Epidemiology and Risk Factors for Bacteremia in Pediatric and Adolescent Patients

2019 ◽  
pp. 089719001986805 ◽  
Author(s):  
Kayla R. Stover ◽  
Austin Morrison ◽  
Tia Collier ◽  
Elisabeth Schneider ◽  
Jamie L. Wagner ◽  
...  
Keyword(s):  
Risk Factors ◽  
Methicillin Resistance ◽  
Control Strategies ◽  
Positive Culture ◽  
Secondary Outcome ◽  
Tertiary Referral Center ◽  
Adolescent Patients ◽  
Causative Agents ◽  
Patients At Risk ◽  
Associated Risk Factors

Background: Epidemiology and risk factors for bacteremia in pediatric and adolescent patients have not been fully elucidated. Objective: The purpose of this study was to identify primary causative agents of bacteremia in pediatric and adolescent patients and associated risk factors. We hypothesized that these would be different than those seen in adults. Patients and Methods: This retrospective cohort, epidemiologic evaluation included patients admitted to a tertiary referral center from January 01, 2013, to December 31, 2015. Patients <18 years old with a confirmed positive blood culture were included; the first positive culture per organism per patient was analyzed. The primary outcome was to determine the most frequent causative organisms of bacteremia; the secondary outcome was an evaluation of risk factors for acquiring staphylococcal bacteremia. Results: A total of 913 isolates were evaluated, including 92 unique organisms. The most frequently identified were Staphylococcus epidermidis (238/913, 26.1%), followed by Staphylococcus aureus (136/913, 14.9%). Methicillin resistance was observed in 60.3% of S aureus. Two hundred thirty-six patients were included in the risk factor analysis. Prematurity, previous antibiotics, and intubation/ventilation were more likely associated with S epidermidis ( P < .001, P < .001, and P = .032, respectively). Patients with a recent or previous hospitalization and those with dermatitis/eczema were statistically more likely to grow S aureus ( P < .001, P = .029, respectively). Conclusions: Although epidemiology of organisms associated with pediatric and adolescent bacteremia was similar to adults, risk factors were different than seen in that population. Further understanding of these risk factors may be helpful in developing preemptive infection control strategies in patients at risk.

scholarly journals Prevalence of dysmenorrhoea, associated risk factors and its relationship with academic performance among graduating female university students in Ethiopia: a cross-sectional study

BMJ Open ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. e043814
Author(s):  
Mesfin Tadese ◽  
Andargachew Kassa ◽  
Abebaw Abeje Muluneh ◽  
Girma Altaye
Keyword(s):  
Risk Factors ◽  
Academic Performance ◽  
University Students ◽  
Cross Sectional Study ◽  
Secondary Outcome ◽  
Sectional Study ◽  
Cross Sectional ◽  
Grade Point ◽  
Significant Difference ◽  
Associated Risk Factors

ObjectivesThe study aimed to provide an association between dysmenorrhoea and academic performance among university students in Ethiopia. Further, the study attempts to determine the prevalence and associated risk factors of dysmenorrhoea.Design and methodInstitution-based cross-sectional study was conducted from 1 April to 28 April 2019. A semistructured and pretested self-administered questionnaire was used to collect data. Binary logistic regression analysis and one-way analysis of variance were performed to model dysmenorrhoea and academic performance, respectively.Setting and participantsEthiopia (2019: n=647 female university students).OutcomesThe primary outcome is dysmenorrhoea, which has been defined as painful menses that prevents normal activity and requires medication. The self-reported cumulative grade point average of students was used as a proxy measure of academic performance, which is the secondary outcome.ResultsThe prevalence of dysmenorrhoea was 317 (51.5%). The educational status of father (adjusted OR (AOR) (95% CI) 2.64 (1.04 to 6.66)), chocolate consumption (AOR (95% CI) 3.39 (95% 1.28 to 8.93)), daily breakfast intake (<5 days/week) (AOR (95% CI) 0.63 (0.42 to 0.95)), irregular menstrual cycle AOR (95% CI) 2.34 (1.55 to 3.54)) and positive family history of dysmenorrhoea AOR (95% CI) 3.29 (2.25 to 4.81)) had statistically significant association with dysmenorrhoea. There was no statistically significant difference in academic performance among students with and without dysmenorrhoea (F (3611)=1.276, p=0.28)).ConclusionsDysmenorrhoea was a common health problem among graduating University students. However, it has no statistically significant impact on academic performance. Reproductive health officers should educate and undermine the negative academic consequences of dysmenorrhoea to reduce the physical and psychological stress that happens to females and their families.

scholarly journals Prevalence and associated risk factors of hypertension among persons aged 15–49 in India: a cross-sectional study

BMJ Open ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. e029714 ◽  
Author(s):  
Soumitra Ghosh ◽  
Manish Kumar
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Family Health ◽  
Cross Sectional Study ◽  
Secondary Outcome ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Effective Interventions ◽  
Life Style Changes ◽  
Associated Risk Factors

ObjectivesThis is the first attempt to provide estimates on the prevalence of hypertension at the national, state and district level, a prerequisite for designing effective interventions. Besides, the study aims to identify the risk factors of hypertension.DesignWe analysed cross-sectional survey data from the fourth round (2015–2016) of National Family Health Survey (NFHS). NFHS was conducted between January 2015 and December 2016, gathering information on a range of indicators including blood pressure. The age adjusted prevalence of hypertension was calculated for state comparison, while multilevel logistic regression analysis was done to assess the correlates of hypertension.Setting and participantsIndia (2015–2016; n=811 917) aged 15–49.Primary and secondary outcome measuresThe primary outcome is hypertension, which has been defined as systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg.ResultsThe age-adjusted prevalence of hypertension in India was 11.3% (95% CI 11.16% to 11.43%) among persons aged between 15 and 49 and was four percentage points higher among males 13.8% (95% CI 13.46% to 14.19%) than among females 10.9% (95% CI 10.79% to 11.06%). Persons in the urban location (12.5%, 95% CI 12.25% to 12.80%) had a marginally higher prevalence than persons in rural location (10.6%, 95% CI 10.50% to 10.78%). The proportion of population suffering from hypertension varied greatly between states, with a prevalence of 8.2% (95% CI 7.58% to 8.85%) in Kerala to 20.3% (95% CI 18.81% to 21.77%) in Sikkim. Advancing age, obesity/overweight, male sex, socioeconomic status and consumption of alcohol were found to be the major predictors of hypertension.ConclusionsHypertension prevalence is now becoming more concentrated among the poor. Policy measures should be taken to improve the hazardous working conditions and growing social pressures of survival responsible for ‘life-style’ changes such as consumption of high calorie food and alcohol.

scholarly journals Investigation of the temporal roaming behaviour of free-roaming domestic dogs in Indigenous communities in northern Australia to inform rabies incursion preparedness

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Elizabeth K. Maher ◽  
Michael P. Ward ◽  
Victoria J. Brookes
Keyword(s):  
Risk Factors ◽  
Control Strategies ◽  
Indigenous Communities ◽  
Domestic Dog ◽  
Northern Australia ◽  
Remote Communities ◽  
Canine Rabies ◽  
Torres Strait ◽  
Associated Risk Factors ◽  
The Impact

Abstract Australia is canine rabies free but free-roaming, domestic dog populations in remote northern communities are at risk of an incursion due to proximity to rabies-endemic south-east Asia. Unrestricted contact between dogs could facilitate rabies spread following an incursion, and increase the impact on both dogs and people. Whilst dog vaccination is the foundation of rabies prevention, control strategies could be enhanced by understanding the temporal pattern of roaming and associated risk factors, so that movement restrictions can be targeted. Global positioning system datasets from 132 dogs in eight Indigenous communities in the Torres Strait and Northern Peninsula Area (NPA) of Australia were analysed using regression methods. The influence of risk factors (including age, sex, location, season and hour of day) on dogs’ distance from their residences were assessed. Dogs roamed furthest in the NPA and during the dry season. Daily peaks in mean roaming distance were observed at 1000–1100 hrs and 1700–1800 hrs in the Torres Strait, and 1700–1800 hrs in the NPA. These findings demonstrate that understanding community-specific temporal roaming patterns can inform targeted movement restrictions during an outbreak of rabies in remote communities in northern Australia.

scholarly journals Intestinal Schistosomiasis among Primary Schoolchildren in Two On-Shore Communities in Rorya District, Northwestern Tanzania: Prevalence, Intensity of Infection and Associated Risk Factors

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
David Z. Munisi ◽  
Joram Buza ◽  
Emmanuel A. Mpolya ◽  
Safari M. Kinung’hi
Keyword(s):  
Risk Factors ◽  
Control Strategies ◽  
Geometric Mean ◽  
Infection Intensity ◽  
Risk Groups ◽  
Public Health Importance ◽  
Cross Sectional ◽  
Level Of Education ◽  
Treatment History ◽  
Associated Risk Factors

In Tanzania,Schistosoma mansoniis of great public health importance. Understanding the prevalence and infection intensity is important for targeted, evidence-based control strategies. This study aimed at studying the prevalence, intensity, and risk factors ofS. mansoniamong schoolchildren in the study area. A cross-sectional study was conducted in Busanga and Kibuyi villages. Sampled 513 schoolchildren provided stool specimens which were examined using kato-katz method. Pretested questionnaire was used to collect sociodemographic data and associated risk factors. The prevalence ofS. mansoniinfection was 84.01%, with geometric mean egg intensity of 167.13 (95% CI: 147.19–189.79) eggs per gram of stool (epg). Other parasites detected wereAscaris lumbricoides(1.4%) and hookworms (1.4%). The geometric mean infection intensity in Busanga and Kibuyi were 203.70 (95% CI: 169.67–244.56) and 135.98 (95% CI: 114.33–161.73) epg, respectively. Light, moderate, and heavy infection intensities were 34.11%, 39.91%, and 25.99%, respectively. Village of residence, parent’s level of education, toilet use, and treatment history were predictors of infection. The high prevalence and infection intensity in this study were associated with village, parent’s level of education, inconsistent toilet use, and treatment history. To control the disease among at-risk groups, these factors need to be considered in designing integrated schistosomiasis control interventions.

scholarly journals Blood lead level risk factors and reference value derivation in a cross-sectional study of potentially lead-exposed workers in Iran

BMJ Open ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. e023867 ◽  
Author(s):  
Sareh Nakhaee ◽  
Alireza Amirabadizadeh ◽  
Samaneh Nakhaee ◽  
Mahmood Zardast ◽  
Jonathan Schimmel ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lead Exposure ◽  
Work Experience ◽  
Lead Level ◽  
Blood Lead ◽  
Secondary Outcome ◽  
Cross Sectional ◽  
Exploratory Investigation ◽  
Exposed Workers ◽  
Associated Risk Factors

ObjectivesThis exploratory investigation aimed to measure blood lead levels and associated risk factors in exposed workers in Iran, and to derive appropriate reference values for blood lead in this population as a means of epidemiological comparison.DesignCross-sectional.SettingManufacturing plants with potential lead exposure in Southern Khorasan Province, Iran.ParticipantsThe study included 630 workers, selected through stratified random sampling.Primary and secondary outcome measuresThe primary measures in this exploratory investigation were venous blood lead concentration (BLC) and associated risk factors of age, gender, work experience, cigarette smoking and history of opium use. The secondary measures were symptoms associated with lead toxicity. Data analyses were conducted using Student’s t-test, Mann-Whitney U test, one-way analysis of variance, Kruskal-Wallis test, Spearman correlation coefficient and regression analysis.ResultsMean and median BLCs were 6.5±8.1 μg/dL and 3.9 μg/dL (IQR: 2.9–5.8), respectively. Of the subjects, 85 (13.5%) had BLC ≥10 μg/dL. The derived reference BLC value in this study was 30 μg/dL for men and 14 μg/dL for women. Increasing work experience and age were associated with BLC >10 μg/dL. Radiator manufacturers were up to 12.9 times (95% CI 4.6 to 35, p<0.005) more likely than painters to have BLC >10 μg/dL. Most subjects reported multiple symptoms.ConclusionsThe mean BLC was above the maximum recommended concentration. There was a significant relationship between higher BLC and age or working in a printing factory or radiator manufacturing. These findings can direct efforts towards reducing occupational lead exposure.

scholarly journals Prevalence of liver fibrosis and associated risk factors in the Korean general population: a retrospective cross-sectional study

BMJ Open ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. e046529
Author(s):  
Eun-Hee Nah ◽  
Seon Cho ◽  
Suyoung Kim ◽  
Jieun Chu ◽  
Eunjoo Kwon ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Fibrosis ◽  
General Population ◽  
Multivariable Analysis ◽  
Age Groups ◽  
Secondary Outcome ◽  
Abnormal Liver Function Test ◽  
Cross Sectional ◽  
Advanced Liver Fibrosis ◽  
Associated Risk Factors

ObjectivesThe health burden of chronic liver disease is increasing worldwide. Its main histological consequence is liver fibrosis, and eventually cirrhosis. This process is rarely diagnosed at the pre-cirrhotic stage due to it being asymptomatic. Little is known about the prevalence of liver fibrosis and associated risk factors in the general population. The aims of this study were to determine the prevalence and distribution of liver fibrosis using magnetic resonance elastography (MRE), as well as the risk factors associated with liver fibrosis in the asymptomatic general population.Design, setting and participantsThis cross-sectional retrospective study consecutively selected subjects who underwent health check-ups including MRE at 13 health promotion centres in Korea between 2018 and 2020. Liver fibrosis was estimated using MRE with cut-off values for significant and advanced liver fibrosis of 2.90 and 3.60 kPa, respectively.Primary and secondary outcome measuresThe Χ2 test was used to compare the prevalence of liver fibrosis according to sex and age groups. Multivariable logistic regression analyses were performed to identify the factors for significant and advanced liver fibrosis.ResultsAmong the 8183 subjects, 778 (9.5%) had ≥significant fibrosis (≥2.9 kPa), which included 214 (2.6%) subjects with ≥advanced fibrosis (≥3.6 kPa). Multivariable analysis revealed that liver fibrosis was associated with age (OR=1.34, 95% CI=1.18 to 1.51), male sex (OR=3.18, 95% CI=1.97 to 5.13), diabetes (OR=2.43, 95% CI=1.8 to 3.28), HBsAg positivity (OR=3.49, 95% CI=2.55 to 4.79), abnormal liver function test (OR=1.9, 95% CI=1.49 to 2.42) and obesity (OR=1.77, 95% CI=1.35 to 2.32) (all p<0.001), as well as metabolic syndrome (OR=1.4, 95% CI=1.05 to 1.87) (p=0.024).ConclusionsThe prevalence of significant or more liver fibrosis was high in the Korean general population and much higher among individuals with risk factors. This suggests that screening of liver fibrosis should be considered in general population, especially among high-risk groups.

scholarly journals Prevalence and Associated Risk Factors of Typhoid Fever in Children Attending “Deo Gratias” Hospital in Douala, Littoral Region

2020 ◽  
Author(s):  
Teh Exodus Akwa ◽  
Nguimbous Simone
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Typhoid Fever ◽  
Communicable Disease ◽  
Control Strategies ◽  
Salmonella Typhi ◽  
Health Concern ◽  
Cross Sectional ◽  
Significant Difference ◽  
Associated Risk Factors

Typhoid fever is a communicable disease transmitted by the bacteria Salmonella typhi, related to serotype paratyphi A, B and C. The disease is of a significant health concern in most developing countries especially Cameroon. Objectives: The study aimed at determining the prevalence and associated risk factors of typhoid fever in children ( 0-18 years) attending the &ldquo;Deo Gratias&rdquo; hospital in Douala. Method: A hospital base cross sectional study from August to September 2018 was carried out in patients&rsquo; age 0-18 years suffering from typhoid fever at the Deo gratias Catholic hospital. Widal slide agglutination test was the diagnostic test used. Positive tested patients were administered questionnaires to evaluate the level of knowledge, attitude and practice toward the disease, as well as their self-management abilities. Data obtained from respondents was analysed by descriptive statistics. One-way ANOVA and means comparison using Tukey&rsquo;s test (&alpha; = 0.05) was performed to check whether the population of respondents differed significantly across risk factor practices. Results were finally presented on bar charts, tables and pie chart. Results: Typhoid fever was more prevalent in females (52.3%) than in males (47.7%), with a high proportion in the ages 5-9 years (38.6%). A significant difference was observed in population of respondents across risk factor practices. Conclusion: Water quality have a great impact on the burden of typhoid fever among children. The identification of risk factors associated to the disease is of great importance in the development of rational control strategies of the disease.

scholarly journals Acquired symptomatic external punctal stenosis: A tertiary referral center study

2021 ◽  
Vol 10 (1) ◽  
pp. 18-23
Author(s):  
Mona Nassief ◽  
Omar Kh M Alduwailah ◽  
Nancy M. Lotfy
Keyword(s):  
Risk Factors ◽  
Tear Film ◽  
Population Based ◽  
Tertiary Referral ◽  
Tertiary Referral Center ◽  
Referral Center ◽  
Inflammatory Mechanism ◽  
Unilateral Involvement ◽  
Associated Risk Factors ◽  
Punctal Stenosis

Background: To report the prevalence of acquired symptomatic external punctal stenosis (EPS) in a tertiary referral center in Kuwait, and to study the associated risk factors, etiologies, and management outcomes. Methods: This prospective interventional hospital-based study was performed at the Farwaniya governmental hospital in Kuwait between November 2018 and November 2019. All patients were referred to the oculoplastic clinic with symptomatic epiphora, age > 18 years, epiphora Munk score ≥ 0, tear film meniscus ≥ 2 mm, and punctum with grade ≤ 2 (smaller than normal size, but recognizable EPS) were included. Exclusion criteria were congenital causes of epiphora, previous eyelid surgeries, and traumatic or neoplastic causes of punctal or canalicular obstruction. Results: A total of 418 patients with symptomatic epiphora, who were referred to our oculoplastic clinic, were enrolled in our study. The prevalence of EPS was 70.3%. Examination of the puncta revealed different shapes, including tangential, pinpoint, elevated, slit-shaped, horse shoe-shaped, and membranous puncta, with the tangential type accounting for the greatest proportion (65.3%). Bilateral punctal stenosis was observed in 206 patients (70.1%) and unilateral involvement in 88 patients (29.9%). Dilatation and syringing were performed for all puncta upon diagnosis, and repeated dilatation was performed for 225 puncta (32.7%). Placement of a Mini-Monoka tube was performed in 11 puncta (1.6%). Conclusions: EPS was a common cause of symptomatic epiphora in our study. Aging and female sex were identified as common risk factors. Most etiological factors of EPS were associated with a pathophysiological inflammatory mechanism. For exact estimates of its prevalence, a population-based study is necessary in future. Keywords: punctal stenosis, dry eye, chronic blepharitis, Mini Monoka, Kuwait, prevalence, epiphora

Incidence and risk factors of clinically significant chemotherapy-induced thrombocytopenia in patients with solid tumors

2010 ◽  
Vol 17 (4) ◽  
pp. 312-319 ◽  
Author(s):  
Anna Hitron ◽  
Doug Steinke ◽  
Stephanie Sutphin ◽  
Amber Lawson ◽  
Jeff Talbert ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lung Cancer ◽  
Bladder Cancer ◽  
Solid Tumors ◽  
Recent Infection ◽  
Factors Associated ◽  
Clinical Complications ◽  
Patients At Risk ◽  
Clinically Significant ◽  
Associated Risk Factors

Purpose and relevance. Chemotherapy-induced thrombocytopenia (CIT) can be a significant problem in patients with cancer, leading to numerous clinical complications. Understanding the types of patients at risk for these complications is essential to improve monitoring, counseling, and provide future targeted prophylaxis measures. Previous studies have limited prospective utility since they do not examine risk factors associated with complications from multi-agent regimens. This evaluation aims to identify the incidence and risk factors associated with clinical complications of CIT in patients receiving common chemotherapy regimens. Methods. Retrospective evaluation of adult patients receiving first or second line regimens for the most common solid tumors associated with high rates (≥5%) of laboratory diagnosed thrombocytopenia. Patients were examined for clinically significant CIT (defined as platelet count <75,000 cells/µL as well as the presence of one of the following: bleeding, dose reduction/delay, platelet transfusion, or therapy cessation) and associated risk factors. Results. About 254 patients receiving a total of 278 regimens were evaluated. The incidence of clinically significant CIT = 10.1%; complications were most common in patients receiving cisplatin/gemcitabine for bladder cancer (57%), or carboplatin/gemcitabine (29%) or cisplatin/etoposide (18%) for lung cancer. Bladder cancer (OR = 13.7 (2.89–64.7); p = 0.001) and concurrent or recent infection (OR = 3.8 (1.45–10.1); p = 0.007) was found to increase the risk of clinical complications while smoking was found to have a protective effect (OR = 0.17 (0.04–0.71)). Conclusions. The incidence of clinically significant CIT is most commonly seen in patients using cisplatin/gemcitabine for bladder cancer, or carboplatin/gemcitabine or cisplatin/etoposide for lung cancer. Further evaluation of these patients is warranted.

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