scholarly journals Состояние гемодинамики у беременных с ожирением

2015 ◽  
Author(s):  
М. М Матлубов ◽  
А. А. Семенихин ◽  
С. А Рузибаев ◽  
Н. И Закирова ◽  
О. В Ким
Keyword(s):  
Adverse Effect ◽  
Body Mass Index ◽  
Pregnant Women ◽  
Cardiovascular System ◽  
Functional State ◽  
Control Group ◽  
Hemodynamic Status ◽  
Uncomplicated Pregnancy ◽  
Normal Body Weight ◽  
Survey Results

СОСТОЯНИЕ ГЕМОДИНАМИКИ У БЕРЕМЕННЫХ С ОЖИРЕНИЕМ - В данной статье представлены изменения состояния гемодинамики у беременных с ожирением при неосложнённой беременности. В исследование включены результаты комплексного обследования 84 беременных в возрасте от 23 до 28 лет с ожирением различной степени выраженности при сроках гестации 36-38 недель. В контрольную группу вошла 21 беременная аналогичного возраста и срока гестации с нормальной массой тела. У всех наблюдаемых пациентов беременность согласно консультациям акушер-гинекологов была признана неосложнённой. Степень ожирения оценивали по индексу массы тела. Проведённое исследование показало, что избыточный вес тела по мере её прогрессирования оказывает крайне неблагоприятное влияние на гемодинамику и функциональное состояние сердечно-сосудистой системы в целом, снижает коронарные резервы. Наиболее выраженные нарушения функционального состояния сердечно-сосудистой системы имеют место при ожирении II и III степеней.<br />СТАН ГЕМОДИНАМІКИ У ВАГІТНИХ З ОЖИРІННЯМ - Уданій статті представлено зміни стану гемодинаміки у вагітних з ожирінням при неускладненій вагітності. У дослідження включені результати комплексного обстеження 84 вагітних у віці від 23 до 28 років з ожирінням різного ступеня вираження при термінах гестації 36-38 тижнів. У контрольну групу ввійшла 21 вагітна аналогічного віку та терміну гестації з нормальною масою тіла. У всіх спостережуваних пацієнтів вагітність згідно з консультаціями акушер-гінекологів була визнана неусклад- неною. Ступінь ожиріння оцінювали за індексом маси тіла. Проведене дослідження показало, що надлишкова маса тіла в міру її прогресування украй несприятливо впливає на гемо- динаміку і функціональний стан серцево-судинної системи в цілому, знижує коронарні резерви. Найбільш виражені порушення функціонального стану серцево-судинної системи мають місце при ожирінні II і III ступенів.<br />HEMODYNAMIC STATUS OF PREGNANT WOMEN WITH OBESITY - In this article are represented the changes in hemodynamic status of pregnant women with obesity in uncomplicated pregnancy. In the study was included the full survey results of 84 pregnant women aged between 23 and 28 years with obesity of varying severity at 36-38 weeks gestation. The control group included 21 pregnant women of similar age and gestational age with normal body weight. All observed patients, pregnancy according obstetrical consultation was recognized uncomplicated. The degree of obesity was assessed by body mass index. Researchers conducted showed that overweight as its progression has a very adverse effect on hemodynamics and functional state of the cardiovascular system as a whole, reduces coronary reserve. The most pronounced violation of the functional state of the cardiovascular system occurs in obesity 2nd and 3rd degree.<br />Ключевые слова: беременность, ожирение, гемодинамика.<br />Ключові слова: вагітність, ожиріння, гемодинаміка

scholarly journals HEMODYNAMIC STATUS OF PREGNANT WOMEN WITH OBESITY

2015 ◽  
Vol 7 (2) ◽  
pp. 86-90
Author(s):  
M M Matlubov ◽  
A A Semenixin ◽  
S A Ruzibaev ◽  
N I Zakirova ◽  
O V Kim
Keyword(s):  
Adverse Effect ◽  
Body Mass Index ◽  
Body Weight ◽  
Pregnant Women ◽  
Cardiovascular System ◽  
Body Mass ◽  
Functional State ◽  
Gestational Age ◽  
Control Group ◽  
Normal Body Weight

In order to study the state of hemodynamics in pregnant women with obesity of varying severity were examined 84 pregnant women aged between 23 and 28 years at 36-38 weeks gestation. The control group included 21 pregnant women of similar age and gestational age with normal body weight. All observed patients, pregnancy according obstetrical consultation was recognized uncomplicated. The degree of obesity was assessed by body mass index. Researches conducted showed that overweight as its progression has a very adverse effect on hemodynamics and functional state of the cardiovascular system as a whole, reduces coronary reserve. The most pronounced violation of the functional state of the cardiovascular system occur in obesity 2nd and 3rd degree.

scholarly journals Profile of D-dimer in Uncomplicated Pregnancy

2019 ◽  
pp. 283-287
Author(s):  
Rahajuningsih Dharma ◽  
Mercy T. Panjaitan ◽  
Kanadi Sumapradja ◽  
Rianto Setiabudy
Keyword(s):  
Pregnant Women ◽  
Clinical Pathology ◽  
Cross Sectional Study ◽  
Control Group ◽  
Sectional Study ◽  
Cross Sectional ◽  
Uncomplicated Pregnancy ◽  
D Dimer

Abstract Objective: To obtain the profile of D-dimer in uncomplicated pregnancy. Methods: A cross sectional study was done on 90 uncomplicated pregnant women consisted of 30 women in each trimester and 30 healthy, nonpregnant women as control group from July to August 2012. D-dimer level was measured by particle enhanced immunoturbidimetry method using Innovance D-dimer and Sysmex CA 1500 in the Department of Clinical Pathology, Dr. Cipto Mangunkusumo Hospital, Jakarta. Results: All women in the control group showed normal D-dimer level (<0.,5 mg/L FEU). The median and range of D-dimer level in the 1st trimester, 2nd trimester, and 3rd trimester were 0.42 mg/L FEU and 0.1-1.07 mg/L FEU, 0.97 mg/L FEU and  0.6-3.34 mg/L FEU, and 1.56 mg/L FEU and  0.69-3.75 mg/L FEU, respectively.  Increased D-dimer level was found in 27% of pregnant women in 1st trimester, 87% in 2nd trimester, and 100% in 3rd trimester. Conclusion: Increased D-dimer level was found in  27% of pregnant women in 1st trimester, 87% in 2nd trimester, and  100% in 3rd trimester. The range of D-dimer level in the 1st trimester was 0.1-1.07 mg/L FEU, in the 2nd trimester was 0.6-3.34 mg/L FEU, and in the 3rd trimester was 0.69-3.75 mg/L FEU. Keywords: D-dimer, trimester, uncomplicated pregnancy   Abstrak Tujuan : Untuk mendapatkan profil  D-dimer pada kehamilan tanpa komplikasi. Metode : Penelitian potong lintang dilakukan pada 90 perempuan hamil tanpa komplikasi yang terdiri atas 30 perempuan pada tiap trimester dan 30 perempuan sehat yang tidak hamil, sebagai kelompok kontrol dari bulan Juli sampai Agustus 2012. Kadar D-dimer diukur dengan cara particle enhanced immunoturbidimetry  menggunakan reagen InnovanceÒ D-dimer dan koagulometer SysmexÒ CA 1500 di  Deparemen Patologi Klinik, Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo, Jakarta. Hasil: Seluruh perempuan dalam kelompok kontrol mempunyai kadar D-dimer dalam batas normal (<0.,5 mg/L FEU). Median (rentang) kadar D-dimer  pada trimester pertama, kedua, dan ketiga berturut-turut  0.42 mg/L FEU  (0.1-1.07 mg/L FEU), 0.97 mg/L FEU (0.6-3.34 mg/L FEU), dan 1.56 mg/L FEU   (0.69-3.75 mg/L FEU).  Peningkatan kadar D-dimer ditemukan pada 27% perempuan hamil trimester pertama, 87%  trimester kedua, dan pada 100%  trimester ketiga.   Kesimpulan: Peningkatan kadar  D-dimer ditemukan pada  27% perempuan hamil trimester pertama,  87% trimester kedua dan   100% pada trimester ketiga.  Rentang kadar D-dimer level pada trimester pertama adalah 0.1-1.07 mg/L FEU, pada trimester kedua  0.6-3.34 mg/L FEU, dan pada trimester ketiga  0.69-3.75 mg/L FEU. Kata kunci: D-dimer, kehamilan tanpa komplikasi, trimester

PECULIARITIES OF THE CONTENT OF PERIPHERAL BLOOD CYTOKINES IN PREGNANT WOMEN WITH A HABITUAL MISCARRIAGE

2020 ◽  
Vol 65 (5) ◽  
pp. 299-303 ◽  
Author(s):  
A. I. Malyshkina ◽  
N. Y. Sotnikova ◽  
N. V. Kroshkina ◽  
I. E. Talanova ◽  
A. V. Kust ◽  
...  
Keyword(s):  
Serum Level ◽  
Pregnant Women ◽  
Peripheral Blood ◽  
Pregnancy Loss ◽  
Main Group ◽  
Simultaneous Increase ◽  
Control Group ◽  
Gm Csf ◽  
Uncomplicated Pregnancy ◽  
Blood Cytokines

A lot of research nowadays is dedicated to the problem of habitual pregnancy loss, and this attention is dictated by the continued high frequency of this condition. The pathogenesis of habitual pregnancy loss is very complicated and includes many factors, at present especially close attention is paid to immune aspects. It is considered, that cytokine imbalance might play a key role in the pathogenesis of habitual pregnancy loss. Examination of 38 pregnant women was carried out at 5-12 weeks of gestation. The main group consisted of 17 women with habitual miscarriage and the threat of interruption at the time of the examination, the control group consisted of 21 women with uncomplicated pregnancy and a favorable obstetric history. As the material for investigation peripheral blood was used. Serum level of a complex of cytokines IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70, IL-13, IL-17A, IL-18, IL-21, IL-22, IL-23, IL-27, IFNγ, TNFα, GM-CSF was assessed on the Luminex 200 multiplex fluorescence analyzer (Luminex Corporation, USA). The significant differences in the serum level of IL-1β, IL-22, IL-23 and IL-27 were observed between the groups, in the main group their level was higher comparing to that of healthy pregnant women. When evaluating the cytokines serum level, fairly high values of IL-27 (in 25%of cases) (p<0,05), TNFα - (in 18% of cases) (p>0,05) were found in the main group, while in the control group they were not registered. Significant differences in the serum level of IL-2, IL-4, IL-9, IL-12p70, IL-18 and IFNγ were not noted in the compared groups (p>0,05). The simultaneous increase in the serum level of pro- and anti-inflammatory cytokines observed in our study can be explained by both an increase in the immune response and triggering of fetoprotection mechanisms. Inadequate cytokine regulation may be a prerequisite for the development of conditions for the development of a threat of termination of a real pregnancy in women with habitual miscarriage.

scholarly journals PREGNANCY, COMPLICATED BY PREECLAMPSIA: FETOPLACENTAL COMPLEX IMMUNE DEADAPTATION AND HISTOSTRUCTURAL FEATURES

2020 ◽  
Vol 73 (1) ◽  
pp. 99-103
Author(s):  
Pavlo V. Yavorskyi ◽  
Vitalii M. Zozulia ◽  
Oleh Ya. Vanchuliak ◽  
Marta S. Garazdiuk
Keyword(s):  
Pregnant Women ◽  
Transforming Growth Factor ◽  
Morphological Changes ◽  
Immunohistochemical Method ◽  
Electron Microscopic Level ◽  
Control Group ◽  
Electron Microscopic ◽  
Correlation Relationship ◽  
Uncomplicated Pregnancy ◽  
Fetoplacental Complex

The aim: to study and compare the features of the interleukins levels and morphological changes of placenta at various stages of preeclampsia. Materials and methods: 109 pregnant women with preeclampsia of varying severity (study group) and 30 pregnant women with uncomplicated pregnancy (control group) were examined. Immunohistochemical method, proinflammatory interleukins levels, morphological and morphometric analysis of peripheral and central placental areas biopsies on the optical and electron-microscopic level have been used. Results: Morphofunctional changes in the placenta in case of preeclampsia and the increase in the expression level of the transforming growth factor have a series of regular stages from the formation, strain and disruption of adaptive mechanisms with more pronounced signs of morphological immaturity of parenchymal and stromal elements of the placenta, especially in the area of syncytiotrophoblast and spiral vessels. The degree of clinical manifestation of preeclampsia has a correlation relationship with IL-10 deficiency and with the increase in TNF-α, stimulation of macrophage-protein production that contributes to the change in the ratio of Thl / Th2, which are antagonists and inhibit each other’s development. Conclusions: The severity of the preeclampsia course correlates with the state of morphofunctional changes in the placenta and changes in the ratio of the pro- and anti-inflammatory interleukins.

Estimation of the efficiency of measures of correction of the functional state of the cardiovascular system of operators of deep water technical means during the course of the voyage

2021 ◽  
Vol 7 (3) ◽  
pp. 20-31
Author(s):  
Yu. R. Khankevich ◽  
K. V. Sapozhnikov ◽  
D. V. Cherkashin ◽  
G. G. Kutelev ◽  
S. A. Parfenov ◽  
...  
Keyword(s):  
Cardiovascular System ◽  
Functional State ◽  
Deep Water ◽  
The State ◽  
Control Group ◽  
Respiratory Arrhythmia ◽  
Positive Effects ◽  
Regulatory Systems ◽  
Psychophysiological Study ◽  
Wide Range

During the course of the voyage, divers experience the effect of the wide range of adverse factors of operator labor and ship's habitability.The objective of the study is to estimate the state of cardiovascular system of operators of deep water technical means after using the complex of measures aimed at correction of function al state of operators during the course of the voyage.Materials and methods. The study was conducted with the participation of 38 operators of deep water technical means from among the crew of nuclear submarine engaged in operator labor activity. The study was performed twice: before the voyage and after return to base and included: cardiorhythmogram and psychophysiological study methodologies of functional state. Patients were divided into two groups: main (n = 13) and control (n = 25).Results and discussion. The control group shows sympathicotonia (reducing heart rate variability, intensity of respiratory arrhythmia). The main group, on the contrary, shows relative balance of regulatory systems. Thus, the conducted assessment of the state of cardiovascular system showed positive effects of using the complex of measures aimed at correction of functional state of operators during the course of the voyage.

scholarly journals 24-Hour Fetal/Maternal Monitoring System Based on Phonocardiogram Analysis

2018 ◽  
Vol 155 ◽  
pp. 01046 ◽  
Author(s):  
Dmitry Zhdanov ◽  
Artem Bureev ◽  
Yana Kosteley
Keyword(s):  
Pregnant Women ◽  
Cardiovascular System ◽  
Monitoring System ◽  
Functional State ◽  
Design Concept ◽  
Software System ◽  
Antenatal Period ◽  
Maternal Monitoring ◽  
Interpretation Process ◽  
Hardware And Software System

The article describes an engineering prototype of the Device for 24-hour monitoring over the functional state of the fetus and mother’s cardiovascular system in the antenatal period of pregnancy. The Device is a hardware and software system that ensures the registration and analysis of fetus and mother’s phonocardiograms with further processing and interpretation. The interpretation process is designed to timely detect conditions that constitute a threat to a fetus. The Device operates as part of a telemedicine network that allows obstetricians-gynecologists managing pregnant women to remotely control their state. The article describes the Device design concept and features of its specific components. The engineering prototype of the Device was used to carry out biomedical tests that confirmed its suitability for 24-hour monitoring over the functional state of fetus and mother’s cardiovascular system in home settings.

The functional state of the cardiovascular system in pregnant women with type 1 diabetes mellitus

2016 ◽  
Vol 1_2016 ◽  
pp. 34-39
Author(s):  
Kanus I.I. Kanus ◽  
Rimashevsky V.V. Rimashevsky ◽  
Skriplenok T.N. Skriplenok ◽  
◽  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Pregnant Women ◽  
Cardiovascular System ◽  
Functional State

scholarly journals PECULIARITIES OF THE FUNCTIONAL STATE OF THE MOTHER-PLACENTA–FETUS SYSTEM IN PREGNANT WOMEN WITH PLACENTAL DYSFUNCTION

2018 ◽  
Vol 17 (3) ◽  
pp. 24-28
Author(s):  
L. M. Yuryeva
Keyword(s):  
Blood Flow ◽  
Pregnant Women ◽  
Vascular Resistance ◽  
Functional State ◽  
Newborn Infants ◽  
Mean Value ◽  
Control Group ◽  
Fetal Blood ◽  
Peripheral Vascular ◽  
Placental Dysfunction

Among the causes that lead to antenatal affliction of the fetus, namely its hypoxia, hypotrophy, ante- and intranatal distress, is placental dysfunction (PD). Perinatal mortality in PDs is 10.3‰ in newborn infants, 49 ‰ – in preterm infants. Perinatal morbidity with PD reaches 70‰, and mortality rate – 20%. Objective. To investigate the functional state of the fetoplacental complex (FPС) in pregnant women with PD. Material and methods. The functional status of the FPC in 104 patients with PD (main group) and in 136 women with uncomplicated pregnancy and delivery (control group) using ultrasound placentalography, Dopplerometry was examined. Research results. The ultrasound characteristics of the placental dysfunction were the following: discrepancy between the degree of maturity of the placenta of the gestation period, true thickening of the placenta, its hypoplasia, reduction of echogenicity of the placenta, oligohydramnios. Dopplerometric signs of disorder of the utero-placental blood flow were high peripheral vascular resistance, both in dominant and in subdominant UA, asymmetry of blood flow in UA. Hemodynamics of fetal-placental circulation against the ground of PD was characterized by a decrease in the final diastolic blood flow velocity, which was manifested by an increase resistance in the peripheral vascular of the fetal part of the placenta,  decrease in placental coefficient. The peculiarity of fetal blood flow in pregnant women with PD was the decrease in the mean value of vascular resistance indices in the middle cerebral artery of the fetus and a significant decrease in the cerebral-umbilical index. Conclusions. In pregnant women with placental dysfunction hemodynamic changes in the utero-placental complex are associated with decrease in the intensity of placental-fetal blood flow and in 16.3% of cases by centralization of the fetal circulation. Timely Dopplerometry is important both in the diagnosis of the compensatory capabilities of the FPK, and during determination of reasonable suggested obstetrical tactics.

scholarly journals Characteristics of anthropometric indicators and eating behavior of pregnant women with obesity

2020 ◽  
Vol 98 (2) ◽  
pp. 149-152
Author(s):  
F. A. Tagieva
Keyword(s):  
Body Mass Index ◽  
Pregnant Women ◽  
Eating Behavior ◽  
Main Group ◽  
Control Group ◽  
Normal Body Mass Index ◽  
Obese Patients ◽  
Obese Women ◽  
Anthropometric Indicators ◽  
Group Evaluation

The paper presents the characteristics of anthropometric indicators and assessment of eating behavior of pregnant women with obesity. 213 pregnant women with abdominal obesity diagnosed before pregnancy (main group) were monitored. The control group consisted of 80 women who had a normal body mass index before pregnancy. When analyzing the differences in anthropometric indicators between the studied groups of pregnant women, statistically significant differences in the parameters of weight, BMI, OT/O ratio were revealed. The average BMI in pregnant women of the main group was 39,5 ± 0,57 kg/m2, which was 1,6 times higher than in women of the control group. In pregnant women with obesity, the ratio of OT/OB corresponded to 0,90 ± 0,004, which significantly exceeded the value of this indicator in women of the control group. Weight gain after the first pregnancy was indicated by 80 (37,5%) women of the main and 38 (47,5%) — control group. Evaluation of the eating behavior of obese patients showed that the nature of nutrition in almost half (48,0%) of obese women was irrational and excessive (3,8% in the control group), and 12,8% of patients abused various tonic drinks. Obese women are undoubtedly at high risk for developing complications during pregnancy.

scholarly journals Relationship between changes in body mass index during pregnancy and pregnancy rhinitis

2021 ◽  
Vol 20 (1) ◽  
pp. 23-26
Author(s):  
L. V. Georgieva ◽  
◽  
V. A. Stepanova ◽  
Keyword(s):  
Body Mass Index ◽  
Weight Gain ◽  
Pregnant Women ◽  
Body Mass ◽  
Body Weight Gain ◽  
Total Weight ◽  
Control Group ◽  
Total Weight Gain ◽  
Pregnancy Rhinitis ◽  
Weight Gain During Pregnancy

Objective of the study: to determine the relationship between the total weight gain during pregnancy and the development of rhinitis during pregnancy. The study involved 49 pregnant women with symptoms of rhinitis during pregnancy, aged 24 to 41 years (30,4 ± 0,6 years), and 33 pregnant women without symptoms of rhinitis aged 20 to 38 years (mean age 29,7 ± 0,7 years). The study included the assessment of complaints, history taking, otorhinolaryngological examination, calculation of body mass index before pregnancy and by the time of delivery and estimation of total body weight gain during pregnancy, and follow-up study. Based on the study, statistically significant differences between body mass indexes by the time of delivery in study group and in healthy pregnant group were not revealed. However, in the group of women with pregnant rhinitis, the dynamics of body mass index (total weight gain) significantly exceeded this indicator in the control group (13,3 ± 0,9 kg and 10,5 ± 1,3 kg, respectively). Pathological weight gain during pregnancy was observed more often in women with pregnancy rhinitis who were overweight before pregnancy.

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