Efficacy and safety of PEGylated recombinant human granulocyte stimulating factor in the prevention of neutropenia during concurrent chemoradiotherapy.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e18018-e18018
Author(s):  
Dongling Zou ◽  
Qi Zhou ◽  
Mingfang Guo
Keyword(s):  
Cervical Cancer ◽  
Concurrent Chemoradiotherapy ◽  
Measurement Data ◽  
Test Group ◽  
Control Group ◽  
Fisher Exact Test ◽  
Combination Regimen ◽  
Efficacy And Safety ◽  
Grade 3 ◽  
Experimental Group

e18018 Background: This randomized controlled prospective study aims to explore the efficacy and safety of using PEG-rhG-CSF to prevent neutropenia during concurrent chemoradiotherapy of paclitaxel and cisplatin (TP) regimen for cervical cancer. Methods: Patients who met the eligibility criteria were divided into two groups according to the randomized principle of 2:1: the experimental group (patients used 6 mg PEG-rhG-CSF prophylactically after chemotherapy) and the control group (patients did not use PEG-rhG-CSF for prevention and were given 5 ug / kg rhG-CSF when ANC < 1✕109). TP combination regimen was used for concurrent chemotherapy, specifically as follows: paclitaxel 150mg / m2 (day 1), cisplatin 35mg / m2 (day 1-2), repeated every three weeks. The PTV dose was 45 Gy in 1.8 Gy daily fractions, with five fractions per week. SPSS 25.0 software was used for statistical analysis of the data, t-test was used for measurement data, and χ2 test Fisher exact test was used for enumeration data. P < 0.05 was considered statistically significant. Results: As of September 2019, 30 patients were enrolled into this study, including 18 in the experimental group and 12 in the control group. One of the 18 patients in the test group (5.6%) had a Grade 3/4 neutropenia. Ten of the 12 patients in the control group (83.3%) developed Grade 3/4 neutropenia. The incidence of Grade 3/4 neutropenia in the two groups was statistically significant (P < 0.001, Table 1). The incidence of FN was 5.6% in the experimental group and 8.3% in the control group (P = 1.000). The incidence of delayed chemotherapy course was 11.1% in the experimental group and 58.3% in the control group (P = 0.013). The incidence of delayed chemotherapy course in the two groups was statistically significant (Table 1). As shown in Figure 4, the experimental group had a completion time of radiotherapy for 46.7 days, while the control group had 49.0 days (P = 0.278). Conclusions: Although the results of bone marrow function and overall survival are still to be obtained, it can be initially seen from the intermediate-term data that the use of PEG-rhG-CSF primary prevention reduced the granulocytopenia and the delay of the chemotherapy course during the concurrent chemoradiotherapy TP regimen for cervical cancer, which has the value of further completing this study. [Table: see text]

scholarly journals A clinical study of pegylated recombinant human granulocyte colony stimulating factor (PEG-rhG-CSF) in preventing neutropenia during concurrent chemoradiotherapy of cervical cancer

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Dongling Zou ◽  
Mingfang Guo ◽  
Qi Zhou
Keyword(s):  
Cervical Cancer ◽  
Control Group ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Prolonged Time ◽  
The Difference ◽  
Grade 3 ◽  
And Control ◽  
Experimental Group ◽  
Stimulating Factor

Abstract Purpose To evaluate the effectiveness and safety of pegylated recombinant human granulocyte colony stimulating factor (PEG-rhG-CSF) in preventing neutropenia during chemoradiotherapy in patients with cervical cancer. Methods From August 2018 to April 2020, 60 patients who were pathologically confirmed as cervical cancer were randomly divided into two groups at a ratio of 2:1: PEG-modified-rhG-CSF experimental group and control group. The primary endpoints were the incidence of grade 3–4 neutropenia. Secondary endpoints included the duration of grade 3–4 neutropenia, the incidence of grade 4 neutropenia, the incidence of febrile neutropenia (FN), delay rate of chemotherapy, prolonged time of chemotherapy, time to complete radiotherapy and safety. Results The incidence of grade 3–4 neutropenia in the experimental group was significantly lower than the control group (10% vs. 77.78%, P < 0.001). However, there was no statistical significance between the two groups in the duration of grade 3–4 neutropenia (3.75 days vs. 5.07 days, P = 0.871). The experimental group was better than the control group in the incidence of grade 4 neutropenia, the incidence of FN and delay rate of chemotherapy, and the difference was statistically significant (P < 0.05). Besides, the prolonged time of chemotherapy and the time to complete radiotherapy in the experimental group were less than those in the control group, but the difference was not statistically significant (P > 0.05). The incidence of adverse events in the experimental group and control group were 55.00 and 94.44%, respectively, and the difference was statistically significant (P = 0.003). Conclusion PEG-rhG-CSF preventive treatment used in the course of chemoradiotherapy for patients with cervical cancer can reduce the incidence of neutropenia and improve the incidence of delayed chemotherapy cycles. Trial registration ClinicalTrials.gov, NCT04542356. Registered 9 September 2020 - Retrospectively registered.

scholarly journals The Efficacy and Safety of Continuous Intravenous Endostar Treatment Combined With Concurrent Chemoradiotherapy in Patients With Locally Advanced Cervical Squamous Cell Carcinoma: A Randomized Controlled Trial

2021 ◽  
Vol 11 ◽  
Author(s):  
Hang Shu ◽  
Yaqin Dong ◽  
Zhonghua Xu ◽  
Weiwei Luo ◽  
Lei Xu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Concurrent Chemoradiotherapy ◽  
Locally Advanced ◽  
Cervical Squamous Cell Carcinoma ◽  
Control Group ◽  
Efficacy And Safety ◽  
Short Term ◽  
Experimental Group

ObjectiveTo investigate the short-term efficacy and safety of Endostar combined with concurrent chemoradiotherapy in the treatment of locally advanced cervical squamous cell carcinoma (LACSC).MethodsA total of 91 patients with LACSC admitted to the First Affiliated Hospital of Anhui Medical University from June 2019 to December 2020 were randomly assigned to either the experimental group (n = 48) or control group (n = 43). The control group received radiotherapy for cervical cancer and paclitaxel combined with platinum chemotherapy (CCRT), and the experimental group received Endostar continuous intravenous infusion of anti-angiogenic therapy plus CCRT. The short-term efficacy, common clinical indicators, tumor indicators, changes in serum vascular endothelial growth factor-A (VEGF-A), and the occurrence of adverse events (AEs) were explored after treatment.ResultsCompared with the control group, the complete response (CR) rate in the experimental group was significantly increased (83.33% vs 65.12%, P &lt; 0.05). Both routine indicators and tumor indicators in the two groups were significantly decreased compared to before treatment. Compared with the control group, patients in the experimental group had higher incidences of neutropenia, hypertension, and infection, but lower incidence of nausea. After treatment, the serological expression of VEGF-A was significantly decreased in both groups.ConclusionEndostar combined with CCRT in the treatment of LACSC can further improve the efficacy of CR rate and significantly reduce serum tumor indicators and VEGF-A levels, with mild and controllable AEs. Endostar combined with CCRT is expected to be a new treatment regimen for LACSC.

scholarly journals Efficacy and safety of daratumumab in the treatment of multiple myeloma: a systematic review and meta-analysis

2021 ◽  
Vol 49 (8) ◽  
pp. 030006052110381
Author(s):  
Yin Wang ◽  
Yanqing Li ◽  
Ye Chai
Keyword(s):  
Multiple Myeloma ◽  
Meta Analysis ◽  
Complete Response ◽  
Library Science ◽  
Cochrane Library ◽  
Control Group ◽  
Efficacy And Safety ◽  
Risk Patients ◽  
Grade 3 ◽  
Combination Regimens

Objective To systematically evaluate the efficacy and safety of combination regimens containing daratumumab in patients with multiple myeloma (MM). Methods A systematic search of publications listed on electronic databases (PubMed®, The Cochrane Library, Science Direct and Web of Science) between inception and 13 November 2020 was conducted to find randomized controlled trials (RCTs) that included patients with MM that were treated with combination regimens containing daratumumab. Results A total of seven RCTs were included ( n = 4268 patients). Meta-analysis showed that compared with the control group, the group containing daratumumab showed a significantly better overall response rate and a complete response or better. Daratumumab improved efficacy in both standard-risk and cytogenetically high-risk patients with MM. The prevalence of neutropenia (≥grade 3) and pneumonia was significantly higher in the daratumumab group compared with the control group. Conclusion The available evidence demonstrated that the clinical application of combination regimens containing daratumumab improved the efficacy in patients with MM and had acceptable safety.

scholarly journals Senam Irama Lagu Gizi Seimbang Meningkatkan Kebugaran Pada Anak Sekolah

2020 ◽  
Vol 5 (1) ◽  
pp. 22-29
Author(s):  
Een Juliasti ◽  
Mury Kuswari ◽  
Idrus Jus’at
Keyword(s):  
Physical Activity ◽  
Elementary School ◽  
Test Group ◽  
Wilcoxon Test ◽  
Control Group ◽  
P Value ◽  
Fitness Level ◽  
Rhythmic Gymnastics ◽  
Post Test ◽  
Experimental Group

Physical activity on students in Jakarta is the lowest if it is compared to various regions in Indonesia. The low physical activity has an impact on the declining of health and fitness so that it affects toward the risk of various non-communicable diseases. The purpose of this research is to know the influence of gymnastics rhythm of Gizi Seimbang’s song to the level of fitness on students in State Elementary School Kebon Jeruk 08 Pagi West Jakarta. The type of research uses design experimental quasi research with design of Pre test - post test group control design. This design involves two groups of subjects, one is given an experimental group and one group is not enforced (control group). The population of this study are children aged 10-12 years old with 60 respondents (30 students of gymnastic group and 30 control group students) with gymnastics 3x/week for 12 times. Data analysis use t-dependent test, wilcoxon test because the data is not normally distributed. The result of the research shows that there is the influence of rhythmic gymnastics of Gizi Seimbang’s song to the significant fitness level (p value = 0.0001). Based on the results of this study, gymnastics rhythm of Gizi Seimbang’s song increases the level of fitness compared with control group on students in State Elementary School Kebon Jeruk 08 Pagi West Jakarta.

scholarly journals Efficacy and safety of a monodisperse solid-in-oil-in-water emulsion in transcatheter arterial chemoembolization in a rabbit VX2 tumor model

2019 ◽  
Author(s):  
Daisuke Yasui ◽  
Aya Yamane ◽  
Hiroshi Itoh ◽  
Masayuki Kobayashi ◽  
Shin-ichiro Kumita
Keyword(s):  
Adverse Events ◽  
Transcatheter Arterial Chemoembolization ◽  
Iodine Concentration ◽  
Control Group ◽  
Efficacy And Safety ◽  
Water Emulsion ◽  
Left Liver Lobe ◽  
Vx2 Tumor ◽  
Experimental Group ◽  
Arterial Chemoembolization

AbstractTranscatheter arterial chemoembolization (TACE) is a standard treatment for unresectable hepatocellular carcinoma; however, it does not always result in tumor control. Nevertheless, treatment outcome can be improved with monodisperse emulsions of anticancer agents. In this study, the efficacy and safety of a monodisperse miriplatin-Lipiodol emulsion were evaluated in Japanese white rabbits. VX2 tumor was implanted into the left liver lobe of each rabbit. The animals were divided into control and experimental groups (of five animals each) and respectively administered a conventional miriplatin suspension or the emulsion via the left hepatic artery. Computed tomography (CT) was performed before, immediately after, and two days following TACE. All rabbits were sacrificed two days after the procedure. Each tumor was removed and cut in half for assessment of iodine concentration in one half by mass spectroscopy and evaluation of Lipiodol accumulation and adverse events in the other half. Mean Hounsfield unit (HU) values were measured using plain CT images taken before and after TACE. Iodine concentration was higher in the experimental group [1100 (750–1500) ppm] than in the control group [840 (660–1800) ppm]. Additionally, the HU value for the experimental group was higher than that for the control group immediately after [199.6 (134.0– 301.7) vs. 165.3 (131.4–280.5)] and two days after [114.2 (56.1–229.8) vs. 58.3 (42.9–132.5)] TACE. Cholecystitis was observed in one rabbit in the control group. Ischemic bile duct injury was not observed in any group. The results show that Lipiodol accumulation and retention in VX2 tumor may be improved by using a monodisperse emulsion. Moreover, no significant adverse events are associated with the use of the emulsion.

scholarly journals Efficiency of zeolite basis preparation in fattening lambs diet

2012 ◽  
Vol 28 (3) ◽  
pp. 545-552 ◽  
Author(s):  
J. Stojkovic ◽  
Z. Ilic ◽  
S. Ciric ◽  
B. Ristanovic ◽  
M.P. Petrovic ◽  
...  
Keyword(s):  
Natural Zeolite ◽  
Dry Matter ◽  
Test Group ◽  
Daily Weight Gain ◽  
Control Group ◽  
Average Weight ◽  
Sheep Milk ◽  
The Impact ◽  
Experimental Group ◽  
At Will

The paper presents the results of a research on the impact of products based on natural zeolite on the production results of fattening lambs. The experiment involved two groups of lambs (the control - C and experimental - E groups), each consisting of 15 heads, for a period of 90 days. The meal was made from sheep milk, feed mixtures for fattening lambs and meadow hay. The test group lambs, unlike the ones from the control group, were given mixtures based on natural zeolite. Min-a-Zel S mixture (in the form of 25% composite) was fed to lambs from birth till their 14th day of life, directly into the mouth, once a day (before the morning feed), in the amount of 10 ml. Min-a-Zel Plus was given to them from their 15th day of life, together with the feed mixture (0.5%). Feeding was at will. The average weight of lambs at the end of the experiment, in accordance with the sequence of treatments (C:E) was 24.40:26.94 kg (P <0.01). Daily weight gain of lambs, during the experiment, was 229:256 g and in the experimental group it was by 27g or 11.79% higher (P <0.01). The test group lambs had a better utilization of dry matter, protein and energy, which justifies the use of products based on natural zeolite in fattening lambs.

scholarly journals Application of Comfortable Nursing in the Preparation of Colostomy of Organs by Oral Magnesium Sulfate

1970 ◽  
Vol 1 (2) ◽  
Author(s):  
Zhou Shu
Keyword(s):  
Magnesium Sulfate ◽  
Intervention Group ◽  
Test Group ◽  
Nursing Intervention ◽  
Satisfaction Score ◽  
Control Group ◽  
Total Satisfaction ◽  
And Control ◽  
Experimental Group ◽  
Oral Magnesium

Objective: To explore the application of comfortable nursing in the preparation of colonoscopy in oral magnesium sulfate, and to provide scientific reference direction for nursing staff. Methods: 68 patients with colonoscopy were randomly divided into experimental group and control group (n = 34). In the control group, the routine nursing intervention was used, and the intervention group was treated with comfortable nursing intervention. Data analysis was performed using SPSS 20.0. Results: The total satisfaction score of the experimental group was (96.88 ± 1.26), the total satisfaction score of the control group was (80.65 ± 3.32), the test group (P < 0.05). The incidence of adverse reactions in the experimental group was significantly lower than that in the control group. The incidence of adverse reactions was 5.88% in the experimental group and 23.53% in the control group. Conclusion: The effect of comfortable nursing on the preparation of colonic gut in the oral magnesium sulfate method is relatively large.

scholarly journals ПРОДУКТИВНЫЕ КАЧЕСТВА КУР РОДИТЕЛЬСКОГО СТАДА БРОЙЛЕРОВ НА ФОНЕ ИММУНОКОРРЕКЦИИ ОРГАНИЗМА

2019 ◽  
Author(s):  
V.G. Semenov ◽  
N.G. Ivanov ◽  
E.E. Lyagina
Keyword(s):  
Specific Resistance ◽  
Initial Period ◽  
Test Group ◽  
Control Group ◽  
Biological Resource ◽  
Resource Potential ◽  
Biological Preparation ◽  
Experimental Group

Разработан биопрепарат Prevention-N-С и дано научно-практическое обоснование целесообразности его применения в сопоставлении с ранее апробированным препаратом PS-7 для реализации биоресурсного потенциала продуктивных качеств кур родительского стада бройлеров кросса Hubbard F-15 за счет активизации неспецифической резистентности организма. Апробированные биопрепараты повышают яйценоскость кур, что проявляется в интенсивном ее нарастании в начальный период продуктивности и более раннем достижении пика яйценоскости. Интенсивность яйценоскости кур 1-й (56,790,70) и 2-й (57,610,79) опытных групп родительского стада бройлеров оказалась выше по сравнению с контролем (54,030,67) на 2,76 и 3,58 соответственно (Р0,05-0,01). Установлено, что куры-несушки второй опытной группы принесли за 70 недель 183,52,06 штук инкубационных яиц, что на 8,97 выше соответствующего показателя в контрольной группе (168,42,25 штук) и на 3,03 больше, чем в 1-й опытной группе (178,12,53 штук). Количество инкубационных яиц кур родительского стада бройлеров первой опытной группы оказалось выше на 5,76, чем в контроле. Оплодотворенность яиц в 1-й и 2-й опытных группах была выше соответственно на 1,7 и 2,2, чем в контрольной группе. По результатам инкубации выводимость яиц в 1-й и 2-й опытных группах достоверно превышала контрольную группу на 4,8 и 5,4 соответственно. Лучшие результаты по выводу цыплят получены в 1-й и 2-й опытных группах 78,3 и 79,5 соответственно, и намного ниже в контрольной группе 77,3.Biological preparation Prevention-N-C has been developed and scientific and practical justification of its expediency in comparison with previously tested preparation PS-7 for realization of biological resource potential of productive qualities of hens of parent herd of Hubbard F-15 cross broilers due to activation of non-specific resistance of organism. Tested biopreparations increase the egg content of chickens, which manifests itself in its intense growth during the initial period of productivity and earlier reaching the peak of egg content. The egg intensity of chickens 1st (56.79 0.70) and 2nd (57.61 0.79) of the test groups of the parent broiler herd was higher compared to the control (54.03 0.67) by 2.76 and 3.58, respectively (P 0.05-0.01). It was found that the carrying chickens of the second experimental group brought 183.5 2.06 pieces of incubation eggs in 70 weeks, which is 8.97 higher than the corresponding indicator in the control group (168.4 2.25 pieces) and 3.03 more than in 1 experimental group (178.1 2.53 pieces). The number of incubation eggs of the parent broiler herd of the first test group was 5.76 higher than in the control. The fertilization of eggs in the 1st and 2nd test groups was 1.7 and 2.2 higher, respectively, than in the control group. According to the results of incubation, egg output in the 1st and 2nd test groups significantly exceeded the control group by 4.8 and 5.4, respectively. The best results on chicken withdrawal were obtained in the 1st and 2nd test groups - 78.3 and 79.5, respectively, and much lower in the control group - 77.3.

scholarly journals Pengaruh Pendidikan Kesehatan Tentang Inspeksi Asam Asetat (IVA) Terhadap Motivasi Wus dalam Deteksi Kanker Serviks di Puskesmas Putri Ayu Jambi

2019 ◽  
Vol 19 (1) ◽  
pp. 42
Author(s):  
Hesty Hesty ◽  
Rahmah Rahmah ◽  
Nurfitriani Nurfitriani
Keyword(s):  
Cervical Cancer ◽  
Health Education ◽  
Early Stage ◽  
Sampling Technique ◽  
World Health ◽  
Control Group ◽  
P Value ◽  
Childbearing Age ◽  
Control Group Design ◽  
Experimental Group

World Health Organization (WHO), cervical cancer is the number two cause of death in the world for women from all existing cancer. Every two minutes a woman dies of this disease. This cancer attack at an early stage does not cause any symptoms. That is why, why does this type of cancer fall into the category of the silent killer. One of the promotive and preventive efforts in women of childbearing age as primary prevention can be through the provision of health education about cervical cancer using the Acetic Acid Inspection (IVA) method. The purpose of this study is to find out whether there is an influence of health education about IVA on WUS motivation in cervical cancer detection in health centers. Putri Ayu Jambi. This type of quantitative research with non randomized pretest-posttest with control group design, with purposive sampling technique totaling 22 WUS, 11 people as controls and 11 experimental people. The instrument in the form of questionnaires was analyzed by univariate and bivariate Paired Test t-test, which was conducted from April to July 2018.  The results of the study revealed that of the 22 WUSs studied, the average motivation of the pretest in the experimental group was 41.1818 and the control group was 39.9091, while the results of the posttest of the experimental group after being given counseling and leaflets increased by 42.9091 with p-value 0.034. There is an influence of health education about IVA tests on WUS motivation in detecting cervical cancer. It is suggested that the Puskesmas can improve activities in planning disease control programs, especially carrying out counseling and counseling both in the puskesmas building and in the working area of the puskesmas by involving cadres in their environment so that WUS is moved to take the IVA examination.

scholarly journals Neoadjuvant Chemotherapy Consisting of Cisplatin and Nab-paclitaxel Improves the Complete Remission Rate of Locally Advanced Cervical Cancer Patients

2021 ◽  
Author(s):  
Xiao-Li Yu ◽  
Miao-Fang Wu ◽  
Lin Ding ◽  
Jin Yang ◽  
Shou-Min Bai
Keyword(s):  
Cervical Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Complete Remission ◽  
Concurrent Chemoradiotherapy ◽  
Remission Rate ◽  
Locally Advanced ◽  
Control Group ◽  
Advanced Cervical Cancer ◽  
External Radiotherapy ◽  
Locally Advanced Cervical Cancer

Abstract Background: This study was aimed to determine the effect of neoadjuvant chemotherapy consisting of nab-paclitaxel and cisplatin (NACT-nPC) in patients with locally advanced cervical cancer.Materials and Methods: The consecutive, newly diagnosed, non-metastatic and locally advanced cervical cancer patients were retrospectively recruited between October 2016 and June 2020 in our hospital. All patients received concurrent chemoradiotherapy alone or following neoadjuvant chemotherapy. Patients were divided into two groups: one receiving NACT-nPC, and the control group receiving no or other regimes of neoadjuvant chemotherapy. We compared the complete remission rate of primary tumor at the end of external radiotherapy and chemoradiotherapy between the two groups. Results: A total of 198 patients were enrolled in this study, including 60 in NACT-nPC group and 138 in control group. At the end of external radiotherapy, 27 patients in NACT-nPC group and 32 patients in control group achieved complete remission (P = 0.002). At the end of chemoradiotherapy, 56 patients in NACT-nPC group and 114 patients in control group achieved complete remission (P = 0.033). The acute side effects above grade 3 in NACT-nPC group was 41.7% (25/60) and manageable, lower than control group which was 77/138 (55.8%).Conclusions: NACT-nPC can improve the complete response rate of patients with locally advanced cervical cancer followed by concurrent chemoradiotherapy, and the toxicity is tolerable. Furthermore, we suspect the NACT-nPC can improve the survival of the patients. However, further prospective studies are needed to confirm this result.

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