Associations with body weight of selected chemical constituents in blood: epidemiologic data.

1978 ◽  
Vol 24 (5) ◽  
pp. 772-777 ◽  
Author(s):  
L Munan ◽  
A Kelly ◽  
C PetitClerc ◽  
B Billon
Keyword(s):  
Body Weight ◽  
Chemical Constituents ◽  
Epidemiologic Data

scholarly journals Assessment of Analgesic, Cytotoxic and Antioxidant activities of Vallaris solanacea (Roth) Kuntze

1970 ◽  
Vol 4 (1) ◽  
pp. 64-68 ◽  
Author(s):  
Utpal Kumar Karmakar ◽  
Dyuti Ghosh ◽  
Samir Kumar Sadhu
Keyword(s):  
Body Weight ◽  
Analgesic Activity ◽  
Antioxidant Activities ◽  
Chemical Constituents ◽  
Radical Scavenging ◽  
Ethanolic Extract ◽  
Free Radical Scavenging ◽  
Phytochemical Analysis ◽  
Phytochemical Study ◽  
Radical Scavenging Properties

The ethanolic extract of leaves and stem of Vallaris solanacea (Roth) Kuntze (Family: Apocynaceae) was screened for its analgesic, cytotoxic and antioxidant activities. Phytochemical analysis of the extract indicated the presence of Reducing Sugar, Tannins, Saponins, Gums, Steroids, Alkaloids, and Glycosides. The ethanolic extract showed statistically significant analgesic activity (p<0.005) in acetic acid induced writhing inhibition in mice at the dose of 500mg/kg body weight and also showed mild effect at the doses of 250mg/kg body weight. In the brine shrimp lethality test, the extract showed cytotoxicity with LC50 80 μg/ml and LC90 320 μg/ml. In the qualitative antioxi-dant assay using DPPH (1, 1-diphenyl-2-picryl hydrazyl) the extract showed free radical scavenging properties. These primary findings suggest that the extract might possess some chemical constituents that are responsible for analgesic, cytotoxic and antioxidant activities. Key words: Vallaris solanacea (Roth) Kuntze; phytochemical study; analgesic activity; cytotoxic activity; antioxi-dant activity. DOI: http://dx.doi.org/10.3329/sjps.v4i1.8869 SJPS 2011; 4(1): 64-68

scholarly journals Chemical Constituents and Pharmacological Properties of Capsule Gurmar - A New Anti-diabetic Formulation of Hamdard Laboratories (Waqf) Bangladesh

1970 ◽  
Vol 3 (1) ◽  
pp. 18-27 ◽  
Author(s):  
Mirola Afroze ◽  
Mridul Kabiraz ◽  
Robiul Islam ◽  
Abdul Ghani
Keyword(s):  
Body Weight ◽  
Analgesic Activity ◽  
Brine Shrimp ◽  
Chemical Constituents ◽  
Field Tests ◽  
Tolerance Test ◽  
Metformin Hydrochloride ◽  
Pharmacological Properties ◽  
Immersion Method ◽  
Standard Drug

Capsule Gurmar is a new polyherbal Unani formulation developed by the R&D department of Hamdard Laboratories (Waqf) Bangladesh for management and treatment of diabetes. This study was aimed to investigate the chemical constituents and analgesic, antioxidant, neuropharmacological, cytotoxic, and hypoglycemic properties of the formulation using standard methods. Phytochemical tests on the hydromethanolic extract of the contents of the capsules showed the presence of carbohydrates, glycosides, saponins, steroids, flavonoids, alkaloids and tannins in the formulation. When tested by acetic acid-induced Writhing test, the extract at higher dose (400mg/kg) showed mild analgesic activity compared to standard drug Diclofenac-Na (10mg/kg). But, by Tail immersion method, the extract at the same dose showed moderate analgesic activity compared to the standard drug, Nalbuphine at 10mg/kg body weight. The Gurmar capsule extract exhibited high total antioxidant capacity (622.326 mg/g) and had high flavonoid (386.43 mg/g) and phenol (184.60 mg/g) contents. In the Hole cross and Open field tests, the extract displayed significant suppression of locomotor activity and exploratory behaviour of the mice. When subjected to Brine shrimp Lethality Bioassay, the extract was found to be significantly toxic to Brine shrimp nauplii (having L50 value of 3.16μg/ml). Glucose Tolerance Test (GTT) demonstrated quite strong hypoglycemic activity of the formulation, which significantly lowered the blood glucose level of the treated mice both at doses of 100 mg and 200mg/kg body weight. The hypoglycemic effect was comparable to that of the standard oral hypoglycemic drug, Metformin hydrochloride at the dose of 100mg/kg. These results indicate that Capsule Gurmar possesses mild analgesic, antioxidant, CNS depressant, cytotoxic, and hypoglycemic properties. Key words: capsule Gurmar; chemical constituents; pharmacological properties; hypoglycemic effects. DOI: 10.3329/sjps.v3i1.6794S. J. Pharm. Sci. 3(1): 18-27

scholarly journals ANTIOXIDANT AND HEPATOPROTECTIVE EFFECT OF QUERCUS ILEX LEAVES EXTRACT IN ETHANOL INDUCED LIVER DAMAGE IN WISTAR RATS

2020 ◽  
pp. 26-31
Author(s):  
RENU MALIK ◽  
K. G. SINGHAL
Keyword(s):  
Body Weight ◽  
Wistar Rats ◽  
Quercus Ilex ◽  
Chemical Constituents ◽  
Liver Weight ◽  
Positive Control ◽  
Positive Control Group ◽  
Ethanol Administration ◽  
Control Group ◽  
Standard Drug

Objective: This study was undertaken to investigate the hepatoprotective and antioxidant activity of Quercus ilex leaves extract (QILE) on ethanol-induced toxicity in Wistar rats. Methods: Hepatotoxicity was induced by administering ethanol (40%) at a dose of 7.9 gm/kg/day; p. o. (1:1 of ethanol in olive oil) for 28 d. Silymarin 100 mg/kg/day; p. o. was used as a standard drug. The whole study was divided into a prophylactic and curative study. In the prophylactic study, the Silymarin and QILE (test drug) 100, 200, and 400 mg/kg Body Weight(BW) given orally one hour before administration of 40% ethanol administration for 28 d. In the curative study, 7 d of treatment of Silymarin and QILE 200 and 400 mg/kg BW was given orally after 28 d of ethanol administration to different groups. Results: Hepatoprotectivity was confirmed by the highly significantly (p<0.001) restoration of elevated biochemical parameters like SGPT, SGOT, ALP, TB, and highly significantly (p<0.001) depleted Albumin and Total protein levels by 200 mg/kg BW QILE in comparison to the positive control group. QILE 200 mg/kg highly significantly (p<0.001) raised the antioxidants by draining the elevated oxidative stress markers in comparison of positive control group. At dose levels QILE 200 mg/kg, significant (p<0.05) protection from loss in body weight and in liver weight was found when the comparison was done with the positive control group. Histopathology revealed that QILE 200 mg/kg reduced the markers of cell necrosis. Conclusion: Present study revealed that Quercus ilex leaves have antioxidant and hepatoprotective activity due to its chemical constituents.

Growth patterns in sheep: changes in the chemical composition of the empty body and its constituent parts during weight loss and compensatory growth

1984 ◽  
Vol 103 (1) ◽  
pp. 17-24 ◽  
Author(s):  
B. W. Butler-Hogg
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Chemical Composition ◽  
Chemical Constituents ◽  
Growth Patterns ◽  
The Body ◽  
Control Group ◽  
Relative Contribution ◽  
Body Components ◽  
Three Body

SummaryChemical compositional (protein, fat, ash and water) changes in the fleece-free empty body, carcass, viscera and ‘remainder’ components of Corriedale wether sheep were measured by serial slaughter of animals following five different growth paths.The composition of sheep, after losing up to 34% of body weight over 18 weeks at 125 g/day, was significantly different from a continuously growing control group at the same body weight, but the actual differences in the weights of tissues were small. At the end of weight loss all treatment sheep contained more fat and protein, and less water than controls.The different growth paths followed during weight loss led to differences in the proportions of protein, fat, ash and water lost and to differences between the three body components in the relative contribution made by each.The periods of weight loss led to changes in the relative growth coefficients for chemical constituents during realimentation, particularly those of fat and ash which were reduced, and of water which was increased.The response to realimentation differed between body components, particularly the carcass and viscera. Above the body weight at which weight loss was imposed the realimented sheep did not differ in chemical composition from the continuously ad libitum fed controls when compared at the same weight.

scholarly journals Comparative Study between Saffron (Crocus sativus L.) and / or Turmeric (Curcuma longa L.) Extracts on D-galactose Deleterious Brain Effects in Rats

2021 ◽  
pp. 33-57
Author(s):  
Fatma Hussien Ahmed ◽  
Kout Elkoloub Baker ◽  
Alyae M. S. Gabal
Keyword(s):  
Body Weight ◽  
Microscopic Examination ◽  
Inflammatory Markers ◽  
Ache Activity ◽  
Biochemical Analysis ◽  
Chemical Constituents ◽  
Immunohistochemical Analysis ◽  
Epigenetic Marker ◽  
Active Chemical ◽  
Ethanolic Extracts

Aims: This study was designed to investigate the active chemical constituents and antioxidant capacities of saffron stigmas and turmeric rhizomes ethanolic extracts (ESE and ETE) respectively. D- galactose deleterious brain effects as well as the role of ESE and ETE supplementation against D-galactose intoxication were evaluated on male rat’s brain. Place of study: Biochemistry and Nutrition Department, Faculty of Women for Arts, Science and Education, Ain Shams University. Methodology: Fifty adult male Sprague-Dawley rats were divided into 5 groups; 10 rats each. Group (1): Healthy control; group (2): D-galactose control; rats were intoxicated with D-galactose (250mg/kg body weight /day/subcutaneously); group (3-5): D-galactose intoxicated rats and supplemented with (30mg /kg body weight /daily orally) of ESE, ETE and (15mg /kg body weight /daily orally) from each extract respectively for six weeks. Results: Research results revealed that saffron and turmeric ethanolic extracts contain active chemical constituents including polyphenols and flavonoids that possess high antioxidant activity. Biochemical analysis of brain tissues documented that injection with D-galactose caused significant increase (p≤0.05) in oxidative stress parameters including [advanced glycation end products (AGEs), protein carbonyl group (PCG), malondialdehyde (MDA) and nitric oxide (NO) Levels], pro-inflammatory markers like [tumor necrosis factor alpha (TNF-α) and interleukin -6 (IL-6) levels] , epigenetic marker [p16INK4a content] as well as neural cell markers [metallothoenins (MTs) and serotonin (5-HT) levels].On the other hand D-galactose intoxication caused significant decrease (p≤0.05) in brain antioxidants as [total antioxidant capacity (TAC), reduced glutathione (GSH) level and catalase (CAT) activity] as well as brain acetylcholinesterase (AChE) activity. All these results were proved by the microscopic examination and apoptotic markers immunohistochemical analysis of brain tissues that revealed degenerative changes in cerebral cortex and hippocampus. Oral administration of saffron and turmeric ethanolic extracts alone or in combination decreased brain oxidants, pro-inflammatory markers, epigenetic marker and neural cell markers levels while increased the levels and activities of antioxidants as well as AChE activity associated with an improvement of brain microscopic examination and immunohistochemical analysis. The most significant improvements (p≤0.05) were recorded in the group that supplemented with both extracts. Conclusion: Study results proved that saffron and turmeric ethanolic extracts active components were able to correct deleterious brain effects induced by D-galactose and using their mixture was more efficient in ameliorating brain toxicity than using each extract alone evidenced by biochemical analysis, microscopic examination as well as immunohistochemical determination of apoptotic markers in bmrain tissues. It is advised to add saffron and turmeric to human foods and to prepare their ethanolic extracts to be available for human beings due to their ability to preserve brain functions and structure as well as their potential to inhibit and retard brain aging and neuro-degeneration.

scholarly journals GC-MS Analysis of Chemical Constituents of Hydroalcoholic Leaf Extract of Cissampelos Pareira and Their Anti-Diabetic Activity

2021 ◽  
pp. 36-49
Author(s):  
Mohammad Asif ◽  
Sadaf Jamal Gilani ◽  
Mohamad Taleuzzaman ◽  
Chandra Kala ◽  
Deepak Godara ◽  
...  
Keyword(s):  
Body Weight ◽  
Liver Enzymes ◽  
Chemical Constituents ◽  
Density Lipoprotein ◽  
Control Group ◽  
Oral Glucose ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Hydroalcoholic Extract ◽  
Ms Analysis

Aim: The present work deals with the GC-MS-analysis of chemical constituents of hydroalcoholic extract of Cissampelos pareira leaves and thier anti-diabetic activity. Methods: GC-MS analysis of extract was performed using Shimadzu QP-2010 plus with thermal desorption system 20. Acute oral toxicity of extract was done using the Organization of Economic Co-operation and Development (OECD) guideline 423. Diabetes was induced by single dose of streptozotocin 65 mg/kg, i.p. to all the rats except in rats of control group. Following which oral glucose tolerance test was performed and the rats were divided into various experimental groups. Various treatments continued for 21 days. Parameters such as blood glucose level, body weight, liver enzymes, lipid profiles and oxidative markers were checked. Results: GC-MS analysis of the extract identified 25 compounds present in it. Based on acute oral toxicity study three doses of hydroalcoholic extract of Cissampelos pareira leaves viz 100, 200 and 400 mg/kg were selected for evaluation of anti-diabetic activity. The extracts at doses 200 and 400 mg/kg BW were able to reduce blood sugar level, liver enzymes, total cholesterol, total triglyceride, low density lipoprotein and Malondialdehyde; and enhance body weight, high density lipoprotein and Glutathione significantly when compared to rats of negative control group. The effect of extract at dose 400 mg/kg was comparable to standard Glibenclamide. Conclusion: Results conclude that the chemical constituents present in the hydroalcoholic extract of Cissampelos pareira contained some anti-diabetic compounds possessing strong anti-diabetic activity.

scholarly journals Identification, Molecular Profiling, Docking Studies and determination of In-vivo Anti-Inflammatory Potential of Teucrium Stocksianum Bioss Fixed Oil (FO)

2021 ◽  
Author(s):  
Syed Muhammad Mukarram Shah ◽  
Syed Muhammad Hassan Shah ◽  
Rehman Zafar ◽  
Mohammad Ijaz Khan ◽  
Fida Hussain ◽  
...  
Keyword(s):  
Body Weight ◽  
Arachidonic Acid ◽  
Acute Toxicity ◽  
Chemical Constituents ◽  
Saturated Fatty Acids ◽  
Prostaglandin E ◽  
Paw Edema ◽  
Teucrium Stocksianum ◽  
Edema Model ◽  
Anti Inflammatory

Abstract Background: Considering the positive and valuable upshots of the naturally occurring ingredients as the complementary treatment for many ailments, this study investigates the Teucrium Stocksianum Bioss Fixed Oil (FO) for the treatment of inflammation.Methods: Different plants of the Teucrium genera have been employed occasionally for the management of different disorders. Teucrium stocksianum (Lamiaceae) is traditionally use as antipyretic along with remedy of inflammation, diabetes and tumors. It also occupies the capacity to purify the blood. The aim of this study is to determine the chemical constituents and anti-inflammatory potentials of Teucrium stocksianum fixed oil (FO). Qualitative and quantitative analysis of fixed oil were performed via GC-MS (Gas Chromatography coupled with Mass Spectrometer). Preliminary inflammation antagonistic activity was calculated in mice using the carrageenan-induced paw edema model while the mechanism behind this inflammatory antagonistic effect was determined by employing various inflammogens including arachidonic acid, prostaglandins E2 and leukotriene via paw edema model.Results: The acute toxicity of fixed oil was determined at 3, 6 and 10 ml/kg body weight of the mouse. The GC-MS analysis documented 21 various unsaturated and saturated fatty acids elements. The methyl esters of octadecadienoic and linoleic acids were found predominantly at 22.60% and 23.84% respectively. In preliminary screening, FO demonstrated substantial anti-inflammatory capacity (67.87%, **P ˂ 0.01) in carrageenan induced paw edema model at 3 ml/kg body weight. The activity reached a peak value at the 3rd hour and continued persistent until the 5th hour of sample administration. FO displayed dose-dependent inhibition against all inflammogens at 3 ml/kg at 3rd h of the FO administration. These have shown marvelous protection i.e. 64.92%, 68.75%and 58.3% against arachidonic acid, prostaglandin E2 and leukotriene accordingly, at 3 ml/kg. The arachidonic acid antagonist (Caffeic acid) demonstrated 69.43% activity at 100 mg/kg after 3rd h of its administration while in the acute toxicity test, FO has shown no grass lethality at 10 ml/kg dose.Conclusion: According to our findings, the FO of T. stocksianum exhibits inflammation antagonistic potential through both lipoxygenase (LOX) and cyclooxygenase (COX) enzyme inhibition strategies that intensely sustenance the traditional practice of T. stocksianum in the management of multiple pathological inflammatory situations. The computed binding energies of the molecules exposed have synergistic potential to avert inflammation.

CHEMICAL GROWTH IN MAN

PEDIATRICS ◽  
1952 ◽  
Vol 9 (1) ◽  
pp. 58-68
Author(s):  
GILBERT B. FORBES
Keyword(s):  
Body Weight ◽  
Young Adulthood ◽  
Chemical Constituents ◽  
Normal Growth ◽  
Growth Equation ◽  
Differential Growth ◽  
Normal Subject ◽  
Total Body

From midfetal life to the period of young adulthood, chemical growth, as regards Na, K and H2O, proceeds in a manner which conforms to the differential growth equation, y = bxk. Equations of this general form have been derived for each of the chemical constituents in question, from which mean total body content can be calculated for any normal subject of given body weight. Retentions of Na, K and H2O resulting from normal growth can be anticipated by means of these equations.

scholarly journals A growth model to predict body weight and body composition of broilers

2018 ◽  
pp. 17-24
Author(s):  
Galyna Dukhta ◽  
Jaap Van Milgen ◽  
György Kövér ◽  
Veronika Halas
Keyword(s):  
Body Weight ◽  
Growth Model ◽  
Feed Intake ◽  
Growth Models ◽  
Chemical Constituents ◽  
The Body ◽  
Feed Conversion ◽  
Livestock Farming ◽  
Protein Deposition ◽  
Nutrient Partitioning

Models predicting the nutrient partitioning and animal performance have been developed for decades. Nowadays, growth models are used in practical animal nutrition, and they have particular importance in precision livestock farming. The aim of the present study was to introduce a broiler model and to provide examples on model application. The model predicts protein and fat deposition as well as the body weight of an individual broiler chicken from digestible nutrient intake over time. Feed intake (FI) and the digestible nutrient content of the feed are inputs as well as some animal factors like: initial BW, feed intake at 1 and 2 kg of BW, precocity and mean protein deposition. The protein and energy metabolism is represented as in the classical nutrient partitioning models. The protein deposition (PD) is driven by digestible amino acid supply and is under “genetic control”, the so-called potential PD limits the actual PD if protein is oversupplied. The authors discuss how the model can be used to simulate the animal response upon different scenarios. Examples are given to show that the diet might be limiting if some animal trait is changed. Applicability of the model has shown through running the model by using different feed strategies (three- vs five-phase-feeding) and variations with animal factors. In conclusion, growth models are useful tools to support decision making for defining the most suitable feeds used in a broiler farm. The model presented in this paper shows a high sensibility and flexibility to test different scenarios. By challenging the model with different inputs, the animal response in terms of changes in body weight and feed conversion can be understood more by studying the shift in deposition of chemical constituents. The examples provided in the present paper shows the benefit of using mathematical models and their applicability in precision nutrition. It can be concluded that the growth model helps to apply “from desired feed to desired food” concept.

Electron microscopic studies on ultrathin frozen sections of lactating mouse mammary gland

1978 ◽  
Vol 36 (2) ◽  
pp. 46-47
Author(s):  
Jan Zarzycki ◽  
Joseph Szroeder
Keyword(s):  
Mammary Gland ◽  
Protein Denaturation ◽  
Chemical Constituents ◽  
Freeze Substitution ◽  
Electron Microscopic Examination ◽  
Mouse Mammary Gland ◽  
Electron Microscopic ◽  
Preparation Methods ◽  
Microscopic Studies ◽  
Ultrathin Frozen Sections

The mammary gland ultrastructure in various functional states is the object of our investigations. The material prepared for electron microscopic examination by the conventional chemical methods has several limitations, the most important are the protein denaturation processes and the loss of large amounts of chemical constituents from the cells. In relevance to this,one can't be sure about a degree the observed images are adequate to the realy ultrastructure of a living cell. To avoid the disadvantages of the chemical preparation methods,some autors worked out alternative physical methods based on tissue freezing / freeze-drying, freeze-substitution, freeze-eatching techniqs/; actually the technique of cryoultraraicrotomy,i,e.cutting ultrathin sections from deep frozen specimens is assented as a complete alternative method. According to the limitations of the routine plastic embbeding methods we were interested to analize the mammary gland ultrastructure during lactation by the cryoultramicrotomy method.

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