ELECTROLYTE METABOLISM IN THE RAT EXPOSED TO IONIZING RADIATION
Some observations concerning electrolyte metabolism in rats subjected to single doses of X irradiation and to prolonged exposure to gamma irradiation are described. Blood electrolyte changes were slight even when severe radiation damage was present. During prolonged exposure to gamma irradiation at 60 roentgens per 24 hr. the adrenal glands first increased in weight then decreased to the pre-exposure values. This may represent a type of adaptation to slowly administered irradiation. Balance studies on rats exposed to gamma irradiation at a dose rate of 60 roentgens per 24 hr. showed a small loss of sodium, potassium, and chloride during the initial period of the exposure. During the remainder of the exposure period the sodium and chloride remained nearly in balance although the body weights decreased. Potassium balance remained negative during the exposure. The stability of the electrolyte composition of the blood and of electrolyte balance, in the presence of widespread damage which results from irradiation, is considered highly significant.