Abstract P082: Lower Adiponectin Levels May Underlie Association Between Depressive Symptoms And Markers of Cardiometabolic Health

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Cari J Clark ◽  
Qi Wang ◽  
Hongfei Guo ◽  
Joyce T Bromberger ◽  
Peter Mancuso ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Depressive Symptoms ◽  
Regression Models ◽  
Missing Values ◽  
Smoking Status ◽  
Depression Scale ◽  
Cardiometabolic Health ◽  
Enzyme Linked Immunosorbent Assay ◽  
Linear Regression Models ◽  
Cvd Risk

Introduction: Depressive symptoms have been linked to CVD risk factors, including metabolic dysregulation. One pathway by which depression may influence CVD risk is via alterations in adiponectin, an abundant adipocytokine with anti-inflammatory effects. This mechanism has not been studied in population-based samples. Hypothesis: The relationship of depressive symptoms with metabolic syndrome (MetSyn) and Framingham Risk Score (FRS) will be partly mediated by adiponectin. Methods: Participants were 581 women (61.3% white; 38.7% black) from the Chicago and Pittsburgh sites of the Study of Women’s Health Across the Nation. Adiponectin was measured from stored serum specimens and assayed in duplicate using a commercially available enzyme linked immunosorbent assay and log transformed for analysis. Depressive symptoms were measured with the 20-item Center for Epidemiological Studies Depression Scale (CES-D); a standard cutoff (>16) was used to determine clinically significant symptoms. MetSyn was defined by ATP-III criteria and considered present if the participant had at least 3 of the following: waist circumference >88cm; triglycerides >150 mg/dl; HDL cholesterol < 50 mg/dl; blood pressure > 130 mmHg systolic and / or 85 mmHg diastolic; impaired fasting glucose (>110 mg/dl) or diabetes. The FRS was defined by the participant’s age, smoking status, blood pressure, cholesterol, and use of anti-hypertensives. Logistic regression models were constructed to examine the cross-sectional relationship between depressive symptoms and MetSyn controlling for age, race and study site. A subsequent model included adiponectin to evaluate whether it attenuated the observed association. Linear regression models were used to conduct the same analysis with FRS as the outcome. Due to missing values, analytic sample sizes were 558 for MetSyn and 568 for FRS. Results: 147 women (25.3%) had elevated CES-D scores and 113 (20.7%) met criteria for MetSyn. Average FRS was 8.7 (sd=4.6) and the mean, untransformed adiponectin value was 9.9 (sd=4.9) μ g/mL. In models adjusted for age, race, and study site, women with high CES-D scores had increased odds of MetSyn (OR=1.64; 95% CI=1.03, 2.60) and a higher FRS (estimate=0.98; se=0.41, p<.02). Separate bivariate analyses showed that adiponectin was inversely related to CES-D scores (p=.03), MetSyn (p<.001) and FRS (p<.001). Subsequently including adiponectin in the regression models attenuated the associations between CES-D and MetSyn (OR=1.45; 95% CI=0.89, 2.36) and FRS (estimate=0.76; se=0.41; p=.06). Conclusions: Adiponectin may partially explain the relation between depressive symptoms and measures of cardiometabolic health. Longitudinal studies are needed to more fully understand the temporality of these associations. Supported by NIH/DHHS grants HL091290, AG012505, AG012546, MH59770, AG17719.

scholarly journals Association of FKBP5 genotype with depressive symptoms in patients with coronary heart disease: a prospective study

2020 ◽  
Vol 127 (12) ◽  
pp. 1651-1662
Author(s):  
Julia Brandt ◽  
Katharina Warnke ◽  
Silke Jörgens ◽  
Volker Arolt ◽  
Katja Beer ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Depressive Symptoms ◽  
Coronary Revascularization ◽  
Central Element ◽  
Depression Scale ◽  
Stress System ◽  
Linear Regression Models ◽  
A Prospective Study

AbstractDepression and coronary heart disease (CHD) are prevalent and often co-occurring disorders. Both have been associated with a dysregulated stress system. As a central element of the stress system, the FKBP5 gene has been shown to be associated with depression. In a prospective design, this study aims to investigate the association of FKBP5 with depressive symptoms in CHD patients. N = 268 hospitalized CHD patients were included. Depressive symptoms were measured using the Hospital Anxiety and Depression Scale (HADS-D) at four time points (baseline, and after 1 month, 6 months, and 12 months). The functional FKBP5 single-nucleotide polymorphism (SNP) rs1360780 was selected for genotyping. Linear regression models showed that a higher number of FKBP5 C alleles was associated with more depressive symptoms in CHD patients both at baseline (p = 0.015) and at 12-months follow-up (p = 0.025) after adjustment for confounders. Further analyses revealed that this effect was driven by an interaction of FKBP5 genotype with patients’ prior CHD course. Specifically, only in patients with a prior myocardial infarction or coronary revascularization, more depressive symptoms were associated with a higher number of C alleles (baseline: p = 0.046; 1-month: p = 0.026; 6-months: p = 0.028). Moreover, a higher number of C alleles was significantly related to a greater risk for dyslipidemia (p = .016). Our results point to a relevance of FKBP5 in the association of the two stress-related diseases depression and CHD.

Abstract WMP14: Association of Systolic Blood Pressure, LDL Cholesterol, and Hgb A1c With White Matter Hyperintensity on MRI in the ACCORDION MIND Study

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Adam H de Havenon ◽  
Tanya Turan ◽  
Rebecca Gottesman ◽  
Sharon Yeatts ◽  
Shyam Prabhakaran ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Risk Factor ◽  
Regression Models ◽  
Ldl Cholesterol ◽  
Vascular Risk Factor ◽  
White Matter Hyperintensity ◽  
Vascular Risk ◽  
Linear Regression Models ◽  
Risk Factor Profile ◽  
The Mean

Introduction: While retrospective studies have shown that poor control of vascular risk factors is associated with progression of white matter hyperintensity (WMH), it has not been studied prospectively. Hypothesis: We hypothesize that higher systolic blood pressure (SBP) mean, LDL cholesterol, and Hgb A1c will be correlated with WMH progression in diabetics. Methods: This is a secondary analysis of the Memory in Diabetes (MIND) substudy of the Action to Control Cardiovascular Risk in Diabetes Follow-on Study (ACCORDION). The primary outcome was WMH progression, evaluated by fitting linear regression models to the WMH volume on the month 80 MRI and adjusting for the WMH volume on the baseline MRI. The primary predictors were the mean values of SBP, LDL, and A1c from baseline to month 80. We defined a good vascular risk factor profile as mean SBP <120 mm Hg and mean LDL <120 mg/dL. Results: We included 292 patients, with a mean (SD) age of 62.6 (5.3) years and 55.8% male. The mean number of SBP, LDL, and A1c measurements per patient was 17, 5, and 12. We identified 86 (29.4%) patients with good vascular risk factor profile. In the linear regression models, mean SBP and LDL were associated with WMH progression and in a second fully adjusted model they both remained associated with WMH progression (Table). Those with a good vascular risk factor profile had less WMH progression (β Coefficient -0.80, 95% CI -1.42, -0.18, p=0.012). Conclusions: Our data reinforce prior research showing that higher SBP and LDL is associated with progression of WMH in diabetics, likely secondary to chronic microvascular ischemia, and suggest that control of these factors may have protective effects. This study has unique strengths, including prospective serial measurement of the exposures, validated algorithmic measurement methodology for WMH, and rigorous adjudication of study data. Clinical trials are needed to investigate the effect of vascular risk factor reduction on WMH progression.

Abstract 15706: Association of Blood Pressure Level With Left Atrial Size and Function in Adolescents (SHIP AHOY)

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Edem Binka ◽  
Cedric Manlhiot ◽  
Elaine M Urbina ◽  
Tarek ALSAIED ◽  
Tammy M Brady
Keyword(s):  
Blood Pressure ◽  
Left Atrial ◽  
Global Longitudinal Strain ◽  
Blood Pressure Level ◽  
Left Ventricular ◽  
Z Score ◽  
Linear Regression Models ◽  
Cvd Risk ◽  
Strain And Strain Rate ◽  
And Function

Introduction: Left atrial (LA) enlargement and dysfunction are risk factors for stroke, atrial fibrillation and death in adults, and are associated with hypertension (HTN). In children, left ventricular hypertrophy is the most common manifestation of cardiac-specific organ damage in those with HTN, but gaps in knowledge remain regarding the association of HTN with LA size and function. Hypothesis: Increasing blood pressure (BP) is associated with increased LA volume and abnormal LA strain in children. Methods: Echocardiographic images of youth, aged 11 to 18 yrs from 5 clinical sites were obtained. LA strain and strain rate were analyzed using 2-D speckle tracking imaging with R-R gating in the apical 4 and 2-chamber views and averages of both views were used. Subjects were grouped by SBP as low-risk (L; <80th %ile), mid-risk (M; 80-<90th %ile), or high-risk, (H;≥90th %ile). Linear regression models were used to determine the association between BP z-score and LA size and function adjusting for age, sex, race and ethnicity. Results: N=347 youth (median age 15.7 yrs) 60% (n=208) male and 40% (n=139) non-white were included. BP groups differed by age (L&H<M) and BMI (L<M&H). BP groups did not differ by LA size and strain but differed by left ventricular mass index (H>L), stroke volume (M&H<L), peak global longitudinal strain (L>H), mitral E/e’ (H>L) and pulse wave velocity (H>L), each indicating worse CVD risk in the H vs. L group (Table). Multivariable analyses revealed DBP z-score to be independently associated with LA conduit strain (beta 0.73, 95% CI 0.01, 1.45, p<0.05). No other LA size or function variables were associated with BP. Conclusions: Greater BP is associated with increased CVD risk among youth as assessed by non-invasive measurements of CV structure and function. DBP is independently associated with LA conduit strain, a finding associated with CV events in adults. Future studies to determine the long-term association of abnormal DBP with LA strain are needed.

scholarly journals Is Drinking Alcohol Really Linked to Cardiovascular Health? Evidence from the Kardiovize 2030 Project

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2848
Author(s):  
Andrea Maugeri ◽  
Ota Hlinomaz ◽  
Antonella Agodi ◽  
Martina Barchitta ◽  
Sarka Kunzova ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Alcohol Consumption ◽  
Cardiovascular Health ◽  
Fasting Glucose ◽  
Smoking Status ◽  
Activity Level ◽  
Drinking Patterns ◽  
Drinking Alcohol ◽  
Cvd Risk ◽  
The Relationship

Existing data have described benefits and drawbacks of alcohol consumption on cardiovascular diseases (CVD), but no research has evaluated its association with the cardiovascular health (CVH) score proposed by the American Heart Association. Here, we conducted a cross-sectional analysis on the Kardiovize cohort (Brno, Czech Republic), to investigate the relationship between alcohol consumption and CVH. We included 1773 subjects (aged 25–64 years; 44.2% men) with no history of CVD. We compared CVD risk factors, CVH metrics (i.e., BMI, healthy diet, physical activity level, smoking status, blood pressure, fasting glucose, and total cholesterol) and CVH score between and within several drinking categories. We found that the relationship between drinking habits and CVH was related to the amount of alcohol consumed, drinking patterns, and beverage choices. Heavy drinkers were more likely to smoke tobacco, and to report diastolic blood pressure, fasting glucose, triglycerides, and low-density lipoprotein (LDL)-cholesterol at higher level than non-drinkers. Among drinkers, however, people who exclusively drank wine exhibited better CVH than those who exclusively drank beer. Although our findings supported the hypothesis that drinking alcohol was related to the CVH in general, further prospective research is needed to understand whether the assessment of CVH should incorporate information on alcohol consumption.

scholarly journals Modeling lifetime abuse and cardiovascular disease risk among women

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Kelly A. Scott-Storey ◽  
Marilyn Hodgins ◽  
Judith Wuest
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Depressive Symptoms ◽  
Risk Behaviors ◽  
Disease Risk ◽  
Community Sample ◽  
Rate Of Change ◽  
Equation Modeling ◽  
Cvd Risk ◽  
Causal Pathways

Abstract Background Cardiovascular disease (CVD) is one of the most significant health challenges facing women today. Abuse is a serious gendered issue also affecting the health of women. Despite beginning evidence that abuse may increase the risk of CVD among women, causal pathways linking abuse to CVD have received little attention. Our purpose was to test Scott-Storey’s conceptual model showing direct and indirect pathways through which lifetime abuse severity may affect women’s CVD risk. Methods Using data collected from a community sample of 227 Canadian women who had left an abusive partner, we conducted structural equation modeling with latent growth curve analysis using a phantom variable approach to test the direct effects of severity of lifetime abuse on CVD risk (indicated by measures of systolic and diastolic blood pressure) as well as its indirect effects through CVD risk behaviors and through women’s initial level of depressive symptoms and the observed rate of change in their depressive symptoms over time. Results Women in this sample had above average CVD risk factors (i.e., smoking, overweight/obesity, depressive symptoms, high blood pressure) in comparison to women in the general population. Further, CVD risk behaviors increased with severity of lifetime abuse and remained present long after leaving the abusive relationship. Results of the tested model provide preliminary evidence supporting many of the hypothesized pathways by which severity of lifetime abuse can increase CVD risk among women; the model fit the data reasonably well explaining 41% of the variance in CVD risk. Conclusions Findings support the growing recognition of the long-term effects of lifetime abuse on cardiovascular health, suggest important implications for clinicians working with women, and provide a novel approach for studying the concept of cumulative lifetime abuse through the use of a phantom variable.

Relationship Between Frailty and Depression Among Community-Dwelling Older Adults: The Mediating and Moderating Role of Social Support

2020 ◽  
Vol 60 (8) ◽  
pp. 1466-1475 ◽  
Author(s):  
Yaru Jin ◽  
Huaxin Si ◽  
Xiaoxia Qiao ◽  
Xiaoyu Tian ◽  
Xinyi Liu ◽  
...  
Keyword(s):  
Social Support ◽  
Older Adults ◽  
Depressive Symptoms ◽  
Rating Scale ◽  
Depression Scale ◽  
Community Dwelling ◽  
Linear Regression Models ◽  
Frailty Phenotype ◽  
Community Dwelling Older Adults ◽  
The Relationship

Abstract Background and Objectives Frailty is associated with depression in older adults and reduces their social support. However, the mechanism underlying such relationship remains unclear. We aim to examine whether social support acts as a mediator or moderator in the relationship between frailty and depression. Research Design and Methods This cross-sectional study was conducted among 1,779 community-dwelling older adults aged 60 and older. Frailty, social support, and depressive symptoms were measured by the Physical Frailty Phenotype, Social Support Rating Scale, and five-item Geriatric Depression Scale, respectively. Data were also collected on age, gender, years of schooling, monthly income, cognitive function, number of chronic diseases, physical function, and pain. Results Linear regression models showed that subjective support and support utilization, but not objective support, mediated and moderated the relationship between frailty and depressive symptoms. The Johnson–Neyman technique determined a threshold of 30 for subjective support, but not for support utilization, beyond which the detrimental effect of frailty on depressive symptoms was offset. Discussion and Implications Social support underlies the association of frailty with depression, and its protective role varies by type. Interventions on depression should address improving perceptions and utilization of social support among frail older adults rather than simply providing them with objective support.

scholarly journals Comparison of Cardiovascular Disease Risks of Actual and Perceptions of Men’s that 40-65 Years Old

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
İbrahim Topuz ◽  
Sebahat Gozum
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
High Risk ◽  
Perceived Risk ◽  
Risk Perceptions ◽  
Smoking Status ◽  
Cvd Risk ◽  
Related Factors ◽  
Risk Reducing ◽  
Very High

Abstract Background Turkey is among the top countries in Europe in coronary mortality in the 45-74 age range. The highest death due to disorders of the circulatory system (50.8%) that is Amasya province. Objective Determine related factors and to compare with actual and perceived cardiovascular disease (CVD) risks of men aged 40-65 living in Amasya. Methods The sample size of cross-sectional and analytical study consisted of 400 people who met the inclusion criteria. Actual CVD risks of men were calculated using HeartScore. Age, systolic blood pressure, total cholesterol measured by blood taken from the capillary and smoking status were used to calculate CVD risk. Actual CVD risk in next decade has been calculated as low, medium, high or very high. Perceived CVD risk in next decade were identified by participants as low, medium, high and very high responses. They also questioned why evaluation of perceived risk. Results It was determined whereas 8.3% of the males had high, 52.5% had a very high level of CVD risk. The main variables affecting actual CVD risk; diastolic blood pressure, BMI and physical activity. 13.3% of males perceived CVD risks at high and 8% at very high. The main variables affecting perceived CVD risk; age and DM. It was found that 48% and 23.8% of males perceived CVD risks lower and higher than actual CVD risk while 28.2% were accurate. Those who perceived CVD risk at a moderate, high and very high think that this is caused by diseases that increase the risk of CVD and smoking. Conclusions Approximately 1/2 men has very high risk of CVD. It was determined that 1/2 men perceived risks are lower with false optimism and couldn’t accurately identify risks of people older and with diabetes. Key messages It can be ensured that develop risk reducing behaviors and individuals with high risk of CVD can raise their awareness. The risk perceptions of males in the very high-risk group from the past to the present are important because they affect their actual risks and risk-reducing behaviors.

Adult children's achievements and ageing parents’ depressive symptoms in China

2020 ◽  
pp. 1-22
Author(s):  
Haowei Wang ◽  
Sae Hwang Han ◽  
Kyungmin Kim ◽  
Jeffrey A. Burr
Keyword(s):  
Older Adults ◽  
Depressive Symptoms ◽  
Occupational Status ◽  
Depression Scale ◽  
Urban China ◽  
Family Type ◽  
Linear Regression Models ◽  
Emotional Wellbeing ◽  
Older Parents ◽  
Ageing Parents

Abstract This study examined the association between adult children's achievements and ageing parents’ depressive symptoms in China. The research topic was examined within the contexts of one-child and multiple-children families in rural and urban China. Older adults (aged 60–113, N = 8,450; nested within 462 communities/villages) from the 2013 China Longitudinal Ageing Social Survey provided information about themselves and their adult children (N = 22,738). Adult children's achievements were assessed with educational attainment, financial status and occupational status; older parents’ depressive symptoms were assessed with nine items of the Chinese version of the Center for Epidemiological Studies Depression Scale. Multilevel linear regression models were estimated separately for older parents with one child only and multiple children. For older parents with multiple children, both having one or more children with any achievement and the total number of children's achievements were associated with fewer depressive symptoms. For parents with only one child, any achievement of the child and the total number of the child's achievements were associated with fewer depressive symptoms. Our results also indicated that the association between children's achievements and parents’ depressive symptoms varied by rural–urban residence and family type. Our findings contributed to the understanding of family dynamics underlying the emotional wellbeing of older adults in China.

The High Prevalence of Depressive Symptoms and Its Correlates With Older Hmong Refugees in the United States

2019 ◽  
Vol 32 (7-8) ◽  
pp. 660-669 ◽  
Author(s):  
Mai S. Yang ◽  
Jan E. Mutchler
Keyword(s):  
United States ◽  
Depressive Symptoms ◽  
Regression Models ◽  
Later Life ◽  
The United States ◽  
High Risk Population ◽  
Linear Regression Models ◽  
Hopkins Symptom Checklist ◽  
High Prevalence ◽  
Reported Health

Objective: We estimate depressive symptoms in a sample of older Hmong refugees in the United States, and investigate factors shaping risk of depression in this population. Method: Data were collected in California and Minnesota ( N = 127). The study sample included Hmong immigrants aged 55 and over. The measure of depression used is the Hopkins Symptom Checklist–10 (HSCL-10) inventory. Linear regression models were used to identify significant correlates of depressive symptoms. Results: More than 72% of the participants indicated being symptomatic of depression, as reflected by having a HSCL-10 score of 1.85 or higher. Self-reported health was a risk factor for depression. Protective factors from depression were larger household size and older age of arrival into the United States. Discussion: This study updated knowledge about the mental health status of Hmong refugees, who are now at later life. Our findings suggest that depression may be a lifelong experience in this high risk population.

scholarly journals Greater glucagon-like peptide-1 responses to oral glucose are associated with lower central and peripheral blood pressures

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Julie R. Lundgren ◽  
Kristine Færch ◽  
Daniel R. Witte ◽  
Anna E. Jonsson ◽  
Oluf Pedersen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Peripheral Blood ◽  
Significant Risk ◽  
Oral Glucose ◽  
Linear Regression Models ◽  
Cvd Risk ◽  
Cross Sectional ◽  
Blood Pressures ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Abstract Background and aim Cardiovascular diseases (CVDs) are globally the leading cause of death and hypertension is a significant risk factor. Treatment with glucagon-like peptide-1 (GLP-1) receptor agonists has been associated with decreases in blood pressure and CVD risk. Our aim was to investigate the association between endogenous GLP-1 responses to oral glucose and peripheral and central haemodynamic measures in a population at risk of diabetes and CVD. Methods This cross-sectional study included 837 Danish individuals from the ADDITION-PRO cohort (52% men, median (interquartile range) age 65.5 (59.8 to 70.7) years, BMI 26.1 (23.4 to 28.5) kg/m2, without antihypertensive treatment and known diabetes). All participants received an oral glucose tolerance test with measurements of GLP-1 at 0, 30 and 120 min. Aortic stiffness was assessed by pulse wave velocity (PWV). The associations between GLP-1 response and central and brachial blood pressure (BP) and PWV were assessed in linear regression models adjusting for age and sex. Results A greater GLP-1 response was associated with lower central systolic and diastolic BP of − 1.17 mmHg (95% confidence interval (CI) − 2.07 to − 0.27 mmHg, P = 0.011) and − 0.74 mmHg (95% CI − 1.29 to − 0.18 mmHg, P = 0.009), respectively, as well as lower brachial systolic and diastolic BP of − 1.27 mmHg (95% CI − 2.20 to − 0.33 mmHg, P = 0.008) and − 1.00 (95% CI − 1.56 to − 0.44 mmHg, P = 0.001), respectively. PWV was not associated with GLP-1 release (P = 0.3). Individuals with the greatest quartile of GLP-1 response had clinically relevant lower BP measures compared to individuals with the lowest quartile of GLP-1 response (central systolic BP: − 4.94 (95% CI − 8.56 to − 1.31) mmHg, central diastolic BP: − 3.05 (95% CI − 5.29 to − 0.80) mmHg, brachial systolic BP: − 5.18 (95% CI − 8.94 to − 1.42) mmHg, and brachial diastolic BP: − 2.96 (95% CI − 5.26 to − 0.67) mmHg). Conclusion Greater glucose-stimulated GLP-1 responses were associated with clinically relevant lower central and peripheral blood pressures, consistent with beneficial effects on the cardiovascular system and reduced risk of CVD and mortality. Trial registration ClinicalTrials.gov Identifier: NCT00237549. Retrospectively registered 10 October 2005

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