scholarly journals Unfortunate Case of Hypoglycemia Induced Seizures Resulting in Anoxic Encephalopathy

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A405-A405
Author(s):  
Kavya Nallamothu ◽  
Steven Douedi ◽  
Katherine Hu ◽  
Raquel Ong ◽  
Jennifer Cheng

Abstract Background: Severe hypoglycemia in patient with diabetes mellitus can manifest as seizures and coma, most commonly occurring after excessive insulin administration. Clinical Case: A 35-year-old woman with uncontrolled type 1 diabetes mellitus on basal-bolus insulin, complicated by gastroparesis, hypoglycemia unawareness, and frequent hypoglycemic episodes due to a tendency to give more than the recommended amount of insulin, who presented with seizures and diffuse brain edema as severe manifestations of profound hypoglycemia. Hemoglobin A1c was 7.3% but patient had wide variation in blood glucose (40- 300 mmol/L) on her glucometer. Patient had initially self-treated overnight hypoglycemic symptoms by drinking soda and then fell asleep without re-checking her blood sugar. She was then unresponsive in the morning. Patient’s husband reported that there was no glucagon at home since he used the last one and did not refill. On EMS arrival, patient had a blood glucose of 25, for which she received dextrose and glucagon with improvement of blood glucose but no change in mentation. En route to the hospital, patient developed tonic-clonic seizures and decerebrate posturing. She received Ativan and was intubated for airway protection. On exam, she had bilateral dilated sluggishly reactive pupils, eyes opened spontaneously but did not track, and limbs moved spontaneously but there was no purposeful movement. Initial CT head without contrast showed significant diffuse brain edema. Repeat MRI brain with and without contrast showed bilateral basal ganglia diffusion restriction with associated T2 and FLAIR hyperintense signal, suggestive of toxic-metabolic etiology including hypoglycemia. Video EEG showed findings consistent with anoxic encephalopathy. Patient received IV mannitol and IV dexamethasone for cerebral edema and Keppra for seizure prophylaxis, but was unable to be weaned from the ventilator and had to undergo tracheostomy and PEG tube placement, and was eventually discharged to inpatient rehabilitation. Conclusion: This case highlights the dangers of accidental overcorrection of high blood sugar with short-acting insulin and not appropriately treating hypoglycemia, which can lead to irreversible brain injury due to prolonged hypoglycemia. This unfortunate case highlights the importance of educating patients with diabetes mellitus on insulin how to appropriately manage low sugars to avoid such outcomes.

2021 ◽  
Vol 1 ◽  
pp. 921-927
Author(s):  
Oki Yanuarti ◽  
Nuniek Nizmah Fajriyah ◽  
Firman Faradisi

AbstractDiabetes melitus is a metabolic disease characterized by high blood glucose levels in the body, caused by abnormalitized in insulin secretion. One of the non-pharmacological method to reduce blood sugar level is progressive muscle relaxation therapy. This study aims to identify the effect of progressive muscle relaxation techniques in lowering blood sugar. A literature review of studies of progressive muscle relaxation therapy in reducing blood sugar publishedin 2011-2020 was conducted. The average number of respondents was 26 male and female responden with and average age of 55-60. The results showed that progressive muscle relaxation therapy was able to control blood glucose among diabetic. This study concludes that progressive muscle relaxation therapy effectively reduce blood sugar levels in patients with diabetes melitus. The findings suggest that progressive muscle relaxation therapy can be used as non-pharmacological therapy to lower blood sugar levels.Keywords: Diabetes mellitus; Progressive muscle relaxation AbstrakDiabetes melitus merupakan suatu penyakit degeneratif yang bermasalah pada sistem metabolik ditandai dengan meningkatnya kadar gula darah dalam tubuh dan disebabkan karena kelainan sekresi insulin. Pada pasien diabetes melitus akan mengalami peningkatan kadar gula darah dalam tubuh, salah satu cara non farmakologis yang dapat dilakukan untuk menurunkan kadar gula darah pada pasien diabetes melitus yaitu dengan terapi relaksasi otot progresif. Tujuan dari Karya Tulis Ilmiah ini yaitu untuk mengetahui gambaran dari pengaruh teknik relaksasi otot progresif terhadap penurunan kadar gula darah pada pasien diabetes melitus. Metode yang dilakukan dengan mencari tiga jurnal penelitian tentang pengaruh terapi relaksasi otot progresif terhadap penurunan kadar gula darah pada pasien diabetes melitus terbit pada tahun 2011-2020. Hasil analisa karakteristik responden dari ketiga jurnal menunjukan jumlah responden rata-rata 26 responden laki-laki dan perempuan dengan usia rata-rata 55-60 tahun. Hasil yang didapatkan setelah dilakukan terapi relaksasi otot progresif kadar gula darah pasien menjadi terkontrol. Simpulan dari karya tulis ilmiah ini yaitu terapi relaksasi otot progresif efektif terhadap penurunan kadar gula darah pada pasien diabetes melitus. Saran bagi perawat atau penderita diabetes melitus terapi relaksasi otot progresif dapat digunakan sebagai terapi non farmakologis untuk menurunkan kadar gula darah pada pasien diabetes melitus. Kata kunci: Diabetes mellitus; Relaksasi Otot Progresif


2019 ◽  
Vol 10 (1) ◽  
pp. 77
Author(s):  
Febria Syafyu Sari ◽  
Ridhyalla Afnuhazi

ABSTRAK Diabetes Melitus merupakan penyakit yang paling menonjol yang disebabkan oleh gagalnya pengaturan gula darah. Lidah buaya berkhasiat untuk menurunkan kadar gula dalam darah bagi penderita diabetes dan dapat mengontrol tekanan darah. Tujuan penelitian untuk mengetahui pengaruh jus lidah buaya (AloeBarbadensis Miller) terhadap penurunan glukosa darah puasa GDP) dan 2 Jam PP (Post Prendial) pada penderita DM (Diabetes Melitus). Desain penelitian merupakan Quasi Eksperimental dengan pendekatan one group pretest – postest design. Sampel terbagi menjadi 14 responden. Data dianalisis dengan paired t-test. Hasil menunjukan rata-rata penurunan glukosa darah puasa pada intervensi (28,42 gr/dl) dan glukosa darah 2 jam pp pada intervensi (40,57 gr/dl). Untuk analisis bivariat terdapat perbedaan antara glukosa puasa dan 2 jam pp dengan glukosa darah puasa GDP) dan 2 Jam PP (Post Prendial) pada penderita DM (Diabetes Melitus). Kesimpulan didapatkanlidah buaya dapat menurunkan kadar glukosa darah.Berdasarkan hasil penelitian jus lidah buaya dapat menjadi salah satu alternatif keperawatan non farmakologi dalam penyakit diabetes melitus. Kata Kunci : Lidah Buaya ; Diabetes Mellitus THE EFFECT OF VEGETABLE VOCATIONAL JUICE ON FAST BLOOD GLUCOSE LEVELS AND 2 HOURS OF PP (Post Prandial) IN DIABETES MELLITUS  ABSTRACT Diabetes mellitus is the most prominent disease caused by the failure of blood sugar regulation. Aloe vera is efficacious can to  reduce blood sugar levels for diabetics and can control blood pressure. The purpose of this study was to determine the effect of Aloe Barbadensis Miller on the reduction of fasting blood glucose GDP and 2 hours of PP (post prendial) in patients with diabetes mellitus. The research design is Experimental Quasi with one group pretest - postest design approach. The sample is divided into 14 respondents. Data were analyzed by paired t-test. The results showed an average decrease in fasting blood glucose at intervention (28.42 gr / dl) and 2 hours pp blood glucose at intervention (40.57 gr / dl). For bivariate analysis there was a difference between fasting glucose and 2 hours pp with fasting blood glucose GDP) and 2 hours PP (Post Prendial) in patients with diabetes mellitus. The conclusion is that aloe vera can reduce blood glucose levels. Based on the results of research on aloe vera juice can be an alternative non-pharmacological nursing in diabetes mellitus. Keywords: Aloe Vera ; Diabetes Mellitus


2017 ◽  
Vol 8 (2) ◽  
pp. 53
Author(s):  
Dani Rosdiana

Prevalence of diabetes mellitus in Riau have reached 10,4 %, it’s higher than national pravelence. Hence, it’s needmore attention from physician. The important thing in managing DM is how to restrain controlled blood sugar level.The best parameter to evaluate controlled blood sugar level is level of HbA1c. Fasting blood glucose is one ofimportant component which determine HbA1c especially HbA1c more than 8,5%. There are some pharmacologyagent to decrease HbA1c level, and insulin is the most effective agent. Why physician needs insulin?It was caused by impairment of betha cell pancreas was directly propotional with DM progressiveness. Comprehensionand capability for using basal insulin are important to physician, not only for internist but also for general practinioner.As we know that general practinioner have a competency to manage DM without complication. Guidance for usingsimple and practical basal insulin is expected will facilitate physician to manage blood sugar level of DM patient.


2017 ◽  
Vol 4 (2) ◽  
pp. 24
Author(s):  
Fatifa Asmarani ◽  
Bambang Wirjatmadi ◽  
Merryana Adriani

Background: Diabetes mellitus (DM) is metabolic disorder syndrome characterized by hyperglycemia due to deficiency of insulin secretion. Patients of diabetic patients increases each year, so it needs proper handling. Corn flour is a source of carbohydrates with a low glycemic index to help reduce the rise in blood sugar levels. In addition, supplementation with tempeh flour containing isoflavones act to protect cells from free radical thereby inhibiting damage cells. Fiber in tempeh affect blood glucose levels because it slows the absorption of glucose.Objective: To determine the effect supplementation of corn flour with tempeh flour on blood sugar levels in diabetes mellitus Wistar rats.Methods: The study was true experimental design with Pre-posttest control group design, samples were 20 male Wistar rats aged 2-3 months were then divided into 4 groups (T0, T1, T2, T3.) T0 was injected with alloxan as 30 mg / 150 grams of BB rats are subsequently treated with standard diet; T1 was dministered by standard diet 50% + 50% corn flour; T2 was administered by standard diet 50% + 30% + corn flour tempeh flour 20%; and T3 was administered by standard diet of corn flour 50% + 15% + 35% tempeh flour for 2 weeks. Blood glucose levels were measured with a glucose kit (GOD FS). Research data were analyzed by One Way ANOVA followed by Tukey's Post Hoc test p-value <0.05.Results: There were significant differences on blood sugar levels in all groups (p = 0.000): control group (only dietary standards), T1 (administered by standard diet 50% + corn flour 50%), T2 (administered by a standard diet 50% + cornstarch 30% tempeh flour + 20%) and T3 (administered by standard diet of corn flour 50% + 15% + 35% tempeh flour).Conclusion: corn flour with tempeh flour supplementation effect on decresing of blood sugar levels.


Author(s):  
Nerdy Nerdy ◽  
Linta Meliala ◽  
Bunga Rimta Barus ◽  
Puji Lestari ◽  
Selamat Ginting ◽  
...  

Male infertility has occurred rapidly in the last few decades, primarily in developing countries. An antioxidant, hesperetin is a flavonoid that is found in abundance in orange peels. The aims of this research were to determine the effect of hesperetin on blood sugar levels, spermatozoaquality, and spermatozoa quantity. The research structure included induction of diabetes mellitus and treatment for 8 weeks, followed bydetermination of blood sugar levels, spermatozoa quality, and spermatozoa quantity. Hesperetin has the ability to restore blood sugar levels, spermatozoa quantity, seminiferous tubules diameter, and testicular weight, volume, and germinal epithelial layer thickness with significant difference from the normal control group. Hesperetin did not fully restore spermatozoa motility, viability, and morphology with significant difference from the normal control group, nor from the positive control group. However, overall, hesperetin decreased blood glucose levels, increased spermatozoa quantity, and improved the spermatozoa quality in alloxan-induced diabetes mellitus mice. Dose-dependent activity was observed with the optimum dose at 200 mg/kg body weight.


2017 ◽  
Vol 2 (1) ◽  
pp. 5
Author(s):  
Ludiana Ludiana

Diabetes mellitus is a chronic metabolic disorder marked increase in blood glucose. According to the World Health Organization (WHO) in 2013 the incidence of diabetes mellitus in the world reached 347 million people in Indonesia alone ranks among the seven countries with the highest diabetes prevalence of 7.6 million people. Among the causes of the increase in blood glucose levels in diabetics is due to psychological factors, namely anxiety. In the pre-survey results in Puskesmas Sumbersari Bantul note that from 8 patients with diabetes mellitus, there are 6 people experiencing anxiety and 2 do not complain any signs of anxiety. The purpose of this study was to determine the relationship of anxiety with blood glucose levels of diabetics mellitus in Puskesmas Sumbersari Bantul District of South Metro City. The type quantitative research, form design used is cross sectional. The population in this study are patients with diabetes mellitus in Puskesmas Sumbersari Bantul District of South Metro totaling 408 samples taken as many as 41 people. The analysis in this study using the test Person Product Moment. Statistical analysis showed that anxiety patients with diabetes mellitus are at an average score of 27.44 with a standard deviation of 4.353 and the average blood sugar levels of people with diabetes mellitus are at 339.78 mg / dL with a standard deviation of 74.742. In the Person Product Moment test results proved no relationship anxiety with blood sugar levels of people with diabetes mellitus (p-value = 0.000 <a 0.05). Pearson correlation results obtained value of 0.817 towards a positive correlation with the strength of the relationship is very strong. Conclusions research shows there is an anxiety relationship with blood glucose levels of diabetics mellitus.


2019 ◽  
Vol 2 (4) ◽  
Author(s):  
Agung B S Satyarsa

Diabetes mellitus is a degenerative disease that commonly found and related to an unhealthy lifestyle and genetic factors. Current management of diabetes mellitus includes control of blood sugar levels and prevention of complications. Recent studies found that many phytochemicals have the potential to control blood sugar levels in patients with diabetes. Alkaloid substances from leaves of Tapak Dara have an effect on decreasing blood glucose. This review article aims to describe the potential effects of the Alkaloid vindolicine from Tapak Dara leaves (Catharanthus Roseus L.) in reducing blood glucose levels in patients with type 2 diabetes mellitus. The activity of vindolicine alkaloid against ? cells in previous studies has shown to improve ? cells activity and induce insulin secretion thus preventing further hyperglycemia. In addition, the vindolicine alkaloid also has a role in activating pancreatic ?-TC6 cells and carrying out an immediate reaction in blood vessels. As conclusion, further research is needed to prove the maximum effect of the utilization of tread leaf extract as well as the toxicity test to determine the toxic effects of the alkaloid substances in the tread leaf. Keywords: Type 2 Diabetes Mellitus, Vindolicine Alkaloid, Tapak Dara, blood glucoselevels


2012 ◽  
Vol 4 (1) ◽  
pp. 28-31 ◽  
Author(s):  
Partha Mukhopadhyay ◽  
Tara Sankar Bag ◽  
Amit Kyal ◽  
Dipta Prasun Saha ◽  
Noori Khalid

ABSTRACT Introduction Gestational diabetes is a common medical disorder in pregnancy. So long, it has been usually treated by insulin. Now it has been found that oral glibenclamide can be used instead of insulin with similar glycemic control and without any adverse maternal and fetal effect. Methods A comparative study between oral glibenclamide and insulin for the management of gestational diabetes mellitus (GDM) was conducted. It was a prospective randomized study and patients attending the antenatal clinic were screened with 75 gm oral glucose between 20 to 28 weeks and GDM was diagnosed based on WHO criteria of 2 hours blood glucose ≥140 mg/dl. Women with gestational diabetes were given medical nutritional therapy (MNT) for 2 weeks. Out of this, 60 women did not achieve the target blood glucose. The goal of treatment was maintenance of mean plasma glucose (MPG) of about 105 mg%. For this the fasting plasma glucose should be around 90 mg/dl and postprandial peaks around 120 mg/dl. Patients were randomly assigned to receive glibenclamide (group A, n = 30) or insulin (group B, n = 30). In group A, glibenclamide was given 2.5 mg orally in morning and doses were increased weekly by 2.5 mg up to a maximum of 20 mg and doses >7.5 mg were given in two divided doses. In group B, insulin 0.7 units per kilogram of body weight at admission was given subcutaneously three times daily and increased weekly as necessary. Self monitoring of blood glucose with glucometer was done. Blood glucose was also measured from the laboratory every week. Glycosylated hemoglobin (HbA1c) was measured before initiation of therapy and repeated in the third trimester before confinement. Terminations of pregnancy in both the groups were done between 37 and 38 weeks. The infant birth weight, blood glucose and serum bilirubin were also recorded in all cases. Results The present study showed that the two groups had similar glycemic status (fasting blood sugar in group A was 103.5 ± 14.62 mg/dl and postprandial blood sugar was 184.1 ± 20.46 mg/dl whereas in group B it was109.3 ± 19.63 mg/dl and 194.3 ± 18.47mg/dl) at the time of entry into the study. The two groups also showed similar levels of glycemic control just before confinement (fasting blood sugar in group A was 88.23 ± 6.55 mg/ dl and postprandial blood sugar was 122.7 ± 10.3 mg/dl whereas in group B it was 88.17 ± mg/dl and 128 ± 12.38 mg/dl) and there was no significant statistical difference in the two groups (p > 0.05). The perinatal outcomes in both the groups were also nearly same. There was no significant difference in birth weight, blood sugar level of neonates and complications between the two groups. There was no case of macrosomia in the two groups and the number of infants large for gestational age (LGA) was four in group A and two in group B. Hypoglycemia in newborn was slightly higher in the group A compared to group B (4 and 3 respectively). Conclusion From our study, it is evident that the use of oral agents is a pragmatic alternative to insulin therapy in cases of gestational diabetes because of similar glycemic control, ease of administration and better patient compliance due to noninvasive treatment. How to cite this article Mukhopadhyay P, Bag TS, Kyal A, Saha DP, Khalid N. Oral Hypoglycemic Glibenclamide: Can it be a Substitute to Insulin in the Management of Gestational Diabetes Mellitus? A Comparative Study. J South Asian Feder Obst Gynae 2012;4(1):28-31.


2021 ◽  
Vol 4 (1) ◽  
pp. 26-30
Author(s):  
Widia Afira ◽  
Prima Dian Furqoni ◽  
Rahma Elliya ◽  
Usastiawaty Cik Ayu Saadiah Isnainy ◽  
Eka Yudha Crisanto ◽  
...  

ABSTRAK Menurut International Diabetes Federation (IDF) (2015), saat ini Indonesia merupakan negara dengan urutan ke-7 jumlah penderita diabetes terbanyak di dunia yaitu sebanyak 10,0 juta jiwa, dan pada tahun 2020 diperkirakan penderita diabetes di Indonesia akan naik ke nomor enam terbanyak di dunia dengan jumlah penderita 16,2 juta jiwa, dan dilaporkan bahwa kota-kota besar seperti Jakarta, Surabaya, sudah hampir 10 % penduduknya menderita diabetes. Diabetes merupakan penyakit kronis yang serius dan terjadi baik saat pankreas tidak menghasilkan cukup insulin (hormon yang mengatur glukosa darah) maupun jika tubuh tidak dapat menggunakan insulin yang dihasilkan secara efektif. pengobatan bisa dilakukan secara non farmakologi, diantaranya dengan menggunakan terapi pijat refleksi. Tujuan setelah penyuluhan dan demonstrasi, diharapkan pemberian pijat refleksi dapat untuk menurunkan glukosa darah. Adapun kegiatan yang dilakukan berupa penyuluhan menggunakan leaflet dan demonstrasi terapi pijat refleksi. Terdapat penurunan gula darah pada klien diabetes melitus setelah pemberian terapi pijat refleksi selama 3 hari di Tiyuh Dayaasri Tumijajar Tulang bawang barat. Dari evaluasi hari terakhir pemeriksaan kadar glukosa darah terjadi penurunan yaitu antara sebelum diberikan terapi dan sesudah diberikan terapi, diperoleh data pada nilai glukosa darah sebelum diberikan asuhan keperawatan yaitu hari pertama GDS: 215 mg/dl, setelah diberikan intervensi pijat refleksi selama kurun waktu 3 hari dan di beri waktu istirahat selama 4 hari tetapi tetap dalam pengontrolan pola makan, untuk memberikan efek rileks kemudian di cek gula darah kembali di hari ke 7 (tujuh),  dari hasil pemeriksaan didapatkan yaitu GDS: 189 mg/dl. Saran agar dapat menerapkan terapi pijat refleksi kepada penderita diabetes melitus dan sebagai pengobatan alternatif untuk menjaga kestabilan glukosa darah, untuk mengurangi efek samping penggunaan obat jangka panjang. Dengan demikian, pemberian pijat refleksi pada klien diabetes melitus sangat efektif dalam menurunkan gula darah.Kata kunci : Diabetes Melitus, Gula Darah, Terapi Pijat Refleksi   ABSTRACT According to the International Diabetes Federation (IDF) (2015), Indonesia is currently the 7th largest number of diabetics in the world with 10.0 million people, and 2020 estimated that diabetics at Indonesia will rise to number 6th in the world with 16.2 million sufferers, and it is reported that big cities like Jakarta, Surabaya, already almost 10% the population suffer of diabetes. Diabetes is a serious chronic disease and occurs both when the pancreas does not produce enough insulin (a hormone that regulates blood glucose) or if the body cannot use insulin produced effectively. treatment can be non-pharmacologically, including by reflexology therapy. The purpose after counseling and demonstration, is expected to provide reflexology to reduce blood glucose. The activities carried out in the form of counseling used leaflets and demonstration of reflexology therapy. There is a decrease in blood sugar in diabetes mellitus clients after giving reflexology therapy for 3 days at Tiyuh Dayaasri Tumijajar West Tulang Bawang. From evaluation of the last day,examination of blood glucose levels there was a decrease between before being given therapy and after being given therapy, obtained data on blood glucose values before being given nursing care that is the first day of GDS: 215 mg / dl, after being given a reflexology intervention for a period of 3 days and given a rest period of 4 days but still in control of eating patterns, to provide a relaxing effect then checked for blood sugar again on day 7 (seven), from the examination results obtained namely GDS: 189 mg / dl. Suggestions for adjust reflexology therapy to people with diabetes mellitus and alternative treatment to maintain blood glucose stability, to reduce the side effects of long-term drug use. Thus, giving reflexology to diabetes mellitus's client is very effective of lowering blood sugar. Keywords: Diabetes Mellitus, Blood Sugar, Reflexology Therapy


Author(s):  
Deepali S. Jadhav ◽  
Uma N. Wankhede

Background: Gestational diabetes mellitus (GDM) is defined as carbohydrate intolerance of variable severity with onset or first recognition during pregnancy. The importance of GDM is that two generations are at risk of developing diabetes in the future. Aim was to study the merits and demerits of capillary blood glucose estimation by glucometer over venous plasma glucose estimation while performing DIPSI test.Methods: It was a hospital based clinical study. 1000 patients were enrolled between 24-28 weeks of gestation and DIPSI test was performed. Patient was instructed to come irrespective of fasting. 75 g glucose dissolved in 200-400 ml of water and patient was asked to drink in 5 minutes. Venous blood was drawn after 2 hours, capillary blood sugar also was measured at the same time by glucometer.Results: Sensitivity of capillary blood sugar (CBS) method in detecting GDM is 100% as compared to venous plasma glucose (VPG) and specificity is 99.46% as compared to VPG. Considering the agreement between two methods for diagnosis of GDM, equal sensitivity of both methods and small number of false positive cases detected by CBS method, due to almost equal specificity (99.46%), CBS method by glucometer can be recommended as an alternative to VPG method as a screening and diagnostic test for GDM.Conclusions: It is appropriate and feasible to offer capillary blood sugar sampling by DIPSI test for screening and diagnosis of GDM. The prevalence of GDM in our study is 8% by capillary blood sugar sampling and 7.5% by venous plasma glucose sampling according to DIPSI test. 


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