scholarly journals Development and Evaluation of Herbal Formulations for Hair Growth

2008 ◽  
Vol 5 (1) ◽  
pp. 34-38 ◽  
Author(s):  
Lipi Purwal ◽  
Surya Prakash B. N. Gupta ◽  
S. Milind Pande
Keyword(s):  
Hair Growth ◽  
Maximum Level ◽  
Preparation Technique ◽  
Murraya Koenigii ◽  
Anagen Phase ◽  
Growth Activity ◽  
Follicular Size ◽  
Crude Drugs ◽  
Herbal Formulations ◽  
Preparation Techniques

Hair formulation ofEmblica officinalis(Euphorbiaceae), Bacopa,monnieri(Scrophulariaceae),Trigonella foenumgraecum(Leguminosae),Murraya koenigii(Rutaceae) in various concentrations in the form of herbal oil were studied for their hair growth activity. Each drug was tested for their hair growth activity in a concentration range for 1-10% separately. Based on these results mixture of crude drugsMurraya koeniigi, leaf (Rutaceae),Bacopa monnieri, leaf (Scrophulariaceae),Trigonella foenumgraecum(Leguminosae),Murraya koenigii(Rutaceae) were prepared in varying concentration in the form of herbal hair oil by three different oils preparation techniques and were tested for hair growth activity. The result revealed that the hair growth activity of each drug was found proportional to the concentration range tested. Similarly higher concentrations of drug in the formulation were found to have higher hair growth activities. But looking towards the formulation viscosity the maximum concentration of combined drug was found to be 30% at their maximum level. The formulation containing 7.5% of each drug used for the study and showed excellent hair growth activity with standard (2% minoxidil ethanolic solution) by an enlargement of follicular size and prolongation of the anagen phase. It holds the promise of potent herbal alternative for minoxidil. Excellent results of hair growth were seen in formulation prepared by cloth pouch decoction method of oils preparation technique.

scholarly journals Development and Evaluation of Herbal Hair Serum: A traditional way to Improve Hair Quality

2021 ◽  
Vol 15 (1) ◽  
pp. 52-58
Author(s):  
Ruchi Tiwari ◽  
Gaurav Tiwari ◽  
Ajeet Yadav ◽  
Vadivelan Ramachandran
Keyword(s):  
Hair Loss ◽  
Hair Growth ◽  
Nigella Sativa ◽  
Zingiber Officinale ◽  
Self Defense ◽  
Growth Activity ◽  
Herbal Cosmetics ◽  
Multiple Treatments ◽  
First Time ◽  
Herbal Formulations

Background: In the mammalian system, the hair follicle is known to be the most significant organ that determines appearance, gender distinction, provides intense temperature protection, and plays a role in self-defense. The younger generations have begun to suffer from extreme hair loss problems due to many lifestyle-related changes such as fatigue, anxiety, intake of junk foods, use of different hairstyling/coloring methods, etc. The loss of hair is not temporary in most cases, but it results in alopecia. Many people suffering from hair loss are in search of multiple treatments due to extreme anxiety and tension, from mythology to traditional and therapeutic healing to the use of minoxidil and finasteride. To improve hair growth and to prevent hair loss, hair root activation is required. Objective: The present study was intended to use different herbs to formulate herbal hair serum for general purposes (hair application). Methods: Crude herbs are obtained from nearby regions. In order to obtain the extract, the required part of herbs, such as Citrus sinensis peel, Zingiber officinale roots, and Linum usitatissimum seeds, Nigella sativa, and Trigonella foenum-graecum were specifically weighed and dispensed in water, boiled, allowed to cool, and then filtered. To the filtrate, castor oil and vitamin E were added. The formulated herbal hair serum was tested, and different criteria were determined and recorded in this text, such as physical appearance, viscosity, pH, homogeneity, eye sensitivity (Draize eye test), hair growth activity, hair weight, stability test, etc. Results: Prepared herbal hair serum was found to be pale brown in color with pseudoplastic behavior. The texture of the formulation was smooth and lubricative, and the pH was within the acceptable limit. Herbal hair serum revealed good hair growth as well as hair weight after application with minor sensitivity for the first time. The formulation was found to be stable for seven days. Conclusion: Herbal cosmetics are still commonly used by average citizens because of fewer side effects and greater protection and safety profile. Current research has revealed that herbal formulations are effective in enhancing hair consistency.

In vivo Hair Growth Activity of Herbal Formulations

2009 ◽  
Vol 6 (1) ◽  
pp. 53-57 ◽  
Author(s):  
M. Semalty ◽  
A. Semalty ◽  
Geeta P. Joshi ◽  
M.S.M. Rawat
Keyword(s):  
Hair Growth ◽  
Growth Activity ◽  
Herbal Formulations

scholarly journals Assessment of Nutraceutical Potential of Herbs for Promoting Hair Growth: Formulation Considerations of Herbal Hair Oil

2021 ◽  
Vol 15 (1) ◽  
pp. 78-83
Author(s):  
Gaurav Tiwari ◽  
Ruchi Tiwari
Keyword(s):  
Hair Loss ◽  
Hair Growth ◽  
Nigella Sativa ◽  
Cocos Nucifera ◽  
Murraya Koenigii ◽  
Hibiscus Rosa Sinensis ◽  
Saponification Value ◽  
Growth Activity ◽  
Hair Development ◽  
Herbal Cosmetics

Background: Hair loss is a relatively common occurrence that causes concern in people of all ages. In most cases, hair loss is permanent, but it can lead to alopecia. Hair root activation is necessary to improve hair development and prevent hair loss. Herbal cosmetics are increasingly widely used by the general public due to the concept of fewer adverse effects and a higher level of safety and security. Objective: The primary goal of this study is to prepare and evaluate herbal hair oil made from fresh components of various plants. Methods: Herbs were acquired from Pranveer Singh Institute of Technology's medicinal garden. Herbs were collected, dried, then ground in a mortar and pestle. Grinded herbs (Murraya koenigii, Hibiscus rosa-sinensis Linn., Nigella sativa, Trigonella foenum-graecum) were combined with 60% Cocos nucifera oil, heated, cooled, and filtered. Physical appearance, viscosity, pH, sensitivity test, hair growth activity, hair weight, antimicrobial test, stability test, and other criteria were determined and are reported in this text for the created herbal hair oil. Results: Herbal hair oil was odourless and reddish brown in appearance. Herbal hair oil had an appropriate refractive index, pH, saponification value, and specific gravity. After application, the herbal oil demonstrated Newtonian flow, as well as good hair growth and weight, with no irritation. Phytochemical screening showed the presence of ascorbic acid, sulphur and saponins. The formulation was found to be stable for 30 days. Conclusion: Conclusively, combination of effective herbs could be used to improve hair growth.

The ionic strength dependence of chromatin folding

1978 ◽  
Vol 36 (2) ◽  
pp. 220-221
Author(s):  
F. Thoma ◽  
TH. Koller
Keyword(s):  
Electron Microscopy ◽  
Electron Microscope ◽  
Ionic Strength ◽  
Specimen Preparation ◽  
Preparation Technique ◽  
Carbon Supports ◽  
Ionic Strength Dependence ◽  
Chromatin Folding ◽  
Strength Dependence ◽  
Preparation Techniques

Under a variety of electron microscope specimen preparation techniques different forms of chromatin appearance can be distinguished: beads-on-a-string, a 100 Å nucleofilament, a 250 Å fiber and a compact 300 to 500 Å fiber.Using a standardized specimen preparation technique we wanted to find out whether there is any relation between these different forms of chromatin or not. We show that with increasing ionic strength a chromatin fiber consisting of a row of nucleo- somes progressively folds up into a solenoid-like structure with a diameter of about 300 Å.For the preparation of chromatin for electron microscopy the avoidance of stretching artifacts during adsorption to the carbon supports is of utmost importance. The samples are fixed with 0.1% glutaraldehyde at 4°C for at least 12 hrs. The material was usually examined between 24 and 48 hrs after the onset of fixation.

scholarly journals Aqueous Extract of Red Deer Antler Promotes Hair Growth by Regulating the Hair Cycle and Cell Proliferation in Hair Follicles

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Jing-jie Li ◽  
Zheng Li ◽  
Li-juan Gu ◽  
Yun-bo Wang ◽  
Mi-ra Lee ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Aqueous Extract ◽  
Hair Growth ◽  
Red Deer ◽  
Growth Parameters ◽  
Hair Follicles ◽  
Control Group ◽  
Deer Antler ◽  
Vehicle Control Group ◽  
Anagen Phase

Deer antlers are the only mammalian appendage capable of regeneration. We aimed to investigate the effect of red deer antler extract in regulating hair growth, using a mouse model. The backs of male mice were shaved at eight weeks of age. Crude aqueous extracts of deer antler were prepared at either 4°C or 100°C and injected subcutaneously to two separate groups of mice (n=9) at 1 mL/day for 10 consecutive days, with water as a vehicle control group. The mice skin quantitative hair growth parameters were measured and 5-bromo-2-deoxyuridine was used to identify label-retaining cells. We found that, in both the 4°C and the 100°C deer antler aqueous extract-injection groups, the anagen phase was extended, while the number of BrdU-incorporated cells was dramatically increased. These results indicate that deer antler aqueous extract promotes hair growth by extending the anagen phase and regulating cell proliferation in the hair follicle region.

Aktivitas Pertumbuhan Rambut Hair Tonic Ekstrak Daun Bandotan (Ageratum conyzoides L.) Pada Kelinci Jantan (Oryctolagus Cuniculus)

2021 ◽  
Vol 1 ◽  
pp. 1194-1204
Author(s):  
Khofifah Fitriani ◽  
S Slamet ◽  
Dwi Bagus Pambudi ◽  
Urmatul Waznah
Keyword(s):  
Hair Growth ◽  
Oryctolagus Cuniculus ◽  
Ethanol Extract ◽  
Positive Control ◽  
Hair Length ◽  
Ageratum Conyzoides ◽  
Significant Difference ◽  
Growth Activity ◽  
Hair Care ◽  
One Way Anova

AbstractHair loss is a disorder or disorder of hair apart from the scalp or body skin so that it interferes with various biological functions of hair on the body. Types of hair care cosmetic that is effective in dealing with hair loss are hair tonic. Hair tonic is a preparation for the treatment of the scalp and hair. Bandotan (Ageratum conyzoides L.) is used by the public as medicine and hair care. The purpose of this study was to determine the formulation of hair tonic preparations from the ethanol extract of bandotan leaves according to the requirements and hair growth activity of local male rabbits. The extraction method used the maceration method with 96% ethanol and applied hair tonic extract of bandotan leaves on the skin of local male rabbits (Oryctolagus cuniculus) which were treated as blanks without smearing, positive control (Natur), negative control hair tonic base, concentration bandotan leaf extract. (5%, 10%, 15% and 20%) for 21 days. The data obtained in the form of hair length, and hair weight. Analysis of the data obtained for hair growth activity was seen from the results of the ANOVA test and continued with the BNT test (Least Significance Different). The results of the research for evaluating hair tonic preparations included organoleptic tests, pH tests, viscosity tests, specific gravity tests, and cycling tests. Hair tonic ethanol extract of bandotan leaves has hair growth activity. Hair tonic ethanol extract of bandotan leaves with a concentration of 20% had the highest hair length and hair weight. From the results of one way ANOVA, a significant value was obtained 0.000 < 0.005, so it was concluded that there was a significant difference between treatments, and continued with the BNT test (Least Significance Different) positive control was not significantly different from hair tonic concentration of 20%.Keywords: Bandotan leaves, Hair tonic, Hair growth AbstrakKerontokan rambut adalah suatu gangguan atau kelainan rambut terlepas dari kulit kepala atau kulit tubuh sehingga mengganggu berbagai fungsi biologis rambut terhadap tubuh. Jenis kosmetik perawatan rambut yang efektif mengatasi rambut rontok adalah hair tonic. Hair tonic adalah sediaan untuk perawatan kulit kepala dan rambut. Bandotan (Ageratum conyzoides L.) digunakan oleh masyarakat sebagai obat dan perawatan rambut. Tujuan dari penelitian ini mengetahui formulasi sediaan hair tonic dari ekstrak etanol daun bandotan yang sesuai dengan persyaratan dan aktivitas pertumbuhan rambut pada kelinci jantan lokal. Metode ekstraksi menggunakan metode maserasi dengan etanol 96% dan dilakukan pengolesan hair tonic ekstrak daun bandotan pada kulit kelinci jantan lokal (Oryctolagus cuniculus) yang diberikan perlakuan sebagai blanko tanpa pengolesan, kontrol positif (Natur), kontrol negatif basis hair tonic, ekstrak daun bandotan konsentrasi (5%,10%,15% dan 20%) selama 21 hari. Data yang diperoleh berupa panjang rambut, dan bobot rambut. Analisa data yang diperoleh untuk aktivitas pertumbuhan rambut dilihat dari hasil uji ANOVA dan dilanjutkan dengan uji BNT (Beda Nyata Terkecil). Hasil penelitian untuk evaluasi sediaan hair tonic antara lain uji organoleptis, uji pH, uji viskositas, uji bobot jenis, dan uji cycling test. Hair tonic ekstrak etanol daun bandotan memiliki aktivitas pertumbuhan rambut. Hair tonic ekstrak etanol daun bandotan dengan konsentrasi 20% memiliki panjang rambut dan bobot rambut tertinggi. Dari hasil one way ANOVA didapatkan nilai signifikan 0,000 < 0,005 sehingga disimpulkan adanya perbedaan signifikan antar perlakuan, dan dilanjutkan uji BNT (Beda Nyata Terkecil) didapatkan kontrol positif tidak berbeda nyata dengan hair tonic konsentrasi 20%.Kata kunci : Daun bandotan; Hair tonic; Pertumbuhan rambut

scholarly journals Hair Growth Activity of Three Plants of the Polynesian Cosmetopoeia and Their Regulatory Effect on Dermal Papilla Cells

Molecules ◽  
2020 ◽  
Vol 25 (19) ◽  
pp. 4360
Author(s):  
Kristelle Hughes ◽  
Raimana Ho ◽  
Stéphane Greff ◽  
Edith Filaire ◽  
Edwige Ranouille ◽  
...  
Keyword(s):  
Hair Loss ◽  
Hair Growth ◽  
Dermal Papilla ◽  
Hair Cycle ◽  
Bidens Pilosa ◽  
Dermal Papilla Cells ◽  
Qpcr Analysis ◽  
Chemical Content ◽  
Growth Activity ◽  
Gene Expression Levels

Hair loss is becoming increasingly prevalent as dietary and living habits change. The search for natural products to limit hair loss has led to tapping into traditional cosmetic knowledge. We studied three plants of the Polynesian cosmetopoeia, Bidens pilosa, Calophyllum inophyllum and Fagraea berteroana, to determine their ability to promote hair growth. Their chemical content was characterized by liquid chromatography coupled to mass spectrometry (LC-MS). Their proliferative activity on dermal papilla cells (DPCs) was assessed via MTT assay and molecular targets were evaluated by RT-qPCR analysis of seven factors involved in the modulation of the hair cycle, CCND1, LEF1, DKK1, WNT5A PPARD, TGFΒ1, PPARD and RSPO2. Our results show that our extracts significantly increased proliferation of dermal papilla cells. Furthermore, LC-MS/MS analysis revealed a diversity of molecules, flavonoids, iridoids and organic acids, some known for hair-inducing properties. Finally, specific extracts and fractions of all three plants either upregulated CCND1, LEF1 and PPARD involved in stimulating hair follicle proliferation and/or lowered the gene expression levels of hair growth inhibiting factors, DKK1 and TGFB1. Our findings suggest that extracts from B. pilosa, C. inophyllum and F. berteroana are interesting candidates to stimulate hair growth.

scholarly journals Comparison of Otolith Readability and Reproducibility of Counts of Translucent Zones Using Different Otolith Preparation Methods for Four Endemic Labeobarbus Species in Lake Tana, Ethiopia

Water ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1336 ◽  
Author(s):  
Gebremedhin ◽  
Bekaert ◽  
Getahun ◽  
Bruneel ◽  
Anteneh ◽  
...  
Keyword(s):  
Management Strategies ◽  
Tropical Fish ◽  
Percentage Error ◽  
Systematic Bias ◽  
Preparation Technique ◽  
Lake Tana ◽  
Preparation Methods ◽  
Average Percentage ◽  
Average Percentage Error ◽  
Preparation Techniques

The analysis of fish age data is vital for the successful conservation of fish. Attempts to develop optimal management strategies for effective conservation of the endemic Labeobarbus species are strongly affected by the lack of accurate age estimates. Although methodological studies are key to acquiring a good insight into the age of fishes, up to now, there have not been any studies comparing different methods for these species. Thus, this study aimed at determining the best method for the endemic Labeobarbus species. Samples were collected from May 2016 to April 2017. Asteriscus otoliths from 150 specimens each of L. intermedius, L. tsanensis, L. platydorsus, and L. megastoma were examined. Six methods were evaluated; however, only three methods resulted in readable images. The procedure in which whole otoliths were first submerged in water, and subsequently placed in glycerol to take the image (MO1), was generally best. Except for L. megastoma, this method produced the clearest image as both the coefficient of variation and average percentage error between readers were lowest. Furthermore, except for L. megastoma, MO1 had high otolith readability and no systematic bias. Therefore, we suggest that MO1 should be used as the standard otolith preparation technique for the first three species, while for L. megastoma, other preparation techniques should be evaluated. This study provides a reference for researchers from Africa, particularly Ethiopia, to develop a suitable otolith preparation method for the different tropical fish species.

scholarly journals CRISPR/Cas9-mediated Disruption of Fibroblast Growth Factor 5 in Rabbits Results in a Systemic Long Hair Phenotype by Prolonging Anagen

Genes ◽  
2020 ◽  
Vol 11 (3) ◽  
pp. 297 ◽  
Author(s):  
Yuxin Xu ◽  
Hongmei Liu ◽  
Huilin Pan ◽  
Xinyue Wang ◽  
Yuxin Zhang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Hair Growth ◽  
Negative Regulator ◽  
Fibroblast Growth ◽  
Hair Cycle ◽  
Ideal Model ◽  
Anagen Phase ◽  
Hematoxylin And Eosin ◽  
Scanning Electron

Hair growth and morphology are generally regulated by the hair cycle in mammals. Fibroblast Growth Factor 5 (FGF5), which is a hair cycle regulator, has a role in regulating the hair cycle during the transition from the anagen phase to the catagen phase, and a hereditary long hair phenotype has been widely reported when FGF5 is mutated in humans and other species. However, there has been no such report in rabbits. Thus, the first exon of rabbit FGF5 was disrupted by the CRISPR/Cas9 system, and the phenotype of FGF5-/- rabbits was characterized while using hematoxylin and eosin (H&E) staining, immunohistochemistry, quantitative PCR, scanning electron microscopy, and western blotting. The results showed a significant and systemic long hair phenotype in the FGF5-/- rabbits, which indicated that FGF5 is a negative regulator of hair growth. In addition, a decreased diameter of the fiber and a higher area proportion of hair follicle clusters were determined in FGF5-/- rabbits as compared with the WT rabbits. Further investigation verified that prolonging the anagen phase in rabbits, with decreased BMP2/4 pathway signaling and increased VERSICAN pathway signaling, caused the systemic long hair phenotype. Taken together, these results indicate a systemic long hair phenotype by prolonging anagen in FGF5-/- rabbits, which could be widely used for Fur production and an ideal model for studying the mechanism of long hair in the future.

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