽  
Preventive Effects

Cadmium (Cd) is widespread in the environment. Cd toxicity targets liver and renal tissues and generates oxidative stress. Medicinal plants produce antioxidants scavenging reactive oxygen species (ROS) and chelate heavy metals. This study aimed to investigate the preventive effects of Myrtus communis leaves hydro-methanol extract (HME) and aqueous extract (AE) on Cdinduced toxicity. The experiments were carried out, during 30 days, on male rats; GR1 (controls), GR2 treated with CdCl2 (18 mg/kg), GR3 co-treated with HME (1 g/kg) and Cd (18 mg/kg), GR4 co-treated with AE (1 g/kg) and Cd (18 mg/kg), GR5 with HME and GR6 with AE. Cd induced changes in biochemical parameters (transaminases, urea, creatinine and blood sugar)related to hepato renal function, increased tissue mortification and decreased animals’ body weight. While the treatment animals, with M. communis leaves (HME) or (AE), regulated blood sugar levels. Hepatic steatosis and loss of glomeruli were particularly induced either by Cd or a co-treatment with Cd and plant extracts. M. communis extracts (HME and EA) can regulate blood sugar levels and prevent cadmium accumulation.

PLASMA FREE FATTY ACID AND BLOOD SUGAR LEVELS IN NEWBORN INFANTS AND THEIR MOTHERS

PEDIATRICS ◽  
1966 ◽  
Vol 37 (4) ◽  
pp. 597-604
Author(s):  
Doman K. Keele ◽  
Jacob L. Kay
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Newborn Infants ◽  
Plasma Free Fatty Acid ◽  
Significant Negative Correlation ◽  
The Mean ◽  
Sugar Levels ◽  
Diabetic Mothers

Simultaneous plasma free fatty acid (FFA) and blood sugar levels were determined for fasting newborn infants during the first 24 hours of life, for their cord bloods, and for their mothers at delivery. The following observations were made. In control infants the mean FFA level rose about three times the cord level after birth and was accompanied by a 25% drop in the mean blood sugar level. Thereafter, the mean blood sugar level remained relatively constant, but the mean FFA level varied from 2½ to 3 times the cord level. There was no significant correlation between the length of maternal fasting prior to delivery and the infant FFA level; there was, however a significant negative correlation between the length of maternal fasting prior to delivery and the infant blood sugar level at 24 hours of age. High FFA levels occurred in the infants of obese mothers and low levels were observed in infants with delayed respirations, in infants of preeclamptic mothers, and in infants of diabetic mothers.

scholarly journals Pengaruh Edukasi Senam Kaki Diabetes Mellitus Berbahasa Tetum Terhadap Sirkulasi Ekstremitas Bawah Dan Kadar Gula Darah Sewaktu Di Centru Saude Comoro, Dili, Timor Leste.

2020 ◽  
Vol 5 (1) ◽  
pp. 16-24
Author(s):  
Carmelita Barros ◽  
Fitri Arofiati
Keyword(s):  
Diabetes Mellitus ◽  
Lower Extremity ◽  
Blood Sugar ◽  
Blood Circulation ◽  
Blood Sugar Level ◽  
Statistical Tests ◽  
Wilcoxon Test ◽  
Timor Leste ◽  
Post Test ◽  
Sugar Levels

ABSTRACT Diabetes mellitus (DM) in Indonesia is better known as diabetes and in Timor Leste DM known as Ra'an Midar has become a very serious health problem, and is the most common endocrine disease. Diabetes mellitus is a degenerative disease that is characterized by metabolic disorders or pancreatic damage so that the pancreas is unable to produce enough insulin to the maximum so that it can cause insulin deficiency in the body both absolute and relative can increase blood sugar levels or hyperglycemia. Data from the Dili District Health Office in 2018 showed that there were 2690 patients with diabetes mellitus, so that diabetic foot exercises were needed. The purpose of this study was to determine the effect of Tetum Language Diabetes Foot Gymnastic Education on Lower Circulation and Lower Blood Sugar Levels at the Saude Comoro Center, Dili, Timor Leste. Method : using the Pre-Experiment method. Independent variable: Education of Tetum Language Diabetes Foot Gymnastics Education, dependent variable: Circulation of Lower Extremity and Blood Sugar Level at a Time. Population 100 people, sample 28 people, sample technique: simple random, data collection: Examination of blood sugar levels, blood circulation, statistical tests: Wilcoxon Test. Results : Most respondents who had good blood circulation were 15 pre- test (53.6%) and 18 post-test (64.3%). And the majority of respondents whose blood sugar levels were good were 14 people pre-test (50.0%) and 20 people post test (71.4%). Based on the results of statistical tests using the Wilcoxon Signed Rank Test, the value of blood circulation is a significant level of 0.005 and the blood sugar level is at a significant level of 0,000. Conclusion : Conclusion there is the influence of Education on Tetun Language Diabetes Foot Gymnastics on Lower Extracurricular Circulation and Blood Sugar Levels At the Saude Comoro Center, Dili, Timor Leste.  Keyword: Leg exercise, lower extremity bloodd circulation, Blood sugar levels, Diabetes mellitus.

scholarly journals Abnormalities in Glucose Blood Level during Antipsychotic Treatment in Schizophrenia Patients

2021 ◽  
Vol 9 (T3) ◽  
pp. 340-344
Author(s):  
Faisal Idrus ◽  
Theodorus Singara ◽  
Dwiwahyu Sunarto ◽  
Saidah Syamsuddin ◽  
Sonny T. Lisal
Keyword(s):  
Side Effects ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Fasting Blood Glucose ◽  
Antipsychotic Treatment ◽  
Antipsychotic Therapy ◽  
Potential Health ◽  
Sugar Levels ◽  
Risperidone Group ◽  
Haloperidol Group

Background: Schizophrenia is one of the mental disorder with many problematic issues, in both psychologically and socially. This disease requires provision of long-term antipsychotic therapy, hence could rise other potential health problems. Antipsychotic treatment can cause serious glucometabolic side-effects, including type 2 diabetes and hyperglycemic emergency. Recent attention has also been focused on antipsychotic-induced hyperglycemic emergencies experienced by new users of typical and atypical antipsychotic. Patients treated with atypical APDs have ~10 times higher risk in developing hyperglycaemic emergencies. In our pre-eliminary study, hyperglycemia condition in new patients occurs in four  in seven patients who received typical and atypical antipsychotics. This condition is often overlooked and is not routinely evaluated. Moreover, it can develop into diabetes and increase the risk of morbidity and mortality in schizophrenia patients. In this study, we would like to determine the acute effects of metabolic (hyperglycemia) in patients treated with antipsychotic (Risperidone and Haloperidol) Measurement of blood sugar levels was performed in groups treated with haloperidol (N = 15) and treated with risperidone (N = 15). Plasma samples were taken at the beginning of treatment, in week IV, and in week VIII. The measurement of glucose levels was performed after meal and in early morning before breakfast (fasting blood glucose level 8 hours). Results: The blood sugar level after meals was significantly higher in the Risperidone group compared to the Haloperidol group  (p <0.001) after IV and VIII weeks. Meanwhile, the fasting blood sugar level was significantly higher in the Risperidone group compared to the Haloperidol group after VIII weeks of treatment ( p <0.001). Conclusions: Both antipsychotics can cause an increase in blood sugar levels. Treatment with Risperidone significantly increased the blood sugar levels compared to treatment with haloperidol. Measurement of blood sugar level is needed to monitor the metabolic effect of antipsychotic, especially in patients treated with Risperidone. It is necessary to have dietary regulation and physical activities to prevent undesired metabolic side effects.

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