scholarly journals Determinants of Antidepressant Treatment and Outpatient Rehabilitation Within the First Year After Stroke

2020 ◽  
pp. 089198872097374
Author(s):  
Simon Ladwig ◽  
Katja Werheid
Keyword(s):  
Depressive Symptoms ◽  
Antidepressant Treatment ◽  
Antidepressant Medication ◽  
Inpatient Rehabilitation ◽  
Outpatient Rehabilitation ◽  
Prospective Longitudinal Study ◽  
Telephone Interviews ◽  
Individual Determinants ◽  
History Of ◽  
Prospective Longitudinal

This study aims to identify individual determinants of antidepressant treatment and outpatient rehabilitation after stroke. People with ischemic stroke ( N = 303) recruited at 2 inpatient rehabilitation clinics were included into a prospective longitudinal study with follow-up telephone interviews 6 and 12 months later. Participants reported on their use of antidepressant medication and psychotherapy as well as physical, occupational, speech, and neuropsychological therapy. The use of antidepressants at discharge ( n = 65, 23.8%) was predicted by the severity of depressive symptoms, severity of stroke, history of depression, and use of antidepressants at admission (all p < .05, R 2= .55). The number of outpatient rehabilitation services used at follow-ups was predicted by higher functional and cognitive impairment, higher education, younger age, severity of depressive symptoms, and lower self-efficacy (all p < .05; R 2 6M = .24, R 2 12M = .49). The relevance of identified determinants for the improvement of treatment rates after stroke is discussed.

scholarly journals The contribution of depressive ‘disorder characteristics’ to determinations of prognosis for adults with depression: an individual patient data meta-analysis

2021 ◽  
pp. 1-14
Author(s):  
Joshua E. J. Buckman ◽  
Rob Saunders ◽  
Zachary D. Cohen ◽  
Phoebe Barnett ◽  
Katherine Clarke ◽  
...  
Keyword(s):  
Primary Care ◽  
Depressive Symptoms ◽  
Depressive Symptom ◽  
Panic Disorder ◽  
Symptom Severity ◽  
Individual Patient Data ◽  
Antidepressant Treatment ◽  
Patient Data ◽  
History Of ◽  
Depressive Symptom Severity

Abstract Background This study aimed to investigate general factors associated with prognosis regardless of the type of treatment received, for adults with depression in primary care. Methods We searched Medline, Embase, PsycINFO and Cochrane Central (inception to 12/01/2020) for RCTs that included the most commonly used comprehensive measure of depressive and anxiety disorder symptoms and diagnoses, in primary care depression RCTs (the Revised Clinical Interview Schedule: CIS-R). Two-stage random-effects meta-analyses were conducted. Results Twelve (n = 6024) of thirteen eligible studies (n = 6175) provided individual patient data. There was a 31% (95%CI: 25 to 37) difference in depressive symptoms at 3–4 months per standard deviation increase in baseline depressive symptoms. Four additional factors: the duration of anxiety; duration of depression; comorbid panic disorder; and a history of antidepressant treatment were also independently associated with poorer prognosis. There was evidence that the difference in prognosis when these factors were combined could be of clinical importance. Adding these variables improved the amount of variance explained in 3–4 month depressive symptoms from 16% using depressive symptom severity alone to 27%. Risk of bias (assessed with QUIPS) was low in all studies and quality (assessed with GRADE) was high. Sensitivity analyses did not alter our conclusions. Conclusions When adults seek treatment for depression clinicians should routinely assess for the duration of anxiety, duration of depression, comorbid panic disorder, and a history of antidepressant treatment alongside depressive symptom severity. This could provide clinicians and patients with useful and desired information to elucidate prognosis and aid the clinical management of depression.

Relation between neuritic plaques and depressive state in Alzheimer's disease

2010 ◽  
Vol 22 (1) ◽  
pp. 14-20 ◽  
Author(s):  
Gerben Meynen ◽  
Heleen Van Stralen ◽  
Jan H. Smit ◽  
Wouter Kamphorst ◽  
Dick F. Swaab ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Depressive Symptoms ◽  
Temporal Cortex ◽  
Clinical Severity ◽  
Depressive State ◽  
Neuritic Plaques ◽  
Prospective Longitudinal Study ◽  
Severity Of Dementia ◽  
Prospective Longitudinal

Meynen G, Van Stralen H, Smit JH, Kamphorst W, Swaab DF, Hoogendijk WJG. Relation between neuritic plaques and depressive state in Alzheimer's disease.Background:To investigate for the first time in a prospective study the relationship between depressive state and the neuropathological hallmarks of Alzheimer's disease, using a scale for depressive symptoms in dementia, while controlling for clinical severity of dementia.Method:Within the framework of a prospective longitudinal study of depression in Alzheimer's disease, patients with dementia underwent a clinical evaluation every six months during the last years of their lives, using the Cornell scale for depression in dementia to assess depressive symptoms and using the Functional Assessment Staging scale to control for clinical severity of dementia. The brains of 43 Alzheimer patients were obtained. The last clinical evaluations prior to death together with post-mortem neuropathology measures were analysed.Results:We found a correlation between the Cornell scores and the sum score for the density of neuritic plaques in the entire cortex (p = 0.027), and even stronger in the temporal cortex (p = 0.012). The observed correlations were independent of sex, age of death, clinical dementia severity and duration of Alzheimer's disease.Conclusions:This study shows a positive relationship between depressive state at time of death and the presence of neuritic plaques in Alzheimer's disease, which is independent of the clinical severity of dementia.

HPA-axis Function and Depression in Adolescence: Are they Related to Prenatal Early Life Stress?

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
B. Van den Bergh ◽  
B. Van Calster ◽  
T. Smits ◽  
S. Van Huffel ◽  
A. Simons ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Hpa Axis ◽  
Early Life ◽  
Ordinary Least Squares ◽  
Repeated Measurements ◽  
Maternal Anxiety ◽  
Future Research ◽  
Postnatal Life ◽  
Prospective Longitudinal Study ◽  
Prospective Longitudinal

Early-life exposure to adverse environmental cues during critical windows of time in the prenatal and/or early postnatal life period could predispose the individual for somatic andmental diseases. This especially holds for stress-related disorders such as depression in which HPA-axis dysregulation plays a pathophysiological role. This is in line with the ‘fetal (or developmental) programming-hypothesis’ which has been tested in numerous preclinical experimental. We tested this hypothesis in humans in a prospective longitudinal study in which maternal emotional state was measured during each pregnancy trimester and after pregnancy. When the offspring was 14-15 years old, HPA-axis function was measured through establishing a saliva day-time cortisol profile. Severity of depressive symptoms was measured with the Children's Depression Inventory. Repeated measurements regression analysis and ordinary least-squares regression analyses indicated that maternal anxiety at 12-22 weeks of pregnancy was in female and male offspring associated with a diurnal cortisol profile that was attenuated due to elevated cortisol secretion in the evening. Moreover, in female adolescents this flattened cortisol curve was associated with depressive symptoms. Our results indicate that maternal anxiety during pregnancy enhances neurobiological vulnerability to depressive symptoms, possibly by altering (or ‘programming") foetal physiology. If our results can be replicated in future research they may lead to a re-orientation of the target of primary prevention and treatment of depressive symptoms. Preliminary results of a study on the association between prenatal exposure to maternal anxiety and cortisol stress responsivity during inoculation in the four month old will be presented.

A prospective longitudinal study of the impact of early postnatal vs. chronic maternal depressive symptoms on child development

2011 ◽  
Vol 26 (8) ◽  
pp. 484-489 ◽  
Author(s):  
A.-L. Sutter-Dallay ◽  
L. Murray ◽  
L. Dequae-Merchadou ◽  
E. Glatigny-Dallay ◽  
M.-L. Bourgeois ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Longitudinal Study ◽  
Child Development ◽  
Postnatal Depression ◽  
Repeated Measures ◽  
Maternal Depressive Symptoms ◽  
Prospective Longitudinal Study ◽  
Postnatal Depressive Symptoms ◽  
Prospective Longitudinal ◽  
The Impact

AbstractBackgroundFew studies of the effects of postnatal depression on child development have considered the chronicity of depressive symptoms. We investigated whether early postnatal depressive symptoms (PNDS) predicted child developmental outcome independently of later maternal depressive symptoms.MethodsIn a prospective, longitudinal study, mothers and children were followed-up from birth to 2 years; repeated measures of PNDS were made using the Edinburgh Postnatal Depression Scale (EPDS); child development was assessed using the Bayley Scales II. Multilevel modelling techniques were used to examine the association between 6 week PNDS, and child development, taking subsequent depressive symptoms into account.ResultsChildren of mothers with 6 week PNDS were significantly more likely than children of non-symptomatic mothers to have poor cognitive outcome; however, this association was reduced to trend level when adjusted for later maternal depressive symptoms.ConclusionEffects of early PNDS on infant development may be partly explained by subsequent depressive symptoms.

scholarly journals Associations between patterns in comorbid diagnostic trajectories of individuals with schizophrenia and etiological factors

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Morten Dybdahl Krebs ◽  
Gonçalo Espregueira Themudo ◽  
Michael Eriksen Benros ◽  
Ole Mors ◽  
Anders D. Børglum ◽  
...  
Keyword(s):  
Latent Factors ◽  
Prospective Longitudinal Study ◽  
Etiological Factors ◽  
Individual Level ◽  
Danish Health ◽  
Stable Clusters ◽  
History Of ◽  
The Individual ◽  
Prospective Longitudinal ◽  
Ordered Pairs

AbstractSchizophrenia is a heterogeneous disorder, exhibiting variability in presentation and outcomes that complicate treatment and recovery. To explore this heterogeneity, we leverage the comprehensive Danish health registries to conduct a prospective, longitudinal study from birth of 5432 individuals who would ultimately be diagnosed with schizophrenia, building individual trajectories that represent sequences of comorbid diagnoses, and describing patterns in the individual-level variability. We show that psychiatric comorbidity is prevalent among individuals with schizophrenia (82%) and multi-morbidity occur more frequently in specific, time-ordered pairs. Three latent factors capture 79% of variation in longitudinal comorbidity and broadly relate to the number of co-occurring diagnoses, the presence of child versus adult comorbidities and substance abuse. Clustering of the factor scores revealed five stable clusters of individuals, associated with specific risk factors and outcomes. The presentation and course of schizophrenia may be associated with heterogeneity in etiological factors including family history of mental disorders.

scholarly journals Increasing mixed-berry flavonoid intake may reduce depressive symptoms in older adults: Framingham Heart Study

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 864-864
Author(s):  
Courtney Millar ◽  
Alyssa Dufour ◽  
Marian Hannan ◽  
Shivani Sahni
Keyword(s):  
Older Adults ◽  
Depressive Symptoms ◽  
Framingham Heart Study ◽  
Randomized Clinical Trials ◽  
Epidemiological Studies ◽  
Prospective Longitudinal Study ◽  
Heart Study ◽  
Flavonoid Intake ◽  
Prospective Longitudinal ◽  
Dietary Flavonoids

Abstract Depression affects more than 250 million people worldwide. Although epidemiological studies have linked higher dietary flavonoids with depression prevention in older women, it is unknown if increasing dietary flavonoids could effectively reduce depression. Mixed berries (blueberry, blackberry, and raspberry) are a rich source of flavonoids, particularly anthocyanin, flavanol, and flavan-3-ol subclasses. Our aim was to determine the association of mixed-berry flavonoid intake with change in depressive symptoms over ~8 years in older adults from the Framingham Heart Study. This community-based prospective longitudinal study included 1,278 adults with assessments on diet (food frequency questionnaire) and depressive symptoms (Center for Epidemiologic Studies Depression, CES-D) at baseline (1998-2001) and follow-up (2005-2008). Absolute change in mixed-berry flavonoid intake (defined as sum of anthocyanin, flavanol, and flavon-3-ols, mg/day) and change in CES-D scores were calculated. Linear regression estimated beta and standard error (SE) for change in CES-D scores per 250 mg/day increase in mixed-berry flavonoids (obtained from ~3/4 cup of mixed berries), adjusting for baseline age, sex, energy-intake, current smoking, body mass index, physical activity, cardiovascular disease, and non-melanoma cancer. Mean age was 59±9 years (range: 33-81), 57% female and mean change in mixed-berry flavonoid intake was 15.0±72.8 mg/day over ~8 years. In adjusted models, each 250 mg/day increase in mixed-berry flavonoid intake was associated with a 1-point reduction in depressive symptoms (beta: -1.06, SE: 0.61, p=0.08) over ~8 years, although this was not statistically significant. These data highlight the need for randomized clinical trials of flavonoid-rich berries to target depressive symptoms in older adults.

Intergenerational Continuity in Child Maltreatment: Explicating Underlying Mechanisms

2020 ◽  
pp. 088626052091454
Author(s):  
Tiffany L. Martoccio ◽  
Lisa J. Berlin ◽  
Elizabeth M. Aparicio ◽  
Karen Appleyard Carmody ◽  
Kenneth A. Dodge
Keyword(s):  
Sexual Abuse ◽  
Child Maltreatment ◽  
Child Protective Services ◽  
Protective Services ◽  
Prospective Longitudinal Study ◽  
Physically Abused ◽  
Child Victimization ◽  
History Of ◽  
Underlying Mechanisms ◽  
Prospective Longitudinal

The current study examined direct and indirect effects of a mother’s history of childhood physical and sexual abuse on her child’s officially reported victimization. This prospective, longitudinal study followed a community-based sample of 499 mothers and their children. Mothers (35% White/non-Latina, 34% Black/non-Latina, 23% Latina, and 7% other) were recruited and interviewed during pregnancy, and child protective services records were reviewed for the presence of the participants’ target child between birth and age 3.5. Whereas both types of maternal maltreatment history doubled the child’s risk of child protective services investigation, mothers’ sexual abuse history conferred significantly greater risk. Pathways to child victimization varied by type of maternal maltreatment history. Mothers who had been physically abused later demonstrated interpersonal aggressive response biases, which mediated the path to child victimization. In contrast, the association between maternal history of sexual abuse and child victimization was mediated by mothers’ substance use problems. Study implications center on targeting child maltreatment prevention efforts according to the mother’s history and current problems.

Antidepressant Medication May Moderate the Effect of Depression Duration on Hippocampus Volume

2016 ◽  
Vol 30 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Mark A. Rogers ◽  
Hidenori Yamasue ◽  
Kiyoto Kasai
Keyword(s):  
Major Depression ◽  
Antidepressant Treatment ◽  
Antidepressant Medication ◽  
Healthy Controls ◽  
Detailed History ◽  
Treatment History ◽  
Left Hippocampus ◽  
History Of ◽  
History Of Depression ◽  
Hippocampus Volume

Abstract. Hippocampus volume has been frequently, but not universally reported to be reduced in people with major depression relative to age-matched healthy controls. Among the potential reasons for this discrepancy in finding across studies is the effect of antidepressant medication. Hippocampus volume was determined by MRI (1.5 Tesla) for 10 people diagnosed with major depression for who detailed history of depression and antidepressant treatment history were known, and 10 age-matched healthy controls with no history of depression. Left, but not right, hippocampus volumes were significantly smaller in the patient group compared to the controls. Furthermore, there was a significant correlation such that left hippocampus volume was smaller with increasing lifetime duration of depression. However, this relationship was moderated by a significant correlation such that greater lifetime duration of antidepressant medication was associated with larger left hippocampus volume. The findings support the contention that antidepressant medication may act to normalize hippocampus volume.

Exposure to Parental Alcoholism During Childhood and Outcome in Adulthood: A Prospective Longitudinal Study

1986 ◽  
Vol 149 (5) ◽  
pp. 584-591 ◽  
Author(s):  
W. R. Beardslee ◽  
L. Son ◽  
G. E. Vaillant
Keyword(s):  
Longitudinal Study ◽  
Family Environment ◽  
Later Life ◽  
Parental Alcoholism ◽  
Prospective Longitudinal Study ◽  
The Family ◽  
History Of ◽  
Highly Correlated ◽  
Prospective Longitudinal ◽  
Children’S Exposure

The effects of children's exposure to parental alcoholism was assessed using records from an existing prospective 40-year longitudinal study of working-class families: 176 men who had grown up with an alcoholic parent or parents were compared with 230 men without such exposure. Degree of exposure to alcoholism in the childhood family environment was highly correlated in later life with alcohol use, alcoholism, time in jail, sociopathy, and death, but not with increased rates of unemployment, poor physical health, or measures of adult ego functioning. Most of the impairments observed occurred in those subjects who actually developed alcoholism. Exposure to alcoholism in the family environment and family history of alcoholism independently contributed to the later development of alcoholism.

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