Trends in Cancer Treatment for Oral Cavity, Oropharynx, and Larynx in 2016 Versus 2009: SEER Patterns of Care Studies

2021 ◽  
pp. 000348942110371
Author(s):  
Kristin S. Weeks ◽  
Charles F. Lynch ◽  
Nitin Pagedar
Keyword(s):  
Oral Cavity ◽  
Systemic Treatment ◽  
Surgical Care ◽  
Patterns Of Care ◽  
Tumor Characteristics ◽  
Chi Square ◽  
Lower Stage ◽  
Targeted Agent ◽  
Logistic Regressions ◽  
Over Time

Purpose: To determine if there was a higher percentage of patients treated surgically and with advanced radiotherapy in 2016 (N = 897) versus 2009 (N = 1136), the patient and tumor characteristics associated with surgical care and advanced radiotherapy, and if chemotherapy or targeted agent use varied over time for squamous cell carcinoma of the head and neck. Methods: We utilized Surveillance Epidemiology and End Results Patterns of Care datasets. Rao-Scott Chi-square tests and logistic regressions were applied to determine differences in surgery, advanced radiotherapy (RT), and chemotherapy by year. Results: There was a lower prevalence of surgery only treatment in 2016 versus 2009 with exception of oral cavity stages IVB/IVC and unknown, and larynx stage unknown. Advanced RT was more common in 2016 for patients receiving definitive RT among all sites, excluding stages I/II glottic larynx. Among each site (oral cavity, oropharynx, and larynx) lower stage was associated with increased odds of surgery. Among each site, advanced RT was more common in patients receiving definitive versus postoperative RT. For the larynx site, 2016 versus 2009 was associated with greater odds of advanced RT. Systemic treatment with fluorouracil, taxanes, or cetuximab was less prevalent in 2016. Conclusion: In 2016 versus 2009, there was largely not a higher percentage of patients treated surgically. There was a higher prevalence of advanced RT for definitive care. Further investigations of these patterns are needed, including trend analysis.

scholarly journals 1136. Trends in Speaker Representation at the Infectious Diseases Society of America (IDSA) IDWeek Conference, 2013-2019

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S597-S597
Author(s):  
Jasmine R Marcelin ◽  
Rohan Khazanchi ◽  
Elizabeth Lyden ◽  
Kelly Cawcutt ◽  
Ravina Kullar ◽  
...  
Keyword(s):  
Gender Equity ◽  
Linear Increase ◽  
Program Committee ◽  
Chi Square ◽  
Poster Sessions ◽  
Professional Degree ◽  
Race Ethnicity ◽  
Chi Square Analysis ◽  
Changes Over Time ◽  
Over Time

Abstract Background Over the last decade, there have been sustained efforts to diversify the healthcare workforce. In 2016, the IDWeek Program Committee was charged to ensure gender equity in speaker sessions. Whether this intervention also resulted in more opportunities for underrepresented speakers has not been determined. Methods This project was supported by IDSA, who provided demographic information on IDWeek speakers (excluding poster sessions) from 2013-2019. Data were summarized using descriptive statistics, and chi-square analysis evaluated changes over time. Each speaker slot was considered an independent event. Data was combined for 2013-2016 (≤2016) and 2017-2019 (>2016). IDSA membership demographics were available from 2014 for gender, race/ethnicity, from 2016 for age, and from 2018 for professional degree. Results A total of 3640 speaker slots were filled by 2504 individuals from 2013-2019. A larger proportion of speaker slots were filled by women >2016 (51%) vs ≤ 2016 (43%), with a linear increase from 38.6% in 2013 to 52.1% in 2019 (p< 0.001). Averaged across 2013-2019, IDSA membership was 67.5% White, 20.6% Asian, 7.7% Latinx, 3.9% Black, and 0.4% Other. IDWeek Speakers during that timeframe were 77.7% White, 13.9% Asian, 4.7% Latinx, 2.7% Black, and 1.0% Other; a larger proportion of slots were filled by Asian speakers >2016 (16.3%) vs ≤ 2016 (12.8%) (p=0.005). The proportion of pharmacist speakers increased over time; 5.1% of speakers in 2019 reflected IDSA pharmacist membership (5.4%). The proportion of individuals invited to speak more than once differed by age (19% in < 40yo, 28% 40-49yo, 32% 50-59yo, and 22% >60yo; p< 0.001), and professional degree (28% physicians, 18% pharmacists, 9% other doctorates, and 7% non-doctorate speakers; p< 0.001). Figure 1: Trends in Gender Distribution of IDWeek Speakers and IDSA Members, 2013-2019 Figure 2: Trends in Race/Ethnicity Distribution of IDWeek Speakers and IDSA Members, 2013-2019 Conclusion Intentional consideration of gender equity by the Program Committee significantly improved equitable gender representation of invited speakers at IDWeek. This effort has not resulted in increased diversity of invited speakers from groups underrepresented in IDSA membership. To ensure that invited speakers represent the membership of IDSA/IDWeek partner organizations and more importantly, the communities we serve, we call for continued application of the principles of Inclusion, Diversity, Access, and Equity at IDWeek. Disclosures All Authors: No reported disclosures

scholarly journals Gender Differences in Cancer Screening Beliefs, Behaviors, and Willingness to Participate

2011 ◽  
Vol 6 (3) ◽  
pp. 211-217 ◽  
Author(s):  
Jenna L. Davis ◽  
Kyrel L. Buchanan ◽  
Ralph V. Katz ◽  
B. Lee Green
Keyword(s):  
Gender Differences ◽  
New York ◽  
Puerto Rico ◽  
Cancer Screening ◽  
Mortality Rates ◽  
Willingness To Participate ◽  
Chi Square ◽  
Random Digit ◽  
Random Digit Dial ◽  
Logistic Regressions

Men have higher cancer mortality rates for all sites combined compared with women. Cancer screening (CS) participation is important for the early detection of cancer. This study explores gender differences in CS beliefs, behaviors, and willingness to participate. The data were collected from a stratified, random-digit dial survey of adults living in New York, Maryland, and Puerto Rico. Chi-square tests and logistic regressions were computed to analyze gender associations among CS beliefs, behaviors, and willingness variables. Men and women believed that CSs were effective, though a higher percentage of men had never had a past CS. Men were less willing to participate in a CS at the present time and in a skin cancer exam; however, when given descriptions of screening conditions, men indicated more willingness to participate. These gender differences highlight the need for health professionals to examine their efforts in providing enhanced CS promotion and education among men.

scholarly journals INFLUENCE OF THE TREATMENT AND PREVENTIVE MEASURES ON THE PHYSICAL INDICATORS OF ORAL LIQUID IN CHILDREN WITH CHRONIC CATARRHIC GINGIVITIS AND DIABETES MELLITUS

2021 ◽  
pp. 60-64
Author(s):  
L.F. Kaskova ◽  
V.A. Honcharenko
Keyword(s):  
Diabetes Mellitus ◽  
Oral Cavity ◽  
Oral Fluid ◽  
Preventive Measures ◽  
Treatment And Prevention ◽  
Prophylactic Measures ◽  
Oral Liquid ◽  
Positive Effect ◽  
Over Time ◽  
Complex Drug

The aim of our study was to find out the effect of our proposed treatment and prevention complex, which included oral administration of «Kvertulin» complex drug, «Imupret» drops, «Pikovit» multivitamin drug and «Exodent» local irrigation of the oral cavity with a solution of tooth elixir that influence on the rate of salivation and viscosity of oral fluid in children with chronic catarrhal gingivitis and diabetes mellitus.The treatment and prophylactic measures had positive effect on the homeostasis of the oral cavity, which assisted to reduce the viscosity of the oral fluid, increase the rate of salivation, as evidenced by observation of patients for 6 months. The treatment and prevention complex are recommended to use 2 times a year, as the studied indicators deteriorate over time.

scholarly journals Maxillofacial injuries among Brazilian children and adolescents victims of traffic accidents

2015 ◽  
Vol 63 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Laís Gonzaga de FARIAS ◽  
Rebeca Valeska Soares PEREIRA ◽  
Lorenna Mendes Temóteo BRANDT ◽  
Thaliny Batista Sarmento de OLIVEIRA ◽  
Alidianne Fábia Cabral XAVIER ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Children And Adolescents ◽  
Traffic Accidents ◽  
Young Male ◽  
Cross Sectional Study ◽  
Body Region ◽  
Maxillofacial Injuries ◽  
Chi Square ◽  
Cross Sectional ◽  
Chi Square Test

OBJECTIVE: To analyze the prevalence of morbidity due to traffic accidents in children and adolescents and its relationship with maxillofacial injuries in the city of Campina Grande, Paraíba, Brazil. METHODS: This cross-sectional study analyzed 533 forensic reports of individuals aged 0-19 years, victims of external causes in Campina Grande, Brazil, in 2013. Data were collected through a form containing variables sex, age, day of week, time, type of traffic accident, injured body region, presence of fractures, maxillofacial and oral cavity injuries. The Statistical Package for Social Sciences software (SPSS) was used for data analysis. Prevalence ratios and confidence intervals at 95% were estimated with the chi-square test. RESULTS: There was predominance of males (75.0%) aged 15-19 years (65.0%), with association between sex and occurrence of traffic accidents (p <0.001). The afternoon shift recorded 36.7% of cases of accidents involving motorcyclists (55.0%). In 25.0% of cases, there were injuries on the head and 26.7% on the face. Head and face injuries were observed in 10.0% of patients, while maxillofacial and oral cavity injuries were present in 21.7% and 6.7%, respectively. There was an association between occurrence of accident and face injuries (p = 0.009). CONCLUSION: Traffic accidents affect mostly young male individuals, causing multiple injuries in different body areas, including maxillofacial and oral cavity injuries.

scholarly journals Levofloxacin Induced Stomatitis: A Case Report

2019 ◽  
Author(s):  
Atousa Hakamifard ◽  
Sarah Mousavi ◽  
Tahereh Gholipur-Shahraki ◽  
Fatemeh Mohaghegh
Keyword(s):  
Oral Cavity ◽  
Systemic Treatment ◽  
Topical Therapy ◽  
Patient Experiences ◽  
Oral Lesions ◽  
Productive Cough ◽  
Dermal Toxicity ◽  
First Case ◽  
The Central Nervous System ◽  
Epidermal Necrosis

Fluoroquinolones have many adverse effects include the gastrointestinal tract and the central nervous system, phototoxicity, and dermal toxicity. Levofloxacin has favorable adverse reaction profiles compared to other fluoroquinolones. Among the reported dermal toxicity there are few reports of toxic epidermal necrosis (TEN) in association with levofloxacin usage. However, there is no published study on levofloxacin induced stomatitis. Stomatitis is characterized by pain, inflammation, and ulceration in the oral cavity. A 36-year-old man was referred to the hospital for ‘painful oral swelling and ulceration’. Before the admission due to fever and productive cough, 750 mg levofloxacin were prescribed for him. After 2 days of consumption, the patient experiences painful ulcerative and erythema lesions in the oral cavity that consistent with stomatitis. Due to the possibility of a drug reaction, levofloxacin was discontinued and no other antibiotic was used. Oral lesions were managed with a mouthwash and after 5 days, lesions recovered. To the best of our knowledge, this is the first case who developed stomatitis after two dose of levofloxacin and recovered just with topical therapy and without any systemic treatment. Caution is advised while administering these drugs.

Abstract 4: Variation and Temporal Trends in the Characteristics of US Hospitals Treating Acute Ischemic Stroke Patients with IV-tPA: Findings from GWTG-Stroke

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
Lee H Schwamm ◽  
Syed F Ali ◽  
Mathew J Reeves ◽  
Eric E Smith ◽  
Jeffrey L Saver ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Systems Of Care ◽  
Team Building ◽  
Temporal Trends ◽  
High Volume ◽  
Wilcoxon Test ◽  
Chi Square ◽  
Over Time ◽  
Iv Tpa

Introduction: Utilization of IV tPA is challenging for many hospitals. Using data from the national Get With The Guidelines-Stroke program, we analyzed changes over time in the characteristics of the hospitals that treated patients with tPA. Methods: We analyzed patient-level data from 2003-2011 at 1600 GWTG hospitals that joined the program at any time during the study period and admitted any acute ischemic stroke (AIS) patients arriving ≤ 2 hr of onset and eligible for tPA. Descriptive trends by time were analyzed by chi-square or Wilcoxon test for continuous data. Results: IV tPA was given within 3 hr at 1394 sites to 50,798/ 75,115 (67.6%) eligible AIS patients arriving ≤ 2 hr; 206 (14.8%) sites had a least one eligible patients but no tPA use. IV tPA treatment rates varied substantially across hospitals (median 61.2%, range 0-100%), with > 200 hospitals providing tPA < 10% of the time (Figure). Over time, more patients and a larger proportion of patients were treated at smaller (median bed size 407 vs. 372, p< 0.001), non-academic, Southern hospitals, and those with lower annualized average ischemic stroke volumes (252.4 vs. 235.2, p< 0.001) (Table). While more than half of all tPA patients were treated at Primary Stroke Centers, this proportion did not change over time. The proportion of patients treated at high volume tPA treatment sites (average > 20/year) increased over time (31.9 vs. 34.5, p< 0.007). Conclusion: Over the past decade, while primary stroke centers still account for more than half of all treatments, tPA has been increasingly delivered in smaller, non-academic hospitals. These data support the continued emphasis on stroke team building and systems of care at US hospitals.

Five Decades of Adult Low-grade Gliomas: Patterns of Care Over Time

2012 ◽  
Vol 84 (3) ◽  
pp. S37
Author(s):  
R. Youland ◽  
P.D. Brown ◽  
J.C. Buckner ◽  
I.F. Parney ◽  
J.H. Uhm ◽  
...  
Keyword(s):  
Patterns Of Care ◽  
Low Grade ◽  
Low Grade Gliomas ◽  
Over Time

scholarly journals 2512. Decreasing Adherence to Antiretroviral Therapy over 4 Years of Follow-up in a Commercially-Insured Population of Patients with HIV

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S872-S872
Author(s):  
Julie Priest ◽  
Rachel Bhak ◽  
Maral DerSarkissian ◽  
Cindy Garris ◽  
Alan Oglesby ◽  
...  
Keyword(s):  
Index Date ◽  
Claims Data ◽  
First Year ◽  
Chi Square ◽  
Proportion Of Days Covered ◽  
Chi Square Test ◽  
Hiv 1 ◽  
Over Time ◽  
Observation Period

Abstract Background This study compared yearly and longer term antiretroviral (ARV) adherence among HIV patients overall and by single-tablet regimens (STRs) vs. multi-tablet regimens (MTRs). Methods A retrospective study using Optum Clinformatics US-based claims data was conducted. Patients with an HIV-1 diagnosis during 2011–2017, age ≥ 18 years at index (date of first complete ARV regimen during the study period), and continuous enrollment for ≥ 3 months before index (baseline) and ≥ 12 months after index (observation) were included. MTRs were required to be comprised of 3 or more agents across at least 2 classes. Adherence was measured as the proportion of days covered (PDC) and compared using a Chi-square test. PDC was examined in the 1-year observation period for the overall analysis, and each year following index among patients with at least 4 years of continuous data. A subgroup analysis was conducted among patients with index during 2014–2016 to evaluate modern ARV adherence. Results Among the 15,153 included patients, median age was 45 years, the majority were male (88%), and 53% were in the South. At baseline, 58% (n = 8,715) were receiving an STR and 43% (n = 6,438) an MTR. Compared with STR patients, MTR patients had higher prevalence of hyperlipidemia (36% vs. 29%), cardiovascular disease (27% vs. 21%), and hypertension (25% vs. 20%). During year 1, the proportion of patients with PDC ≥ 0.90 was 63% overall (Table 1), and greater for STR than MTR (67% vs. 58%, P < .001). Among patients with at least 4 years of observation, PDC ≥ 0.90 decreased over time (from 67% in year 1 to 53% in year 4). In the subgroup of patients with index during 2014–2016 (Table 2), similar but slightly worse trends were observed, with PDC ≥ 0.90 for 57% of patients overall, and decreasing over time for those patients with at least 3 years of observation (59% in year 1 to 42% in year 3). Conclusion Adherence in this population of patients with HIV showed room for improvement in the first year of observation overall and in the modern ARV era, with those receiving STRs having higher adherence when compared with those receiving MTRs. For the patients with 4 years of follow-up, adherence tended to decrease year on year. Maintaining high rates of ARV adherence is a critically important aspect of therapy for patients with HIV. Disclosures All authors: No reported disclosures.

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