Differential induction of peroxisomal β-oxidation enzymes by clofibric acid and aspirin in piglet tissues

2001 ◽  
Vol 281 (5) ◽  
pp. R1553-R1561 ◽  
Author(s):  
Xing Xian Yu ◽  
Jack Odle ◽  
James K. Drackley
Keyword(s):  
Body Weight ◽  
Liver Weight ◽  
Fatty Acyl ◽  
Clofibric Acid ◽  
Heart Weight ◽  
Final Body Weight ◽  
Daily Food ◽  
Newborn Pigs ◽  
Acyl Coa Oxidase ◽  
Total Carnitine

Peroxisomal β-oxidation (POX) of fatty acids is important in lipid catabolism and thermogenesis. To investigate the effects of peroxisome proliferators on peroxisomal and mitochondrial β-oxidation in piglet tissues, newborn pigs (1–2 days old) were allowed ad libitum access to milk replacer supplemented with 0.5% clofibric acid (CA) or 1% aspirin for 14 days. CA increased ratios of liver weight to body weight ( P < 0.07), kidney weight to body weight ( P< 0.05), and heart weight to body weight ( P < 0.001). Aspirin decreased daily food intake and final body weight but increased the ratio of heart weight to body weight ( P < 0.01). In liver, activities of POX, fatty acyl-CoA oxidase (FAO), total carnitine palmitoyltransferase (CPT), and catalase were 2.7-, 2.2-, 1.5-fold, and 33% greater, respectively, for pigs given CA than for control pigs. In heart, these variables were 2.2-, 4.1-, 1.9-, and 1.8-fold greater, respectively, for pigs given CA than for control pigs. CA did not change these variables in either kidney or muscle, except that CPT activity was increased ∼110% ( P < 0.01) in kidney. Aspirin increased only hepatic FAO and CPT activities. Northern blot analysis revealed that CA increased the abundance of catalase mRNA in heart by ∼2.2-fold. We conclude that 1) POX and CPT in newborn pigs can be induced by peroxisomal proliferators with tissue specificity and 2) the relatively smaller induction of POX in piglets (compared with that in young or adult rodents) may be related to either age or species differences.

scholarly journals KARATERISTIK ORGAN BAGIAN DALAM AYAM BURAS YANG DIBERI PAKAN MINYAK KELAPA (Cocos nucifera) DALAM RANSUM

ZOOTEC ◽  
2019 ◽  
Vol 39 (2) ◽  
pp. 233
Author(s):  
Jein Rinny Leke ◽  
F.N. Sompie ◽  
E. Wantasen ◽  
T. Widyastuti ◽  
E.H.B. Sondakh
Keyword(s):  
Body Weight ◽  
Cocos Nucifera ◽  
Coconut Oil ◽  
Liver Weight ◽  
The Body ◽  
Heart Weight ◽  
Internal Organs ◽  
Randomized Design ◽  
Dietary Treatments ◽  
Pancreas Weight

INTERNAL ORGANS CHAR ACTERISTICS OF NATIVE CHICKEN FED BY COCONUT OIL (Cocos nucifera) ON DIET. The research was carried to determine the internal organs characteristics of buras chickens fed coconut (Cocos mucifera) oil in diet. A total 100 unsexed buras chickens was used in this experiment. The design used in this study was a completely randomized design (CRD) consisting of 5 treatments and 5 replications (4 hens each). The data were subjected to analysis of variance, when the treatments indicated significant effect it was continued Duncan’s Multiple Range Test. Five dietary treatments containing 0, 0.5%, 1 %, 1,5%, and 2% levels of coconut oil (CO) with five replicates were applied to chickens.  Parameters measured were body weight, heart, liver, pancreas  and gizzard weight. Result showed that CO in the ration significantly increased the body weight (P<0.01) but did not affect to heart weight, liver weight, pancreas weight and gizzard weight.(P>0.05) It can be concluded that coconut oil in the diet can’t increase the internal organ characteristics. We can gave the 2% CO in the diet for the best results. Key words: Internal Organs, Coconut Oil, Buras Chickens

Influence of starvation on enzyme-induced emphysema

1980 ◽  
Vol 48 (2) ◽  
pp. 284-288 ◽  
Author(s):  
H. Sahebjami ◽  
C. L. Vassallo
Keyword(s):  
Body Weight ◽  
Isotonic Saline ◽  
Internal Surface ◽  
High Volume ◽  
Elastic Recoil ◽  
Internal Surface Area ◽  
Adult Rats ◽  
Final Body Weight ◽  
Daily Food ◽  
And Control

Adult rats were exposed to an aerosol of 10% papain for 8 h twice in a 2-wk interval. The control rats were exposed to isotonic saline in the same manner. Three weeks after the final exposure rats were divided into four groups: emphysema-fed, emphysema-starved, control-fed, and control-starved. Starved animals received one-third of their measured daily food consumption and water ad libitum for 6 wk. Final body weight, dry and wet weights of lungs and postfixation lung volume (VL) were significantly lower in starved rats. Dry-to-wet weight ratios were not significantly different among the groups, but VL/body weight was significantly higher in starved animals. Elastic recoil pressure of lung tissue determined in saline-filled lungs decreased and chord compliance over mid- and high-volume ranges increased significantly in starved animals both in control and emphysema groups. Mean linear intercept of air spaces was greater and internal surface area was smaller in starved rats in each group. Therefore, it appears that starvation aggravates the preexisting emphysematous processes in rat lungs.

scholarly journals Effects of Acacia nilotica Leaf Extract on Adrenaline-induced Hyperlipidemia and Cardiac Remodeling in Rats

2012 ◽  
Vol 15 (2) ◽  
pp. 135-139
Author(s):  
Nazmun Nahar ◽  
AHM Khurshid Alam ◽  
Saiful Islam ◽  
Al Mamun ◽  
AKM Motahar Hossain ◽  
...  
Keyword(s):  
Body Weight ◽  
Cardiac Remodeling ◽  
Leaf Extract ◽  
Liver Weight ◽  
Pharmaceutical Journal ◽  
Left Ventricular ◽  
Acacia Nilotica ◽  
Lipid Lowering ◽  
Heart Weight ◽  
Long Term Treatment

Hyperlipidemia is one of the major causes of disability in western as well as in developing countries. The present study was designed to investigate the effect of the ethanolic leaf extract of a Bangladeshi medicinal plant Acacia nilotica (AN) on adrenaline-induced hyperlipidemia and cardiac remodeling in rats. The plant extract and commercial lipid lowering drug atorvastatine were administered in adrenaline-induced hyperlipidemic rats (AIHRs) through intraperitoneal route for one week at a dose of 30 mg and 0.04 mg per 150 gm body weight of rat, respectively. The AN extract showed a significant (P<0.01) decrease in lipid profile, and reducing the left ventricular hypertrophy (heart weight/body weight), heart weight, cardiac myocytes size as well as kidney, pancreas and liver weight of AIHRs. The observation was also made for consecutive four weeks (long term treatment) to confirm the results obtained in one week model. The results indicated that the leaf extract of A. nilotica in comparison with atorvastatine has got profound hypolipidemic and anticardiac remodeling activities. DOI: http://dx.doi.org/10.3329/bpj.v15i2.12578 Bangladesh Pharmaceutical Journal 15(2): 135-139, 2012

Effects of a semi-intensive raising system on growth performance, carcass traits and meat quality of broiler chicks

2017 ◽  
Author(s):  
Serafettin Kaya ◽  
Hakan Yildirim
Keyword(s):  
Body Weight ◽  
Growth Performance ◽  
Production System ◽  
Broiler Chickens ◽  
Abdominal Fat ◽  
Carcass Weight ◽  
Heart Weight ◽  
Nutrient Level ◽  
Broiler Chicks ◽  
Final Body Weight

Abstract The present study was carried out to compare the growth performance and carcass yield of broiler chickens reared in semi-intensive and conventional systems (Ross 308, n=120). Chickens were raised in a pen on wooden shavings for 21 days. On day 21 of age, chicks were assigned to 2 treatments (indoor treatment and semi-intensive treatment). The experiment was conducted at until 6 weeks of age. Production system has a significant effect on wing (P less than 0.05) and heart weight (P less than 0.01), but has no any effect on final body weight, hot or cold carcass weight, thigh, breast, back and neck, gizzard, liver and abdominal fat weights (P>0.05).  The final body weight, hot and cold carcass weight, thigh, wings and heart weights were affected by sex of birds (p less than 0.05) while breast, back, liver, gizzard and abdominal fat were not affected by sex (P>0.05). The nutrient level of carcass parts was not influenced by production system or sex (P>0.05). In our study, breast of birds reared under semi-intensive system had significantly lower ‘L’ (P less than 0.05), higher ‘a’ statistically different (P less than 0.01); while ‘b’ value was significantly (P less than 0.01) higher in skin of semi-intensive reared birds

Use of Chou’s 5-steps Rule to Study the Effect of Cereal Dietary Protein on Liver and Coronary Heart Disease Prevention

2020 ◽  
Vol 17 (1) ◽  
pp. 11-27
Author(s):  
Mohammad Mainuddin Molla ◽  
Xin Ren ◽  
Ebeydulla Rahman ◽  
Md. M. Kamal ◽  
Ashfak A. Sabuz ◽  
...  
Keyword(s):  
Body Weight ◽  
Randomized Controlled Trials ◽  
Enzyme Activities ◽  
Medical Science ◽  
Liver Weight ◽  
Controlled Trials ◽  
Serum Enzyme ◽  
Daily Food Intake ◽  
Randomized Controlled ◽  
Daily Food

Background: The liver is a vital organ in the human body involved in the metabolic processes. The liver can be damaged due to factors such as protein deficiency, viral infection, as well as consumption of alcohol, chemical contaminants, and adulterated food. High blood cholesterol, high blood pressure, diabetes, lack of exercise, poor diet, obesity and cigarette smoking are the major risk factors for stroke, heart attack and coronary heart disease (CHD). In medical science, several synthetic drugs have been discovered and used for the treatment of people suffering from liver injury and CHD, but these are not always effective and sometimes difficult to manage by medical therapies and also found to be accompanied by other side effects. Objective: The study aimed to critically review the recent research and studies of epidemiological and randomized controlled trials to find out the effective cereal protein as an alternative preventive food to reduce the risk of CHD and protect the liver from viral hepatic diseases, focusing on daily food intake, body weight, liver weight, serum enzyme activities and cholesterols. Methods: A few of the data from our experiment were used. A literature search was performed for a reliable source of published research articles, review papers, and epidemiological and randomized controlled trials on the effects of cereal protein on animals and human intervention on Google, Google scholar, Redcube, Endnote, Scopus, SpringerDirect.com, PubMed and Web of Science. Then, the data was organized, summarized and analyzed. Results: In medical science, serum enzyme activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and lipid peroxidation stress malondialdehyde (MDA) are commonly used as biochemical markers of the liver-damaging agents. Blood cholesterols (total cholesterol-TC, triglyceride-TG, low-density lipoprotein cholesterol-LDLC and highdensity lipoprotein cholesterol-HDLC) are used as the markers of heart diseases. The review shows that daily food intake and body weight data are not significantly differed among normal diet, casein (CAS) and cereals protein. The millet and wheat protein increase the liver weight, whereas the rice protein lowers the liver weight. The intake of cereal protein significantly reduces the activities of serum AST, ALT, LDH, MDA, TC, TG and LDLC, whereas it increases the HDLC. Conclusion: Experimental, review and randomized controlled trials (RCTs) data confirm that cereal protein appears to be beneficial in reducing the hepatic liver injury and CHD by maintaining body weight, liver weight, blood pressure, serum enzyme activities of AST, ALT and LDH, lipid peroxidation stress MDA and cholesterol concentrations both in plasma and liver.

scholarly journals Effects of zeolite inclusion in aflatoxin B1-contaminated diet on the performance of laying duck

2019 ◽  
Vol 44 (3) ◽  
pp. 277
Author(s):  
I. Sumantri ◽  
H. Herliani ◽  
A. N. Rajibi ◽  
R. Edriantina
Keyword(s):  
Body Weight ◽  
Aflatoxin B1 ◽  
Egg Production ◽  
Liver Weight ◽  
The Body ◽  
Final Body Weight ◽  
Randomized Design ◽  
Commercial Feed ◽  
Feed Control

The researchwas objected to study the effect of zeolite inclusion in aflatoxin B1 (AFB1) contaminated diet on the performance of laying duck. A completely randomized design was adopted in the in vivo experiment that consisted of 4 treatments, namely: (1) commercial feed (Control); (2) AFB1-contaminated feed 70 ppb (AFC); (3) Control + 2% zeolite; and (4) AFC + 2% zeolite. Each treatment had 4 replications with 4 ducks in each replication. A total of 64 eight months-female Alabio duck (Anas platyrinchos Borneo) were used in 28 days of the feeding experiment. Data were analyzed according to the general linear model of SPSS 21.0 statistical software. Results indicated that AFB1 exposure significantly (P<0.05) decreased the body weight of laying duck by 1.12%. Zeolite inclusion could prevent the adverse effect of AFB1 on body weight that increased by 2.95% in AFC+2% zeolite. Treatments had no significant effect on egg production and egg weight (P>0.05). Zeolite inclusion resulted in the highest final body weight whilst AFB1 diet without zeolite resulted in the lowest final body weight (P<0.05). Relative liver weight of duck fedAFC diet was 16.62% and to be 15.4% by zeolite addition in the diet. In conclusion, 2% of zeolite inclusion could reduce the adverse effects of AFB1 exposure on the performance of laying duck.

scholarly journals Identification and purification of a peroxisomal branched chain fatty acyl-CoA oxidase.

1991 ◽  
Vol 266 (36) ◽  
pp. 24676-24683
Author(s):  
P.P. Van Veldhoven ◽  
G. Vanhove ◽  
F. Vanhoutte ◽  
G. Dacremont ◽  
G. Parmentier ◽  
...  
Keyword(s):  
Fatty Acyl ◽  
Acyl Coa Oxidase ◽  
Branched Chain

scholarly journals Understanding the Interaction Effects between Dietary Lipid Content and Rearing Temperature on Growth Performance, Feed Utilization, and Fat Deposition of Sea Bass (Dicentrarchus labrax)

Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 392
Author(s):  
Lydia Katsika ◽  
Mario Huesca Flores ◽  
Yannis Kotzamanis ◽  
Alicia Estevez ◽  
Stavros Chatzifotis
Keyword(s):  
Growth Rate ◽  
Body Weight ◽  
Specific Growth ◽  
Dicentrarchus Labrax ◽  
Sea Bass ◽  
Dietary Lipid ◽  
Lipid Levels ◽  
Final Body Weight ◽  
Temperature Regimes ◽  
Fish Group

This study was conducted to elucidate the interaction effects of temperature and dietary lipid levels (2 × 2 factorial experiment) on the growth performance, muscle, and liver composition in adult farmed European sea bass (Dicentrarchus labrax). Two groups of fish (190 g; 60 fish per group) were distributed in 12 tanks in triplicates and kept at two different temperature regimes; one starting at 23 °C and then changed to 17 °C for 61 days, and the other starting at 17 °C and then changed to 23 °C for 39 days. Two commercial diets containing both ~44% crude protein but incorporating different dietary lipid levels, 16.5% (D16) and 20.0% (D20) (dry matter (DM)), were fed to the fish to apparent satiation; the type of diet fed to each fish group remained constant throughout the experiment. Final body weight, weight gain, and specific growth rate were significantly higher for the fish group held at 23 °C compared to the fish group at 17 °C (before the temperature changes), while the dietary fat content did not have any profound effect in both groups. Furthermore, the different temperature regimes did not affect muscle or liver composition, but, on the contrary, dietary lipids affected hepatosomatic, perivisceral fat, and visceral indexes. Feed conversion ratio and specific growth rate were not affected by the dietary lipid level. An interaction of temperature and dietary lipid content was observed in daily feed consumption (DFC) and final body weight (FBW).

scholarly journals Protective Effects of Polyphenol Enriched Complex Plants Extract on Metabolic Dysfunctions Associated with Obesity and Related Nonalcoholic Fatty Liver Diseases in High Fat Diet-Induced C57BL/6 Mice

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 302
Author(s):  
Ahtesham Hussain ◽  
Jin Sook Cho ◽  
Jong-Seok Kim ◽  
Young Ik Lee
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Mouse Model ◽  
High Fat Diet ◽  
Liver Diseases ◽  
Liver Weight ◽  
Control Group ◽  
High Fat ◽  
Herbal Formulation ◽  
Plants Extract

Background: Currently, obesity is a global health challenge due to its increasing prevalence and associated health risk. It is associated with various metabolic diseases, including diabetes, hypertension, cardiovascular disease, stroke, certain forms of cancer, and non-alcoholic liver diseases (NAFLD). Objective: The aim of this study to evaluate the effects of polyphenol enriched herbal complex (Rubus crataegifolius/ellagic acid, Crataegus pinnatifida Bunge/vitexin, chlorogenic acid, Cinnamomum cassiaa/cinnamic acid) on obesity and obesity induced NAFLD in the high-fat diet (HFD)-induced obese mouse model. Methods: Obesity was induced in male C57BL/6 mice using HFD. After 8 weeks, the mice were treated with HFD+ plants extract for 8 weeks. Body weight, food intake weekly, and blood sugar level were measured. After sacrifice, changes in the treated group’s liver weight, fat weight, serum biochemical parameters, hormone levels, and enzyme levels were measured. For histological analysis, tissues were stained with hematoxylin-eosin (H&E) and Oil Red-O. Results: Our results showed that the herbal complex ameliorated body weight and liver weight gain, and decreased total body fat in HFD-fed animals. Post prandial blood glucose (PBG) and fasting blood glucose (FBG) were lower in the herbal complex-treated group than in the HFD control group. Additionally, herbal formulation treatment significantly increased HDL levels in serum and decreased TC, TG, AST, ALT, deposition of fat droplets in the liver, and intima media thickness (IMT) in the aorta. Herbal complex increased serum adiponectin and decreased serum leptin. Herbal complex also increased carnitine palmityl transferase (CPT) activity and significantly decreased enzyme activity of beta-hydroxy beta methyl glutamyl-CoA (HMG-CoA) reductase, and fatty acid synthase (FAS). Conclusions: The results of this study demonstrated that the herbal complex is an effective herbal formulation in the attenuation of obesity and obesity-induced metabolic dysfunction including NAFLD in HFD-induced mouse model.

scholarly journals High Intakes of [6S]-5-Methyltetrahydrofolic Acid Compared with Folic Acid during Pregnancy Programs Central and Peripheral Mechanisms Favouring Increased Food Intake and Body Weight of Mature Female Offspring

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1477
Author(s):  
Emanuela Pannia ◽  
Rola Hammoud ◽  
Ruslan Kubant ◽  
Jong Yup Sa ◽  
Rebecca Simonian ◽  
...  
Keyword(s):  
Body Weight ◽  
Folic Acid ◽  
Food Intake ◽  
Leptin Receptor ◽  
Liver Weight ◽  
Female Offspring ◽  
Mature Female ◽  
Cytokine Signaling ◽  
Light Cycle ◽  
Energy Regulation

Supplementation with [6S]-5-methyltetrahydrofolic acid (MTHF) is recommended as an alternative to folic acid (FA) in prenatal supplements. This study compared equimolar gestational FA and MTHF diets on energy regulation of female offspring. Wistar rats were fed an AIN-93G diet with recommended (2 mg/kg diet) or 5-fold (5X) intakes of MTHF or FA. At weaning, female offspring were fed a 45% fat diet until 19 weeks. The 5X-MTHF offspring had higher body weight (>15%), food intake (8%), light-cycle energy expenditure, and lower activity compared to 5X-FA offspring (p < 0.05). Both the 5X offspring had higher plasma levels of the anorectic hormone leptin at birth (60%) and at 19 weeks (40%), and lower liver weight and total liver lipids compared to the 1X offspring (p < 0.05). Hypothalamic mRNA expression of leptin receptor (ObRb) was lower, and of suppressor of cytokine signaling-3 (Socs3) was higher in the 5X-MTHF offspring (p < 0.05), suggesting central leptin dysregulation. In contrast, the 5X-FA offspring had higher expression of genes encoding for dopamine and GABA- neurotransmitter receptors (p < 0.01), consistent with their phenotype and reduced food intake. When fed folate diets at the requirement level, no differences were found due to form in the offspring. We conclude that MTHF compared to FA consumed at high levels in the gestational diets program central and peripheral mechanisms to favour increased weight gain in the offspring. These pre-clinical findings caution against high gestational intakes of folates of either form and encourage clinical trials examining their long-term health effects when consumed during pregnancy.

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