scholarly journals Anti-inflammatory activities of ethnomedicinal plants from Dayak Abai in North Kalimantan, Indonesia

2017 ◽  
Vol 18 (4) ◽  
pp. 1556-1561 ◽  
Author(s):  
SWANDARI PARAMITA ◽  
KHEMASILI KOSALA ◽  
DZULKIFLI DZULKIFLI ◽  
DEBY INDAH SAPUTRI ◽  
ENGGAR WIJAYANTI
Keyword(s):  
Medicinal Plants ◽  
Healing Process ◽  
Area Under The Curve ◽  
Ethanol Extract ◽  
Health Problems ◽  
Negative Control ◽  
Antiinflammatory Drugs ◽  
Ethnomedicinal Plants ◽  
Rat Paw Edema ◽  
Anti Inflammatory

Paramita S, Kosala K, Dzulkifli D, Saputri DI, Wijayanti E. 2017. Anti-inflammatory activities of ethnomedicinal plants from Dayak Abai in North Kalimantan, Indonesia. Biodiversitas 18: 1556-1561. Inflammation is a normal process in the human body as a response to injury from the healing process. Meanwhile, chronic inflammation will cause new health problems to patients. Antiinflammatory drugs generally used for those conditions, have several side effects to patients. The objective of this research was to find alternative anti-inflammatory drugs, especially from natural sources. Three medicinal plants recorded from Dayak Abai in North Kalimantan, Indonesia for health problems caused by the inflammation process i.e. Amomum xanthophlebium Baker, Clerodendrum buchananii (Roxb.) Walp., and Donax canniformis (G.Forst.) K.Schum. were used as material in this research. The experimental method using carrageenan-induced rat paw edema was used followed by the resulting measurement using plethysmometer. The results showed that significant differences of AUC (area under the curve) with p = 0.001 (p < 0.05) were achieved between negative control, positive control, and treatment group with plant medicinal extracts. AUC of leaves ethanol extract of C. buchananii showed the strongest antiinflammatory activities. It could be concluded that the medicinal plants recorded from ethnomedicinal data from Dayak Abai in North Kalimantan, have anti-inflammatory activities, with C. buchananii as the most potential ones which could be further developed as a new source of the anti-inflammatory drug.

scholarly journals ANTIINFLAMMATION ACTIVITY ETHANOL EXTRACT OF MARBOSI-BOSI LEAVES (Tarenna polycarpa (Miq.) Koord.Ex Valeton) ON WHITE RAT IN CARRAGEENAN INDUCED PAW INFLAMMATION

2018 ◽  
Vol 6 (3) ◽  
pp. 1-4
Author(s):  
Haris Munandarnst ◽  
Marline N
Keyword(s):  
Diclofenac Sodium ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Inflammatory Activity ◽  
Group Iii ◽  
Rat Paw Edema ◽  
Group I ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Traditionally, (Tarenna polycarpa (Miq.) Koord Ex Valeton as known as marbosi-bosi which commonly found in Sibolga, North Sumatera, Indonesia has been used as antidiabetes, cholesterol, anti-inflammatory and antibacterial. Tarenna species has been found its activities as antimicrobial, anti-oxidant and anti-inflammatory activity. The aim of this study was to investigate the anti inflammatory effect ethanol extract of marbosi-bosi leaves (Tarenna polycarpa (Miq.) Koord Ex Valeton in terms of decreased edema volume of male white rat in 1% carrageenan-induced and also to determine the effective dose of extract to decrease the volume of rat paw edema Ethanol extract of marbosi-bosi (Tarenna polycarpa (Miq.) Koord Ex Valeton was obtained by maceration. The antiinflammatory activity test was divided into 5 groups. The Group I (negative control) was given CMC 0.5%, Group II (positive control) was given diclofenac sodium 2,25 mg / kg BW, while Group III, IV and V were  given marbosi-bosi leaf extract at a dose of 50, 100 and 200 mg/kgBW respectively.  Each rat was induced by 1% carrageenan subplantar injection. Examination of antiinflammatory effect was measured by using digital plethysmometer at minute of 30 to minute of 360. The data were analyzed statistically using ANOVA (analysis of variance).The results showed that negative control did not show anti-inflammatory effect had significant differences with other treatment groups. In conclusion, ethanol extract marbosi-bosi (Tarenna polycarpa (Miq.) Koord Ex Valeton has an effective anti-inflammatory activity at a dose of 100 mg / kgBW.

scholarly journals AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL 70% DAUN ASHITABA (Angelica keiskei) SECARA IN VIVO DENGAN PENGINDUKSI KARAGENAN

2019 ◽  
Author(s):  
Haka As'ada ◽  
Yardi Saibi ◽  
Hendri Aldrat
Keyword(s):  
Dose Range ◽  
White Male ◽  
Ethanol Extract ◽  
Negative Control ◽  
Inflammatory Activity ◽  
Male Rat ◽  
Control Group ◽  
Angelica Keiskei ◽  
Anti Inflammatory

Ashitaba leaves (Angelica keiskei) or also known as tommorow's leaf is plant that known to have various health benefit, one of them is as an anti-inflammatory activity. The anti-inflammatory activity of ashitaba leaves has been known through in vitro assays. This study aims to determine the anti-inflammatory activity of 70% ethanol extract of ashitaba leaves through in vivo assay. Anti-inflammatory activity was performed on white male rat of Sprague dawley strain with induction method of edema on rat's foot using 1% carrageenan 0.2 ml. Rats were divided into 5 groups. The negative control group was given a 0.5% Na-CMC suspension, a positive control group was given sodium diclofenac suspension of 5.14 mg / kgBW, and the test group was given 70% ethanol extract of ashitaba leaves at a dose of 1000; 2000; and 4000 mg / kgBW suspended in 0.5% Na-CMC. The results showed that in that dose range the 70% ethanol extract of ashitaba leaves had anti-inflammatory activity that did not depend on the dose. Percentage of edema of 70% ethanol extract of ashitaba leaves dose 1000; 2000; 4000 mg / kgBB was significantly different with negative control (p ≤ 0,05) and had percentage of edema inhibition respectively 83,95%, 79,01%, and 80,25%. The results of this study showed that 70% ethanol extract of ashitaba leaves have anti-inflammatory activity. Keywords: Ashitaba, Angelica keiskei, tommorow's leaf, anti-inflammatory, carrageenan.

scholarly journals Antihyperlipidemic Effect of Ethanol Extract of Lansau a Traditional Medicine of Muna Ethnic, Indonesia

2020 ◽  
Vol 10 (6) ◽  
pp. 7061-7069
Keyword(s):  
Herbal Medicine ◽  
Medicinal Plants ◽  
Total Cholesterol ◽  
Ethanol Extract ◽  
Negative Control ◽  
Significant Activity ◽  
High Cholesterol ◽  
Control Groups ◽  
Wistar Strain ◽  
Herb Medicine

Lansau is a traditional herb medicine from Muna ethnic, Southeast Sulawesi, Indonesia, consisting of 44 medicinal plants. This study was performed to determine and evaluate the antihyperlipidemic effect of ethanol extract of Lansau in high cholesterol and propylthiouracil induced hyperlipidemic rats. The animal test Wistar strain were used and divided into six groups namely KN (Na. CMC 1%), K (-) (Na CMC 1% + MDLT), K (+) (simvastatin 0.40 mg/kg BW), LS I (Lansau ethanol extract 6.907 mg/kg BW), LS II (ethanol extract Lansau 13.814 mg/kg BW) and LS III (Lansau LS III ethanol extract 27.628 mg/kg BW. The results showed that ethanol extract of traditional Lansau medicine with dose LS I 6.907 mg/kg BW, LS II 27.628 mg/kg BW and LS III 27.628 mg/kg BW have significant activity as antihyperlipidemic (cholesterol and triglyceride) compared to negative control groups (p <0.05) and showed the same activity with simvastatin in lowering total cholesterol and triglyceride levels (p> 0.05), which shows its potential as antihyperlipidemic herbal medicine.

scholarly journals Evaluation Patch of Rhizoma Extract Kencur (Kaempferia galanga L.) as Anti-Inflammatory with Enhancer

2019 ◽  
Vol 6 (2) ◽  
pp. 59
Author(s):  
Hesti Riasari ◽  
Revika Rachmaniar ◽  
Sri Wahyuni
Keyword(s):  
Ethyl Acetate ◽  
Propylene Glycol ◽  
Ethyl Acetate Extract ◽  
Diclofenac Sodium ◽  
Pharmaceutical Preparations ◽  
Ethanol Extract ◽  
Negative Control ◽  
Hexane Extract ◽  
Kaempferia Galanga ◽  
Anti Inflammatory

Kencur (Kaempferia galanga L.) is a family of Zingiberaceae. Several studies have shown that kencur can help reduce inflammation because kencur is known to contain anti-inflammatory compounds, namely marker compounds from flavonoids, kaempferol. For the development of pharmaceutical preparations, research on anti-inflammatory plasters containing 96% ethanol extract, n-hexane extract, ethyl acetate extract and 70% ethanol extract from ginger rhizome with the addition of penetration enhancer (enhancer), namely propylene glycol. This anti-inflammatory plaster was tested for its activity in 5 groups of Wistar strain rat feet which had been induced 1% carrageenan (negative control); positive control (diclofenac sodium), ethanol96% extract, n-hexane extract, ethyl acetate extract and 70% ethanol extract from kencur rhizome and compared with plaster of kencur rhizome ethanol extract without enhancer. The results showed the effect of adding enhancers 30 minutes after administration. 96% ethanol extract and ethyl acetate extract had reduced inflammation by 79.99% in rat test animals compared to plaster ethanol extract of rhizome kencur without the addition of enhancers. Keywords :  Kaempferia galanga. L., patch, anti-inflammatory, enhancer, propylene glycol

UJI AKTIVITAS EKSTRAK ETANOL GAMBIR (Uncaria gambir Roxb.) TERHADAP PENYEMBUHAN LUKA BAKAR PADA KULIT PUNGGUNG MENCIT PUTIH JANTAN (Mus musculus)

2017 ◽  
Vol 1 (2) ◽  
pp. 133
Author(s):  
Fitri Handayani ◽  
Eka Siswanto ◽  
Lintang Ayu Trisna Pangesti
Keyword(s):  
Treatment Group ◽  
Healing Process ◽  
Ethanol Extract ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Test Results ◽  
Anova Analysis ◽  
The People

Gambir (Uncaria gambir Roxb.) contains flavonoids, tannins, saponins and alkaloids that can help in the healing process of burns on the back skin of mice. Gambir has been used for the treatment because it has the effect of antimicrobial and anti-inflammatory. Gambir is used by the people as a traditional medicine to treat burns.This research is experimental research. The object studied is the potential of gambir extract on healing burns of mice back skin. The number of mice used are 15 which divided into 5 groups: the positive control group (branded ointment), negative control group (vaseline flavum), group of gambir ethanol extract and vaseline flavum concentration of 25%, 35%, and 45%. Each group consisted of 3 mice.Backs of the mice induced using a heated solder which tip contained stainlees plate measuring 1x1 cm and placed for 2 seconds on the back skin of mice. The percentage of burns healing is obtained by calculating the surface area of the wound. The data were analyzed using ANOVA analysis followed by LSD test. The results showed that ethanol extract of gambir concentration of 25% with the healing burns percentage of (72.00%), the concentration of 35% (85.00%), and the concentration of 45% (88.67%) have activity on healing burns of back skin of mice. The results of data analysis using ANOVA showed that the data has significant differences with a significance value <0.05 is 0.000. LSD test results stated that each treatment group have significant differences with a significance value <0.05. It can be seen that with increasing dose will be followed by duration of burns healing

scholarly journals Topical treatment of ointment containing ethanol extract of Archidendron pauciflorum fruit peel on the wound healing in streptozotocin-induced diabetic mice

2017 ◽  
Vol 9 (3) ◽  
pp. 306-311 ◽  
Author(s):  
DESAK MADE MALINI ◽  
MADIHAH MADIHAH ◽  
FITRI KAMILAWATI ◽  
NINING RATNINGSIH ◽  
KARTIAWATI ALIPIN ◽  
...  
Keyword(s):  
Wound Healing ◽  
Topical Application ◽  
Topical Treatment ◽  
Healing Process ◽  
Ethanol Extract ◽  
Negative Control ◽  
Control Group ◽  
Diabetic Mice ◽  
Fruit Peel ◽  
Diabetic Wounds

Malini DM, Madihah, Kamilawati F, Ratningsih N, Alipin K, Iskandar J. 2017. Topical treatment of ointment containing ethanol extract of Archidendron pauciflorum fruit peel on the wound healing in streptozotocin-induced diabetic mice. Nusantara Bioscience 9: 306-311. Diabetic wounds lead to severe tissue damage and are difficult to cure. One alternative medicine known well by local Indonesian communities to treat diabetic wounds is the fruit peel of djengkol. This study aimed to evaluate the ointment containing ethanol extract of djengkol fruit peel to accelerate wound healing process in the skin of streptozotocin-induced diabetic mice. The method was experimental using completely randomized design with six treatments and four replications. Diabetes was induced by intraperitoneal injection of streptozotocin 180 mg/kg BW. Mice with blood glucose level ≥150 mg/dL were used for diabetic mice models. The incision wound created at dorsolateral region of shaven skin at ±1 cm2 using sterile scissors. The ointment containing extract was applied topically to the diabetic mice wounds at concentration of 5%, 10% and 15%, as well as Betadine® as the reference group. The ointment basis was applied to the wound of diabetic mice as a positive control and to the wound of non-diabetic mice as a negative control. The treatment was done twice a day for 14 days. The results showed that topical application of ointment containing ethanol extract of djengkol fruit peel at concentration of 10% gave significant recovery (p<0.05) on the wounded skin by the enhancement of re-epithelization and granulation tissue, as well as the increase of capillary number and collagen density which were higher than other treatments and comparable to negative control group. It was concluded that the topical application of ointment containing ethanol extract of djengkol fruit peel can support the healing of diabetic wounds.

scholarly journals UJI AKTIVITAS SEDIAAN KRIM EKSTRAK ETANOL HERBA SELEDRI (Apium graveolens L.) TERHADAP LUKA SAYAT PADA KELINCI (Oryctolagus cuniculus L.)

2018 ◽  
Vol 13 (2) ◽  
pp. 40
Author(s):  
Agust Dwi Djajanti ◽  
Dzul Asfi
Keyword(s):  
Oryctolagus Cuniculus ◽  
Ethanol Extract ◽  
Negative Control ◽  
Apium Graveolens ◽  
Entire Surface ◽  
Activity Test ◽  
Anti Inflammatory ◽  
Negative Controls ◽  
Incision Wound ◽  
Inflammatory Effect

ABSTRACT Research has been carried out on the activity test of preparations for the ethanol extract of celery herbs (Apium graveolens L.) on vegetable wounds on rabbits (Oryctolagus cuniculus L). The aim of this study was to determine the activity of cream preparations for celery herb extract using concentrations of 2% b / v, 4% b / v and negative controls. The activity test was carried out on 2 rabbit test animals by carrying out the same 3 incisions on each rabbit's back with a length of 2 cm, 0.3 cm depth and 1 incision wound for negative control. The observation was carried out to see the pharmacological effects of the cream preparation, namely anti-inflammatory effect, proliferation, and its remodeling as an anti-inflammatory effect is swollen or red, while the proliferation effect is the formation of stopped granulation tissue after the entire surface is covered in the epithelium and the process of wound maturation, and while the remodeling effect is the phase that ends when the inflammation sign is gone. Keywords: Activity, Ethanol Extract, Herbs Celery (Apium graveolens L.), Cut wounds, Rabbits (Oryctolagus cuniculus L.) ABSTRAK Telah dilakukan penelitian tentang Uji Aktivitas Sediaan Krim Ekstrak Etanol Herba Seledri (Apium graveolens L.) Terhadap Luka Sayat Pada Kelinci (Oryctolagus cuniculus L). Penelitian ini bertujuan untuk mengetahui aktivitas sediaan krim ekstrak herba seledri dengan menggunakan konsentrasi 2% b/v, 4% b/v dan kontrol negatif. Uji aktivitas dilakukan pada 2 hewan uji kelinci dengan melakukan 3 luka sayat yang sama disetiap punggung kelinci dengan panjang 2 cm, kedalaman 0,3 cm dan 1 luka sayatan untuk kontrol negatif pengamatan dilakukan untuk melihat efek farmakologi dari sediaan krim tersebut yaitu efek anti inflamasi, proliferasi, dan remodelingnya yang dimaksud efek anti inflamasi adalah bengkak atau merah, sedangkan efek proliferasi adalah pembentukan jaringan granulasi berhenti setelah seluruh permukaan tertutup epitel dan proses pendewasaan luka, dan sedangkan efek remodelingnya adalah fase yang berakhir bila tanda radang sudah hilang. Kata kunci : Aktivitas, Ekstrak etanol, Herba Seledri (Apium graveolens L.), Luka sayat, Kelinci (Oryctolagus cuniculus L.)

scholarly journals Ethanolic Extract of The Graptophyllum Pictum Griff Leaves as Antipyretic agent to Male White Rat

2018 ◽  
Vol 1 (1) ◽  
pp. 59
Author(s):  
Setya Enti Rikomah ◽  
Gina Lestari ◽  
Juwita Winanti
Keyword(s):  
Rural Areas ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Induction Method ◽  
Antipyretic Effect ◽  
Anti Inflammatory ◽  
Statistic Result ◽  
Dpt Vaccine

<p><em>Utilization of plants as traditional medicinal are still always be  used by people in Indonesian. Especially in rural areas that  still rich with variety of plants. Plants  of black pudding leaves (Graptophyllum pictum Griff) are one that efficacious for treating various of diseases. The content of  flavonoid  in the black pudding leaves have  antipyretic effect, analgesic and anti-inflammatory. This research aims to find  out  whether the black pudding leaves have  antipyretic effect or not. This research  used the induction method  of vaccineDPT-Hb 0.022 / 20 gr a white rat as stimulant fever. Positive control with paracetamol 1.3 mg / 20 gram a white rat, negative control with Na CMC 0.5 ml / 20 grams a white rat, first extract test of black pudding leaves  0.8 mg / 20 gram a white rat, second extract test of  black pudding leaves 1.6 / 20 gram a white rat, and third extract test  of black pudding leaves 3.2 / 20 gram a white rat. The results of research showed that ethanol extract of black pudding leaves if it’s looked from  statistic result of SPSS 16 program , it doesn’t  show out of any effect as antipyretic effect because  the significant value  is P&gt; 0.05.</em><em></em></p><strong><em>Keywords: Antipyretic, DPT vaccine Hb, (Graptophyllum pictum)</em></strong>

scholarly journals Inhibitory effects of hydroethanolic extracts from three Cameroonian medicinal plants on proteins inflammation and growth of multi-resistant strains of Mycobacterium tuberculosis

2021 ◽  
Vol 11 (4-S) ◽  
pp. 15-21
Author(s):  
Esther Del florence Ndedi Moni ◽  
Patrick Hervé Diboue Betote ◽  
Christelle Wayoue Kom ◽  
Chimène Félicite Mekoulou Benga ◽  
Armelle Deutou Tchamgoue ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Medicinal Plants ◽  
Inhibitory Action ◽  
Ethanol Extract ◽  
Inflammatory Activity ◽  
Phytochemical Screening ◽  
Resistant Strains ◽  
Anti Inflammatory ◽  
Ethanol Extracts

The present work aimed to determine the phytochemical components and evaluate the in vitro anti-inflammatory and anti-mycobacterial effects of hydroethanolic extracts of Allium sativum L bulbs, Drypetes gossweileri S. MOORE stem-barks and Pentadiplandra brazzeana Baill roots against several resistant strains of Mycobacterium tuberculosis. The phytochemical screenings of extracts were carried out according the colorimetric and precipitation tests to reveal the presence of phytochemical compounds. The anti-inflammatory effects of extracts were evaluated using in vitro Bovine Serum Albumin denaturation and proteinase inhibitory action assays. The inhibitory parameters of hydro-ethanol extracts were evaluated by the microdilution method agaisnt Mycobacterium tuberculosis. The phytochemical screening of hydro-ethanol extracts revealed the presence of phenols, polyphenols, flavonoids, alkaloids, cathechic tannins, triterpens, steroids, anthocyanins and leucoanthocyanins. The anti-inflammatory activity of hydro-ethanol extracts of D. gossweileri, P. brazzeana and A. sativum have shown the inhibitory concentrations 50 (IC50) values ranging from 356.70, 183.30 and 226.30 mg/mL for BSA denaturation and 31.92, 33.62 and 56.93 mg/mL for proteinase inhibitory action respectively. The hydroethanolic extracts of D. gossweileri, P. brazzeana and A. sativum exhibited moderate and weak anti-mycobacterial activities with the minimum inhibitory concentrations (MICs) ranging from 312.5 to 2500 μg/mL. A. sativum hydro-ethanol extract has shown the highest anti-mycobacterial activity with MIC of 312.5 μg/mL against isoniazid resistant of M. tuberculosis and extremely resistant drug strain of M. tuberculosis. These results suggest that hydro-ethanol extracts of A. sativum, D. gossweileri and P. brazzeana are efficient against tuberculosis caused by multi-resistant Mycobacterium tuberculosis strains and are able to resorb the inflammation induced during infection. Keywords: Anti-inflammatory activity, Anti-mycobacterial effect, Hydroethanolic extracts, Medicinal plants, Phytochemical screening.

scholarly journals Anti-Inflammatory Activity ofDelonix regia(Boj. Ex. Hook)

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Vaishali D. Shewale ◽  
Tushar A. Deshmukh ◽  
Liladhar S. Patil ◽  
Vijay R. Patil
Keyword(s):  
Ethanol Extract ◽  
Inflammatory Activity ◽  
Control Group ◽  
Delonix Regia ◽  
Rat Paw Edema ◽  
Phytochemical Investigation ◽  
Cotton Pellet Granuloma ◽  
Anti Inflammatory ◽  
Rat Paw ◽  
Different Doses

The present work was to evaluate the anti-inflammatory activity ofDelonix regialeaves (Family: Caesalpiniaceae). The powder ofDelonix regialeaves was subjected to extraction with ethanol in soxhlet extractor. The ethanol extract after preliminary phytochemical investigation showed the presence of sterols, triterpenoids, phenolic compounds and flavonoids. The anti-inflammatory activity was studied using carrageenan-induced rat paw edema and cotton pellet granuloma at a three different doses (100, 200, and 400 mg/kg b.w. p.o.) of ethanol extract. The ethanol extract ofDelonix regialeaves was exhibited significant anti-inflammatory activity at the dose of 400 mg/kg in both models when compared with control group. Indomethacin (10 mg/kg b.w. p.o) was also shown significant anti-inflammatory activity in both models.

Sign in / Sign up

Export Citation Format

Share Document