scholarly journals Is Autism a Member of a Family of Diseases Resulting from Genetic/Cultural Mismatches? Implications for Treatment and Prevention

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Staci D. Bilbo ◽  
John P. Jones ◽  
William Parker
Keyword(s):  
Large Family ◽  
Modern Medicine ◽  
Entire Family ◽  
Postindustrial Society ◽  
Typical Member ◽  
Treatment And Prevention ◽  
Wide Range ◽  
High Prevalence ◽  
Lines Of Evidence

Several lines of evidence support the view that autism is a typical member of a large family of immune-related, noninfectious, chronic diseases associated with postindustrial society. This family of diseases includes a wide range of inflammatory, allergic, and autoimmune diseases and results from consequences of genetic/culture mismatches which profoundly destabilize the immune system. Principle among these consequences is depletion of important components, particularly helminths, from the ecosystem of the human body, the human biome. Autism shares a wide range of features in common with this family of diseases, including the contribution of genetics/epigenetics, the identification of disease-inducing triggers, the apparent role of immunity in pathogenesis, high prevalence, complex etiologies and manifestations, and potentially some aspects of epidemiology. Fortunately, using available resources and technology, modern medicine has the potential to effectively reconstitute the human biome, thus treating or even avoiding altogether the consequences of genetic/cultural mismatches which underpin this entire family of disease. Thus, if indeed autism is an epidemic of postindustrial society associated with immune hypersensitivity, we can expect that the disease is readily preventable.

scholarly journals Epidemiología enfermera del duelo en Canarias

2020 ◽  
pp. 27-48
Author(s):  
Martín Rodríguez-Álvaro ◽  
Keyword(s):  
Protective Factors ◽  
Canary Islands ◽  
Significant Loss ◽  
Care Needs ◽  
Diagnostic Labels ◽  
Wide Range ◽  
High Prevalence ◽  
Functional Patterns ◽  
Limited Process

Grief is a natural and self-limited process of adaptation to a new reality that arises after a significant loss, real or perceived, with a wide range of manifestations that produce an impact on the health of the mourner. Objective: To know and identify, broken down by diagnostic gradient, the prevalence of mourning in the Canary Islands, as well as the needs of care before the diagnosis of mourning of the mourners. Results: Significantly, more women than men are identified in the three diagnostic labels under study. Patients with bereavement complications previously presented depression, anxiety, and risk of loneliness. The result of the pattern assessment is paradoxical. Conclusion: Grief is a multidimensional phenomenon that can hardly be assessed from a reductionist tool such as functional patterns. The high prevalence of complications in women’s grief should be studied in-depth, associating it with their previous burdens of care and vulnerability. The association between loneliness and complicated grief is evident, and the role of community nurses in these patients may be essential. Further research is needed on the care needs of bereaved persons, both complicated and uncomplicated, as well as on their predictive and protective factors.

scholarly journals THE ROLE OF GUT MICROBIOTA IN THE DEVELOPMENT OF OBESITY

2019 ◽  
pp. 4-10
Author(s):  
V.A. Volovnikova ◽  
A.D. Kotrova ◽  
K.A. Ivanova ◽  
E.I. Ermolenko ◽  
A.N. Shishkin
Keyword(s):  
Intestinal Microbiota ◽  
Modern Medicine ◽  
Overweight And Obesity ◽  
Global Epidemic ◽  
Treatment And Prevention ◽  
Normal Composition ◽  
Medicine Today ◽  
And Function

Obesity is a global epidemic of modern times and has serious health consequences, as it is a major risk factor for the development of chronic diseases such as hypertension, type 2 diabetes, dyslipidemia, atherosclerosis and its complications. The study of risk factors, pathogenetic mechanisms, as well as the search for new methods of treatment and prevention of this pathology is an important task of modern medicine. Today it is known that the composition and function of the intestinal microbiota play a certain role in the development of obesity and a number of metabolic disorders. One of the areas of prevention of early onset and development of these diseases may be the maintenance of a normal composition and correction of disorders of the intestinal ecosystem. In this review, the currently known interrelationships of changes in the composition of the intestinal microbiota and obesity are reviewed, and studies have been analyzed to assess the composition of the adult intestinal microbiota in obesity. The presently available data on the correction of overweight and obesity by exposing the composition of the intestinal microbiota are presented.

Analysis of the teaching of genetics for junior students of Sechenov university

2020 ◽  
pp. 90-92
Author(s):  
С.М. Кузин ◽  
Н.В. Чебышев ◽  
Д.В. Богомолов ◽  
И.А. Беречикидзе ◽  
Т.В. Сахарова ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Regenerative Medicine ◽  
Functional Genomics ◽  
Modern Medicine ◽  
Professional Activities ◽  
Wide Range ◽  
Prevention And Treatment ◽  
The Subject ◽  
Junior Students

Развитие генетики оказывает все большее влияние на современную медицину. На основе достижений в области структурной, функциональной геномики и эпигенетики сформировались новые наиболее перспективные направления - таргетная терапия, персонализированная и регенеративная медицина. Появились принципиально новые возможности для диагностики, прогнозирования, профилактики и лечения широкого спектра заболеваний. Все возрастающая роль генетики предъявляет принципиально иные требования к ее преподаванию в медицинских ВУЗах с использованием новых педагогических методик. Простого увеличения количества часов в рамках предмета «Биология» уже недостаточно для подготовки специалистов, чья профессиональная деятельность напрямую связана с генетикой: онкологов, вирусологов, иммунологов и многих других. The development of genetics has an increasing influence on modern medicine. Based on the achievements in the field of structural, functional genomics and epigenetics, new most promising directions have been formed - targeted therapy, personalized and regenerative medicine. There are fundamentally new opportunities for the diagnosis, prediction, prevention and treatment of a wide range of diseases. The increasing role of genetics imposes fundamentally different requirements for its teaching in medical Schools using new pedagogical methods. Simply increasing the number of academic hours in the subject “Biology” is no longer enough to train specialists whose professional activities are directly related to genetics: oncologists, virologists, immunologists, and many others.

Immunology of Bipolar Disorder

2018 ◽  
pp. 211-226
Author(s):  
Izabela G. Barbosa ◽  
Moises E. Bauer ◽  
Jair C. Soares ◽  
Antônio L. Teixeira
Keyword(s):  
Bipolar Disorder ◽  
Mononuclear Cells ◽  
Immune Cell ◽  
Course Of Illness ◽  
Wide Range ◽  
High Prevalence ◽  
The Central Nervous System ◽  
Immune Changes ◽  
Inflammatory Changes

Bipolar disorder (BD) is a severe, chronic, and recurrent psychiatric illness. It has been associated with a high prevalence of medical and psychiatric comorbidities, cognitive impairment, and a progressive course of illness. Its neurobiology is not completely understood, but recent evidence has shown a wide range of immune changes. Here we review several data supporting the presence of immunological dysfunction in BD: (1) increased frequency of autoimmune diseases; (2) distinct immune cell profile; (3) altered release of cytokines by stimulated mononuclear cells; (4) elevated levels of circulating immune markers; (5) inflammatory changes in the central nervous system; (6) relationship with clinical comorbidities; and (7) the effect of current treatments on the immune system and the role of immunomodulatory agents.

scholarly journals The Role of TRP Channels in Migraine

2013 ◽  
Vol 6 (1) ◽  
pp. 37-49 ◽  
Author(s):  
Gerry Stephen Oxford ◽  
Joyce Harts Hurley
Keyword(s):  
Trp Channels ◽  
Large Family ◽  
Trigeminovascular System ◽  
Peripheral Tissues ◽  
Wide Range ◽  
The Family ◽  
The Status ◽  
Physical Stimuli ◽  
Pain Transduction

TRP channels are members of a large family of non-selective cation channels. The family which numbers over 30 is classified into 6 groups based on amino acid sequence homology. TRP channels are distributed in many peripheral tissues as well as central and peripheral nervous system. These channels are important in sensing a wide range of chemical and physical stimuli. Several TRP channels, including TRPV1 and TRPA1 are important in pain transduction pathways. This review will focus on the function of TRP channels in the trigeminovascular system and other anatomical regions which are relevant to migraine. We will discuss the possible role of TRP channels in migraine, including the potential role of TRPV1 in the hypersensitivity and allodynia frequently observed in migraine patients. We will review the status of TRP channel drugs in migraine therapeutics. We will also discuss the possible roles of TRP channels in triggering migraine attacks, a process which is not well-understood.

Risk assessment and analysis of outcomes

2018 ◽  
pp. 25-48
Author(s):  
Peter F. Ludman
Keyword(s):  
Information Needs ◽  
Healthcare Delivery ◽  
Patient Characteristics ◽  
Modern Medicine ◽  
Optimal Care ◽  
Complex Process ◽  
Wide Range ◽  
Potential Problems ◽  
Risk Assessment And Analysis

To ensure that patients receive optimal care, and to find ways to improve, we have to measure the therapy delivered and patient outcomes. Increasingly this happens in a public forum. This chapter deals with this complex process and potential pitfalls. To assess care a wide range of information needs to be collected for each patient, and must be as complete and accurate as possible. Analysis needs to take into account different patient characteristics to tease out differences in outcome that might be due to healthcare delivery rather than patient comorbidity. The methods used to display these results are pivotal in interpretation and triggering early warning of potential problems, and are discussed. In this era of transparency and openness, the central role of patients is acknowledged—patient involvement is now central to modern medicine. The benefits and potential undesirable consequences of public reporting of outcomes are also explored in this chapter.

scholarly journals Contributions of Distribution Modelling to the Ecological Study of Psittaciformes

Diversity ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 611
Author(s):  
José R. Ferrer-Paris ◽  
Ada Sánchez-Mercado
Keyword(s):  
Species Distribution ◽  
Abiotic Factors ◽  
Global Scale ◽  
Distribution Models ◽  
Wide Range ◽  
High Prevalence ◽  
Parrot Species ◽  
Nuanced Understanding ◽  
Research Action

We provide an overview of the use of species distribution modeling to address research questions related to parrot ecology and conservation at a global scale. We conducted a literature search and applied filters to select the 82 most relevant studies to discuss. The study of parrot species distribution has increased steadily in the past 30 years, with methods and computing development maturing and facilitating their application for a wide range of research and applied questions. Conservation topics was the most popular topic (37%), followed by ecology (34%) and invasion ecology (20%). The role of abiotic factors explaining parrot distribution is the most frequent ecological application. The high prevalence of studies supporting on-ground conservation problems is a remarkable example of reduction in the research–action gap. Prediction of invasion risk and assessment of invasion effect were more prevalent than examples evaluating the environmental or economic impact of these invasions. The integration of species distribution models with other tools in the decision-making process and other data (e.g., landscape metrics, genetic, behavior) could even further expand the range of applications and provide a more nuanced understanding of how parrot species are responding to their even more changing landscape and threats.

scholarly journals The role of philosophy and ethics at the edges of medicine

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Bjørn Hofmann
Keyword(s):  
Present Situation ◽  
Modern Medicine ◽  
Human Beings ◽  
Modern Health Care ◽  
New Concepts ◽  
Literature Searches ◽  
Wide Range ◽  
The World ◽  
Conventional Content Analysis

Abstract Background The edge metaphor is ubiquitous in describing the present situation in the world, and nowhere is this as clearly visible as in medicine. “The edge of medicine” has become the title of books, scholarly articles, media headlines, and lecture series and seems to be imbued with hype, hope, and aversion. In order better to understand what is at stake at “the edge of medicine” this article addresses three questions: What does “the edge of medicine” mean in contemporary debates on modern medicine? What are the challenges “on the edge of medicine” (in these various meanings of “on the edge”)? How can philosophy and ethics contribute with addressing these challenges? Methods Literature searches in PubMed and Google Scholar are used to identify uses of the phrase “the edge of medicine” while conventional content analysis is used to analyze meanings of and challenges with “the edge of medicine.” These results are then investigated with respect to how philosophy and ethics can address the identified challenges. Results The literature reveals that “the edge of medicine” has many meanings, such as: Border; Margin (of life); Frontier; Forefront; Fringes; Plunge (abyss); Brink (verge); Conflict; and Balancing. In general, the various meanings address four basic challenges: setting limits, keeping control, make meaning, and handling conflicts or aporias. The analysis of each of the meanings of “the edge of medicine” identifies a wide range of important and urgent tasks for the humanities in general, and for philosophy and ethics in particular: 1) clarifying concepts; 2) clarifying assumptions and premises of arguments, methods, advice, and decisions; 3) elaborate new concepts and new theories; 4) conceptualize and handle uncertainty, moral regret, and residue; 5) reveal “the emperor’s new clothes;” 6) identify trends and reflect on their implications; 7) demarcation; and 8) reflecting on goodness in medicine. Conclusion The phrase “the edge of medicine” expresses a wide range of challenges for modern health care. Together with other disciplines philosophy and ethics can and should make crucial contributions at “the edge of medicine,” which is where the future of human beings and societies is created and formed.

scholarly journals NTPase/helicase of Flaviviridae: inhibitors and inhibition of the enzyme.

2002 ◽  
Vol 49 (3) ◽  
pp. 597-614 ◽  
Author(s):  
Peter Borowski ◽  
Andreas Niebuhr ◽  
Herbert Schmitz ◽  
Ramachandra S Hosmane ◽  
Maria Bretner ◽  
...  
Keyword(s):  
Antiviral Agents ◽  
Large Family ◽  
Enzymatic Activities ◽  
Structural Protein ◽  
Knock Out ◽  
Antiviral Therapies ◽  
Wide Range ◽  
Development And Differentiation ◽  
Transcription And Replication

RNA nucleoside triphosphatases (NTPase)/helicases represent a large family of proteins that are ubiquitously distributed over a wide range of organisms. The enzymes play essential role in cell development and differentiation, and some of them are involved in transcription and replication of viral single-stranded RNA genomes. The enzymatic activities of a NTPase/helicase were also detected in the carboxyl-terminal non-structural protein 3 (NS3) of members of the Flaviviridae family. The crucial role of the enzyme for the virus life cycle was demonstrated in knock out experiments and by using NTPase/helicase specific inhibitors. This makes the enzyme an attractive target for development of Flaviviridae-specific antiviral therapies. This review will summarize our knowledge about the function and structure of the enzyme, update the spectrum of inhibitors of the enzymatic activities of the NTPase/helicase and describe the different mechanisms by which the compounds act. Some of the compounds reviewed herein could show potential utility as antiviral agents against Flaviviridae viruses.

scholarly journals Prevalence of Salivary IgA Reacting with SARS-CoV-2 among Japanese People Unexposed to the Virus

2022 ◽  
Author(s):  
Keiichi Tsukinoki ◽  
Tetsuro Yamamoto ◽  
Jiro Saito ◽  
Wakako Sakaguchi ◽  
Keiichiro Iguchi ◽  
...  
Keyword(s):  
Public Health ◽  
Virus Infection ◽  
Host Defense ◽  
Negative Trend ◽  
Secretory Iga ◽  
Japanese People ◽  
Salivary Iga ◽  
Wide Range ◽  
High Prevalence

While the COVID-19 pandemic caused by SARS-CoV-2 has posed a threat to public health as the number of cases and COVID-19-related deaths are increasing worldwide, the incidence of the virus infection are extremely low in Japan compared with many other countries. To explore the reason for this strange phenomenon, we hypothesized the high prevalence of natural secretory IgA in saliva as mucosal IgA reacting with SARS-CoV-2, and thus surveyed the positivity for, as well as levels of, such reactive salivary IgA in a cohort of Japanese people of a wide range of age. The major findings were that 95/180 (52.78 %) of overall individuals who had not been exposed to SARS-CoV-2 were positive for salivary IgA with the levels ranging from 0.002 to 3.272 ng/ml, and that there may be a negative trend in positivity for salivary IgA according to age. These results suggest a role of mucosal IgA in host defense against SARS-CoV-2 infection.

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