To the question of the pathogenetic mechanisms of the influence of obesity on the level of vitamin D

The influence of obesity on human health, as a multifactorial and multigenic disorder, is a rather complex, interdisciplinary and at the same time extremely urgent problem of modern society. Vitamin D deficiency is one of the consequences of obesity that negatively affects a person’s life expectancy. Vitamin D deficiency is rightfully considered a silent, non-infectious metabolic pandemic of the 21st century. Its significant role in the functioning of the human body is deep and multifaceted, since vitamin D is an integral regulator of the transcriptional activity of genes that control 3–5% of the human genome. There are ongoing discussions among experts in the medical community about the negative impact of obesity on 25 (OH) D levels, and the opposite hypothesis is also being discussed, where vitamin D deficiency is considered an independent risk factor for obesity. Both external causes of the formation of vitamin D deficiency against the background of excessive deposition of adipose tissue and internal metabolic processes underlying the pathogenetic association are analyzed two pathological conditions.

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Vitamin D3 and women's health

GYNECOLOGY ◽

10.26442/20795696.2019.1.190235 ◽

2019 ◽

Vol 21 (1) ◽

pp. 44-51

Author(s):

Iuliia E Dobrokhotova ◽

Ekaterina I Borovkova ◽

Sofya A Zalesskaya ◽

Victoria S Skalnaya ◽

Ivan M Borovkov ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Vitamin D3 ◽

Negative Impact ◽

Perinatal Outcomes ◽

Hypovitaminosis D ◽

Malignant Neoplasms ◽

Cellular Functions ◽

Prophylactic Drug ◽

Drug Doses

Background. Vitamin D is an essential component that regulates calcium homeostasis and many other cellular functions. Hypovitaminosis D is associated with a risk of osteopenia, obesity, type 1 and type 2 diabetes, malignant neoplasms and immune disorders. Inadequate vitamin D intake during pregnancy increases a risk of pre-eclampsia, preterm birth, low birth weight as well as it has a negative impact on both children’s and adolescents’ health. It is important for the clinician to be known administrating of vitamin D prophylactic and therapeutic regimens according to serum 25(OH)D levels. Aim. To determine causes and effects of vitamin D deficiency and to elaborate ways of their correction. Materials and methods. To write this review a search for domestic and foreign publications in Russian and international search systems (PubMed, eLibrary, etc.) for the last 2-15 years was conducted. The review includes articles from peer-reviewed literature. Results. The article shows that vitamin D has a significant impact on both the cardiovascular, endocrine, digestive, respiratory and other systems functioning and perinatal outcomes that necessitates vitamin D deficiency correction. It provides schemes for effective therapeutic and prophylactic drug doses calculating depending on vitamin D3 blood serum concentration. Conclusion. Preference should be given to cholecalciferol (vitamin D3) due to its better absorption properties and more efficient conversion to active vitamin metabolites (class IIC).

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Preoperative severe vitamin D deficiency is a significant independent risk factor for poorer functional outcome and quality of life 6 months after surgery for fragility hip fractures

Osteoporosis International ◽

10.1007/s00198-021-05970-y ◽

2021 ◽

Author(s):

D.S. Sim ◽

K. Tay ◽

T.S. Howe ◽

S.B.J. Koh

Keyword(s):

Quality Of Life ◽

Vitamin D ◽

Risk Factor ◽

Functional Outcome ◽

Vitamin D Deficiency ◽

Hip Fractures ◽

Independent Risk Factor ◽

Severe Vitamin ◽

Significant Independent Risk Factor

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Vitamin D Deficiency Is an Independent Risk Factor for Urinary Tract Infections After Renal Transplants

Medicine ◽

10.1097/md.0000000000000594 ◽

2015 ◽

Vol 94 (9) ◽

pp. e594 ◽

Cited By ~ 17

Author(s):

Young Eun Kwon ◽

Hyunwook Kim ◽

Hyung Jung Oh ◽

Jung Tak Park ◽

Seung Hyeok Han ◽

...

Keyword(s):

Vitamin D ◽

Risk Factor ◽

Urinary Tract ◽

Vitamin D Deficiency ◽

Urinary Tract Infections ◽

Independent Risk Factor ◽

Renal Transplants ◽

Tract Infections

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ACTUAL VIEW ON THE VITAMIN D EFFECT ON WOMEN’S HEALTH

V F Snegirev Archives of Obstetrics and Gynecology ◽

10.18821/2313-8726-2019-6-2-73-79 ◽

2019 ◽

Vol 6 (2) ◽

pp. 73-79 ◽

Cited By ~ 1

Author(s):

T. N Savchenko ◽

I. A Dergacheva ◽

Lyudmila A. Ozolinya

Keyword(s):

Vitamin D ◽

Cell Proliferation ◽

Gestational Diabetes ◽

Autoimmune Diseases ◽

Pregnant Women ◽

Cardiovascular System ◽

Vitamin D Deficiency ◽

Inverse Correlation ◽

Acquired Immunity ◽

Pathological Conditions

According to last research, receptors for vitamin D are found in many organs and tissues. Vitamin D deficiency leads to the development of pathological conditions in children and adults. The non-classical effects of vitamin D are important in modulating congenital and acquired immunity, regulating cell proliferation, in the progress of diabetes, the pathology of the cardiovascular system, and autoimmune diseases. The inverse correlation between the level of 25(OH)D3 and the incidence of cancer has been determined. Vitamin D affects the course of pregnancy, and the decidual and placental tissues synthesize 1.25(OH)2D. Vitamin deficiency is found in pregnant women with preeclampsia and gestational diabetes. Timely diagnosis and adequate correction of the level of vitamin D in the blood reduces the risk of developing diseases.

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Do extreme summers increase blood vitamin D (25-hydroxyvitamin D) levels?

PLoS ONE ◽

10.1371/journal.pone.0242230 ◽

2020 ◽

Vol 15 (11) ◽

pp. e0242230

Author(s):

Frank Bernhard Kraus ◽

Daniel Medenwald ◽

Beatrice Ludwig-Kraus

Keyword(s):

Climate Change ◽

Vitamin D ◽

Heat Waves ◽

Negative Impact ◽

Plasma Concentrations ◽

Laboratory Data ◽

Medical Community ◽

Extreme Weather Events ◽

Human Populations ◽

Beneficial Effects

Climate change is expected to increase the frequency of extreme weather events, such as extended heat waves and droughts in the northern hemisphere. Besides affecting ecosystems worldwide, these changes in climate patterns will also affect the environmental health of human populations. While the medical community is mostly concerned with the negative impact of climate change, there might also be some beneficial effects. In this study we used laboratory data from a large university clinic in Germany (n = 13 406), to test for any detectable impact of two extreme summers on Vitamin-D [25(OH)D] plasma concentrations over a six year period (2014–2019). For the two years with extreme summers (2018 and 2019) the 25(OH)D plasma concentrations were significantly higher than in the previous four years (p < 0.001). A time series analysis (autoregressive term, AR, φ = 0.84, with an AR of one indicating a persistent effect) showed that 25(OH)D concentrations rise by 0.04 nmol/l (95% CI: 0.04–0.05 nmol/l) per hour of sunshine. The incidence of vitamin D deficiency was generally high (60% for 2014–2017) but dropped by 10% in 2018 and 2019. As such, the summers of 2018 and 2019, which are among the hottest and driest in Germany since the start of modern climate recordings, had a measurable positive effect on 25(OH)D plasma levels of the examined population. Given that 25(OH)D deficiency is widespread in higher latitudes, this implies that while mostly considered negative, climate change might also confer some health benefits with regard to vitamin D related medical conditions.

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Vitamin D and Platelets: A Menacing Duo in COVID-19 and Potential Relation to Bone Remodeling

International Journal of Molecular Sciences ◽

10.3390/ijms221810010 ◽

2021 ◽

Vol 22 (18) ◽

pp. 10010

Author(s):

Francesca Salamanna ◽

Melania Maglio ◽

Maria Sartori ◽

Maria Paola Landini ◽

Milena Fini

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Bone Remodeling ◽

Bone Health ◽

Feedback Loop ◽

Mineral Metabolism ◽

Bone Fragility ◽

Preliminary Information ◽

Pathological Conditions ◽

Global Data

Global data correlate severe vitamin D deficiency with COVID-19-associated coagulopathy, further suggesting the presence of a hypercoagulable state in severe COVID-19 patients, which could promote thrombosis in the lungs and in other organs. The feedback loop between COVID-19-associated coagulopathy and vitamin D also involves platelets (PLTs), since vitamin D deficiency stimulates PLT activation and aggregation and increases fibrinolysis and thrombosis. Vitamin D and PLTs share and play specific roles not only in coagulation and thrombosis but also during inflammation, endothelial dysfunction, and immune response. Additionally, another ‘fil rouge’ between vitamin D and PLTs is represented by their role in mineral metabolism and bone health, since vitamin D deficiency, low PLT count, and altered PLT-related parameters are linked to abnormal bone remodeling in certain pathological conditions, such as osteoporosis (OP). Hence, it is possible to speculate that severe COVID-19 patients are characterized by the presence of several predisposing factors to bone fragility and OP that may be monitored to avoid potential complications. Here, we hypothesize different pervasive actions of vitamin D and PLT association in COVID-19, also allowing for potential preliminary information on bone health status during COVID-19 infection.

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Association Of Vitamin D Deficiency With Risk Factors In Postmenopausal Women

The American Journal of Applied Sciences ◽

10.37547/tajas/volume03issue04-09 ◽

2021 ◽

Vol 03 (04) ◽

pp. 70-77

Author(s):

N.M. Inoyatova ◽

Keyword(s):

Risk Factors ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Postmenopausal Women ◽

Geographic Location ◽

Overweight And Obesity ◽

Pathological Conditions ◽

Age Related ◽

Oncological Diseases ◽

Basic Level

In conditions of age-related decrease in sex hormones and a number of pathological conditions and diseases in postmenopausal women, there is a deficiency of D hormone. In our country, the geographic location of which is below northern latitude and sufficient ultraviolet radiation, an insufficient content of vitamin D is seen in postmenopausal women. There are a lot of risk factors leading to vitamin D deficiency - the presence of smog and dust in cities, insufficient consumption of vitamin-fortified foods, the presence of problems with the gastrointestinal tract and excretory system and a number of others. One of the important factors that reduce vitamin storage is overweight and obesity, especially in combination with old age, when all absorption processes are reduced. The aim of our research was to study risk factors in women with vitamin D deficiency with subsequent correction of the deficiency state. We examined the level of total 25 (OH) D in the blood serum in 46 postmenopausal women, and identified risk factors. Vitamin D deficiency was detected in 86.96% of women, and its deficiency was registered in 10.87%. At the same time, a pronounced vitamin deficiency was not registered in any patient. Overweight was registered in 32.6%, obesity of varying degrees in 26.1%. Given the indicators, recommendations were given for correcting vitamin D deficiency. All postmenopausal women, especially those with risk factors for deficiency, are recommended to determine the basic level of vitamin D. In case of deficiency, drug correction is recommended to reduce the risk of cardiovascular and oncological diseases.

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INFLUENCE OF MODERN INFORMATION TECHNOLOGIES ON HUMAN PSYCHES

Russian science: actual researches and developments,Part 1 ◽

10.46554/russian.science-2020.03-1-332/334 ◽

2020 ◽

Author(s):

Maria Pavlovna Selezneva ◽

◽

Tatyana Vasilievna Korotaeva ◽

Keyword(s):

Information Technology ◽

Psychological Health ◽

Information Technologies ◽

Negative Impact ◽

Modern Society ◽

Urgent Problem ◽

Advantages And Disadvantages ◽

Full Knowledge ◽

Modern Information

In modern society, the psychological health of a person directly depends on his enlightenment in the field of information technology. It is very important to approach these technologies wisely and evaluate their advantages and disadvantages. Only with full knowledge of information technology, we can know what to do in a given situation. The health of the user of information technology is a very urgent problem. The article considers the positive and negative impact of information technology on the life and psyche of a person.

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