P1033Impact of workflow modifications in atrial fibrillation ablation for reducing the incidence of silent cerebral lesions with a new multi-electrode radiofrequency balloon catheter

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
M Grimaldi ◽  
C Tondo ◽  
S Riva ◽  
P Neuzil ◽  
N Ghaly ◽  
...  
Keyword(s):  
Balloon Catheter ◽  
Temperature Limit ◽  
Maximum Temperature ◽  
The Novel ◽  
Neurological Assessment ◽  
Cerebral Lesions ◽  
Activated Clotting Time ◽  
Cardiac Procedures ◽  
History Of ◽  
The Impact

Abstract Background Silent cerebral lesions (SCL) often occur after invasive cardiac procedures. Reported SCL incidence with AF ablation varies (incidence, up to 50%), depending on technology used, procedural workflow, and detection method. Objective To evaluate the impact of ablation workflow modifications on SCL incidence following pulmonary vein isolation radiofrequency (RF) ablation with a novel multi-electrode RF balloon catheter in patients with symptomatic paroxysmal AF (PAF). Methods In the RADIANCE feasibility study of the balloon catheter, all enrolled patients who underwent ablation were screened for SCL using pre- and post-procedural diffusion-weighted MRI. Several modifications were made to the ablation workflow in a subsequent European registration study (SHINE) of the same catheter: eliminating dual transseptal access, using an over-the-wire mini lasso, continuously irrigating all side ports, bolus dosing with heparin before transseptal puncture, maintaining activated clotting time (ACT) at 350–400 sec, and setting a maximum temperature limit of 55°C (previously, 60–65°C). Interim data are presented for SHINE (data cutoff, 22 Oct 2018). Results In the neurological assessment evaluable (NAE) populations of RADIANCE (n=38) and SHINE (n=30), respectively, mean ages were 60.8±10.04 and 59.7±7.83 years, and 57.9% and 70.0% were male. One patient in each study had a history of TIAs. SCL incidences were 23.7% (10 lesions in 9 patients) in RADIANCE and 7.1% (2 lesions in 2 patients) in SHINE (excluding 1 SCL that occurred in a patient who failed to meet inclusion criteria [age>75] and 1 SCL that occurred after data cut-off). SHINE NAE enrollment has since completed with no further SCL occurrences. Overall, mean ACTs were 344.3±24.55 sec in RADIANCE and 381.6±73.31 sec in SHINE (p=0.01); in patients with SCL, mean ACTs were 349.3±25.65 and 417.8±87.33 sec, respectively. Conclusion(s) Modifications to the workflow led to a decrease in the SCL incidence for PAF ablation using the novel RF balloon catheter. Acknowledgement/Funding These studies were sponsored by Biosense Webster, Inc.

scholarly journals Respiratory Care in Corona

2021 ◽  
Vol 58 (2) ◽  
pp. 613-620
Author(s):  
Mustafa Amdani, Dr. Swaroopa Chakole
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Human Life ◽  
The Body ◽  
Respiratory Care ◽  
The Novel ◽  
Specific Therapy ◽  
History Of ◽  
Novel Coronavirus ◽  
Almost All ◽  
The Impact

BACKGROUND The expanse of the coronavirus disease 2019 or COVID-19 is huge. The impact is multispectral and affected almost all aspects of human life. SUMMARY Respiratory impact of the COVID-19 is the most felt and widely reported impact. As the novel coronavirus maintained its history of affecting lungs as seen previously in severe acute respiratory syndrome (SARS) outbreak. Ventilators and oxygen support system are required mostly in comorbid patients particularly amongpatientsbearing illnesses like asthma, bronchial impairment and so on. CONCLUSION More study needs to be done in order to assess the impact on the respiratory functioning of the body. Respiratory care must be including proper instruments so that more efficient result can be obtained. Research is needed to promote the invention of specific therapy for targeted action for respiratory functioning improvement.

scholarly journals Role of Selenium in Viral Infections with a Major Focus on SARS-CoV-2

2021 ◽  
Vol 23 (1) ◽  
pp. 280
Author(s):  
Sabrina Sales Martinez ◽  
Yongjun Huang ◽  
Leonardo Acuna ◽  
Eduardo Laverde ◽  
David Trujillo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Immune System ◽  
Viral Infections ◽  
Selenium Deficiency ◽  
The Novel ◽  
Stress Studies ◽  
History Of ◽  
The Impact ◽  
Nutritional Strategies ◽  
Healthy Immune System

Viral infections have afflicted human health and despite great advancements in scientific knowledge and technologies, continue to affect our society today. The current coronavirus (COVID-19) pandemic has put a spotlight on the need to review the evidence on the impact of nutritional strategies to maintain a healthy immune system, particularly in instances where there are limited therapeutic treatments. Selenium, an essential trace element in humans, has a long history of lowering the occurrence and severity of viral infections. Much of the benefits derived from selenium are due to its incorporation into selenocysteine, an important component of proteins known as selenoproteins. Viral infections are associated with an increase in reactive oxygen species and may result in oxidative stress. Studies suggest that selenium deficiency alters immune response and viral infection by increasing oxidative stress and the rate of mutations in the viral genome, leading to an increase in pathogenicity and damage to the host. This review examines viral infections, including the novel SARS-CoV-2, in the context of selenium, in order to inform potential nutritional strategies to maintain a healthy immune system.

scholarly journals Did COVID-19 Lockdown Brew “Amphan” into a Super Cyclone?

2020 ◽  
Author(s):  
Velu Vinoj ◽  
Debadatta Swain
Keyword(s):  
West Bengal ◽  
The Novel ◽  
Wind Speeds ◽  
The World ◽  
History Of ◽  
The Indian Ocean ◽  
Super Cyclone ◽  
Novel Coronavirus ◽  
The Impact ◽  
Joint Typhoon Warning Center

The world witnessed one of the largest lockdowns in the history of mankind ever, spread over months in an attempt to contain the contact spreading of the novel coronavirus induced COVID-19. As billions around the world stood witness to the staggered lockdown measures, a storm brewed up in the urns of the rather hot Bay of Bengal (BoB) in the Indian Ocean realm. When Thailand proposed the name “Amphan” (pronounced as “Um-pun” meaning ‘the sky’), way back in 2004, little did they realize that it was the christening of the 1st super cyclone (Category-5 hurricane) of the century in this region and the strongest on the globe this year. At the peak, Amphan clocked wind speeds of 168 mph (Joint Typhoon Warning Center) with the pressure drop to 925 h.Pa. What started as a depression in the southeast BoB at 00 UTC on 16th May 2020 developed into a Super Cyclone in less than 48 hours and finally made landfall in the evening hours of 20th May 2020 through the Sundarbans between West Bengal and Bangladesh. Did the impact of the COVID-19 induced lockdown drive an otherwise typical pre-monsoon tropical depression into a super cyclone?

The Indulekha Moment and the Malayalam Literary Canon: On the Literary History of the Early Twentieth-century Novels in Kerala, South India

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Sruthi Vinayan ◽  
◽  
Merin Simi Raj ◽  
Keyword(s):  
Twentieth Century ◽  
Literary History ◽  
The Novel ◽  
Literary Canon ◽  
Colonial Modernity ◽  
Early Twentieth Century ◽  
History Of ◽  
Literary Histories ◽  
The Impact ◽  
Point Of Departure

This article analyses the politics of the literary canon of the early twentieth century Malayalam novels with particular focus on the impact of the novel Indulekha (1889) in literary history. The inception of novel as a literary genre is widely regarded as a point of departure for Malayalam literature leading to the development of modern Malayalam, thereby shaping a distinct Malayali identity. Interestingly, the literary histories which established the legacy of Malayalam prose tend to trace a linear history of Malayalam novels which favoured the ‘Kerala Renaissance’ narrative, especially while discussing its initial phase. This calls for a perusal of the literary critical tradition in which the overarching presence of Indulekha has led to the eclipsing of several other works written during the turn of the twentieth-century, resulting in a skewed understanding of the evolution of the genre. This article would explicate in detail, on what gets compromised in canon formation when aesthetic criteria overshadow the extraliterary features. It also examines how the literary history of early Malayalam novels shaped the cultural memory of colonial modernity in Kerala.

Introduction

2021 ◽  
pp. 1-36
Author(s):  
Josephine McDonagh
Keyword(s):  
British Literature ◽  
World Wide ◽  
New Technologies ◽  
Human Mobility ◽  
Common Denominator ◽  
The Novel ◽  
English Novel ◽  
History Of ◽  
The Common ◽  
The Impact

The increased extent and rapidity of migration was a world-wide phenomenon in the nineteenth century and forms the context of a dynamic period in the history of the English novel. Although British literature often seems unwilling to represent migration, nevertheless the form of the novel in this period is shaped in the context of the frenetic transcontinental movement of people. The common denominator of migration and fiction in this period is print, which, in this period, through new technologies was cheaper and more easily produced. Print helped to stimulate and sustain migration through the production of information for emigrants. Moreover, the development of printing presses in settler colonies stimulated important new readerships especially for fiction, which flourished as a consequence. Fictions in this period show the impact of increased human mobility in both their themes, and their formal attributes. They interrogate questions that are provoked by colonization and mass mobility, regarding community, freedom, democracy, and displacement; and they develop an aesthetic that is characterized by an emphasis on contiguity, and adjacent relations.

His own Chernobyl: The embodiment of radiation and the resistance to nuclear extractivism in Nadine Gordimer’s Get a Life

2020 ◽  
pp. 002198942093398
Author(s):  
Vivek Santayana
Keyword(s):  
Nuclear Power ◽  
The Novel ◽  
Human Beings ◽  
Racial Oppression ◽  
The People ◽  
Human Ecosystem ◽  
History Of ◽  
Slow Violence ◽  
The Impact ◽  
Human Landscape

According to Gabrielle Hecht, nuclear energy in South Africa is mired in a wider history of colonial extractivism and racial oppression. Nadine Gordimer’s 2005 novel Get a Life critiques this politics of nuclear power and the way in which it extends the logic of colonialism to the exploitation of the non-human ecosystem in the interest of capital. However, the spatial and temporal scale of nuclear colonialism defy representation in discursive knowledge. This is because the threat posed by nuclear contamination, on both the non-human ecosystem and the people who have been exposed to radiation, is what Rob Nixon describes as a form of “slow violence”, dispersed across vast temporal and geographical scales that are unrepresentable within human understanding. In response, Get a Life marks a phenomenological shift in Gordimer’s strategies of engagement: through the ambiguities and contradictions of form, the novel demonstrates the reconfiguration in the human subject’s encounter with the non-human ecosystem following the impact of nuclear technology in neo-imperial contexts. Through the protagonist Paul Bannerman’s emerging radioactivity, the novel tentatively imagines a shared vulnerability of both human and non-human beings to nuclear catastrophe in a way that rejects the binary logic of human exploitation of the non-human landscape and characterizes what Donna Haraway terms “response-ability” towards the non-human. Through this embodied response-ability, Gordimer presents a new idiom that offers an alternative way of engaging with the unrepresentable scale of nuclear colonialism.

scholarly journals Cartesius dissoluto / Dissolute Cartesius

2021 ◽  
Vol 30 (3) ◽  
pp. 59
Author(s):  
Danilo Bernardes Teixeira
Keyword(s):  
Rene Descartes ◽  
Botanical Garden ◽  
The Novel ◽  
Brazilian Literature ◽  
French Mathematician ◽  
René Descartes ◽  
History Of ◽  
The Mind ◽  
European Thought ◽  
The Impact

Resumo: No romance Catatau, de Paulo Leminski, uma personagem reconhecível se projeta: Renatus Cartesius, produtor do imenso solilóquio que constitui a totalidade do texto, parece corresponder a René Descartes, o famoso matemático francês do século XVII. Postado sob uma árvore do Jardim Botânico de Recife, entre as lentes de sua luneta e o cachimbo de erva narcótica que vorazmente aspira, Cartesius toma contato com a selvagem natureza brasileira, ainda que (cartesianamente) organizada sob as formas de um jardim zoobotânico. Este artigo pretende investigar, a princípio, o modo pelo qual o romance- ideia de Leminski agencia esse inevitável contraste entre dois Descartes: o Descartes da história da filosofia, autor das Regras para a direção do espírito, e o desregrado Cartesius da situação ficcional engendrada por Leminski. Para realizar tal investigação, este artigo procurou se ater a algumas passagens do romance, com o intuito de checar os modos pelos quais a paródica e carnavalesca figuração de Descartes se baseia em uma anticartesiana dissolução da integridade egoica da personagem, gerando, com isso, muito mais que superficial humorismo. Antes, o artigo defende a hipótese de que, com a dissolução da figura de Descartes, o romance esboça antropofágica reação aos processos coloniais a que o Brasil teria sido exposto, ao longo de sua história. Tal reação, contracolonizadora, se sustenta na medida em que associa o esfacelamento egoico de Cartesius ao impacto causado por uma exuberante natureza que, por sua hiperbólica constituição, não se submete às quadraturas impostas pelo pensamento europeu – de que Descartes se faz emblema.Palavras-chave: Paulo Leminski; Catatau; René Descartes; literatura brasileira; estudo de personagem; filosofia.Abstract: In Paulo Leminski’s novel, Catatau, a recognizable character is projected: Renatus Cartesius, the immense soliloquy’s producer that constitutes the entire text, seems to correspond to René Descartes, the famous 17th century French mathematician. Standing under a tree at the Recife Botanical Garden between the lenses of his bezel and the narcotic weed pipe he voraciously smokes, Cartesius makes contact with the wild Brazilian nature, although (Cartesian) organized in the form of a zoobotanical garden. This article intends to investigate at first the way in which Leminski’s novel-idea handles this inevitable contrast between both Descartes: Descartes from the History of Philosophy, author of Rules for the Direction of the Mind and the intemperate Cartesius from the fictional situation engendered by Leminski. To conduct such an investigation, this article sought to stick to some passages of the novel in order to check the ways in which Descartes’s parody and carnival figuration are based on an anticartesian dissolution of the character’s egoic integrity, thus generating much more than superficial humor. Rather, the article defends the hypothesis that with the dissolution of Descartes’s figure, the novel outlines an anthropophagic reaction to the colonial processes to which Brazil would have been exposed throughout its history. This counter-colonizing reaction is sustained insofar as it associates Cartesius’s egoic disintegration with the impact caused by an exuberant nature, which due to its hyperbolic constitution, does not submit to the quadratues imposed by the European thought – of which Descartes becomes an emblem.Keywords: Paulo Leminski; Catatau; René Descartes; Brazilian literature; character study; philosophy.

scholarly journals 'Something entirely new': A Critical History of An Béal Bocht, 1941–75

2021 ◽  
Vol 5 (2) ◽  
Author(s):  
Tobias Harris
Keyword(s):  
Reception History ◽  
The Novel ◽  
Irish Language ◽  
Critical History ◽  
The Poor ◽  
History Of ◽  
The Impact

This article reconstructs an early reception of Brian Ó Nualláin’s An Béal Bocht (1941) in which the novel was hailed as a breakthrough work that advanced the Irish-language prose tradition and promised to win new readers of Irish. The story of how this initial enthusiasm hardened into a critical diminishment of Ó Nualláin’s achievement as an obscure parody involves the author’s own efforts to associate the novel with Tomás Ó Criomhthain’s An tOileánach, the dampening of the optimism which surrounded the Irish language in the 1940s, and the impact of Patrick C. Power’s translation, The Poor Mouth, on how An Béal Bocht was understood. By charting the evolution of An Béal Bocht’s reception history, this article furthers contemporary scholarship on the promise Ó Nualláin’s novel still holds for Irish-language prose.

scholarly journals Mapping the International Underground: Jeff Nuttall and Global Counterculture

2017 ◽  
Vol 93 (1) ◽  
pp. 1-21
Author(s):  
Douglas Field
Keyword(s):  
Visual Art ◽  
The Novel ◽  
Avant Garde ◽  
History Of ◽  
A Minor ◽  
The Impact

Despite publishing nearly forty books between 1963 and 2003, Jeff Nuttall remains a minor figure in the history of the International Underground of the long 1960s. Drawing on his uncatalogued papers at the John Rylands Library, this article seeks to recoup Nuttall as one of the key architects of the International Underground. In so doing, my article argues that Nuttalls contributions to global counterculture challenge the critical consensus that British avant-garde writers were merely imitators of their US counterparts. By exploring the impact of Nuttalls My Own Mag (1963–67) and Bomb Culture(1968), it can be shown that Nuttall was a central catalyst of, and contributor to, the International Underground. As a poet, novelist and artist, Nuttalls multidisciplinary contributions to art were at the forefront of avant-garde practices that sought to challenge the perceived limitations of the novel as a social realist document and visual art as a medium confined to canvas.

Investigating the Relationship Between Self-Esteem and Stigma Among Young Adults With History of Suicide Attempts

Crisis ◽  
2016 ◽  
Vol 37 (4) ◽  
pp. 265-270 ◽  
Author(s):  
Meshan Lehmann ◽  
Matthew R. Hilimire ◽  
Lawrence H. Yang ◽  
Bruce G. Link ◽  
Jordan E. DeVylder
Keyword(s):  
Young Adults ◽  
Suicide Attempts ◽  
Self Esteem ◽  
High Risk Population ◽  
High Functioning ◽  
People With Mental Illness ◽  
History Of ◽  
The Individual ◽  
The Impact ◽  
The Relationship

Abstract. Background: Self-esteem is a major contributor to risk for repeated suicide attempts. Prior research has shown that awareness of stigma is associated with reduced self-esteem among people with mental illness. No prior studies have examined the association between self-esteem and stereotype awareness among individuals with past suicide attempts. Aims: To understand the relationship between stereotype awareness and self-esteem among young adults who have and have not attempted suicide. Method: Computerized surveys were administered to college students (N = 637). Linear regression analyses were used to test associations between self-esteem and stereotype awareness, attempt history, and their interaction. Results: There was a significant stereotype awareness by attempt interaction (β = –.74, p = .006) in the regression analysis. The interaction was explained by a stronger negative association between stereotype awareness and self-esteem among individuals with past suicide attempts (β = –.50, p = .013) compared with those without attempts (β = –.09, p = .037). Conclusion: Stigma is associated with lower self-esteem within this high-functioning sample of young adults with histories of suicide attempts. Alleviating the impact of stigma at the individual (clinical) or community (public health) levels may improve self-esteem among this high-risk population, which could potentially influence subsequent suicide risk.

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