Serum Follistatin Is Increased in Thyroid Cancer and Is Associated With Adverse Tumor Characteristics in Humans

2021 ◽  
Author(s):  
Grigorios Panagiotou ◽  
Wael Ghaly ◽  
Jagriti Upadhyay ◽  
Kalliopi Pazaitou-Panayiotou ◽  
Christos S Mantzoros
Keyword(s):  
Thyroid Cancer ◽  
Growth Factors ◽  
Distant Metastases ◽  
Serum Levels ◽  
Tnm Staging ◽  
Multivariate Models ◽  
Serum Samples ◽  
Advanced Tumor ◽  
Increased Risk ◽  
History Of

Abstract Context Obesity and classical growth factors are associated with thyroid cancer (TC). However, less is known regarding novel hormones such as follistatins and activins. We hypothesized that serum follistatin but not activins would be increased in TC. Objective This work aimed to assess circulating levels of follistatins, activins, and growth factors in patients with a history of TC vs patients with nonmalignant thyroid diseases. Methods A hospital-based, unmatched case-control study was conducted with 170 thyroidectomized patients due to well-differentiated TC and 106 thyroidectomized patients without history of malignancy. Anthropometric, biochemical, and histological parameters were recorded. Serum samples were collected in the steady state 45 days after surgery. Multivariate models were used to adjust for baseline differences of the unmatched variables. Serum levels of follistatin (FST), follistatin like-3, activin A, activin B, bioactive insulin-like growth factor-1, and stanniocalcin-2 were assayed with novel, highly specific ELISA kits. Results In unmatched univariate models, TC patients had higher FST serum levels compared to cancer-free individuals, independently of histological subtype. In multivariate models adjusting for covariates, individuals in the highest tertile of FST levels were associated with an increased risk for the presence of any type of TC or specific histological subtypes, including papillary, follicular and Hürthle-cell carcinoma, and medullary TC. Higher postoperative FST concentrations were found in patients with vascular invasion and distant metastases and associated with TNM staging at diagnosis. Conclusion FST serum levels are increased in TC patients and correlate with advanced tumor aggressiveness. Future longitudinal studies are needed to confirm and extend our observations.

scholarly journals Mortality from thyroid cancer in patients with hyperthyroidism: the Theagenion Cancer Hospital experience

2008 ◽  
Vol 159 (6) ◽  
pp. 799-803 ◽  
Author(s):  
Kalliopi Pazaitou-Panayiotou ◽  
Petros Perros ◽  
Maria Boudina ◽  
George Siardos ◽  
Apostolos Drimonitis ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Previous History ◽  
Distant Metastases ◽  
Northern Greece ◽  
Hot Nodule ◽  
Increased Risk ◽  
History Of ◽  
The Relationship ◽  
Diagnosis Of Thyroid Cancer ◽  
Autonomous Adenoma

BackgroundThyroid carcinoma has been reported in patients operated for different types of hyperthyroidism and the probability of a hot nodule being malignant seems to be low. The aim of the present study was to explore the relationship between thyroid cancer, hyperthyroidism and outcome in a large cohort of patients who presented to a tertiary cancer centre in Northern Greece.PatientsAmong 720 patients treated for thyroid cancer, 60 had a concomitant diagnosis of hyperthyroidism due to Graves' disease (n=14), solitary autonomous adenoma (n=17), or multinodular goiter (n=29). Adverse prognostic factors were common in patients with a previous history of hyperthyroidism at the time of diagnosis of thyroid cancer, including cases where the cancer was discovered coincidentally after thyroid surgery for hyperthyroidism and cases where tumor size was more than 10 mm.ResultsIn 10 out of 17 patients with hyperthyroidism due to solitary autonomous adenomas, the tumor was located within the hot nodule and two of these patients developed local and distant metastases and died from the disease 4 and 15 years after thyroidectomy.ConclusionClinicians managing patients with hyperthyroidism need to be aware of the possible increased risk of thyroid cancer in this patient group.

scholarly journals Mannan-Binding Lectin Levels and Activity Are Not Altered in Atopic Dermatitis Patients with a History of Eczema Herpeticum

2011 ◽  
Vol 2011 ◽  
pp. 1-3 ◽  
Author(s):  
Kemp W. Bundy ◽  
Laura Y. McGirt ◽  
Lora G. Bankova ◽  
Andreas Wollenberg ◽  
Lisa A. Beck ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Functional Activity ◽  
Viral Infections ◽  
Serum Levels ◽  
Small Samples ◽  
Eczema Herpeticum ◽  
Increased Risk ◽  
History Of ◽  
Mannan Binding Lectin ◽  
Binding Lectin

Background. Eczema herpeticum (EH) is a potentially serious, systemic complication in subjects with atopic dermatitis (AD) caused by herpes simplex virus (HSV). The innate immune dysregulation that predisposes these subjects to cutaneous viral infections is not well understood. We tested the hypothesis that defects in mannan-binding lectin (MBL) may be associated with an increased risk of EH.Methods. We evaluated serum MBL levels and functional activity in 13 AD subjects with a history of EH (EH+) and 21 AD subjects with no history of EH (EH−). MBL levels were detected by enzyme immunoassay. MBL pathway functional activity was evaluated by determining MBL C4b deposition capacity.Results. We found no statistical difference in MBL serum levels or function between EH+ and EH− groups.Conclusion. Considering the limitations of this study (e.g., small samples size) our findings suggest that MBL defects do not play a role in EH.

scholarly journals Regional Variation across Canadian Centers in Radioiodine Administration for Thyroid Remnant Ablation in Well-Differentiated Thyroid Cancer Diagnosed in 2000–2010

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
I. Rachinsky ◽  
M. Rajaraman ◽  
W. D. Leslie ◽  
A. Zahedi ◽  
C. Jefford ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
Distant Metastases ◽  
Tnm Staging ◽  
Remnant Ablation ◽  
Thyroid Hormone Withdrawal ◽  
Care Patterns ◽  
Major Variation ◽  
Well Differentiated ◽  
Over Time

Background. Use of radioactive iodine (RAI) ablation has been reported to vary significantly between studies. We explored variation in RAI ablation care patterns between seven thyroid cancer treatment centers in Canada.Methods. The Canadian Collaborative Network for Cancer of the Thyroid (CANNECT) is a collaborative registry to describe and analyze patterns of care for thyroid cancer. We analyzed data from seven participating centers on RAI ablation in patients diagnosed with well-differentiated (papillary and follicular) thyroid cancer between 2000 and 2010. We compared RAI ablation protocols including indications (based on TNM staging), preparation protocols, and administered dose. We excluded patients with known distant metastases at time of RAI ablation.Results. We included 3072 patients. There were no significant differences in TNM stage over time. RAI use increased in earlier years and then declined. The fraction of patients receiving RAI varied significantly between centers, ranging between 20–85% for T1, 44–100% for T2, 58–100% for T3, and 59–100% for T4. There were significant differences in the RAI doses between centers. Finally, there was major variation in the use of thyroid hormone withdrawal or rhTSH for preparation of RAI ablation.Conclusion. Our study identified significant variation in use of RAI for ablation in patients with well-differentiated thyroid cancer both between Canadian centers and over time.

scholarly journals Polymorphism of the IL13 gene may be associated with Uterine leiomyomas in Slovenian women

2016 ◽  
Vol 19 (2) ◽  
pp. 51-60 ◽  
Author(s):  
J Krsteski ◽  
S Jurgec ◽  
M Pakiž ◽  
I But ◽  
U Potočnik
Keyword(s):  
Tumor Biology ◽  
Serum Levels ◽  
Uterine Leiomyomas ◽  
Nucleotide Polymorphisms ◽  
First Sexual Intercourse ◽  
Pelvic Tumors ◽  
Increased Risk ◽  
Pcr Rflp ◽  
History Of ◽  
First Time

AbstractUterine leiomyomas (ULM) are a common cause of solid pelvic tumors in women. Their etiopathogenesis remains unclear. Interleukins (ILs) and their receptors can influence tumor biology of ULM. The aim of this study was to evaluate single nucleotide polymorphisms (SNPs) exhibited in the genes IL4 (rs2070874), IL4R (rs1801275), IL12RB1 (rs11575934), IL12B (rs6887695), IL13 (rs20541) and IL23R (rs7517847) as risk factors for ULM in Slovenian women and to identify associations between corresponding clinical parameters and the analyzed SNPs. In addition, solitary and multiple ULM were compared to identify clinical and/or genetic parameters influencing their occurrence. We conducted a case-control study that included 181 women with leiomyomas and 133 control subjects. Genotyping of selected SNPs was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and high resolution melting (HRM) techniques. The TT genotype of rs20541 (IL13) was significantly associated with decreased risk of ULM compared to both the CC and CT genotypes [p = 0.018; odds ratio (OR) = 0.184; 95% confidence interval (95% CI) = 0.048-0.7121. Using genetic and clinical data to develop a predictive model with logistic regression, we found that adenomyosis, higher age at diagnosis, family history of ULM occurrence, earlier menarche, lower number of pregnancies and lower age at first sexual intercourse, the G allele and genotypes AG and GG of rs1801275 (IL4R) were associated with an increased risk of multiple ULM occurrence. We also found an association between rs20541 (IL13) and 17ß-estradiol serum levels in patients with multiple ULM (p 0.003). Our study showed, for the first time, that rs20541 (IL13) may contribute to susceptibility of ULM development and that rs1801275 (IL4R) can predispose patients to develop multiple ULM.

scholarly journals Acromegaly and thyroid cancer: analysis of evolution in a series of patients

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Karina Danilowicz ◽  
Soledad Sosa ◽  
Mariana Soledad Gonzalez Pernas ◽  
Elizabeth Bamberger ◽  
Sabrina Mara Diez ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Median Time ◽  
Staging System ◽  
Distant Metastases ◽  
Tnm Staging ◽  
Control Group ◽  
Tumor Diameter ◽  
Delay In Diagnosis ◽  
Incomplete Response ◽  
Radioiodine Ablation

Abstract Background Acromegaly is associated with higher morbidity and mortality mainly due to cardiovascular disease. Data on the incidence and evolution of thyroid cancer in acromegaly are controversial. Our objective was to describe the characteristics of a group of acromegalic patients with differentiated thyroid carcinoma (DTC) and analyze their evolution. Methods This is a retrospective multicenter study of 24 acromegalic patients with DTC. The AJCC Staging System 8th Edition was used for TNM staging, and the initial risk of recurrence (RR), initial response and response at the end of follow-up (RFU) were defined according to the 2015 ATA Guidelines. As a control group, 92 patients with DTC without acromegaly were randomly included. Statistical analyses were done using SPSS Statistics 20.0. Results Median age of patients at diagnosis of acromegaly was 49.5 years (range 12–69). The median delay in diagnosis of acromegaly was 3 years (range 0.5–23). Mean baseline IGF-1 level was 2.9 ± 1.1 ULN. Median age at DTC diagnosis was 51.5 years (18–69). At the moment of diagnosis of DTC, 58.3% of the patients had active acromegaly. Median time from DTC diagnosis to acromegaly control was 1.25 years (0.5–7). Mean DTC tumor diameter of the biggest lesion was 14.6 ± 9.2 mm, being multifocal in 37.5%. All tumors were papillary carcinomas, two cases being of an aggressive variety. Lymph node dissection was performed in 8 out of 24 patients and 62.5% had metastases. Only one patient had distant metastases. Radioiodine ablation was given to 87.5% of patients. Nineteen patients (79%) were stage I, four (17%) stage II and one (4%) stage IVb. Initial RR was low in 87% (21/24), intermediate in 9% (2/24) and high in 4% (1/24) patient. RFU was: 83% (19/23) patients with no evidence of disease, 9% (2/23) with indeterminate response, 4% (1/23) with biochemical incomplete response and 4% (1/23) with structural incomplete response, at a median time of FU of 36.5 months. When comparing RFU between acromegalics and controls no statistically significant differences were found. Conclusions Patients with acromegaly and DTC mostly had a low initial RR. When compared with the control group, we found that DTC patients with acromegaly did not have a worse evolution.

Severe Post Thrombotic Syndrome Is Associated to Lower Echogenicity of the Residual Venous Thrombosis

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 4252-4252
Author(s):  
Bruna M Mazetto ◽  
Fernanda Loureiro de Andrade Orsi ◽  
Sandra A.F Silveira ◽  
Mariane Cristina Flores-Nascimento ◽  
Luis Fernando Bittar ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Serum Levels ◽  
Lower Limbs ◽  
Categorical Variables ◽  
Medical Conditions ◽  
Acute Thrombosis ◽  
Post Thrombotic Syndrome ◽  
Increased Risk ◽  
Tnf Α ◽  
History Of

Abstract Introduction: The post-thrombotic syndrome (PTS) is a common chronic complication of deep venous thrombosis (DVT) of the lower limbs and may occur even after an appropriate anticoagulant treatment. PTS may develop in the first two years after DVT in about 20-50% of patients; 5–10% of those may present severe manifestations of the disease. PTS is associated to an increased risk for DVT recurrence, morbidity, poor quality of life and significant cost to public health. The diagnosis of PTS is performed by clinical evaluation; particularly, the Villalta scale is recommended by the ISTH for PTS diagnosis and severity evaluation. The PTS-associated medical conditions are poorly understood, and it seems that hypercoagulability and inflammation, after the first episode of DVT, may play an important role in the disease development. Therefore, we performed a comprehensive analysis of clinical parameters, inflammation and ultrasound (US) examination of the affected limb in patients with history of previous DVT and PTS. Objective: The aim of this study was to evaluate possible medical conditions associated to PTS and its severity. Material and Methods: Between February 2013 and October 2013, consecutive patients with history of previous unprovoked DVT of lower limbs (> 6 months from the diagnosis), attended at the Hematology Center of the University of Campinas, Brasil, were included. Patients were submitted to physical evaluation for body mass index (BMI) determination and PTS diagnosis, by Villalta scale. Levels of the IL-8, IL-6 and TNF-α were performed by ELISA, D-dimer by turbidimetry and CRP by nephelometry. US examination was performed by duplex. In patients with residual venous thrombosis (RVT), the thrombus echogenicity was determined by grayscale median (GSM) evaluation, as described for atherosclerotic plaques. The GSM analysis was performed by a computer based US using specific software. Only the region containing the thrombus was analyzed, the image was depicted manually point by point to trace the line surrounding the thrombus, the final GSM values were automatic calculated and translated the thrombus echogenicity. A low GSM value (<25) suggests acute thrombosis and a high GSM vlaue (> 25) suggest subacute thrombosis.. Continuous variables were analyzed by Kruskal-Wallis test and categorical variables were compared using the Fisher´ s exact test. Results: From the 56 patients included, 15 did not present PTS, 23 were classified as mild, 11 as moderate and 7 as severe PTS. Serum levels of CRP was significantly higher in patients with severe PTS when compared to patients with mild+moderate PTS and to those without PTS (respectivelly 0.64mg/dL, 0.31mg/dL and 0.13mg/dL; P=0.02).Serum levels of IL-6 and TNF-α were higher in patients with severe PTS compared to patients with mild/moderate PTS and without PTS (IL-6= 2.81pg/mL vs. 1.48pg/mL vs. 0.80pg/mL respectively, and TNF 1.68pg/mL vs. 1.33pg/mL vs 1.17pg/mL respectively), however the differences did not reach statistical significance. Levels of IL-8 and DD were similar between severe PTS and the other two groups. The presence of RVT was similar between groups, however US-generated GSM was significantly lower in patients with severe PTS compared to patients with mild+moderate PTS and patients without PTS (GSM= 22, 31 and 28.5, respectively; P=0.04). As predicted, the BMI was also higher in patients with severe PTS when compared to mild+moderate PTS and no PTS group (BMI= 34,8 vs. 29,3 vs. 25,9, respectively P=0.007). Conclusion: Our results suggest that severe PTS may be associated with a chronic inflammatory response, characterized by obesity and higher levels of CRP. Besides, we could also observe that severe PTS may be associated with the persistence of a hypoechoic residual thrombus, determined by lower US-generated GSM values. The finding about the persistence of a hypoechoic thrombus in patients with severe PTS, even long time after the acute thrombosis event, is new and may possibly suggest that an adequate thrombus organization process is required to avoid the development of PTS. Disclosures No relevant conflicts of interest to declare.

scholarly journals Zinc Sulphate Turbidity as a Screening Test of Passive Transfer of Immunity in Newborn Foals

2019 ◽  
Vol 47 (1) ◽  
Author(s):  
Endrigo Pompermayer ◽  
Flávio Desessards De La Cortê ◽  
Mara Iolanda Batistella Rubin
Keyword(s):  
Zinc Sulphate ◽  
Reference Method ◽  
Serum Levels ◽  
Passive Transfer ◽  
False Positives ◽  
Effect Of Temperature ◽  
Serum Samples ◽  
Paired Samples ◽  
False Positive Diagnosis ◽  
Increased Risk

Background: Passive immunity acquired by colostrum ingestion is essential to prevent neonatal infections. Failure of passive transfer (FPT) of maternal immunity occurs in foals that fail to absorb enough immunoglobulins within 24 h after birth. Foals with FPT are at increased risk of infections and death. Serum samples from neonatal foals might be examined for FPT using the zinc sulphate turbidity (ZST) test. The aim of this study was to investigate the accuracy of the ZST test, performed at two different times after first suckling (12 and 18 h), to detect FPT in newborn foals. The effect of temperature on the turbidity intensity resulting from the ZST reaction was also investigated.Materials, Methods & Results: Blood samples were collected from 112 newborn foals at 12 h after the first colostrum intake. In 36 foals, additional serum samples were collected at 18 h after first colostrum intake. The serum samples were tested with the ZST test and, later, in the laboratory setting, the ZST test was repeated. The IgG levels were measured by single radial immunodiffusion (SRID), which was used as the reference method. The standard solution used for the interpretation of results had a turbidity corresponding to approximately 800 mg/dL of immunoglobulins (IgG). The mean IgG concentration measured at 12 and 18 h after the first colostrum intake was analyzed using the t-test for paired samples. Values of absorbance of ZST test under different temperatures were analyzed using a one-way analysis of variance, and means were compared using the Tukey test. The relationship between the temperature of the solution and absorbance was determined using the Pearson’s correlation coefficient. Based on SRID results, 12 foals (10.7%) had serum IgG concentration < 400 mg and 26 foals (23.2%) had IgG levels between 400 and 800 mg/dL. Serum levels of IgG determined by SRID in 36 foals were similar (P > 0.05) between 12 h (943.9 ± 508.6 mg/dL) and 18 h (975.9 ± 525.6 mg/dL) after the first colostrum intake. The sensitivity values were 76.3% and 71.0% (P > 0.05) for tests performed at farm and laboratory, respectively. The specificity was higher (P < 0.05) for ZST tests performed at laboratory (94.6%) than at farms (73.0%). Twenty-nine of the 38 foals (76.3%) with IgG < 800 mg/dL were correctly detected using the ZST test at farms. There was a strong correlation (r = 0.92; P < 0.0001) between the temperature of the solution test and the degree of turbidity. The absorbance after the reaction of serum with zinc sulphate was similar between the temperatures of 30, 34 and 37ºC, which had higher values than 20 and 25ºC.Discussion: The ZST test can be performed at 12 h after the first suckling. The lower specificity of tests run at farms compared to laboratory resulted in more foals with false positive diagnosis. The main cause of false positives at farms was probably the low temperature of the zinc sulphate solution at the time of testing, delaying the reaction and underestimating the IgG concentration. This assumption was reinforced by the increased specificity observed when the test was repeated with the same serum samples under controlled temperature of a laboratory. Additionally, the positive correlation observed between the temperature and degree of turbidity confirms that the reaction is temperature dependent. In the Southern hemisphere, most Thoroughbred foals are born during winter, when room temperature is far below the ideal temperature for good performance of the ZST test. Therefore, the number of false positives will likely be reduced if tests are performed at the farms under adequate temperature of solution (between 30 and 37ºC). This will reduce the number of foals receiving unnecessary treatment.

scholarly journals Association of BMI with markers of angiogenesis in healthy population

2018 ◽  
Vol 5 (4) ◽  
pp. 1065
Author(s):  
Shivani Jaswal ◽  
Harjeet Kaur ◽  
Jasbinder Kaur ◽  
Seema Gupta
Keyword(s):  
Serum Levels ◽  
Healthy Population ◽  
Study Group ◽  
Lifestyle Modifications ◽  
Positive Correlation ◽  
Increased Risk ◽  
Significant Difference ◽  
History Of ◽  
Student’S T

Background: Obesity is associated with an increased risk of atherosclerosis, which can be mediated by an increase in angiogenesis and inflammation. The objective of the present study was to explore the relationship between BMI and levels of VEGF, a circulating biomarker of angiogenesis.Methods: 225 healthy volunteers in the age group of >18 years formed the subjects of the study. Individuals with any acute or chronic illness including history of HT, DM, and smoking, alcohol or drug abuse or on any long term medication were excluded from the study. Anthropometric measurements were taken, and BMI calculated. Blood samples were taken, and serum levels of VEGF were estimated using commercially available ELISA kits. Student’s ‘t’ test was done for comparison and correlation was assessed using Pearson’s method.Results: A statistically significant difference in the levels of VEGF was found in subjects with BMI < 25 kg/m2 as compared to subjects with BMI > 25 kg/m2 (p<0.001). A significant positive correlation was found between the levels of VEGF and BMI in both males and female subjects of the study group (r=0.68 and 0.73 respectively).Conclusions: The positive correlation of levels of VEGF with BMI in the healthy subjects of the study group may be related to the expansion of adipose tissue and to the concomitant formation of new vessels to support tissue deposition. These factors may predispose an individual to an increased risk of atherosclerotic damage later in life. VEGF may therefore, have a potential as a biomarker for the prediction of cardiovascular risk and estimation may allow intervening with lifestyle modifications and nutritional changes before the disease is manifested and pharmacotherapy is required.

Initial Management and Follow-up of Differentiated Thyroid Cancer in Children

2010 ◽  
Vol 8 (11) ◽  
pp. 1289-1300 ◽  
Author(s):  
Steven G. Waguespack ◽  
Gary Francis
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Hormone ◽  
High Risk ◽  
Differentiated Thyroid Cancer ◽  
Residual Disease ◽  
Distant Metastases ◽  
High Volume ◽  
Increased Risk ◽  
Initial Care

Children with differentiated thyroid cancer (DTC) often present with metastatic disease and have a high risk for recurrence, but rarely die of the disease. This article reviews DTC in children and discusses current approaches to their initial care and follow-up. These recommendations take into account the greater risk for recurrence and lower disease-specific mortality in these patients. Total thyroidectomy and central compartment lymph node dissection are appropriate for most children, but should be performed by a high-volume thyroid surgeon. Radioactive iodine (RAI) should generally be prescribed for those at very high risk for recurrence or known to have microscopic residual disease, and those with iodine-avid distant metastases. RAI should be considered in other patients only after carefully weighing the relative risks and benefits and the aggressiveness of the clinical presentation, because RAI may be associated with an increased risk for second malignancies and an increase in overall morbidity and mortality. All patients should be treated with thyroid hormone suppression, and follow-up should be lifelong. However, the degree of thyroid hormone suppression and frequency of disease surveillance usually decrease over time as patients are determined to be disease-free.

scholarly journals Serum oxidative stress influences neurological recovery after surgery to treat acutely worsening symptoms of compression myelopathy: a cross-sectional human study

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Hiroshi Takahashi ◽  
Yasuchika Aoki ◽  
Junya Saito ◽  
Arata Nakajima ◽  
Masato Sonobe ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen ◽  
Serum Levels ◽  
Neurological Recovery ◽  
Reactive Oxygen Metabolites ◽  
Serum Samples ◽  
Cross Sectional ◽  
Significant Difference ◽  
History Of ◽  
Compression Myelopathy

Abstract Background Recent reports indicate that oxidative stress induced by reactive oxygen species is associated with the pathobiology of neurodegenerative disorders that involve neuronal cell apoptosis. Here we conducted a cross-sectional study to evaluate serum levels of oxidative stress in cervical compression myelopathy. Methods Thirty-six serum samples were collected preoperatively from patients treated for acutely worsening compression myelopathy (AM) and chronic compression myelopathy (CM). Serum levels of oxidative stress markers were evaluated by measuring derivatives of reactive oxygen metabolites (ROM), which reflect concentrations of hydroperoxides. ROM in healthy individuals range from 250 to 300 (U. CARR), whereas ROM >340–400 and > 400 define moderate and severe levels of oxidative stress, respectively. Difference of ROM by the cause of disorders whether cervical spondylotic myelopathy (CSM) or cervical ossification of longitudinal ligament (OPLL), correlations between ROM and patient age, body mass index (BMI), history of smoking, existence of diabetes were examined. Neurological evaluations according to Japanese Orthopaedic Association (JOA) scores were performed and correlated with ROM. Results ROM increased to 349.5 ± 54.8, representing a moderate oxidative stress, in CM samples. ROM increased to 409.2 ± 77.9 in AM samples, reflecting severe oxidative stress which were significantly higher than for CM samples (p < 0.05). There was no significant difference by the cause of disorders (CSM or OPLL). ROM were significantly increased in AM serum samples from female patients versus AM male and CM patients (p < 0.05). There were no correlations between ROM and age, BMI, history of smoking, and existence of diabetes. A negative correlation between ROM and recovery rate of JOA score (R2 = 0.454, p = 0.047) was observed in the AM group. Conclusions Although moderate oxidative stress was present in patients with CM, levels of oxidative stress increased in severity in patients with AM. These results suggest that postsurgical neurological recovery is influenced by severe oxidative stress in AM.

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