scholarly journals The influence of sibutramine therapy on the body composition and metabolic characteristics of the patients presenting with exogenous constitutional obesity

2012 ◽  
Vol 58 (1) ◽  
pp. 34-38
Author(s):  
Iu Iu Vlasova ◽  
A S Ametov

The treatment of 36 patients suffering exogenous constitutional obesity (ECO) with sibutramine during 12 weeks resulted in the substantial reduction of body weight, waist circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR). Simultaneously, the total cholesterol level in the blood decreased. The reduction in the body weight had positive effect on carbohydrate metabolism. Medicamental treatment of obesity caused a drop in systolic arterial pressure and a substantial change in the body composition. Specifically, percentage of both total and visceral fat as well as basal metabolism decreased, water retention in the body increased while the muscular mass remained unaltered. It is concluded that the introduction of Sibutramine into the combined treatment of exogenous constitutional obesity effectively promotes the reduction of the body weight, improvement of the body composition and metabolic characteristics.

2013 ◽  
Vol 59 (2) ◽  
pp. 26-33
Author(s):  
V A Peterkova ◽  
O V Vasiukova ◽  
P L Okorokov

The objective of the present study was to analyse dynamics of the serum adiponectin levels during treatment of obesity in the adolescents. A total of 34 patients at the age varying from 12 to 17 years presenting with "simple" constitutional exogenous obesity were available for observation. All of them had metabolic complications, such as impaired glucose tolerance, insulin resistance, dyslipidemia, and arterial hypertension. A course of motivational education for the change of lifestyle was provided to 15 patients and their parents in combination with healthy diets, physical activities, and orlistat intake (120 mg, one capsule thrice daily) during 6 months. The patients of the control group (n=19) were given non-medicamental therapy alone. The effectiveness of therapy was estimated before, 6 and 12 months after its initiation. The combined treatment of complicated obesity in the adolescents was shown to promote a decrease of the body weight by 0.04-0.08 SDS of MBI within one year after the onset of therapy. Simultaneously, the degree of dyslipidemia, insulin resistance, and disturbances of carbohydrate metabolism was reduced whereas the serum adiponectin levels increased. The study failed to reveal advantages of orlistat treatment for the reduction of BMI. At the same time, the introduction of this medication into combined therapy of obesity in adolescents resulted in a clinically significant decrease of the frequency of dyslipidemia, largely due to lowering the total cholesterol and LDLP cholesterol levels. Orlistat therapy was well tolerated by the patients. Variations in the adiponectin level were in agreement with body weight dynamics and changes of insulin resistance. It is concluded that low serum adiponectin levels in association with the high frequency of complications may suggest high risk of progression of metabolic disturbances in obese adolescents towards adulthood.


2021 ◽  
Author(s):  
Thiago Ramos de Barros ◽  
Verônica Pinto Salerno ◽  
Thalita Ponce ◽  
Míriam Raquel Meira Mainenti

ABSTRACT Introduction To train and prepare cadets for a career as firefighters in Rio de Janeiro, the second-year students of the Officers Training Course are submitted to a Search, Rescue, and Survival Training (SRST) course, which is characterized by long periods of high physical exertion and sleep restriction during a 9-day instruction module, and food restriction during a 7-day survival module. The present study investigated changes in the body composition of 39 male cadets submitted to SRST during training and 4 weeks of recovery with no restrictions in food consumption. Materials and Methods Each cadet was evaluated by anthropometric measurements at six time points: pre-SRST; after the first module; after the second module; and after 1, 2, and 4 weeks of recovery. Measurements included body girths and skinfolds, to estimate trunk (chest and waist) and limbs (arm and thigh) dimensions, as well as body composition. Repeated measures ANOVA and Friedman test were applied (depending on each data distribution). Results Statistically significant decreases in body weight (76.2; 69.8-87.2 to 63.9; 58.9-73.5 kg) and fat free mass (FFM, 69.2; 63.7-77.2 to 60.1; 56.2-68.0 kg) were observed following the second module of SRST. Following a single week of recovery, the FFM returned to pre-SRST values. Body weight returned to pre-training levels in 2 weeks. Body fat percentage and mass also significantly decreased during SRST (9.0; 7.7-12.3 to 6.5; 5.1-9.3% and 6.9; 5.6-10.0 to 6.9; 5.6-10.0 kg, respectively), which showed a slower and more gradual recovery that reached pre-SRST values after 4 weeks. The girths of arm, thigh, chest and waist significantly decreased due to SRST. The girths of the limbs (arm and thigh) returned to pre-training values after one month of recovery, while the girths of the trunk (chest and waist) did not return to pre-SRST values during the study period. Conclusions The findings suggest that men who experience periods of high energy demands and sleep restriction followed by a period of food restriction will endure unavoidable physical consequences that can be mostly reversed by a 1-month recovery.


Author(s):  
Marius Baranauskas ◽  
Valerija Jablonskienė ◽  
Jonas Algis Abaravičius ◽  
Rimantas Stukas

There are about 466 million people with hearing impairments in the world. The scientific literature does not provide sufficient data on the actual nutrition and other variables of professional deaf athletes. The objectives of this study were to investigate and evaluate the body composition, the physical working capacity, the nutrition intake, and the blood parameters of iron and vitamin D in the Lithuanian high-performance deaf women’s basketball team players. The female athletes (n = 14) of the Lithuanian deaf basketball team aged 26.4 ± 4.5 years were recruited for an observational cross-sectional study. A 7-day food recall survey method was used to investigate their actual diet. The measurements of the body composition were performed using the BIA (bioelectrical impedance analysis) tetra-polar electrodes. In order to assess the cardiorespiratory and aerobic fitness levels of athletes, ergo-spirometry (on a cycle ergometer) was used to measure the peak oxygen uptake (VO2peak) and the physical working capacity at a heart rate of 170 beats per minute (PWC170). The athletes’ blood tests were taken to investigate the red blood cells, hemoglobin, 25-hydroxyvitamin D, ferritin, transferrin, iron concentrations, and total iron-binding capacity (TIBC). The consideration of the VO2peak (55.9 ± 6.1 mL/min/kg of body weight, 95% CI: 51.8, 58.9) and the low VO2peak (56–60 mL/min/kg of body weight) (p = 0.966) in the deaf women’s basketball team players revealed no differences. For the deaf female athletes, the PWC170 was equal to 20.3 ± 2.0 kgm/min/kg of body weight and represented only the average aerobic fitness level. The carbohydrate and protein intakes (5.0 ± 1.3 and 1.3 ± 0.3 g/kg of body weight, respectively) met only the minimum levels recommended for athletes. The fat content of the diet (38.1 ± 4.1% of energy intake) exceeded the maximum recommended content (35% of energy intake) (p = 0.012). The mean blood serum concentrations of 25(OH)D and ferritin (24.1 ± 6.6 nmol/L and 11.0 ± 4.1 µg/L, respectively) predicted vitamin D and iron deficits in athletes. Female athletes had an increased risk of vitamin D and iron deficiencies. Regardless of iron deficiency in the body, the better cardiorespiratory fitness of the deaf female athletes was essentially correlated with the higher skeletal muscle mass (in terms of size) (r = 0.61, p = 0.023), the lower percentage of body fat mass (r = −0.53, p = 0.049), and the reduced intake of fat (r = −0.57, p = 0.040).


1972 ◽  
Vol 27 (2) ◽  
pp. 305-312 ◽  
Author(s):  
Sharad V. Apte ◽  
Leela Iyengar

1. The body composition was determined of forty-one fetuses of different gestational ages born to mothers belonging to a low socio-economic group of the population.2. With increasing gestational age the water content fell from 88% at 28 weeks to 76% at term; the fat content increased from 2.1% to 11.2% and the protein content increased from 6.9 to 9.3%.3. The changes in body composition were more closely related to body-weight than to gestational age.4. The calcium, Phosphorus and magnesium contents of the body per unit fat-free weight progressively increased with gestational age, and at term the values appeared to be considerably lower than those reported in the literature. The Ca:P ratio was constant at different body-weights.5. The body iron content per unit of fat-free weight increased marginally with increasing gestational age. The value was almost 30% lower than the values reported from elsewhere.6. It is suggested that chemical composition and nutrient stores of the developing foetus can be considerably influenced by the state of maternal nutrition.


Author(s):  
M Wan Zahari ◽  
J K Thompson ◽  
D Scott

The effects of plane of nutrition on the body composition of growing sheep are very apparent when animals are compared at the same age following different nutritional histories. These differences are, however, less obvious when animals of the same breed and sex are compared at the same body weight and at present there is some conjecture whether composition is affected by growth rate. This uncertainty is not limited to fat and protein but includes the bone and ash, fraction and the ash composition.The primary objective of this trial was to study the effects of different growth rates achieved by feeding different amounts of the same concentrate diet on the composition of empty-body gain and on the retention of minerals by growing lambs. A secondary objective was to examine the effect of adding supplementary calcium carbonate to the basal diet at the fast rate of growth.


1985 ◽  
Vol 58 (2) ◽  
pp. 500-505 ◽  
Author(s):  
R. Bulbulian ◽  
K. K. Grunewald ◽  
R. R. Haack

The purpose of this study was to examine the effects of daily exercise of varying duration on the body composition, weight, and feed intake of mature Swiss albino mice. Fifty-four male mice were equally divided into a control group and five exercise groups (n = 9) performing 20, 40, 60, 120, and 240 min of daily exercise on a treadmill (7.2 m/min). Feed intake and body weight were measured weekly for 10 wk. At the completion of the study the mice were killed and the animal carcasses were chemically analyzed for fat, dry matter, and protein content. The results of this study demonstrate no differences in the body weight among groups (P less than 0.97) with all groups gaining 4.5–5.8 g during the 10-wk period. However, fat content decreased significantly from 15.7% in the control to 12.0% in the 120- and 240-min exercise groups (P less than 0.05). In contrast, protein content showed an insignificant rising trend from 13.0 to 14.6% with increasing duration of exercise. Feed intake showed a nonsignificant drop during the 20-min exercise treatment and remained unchanged among groups. These data show a slight but variable appetite-suppressing effect of light exercise in mice accompanied by favorable body composition changes even in the absence of differences in body weight. These findings suggest the mouse to be an acceptable experimental model for body composition and exercise studies.


2020 ◽  
Vol 92 (1) ◽  
pp. 1-5
Author(s):  
Przemysław Dzierżek ◽  
Krzysztof Kurnol ◽  
Wojciech Hap ◽  
Ewelina Frejlich ◽  
Agata Diakun ◽  
...  

Introduction An adequate level of nutrition is important in the period of reconvalescence in patients undergoing major surgery, in particular due to neoplastic disease. Bioelectrical impedance (BIA - Bioelectrical Impedance Analysis) is a widely used technique for assessing body composition. BIA measurement is easy, fast, cheap and repeatable. Material and methods The body composition of 56 patients (25 women and 31 men) was assessed with bioelectrical impedance analysys. All patients was hospitalized and operated in the Department of General and Oncological Surgery, Wrocław Clinical University Hospital in 2017-2018. Results The average weight loss on the 4th postoperative day is 1.32%, and at discharge from hospital 4.23% of body weight in relation to body weight at admission to the ward. The percentage of fat tissue (FM-Fatt Mass) in patients admitted to the ward is above the normal range. The change in body weight composition in hospitalized patients is mainly related to the amount of adipose tissue and the amount of extra- and intracellular water (ECW-Extracellular Water, ICW-Intracellular Water). Conclusions Bioelectrical impedance can be an easy and effective method to assess body composition and its change in patients undergoing major surgery. Patients operated on due to pancreatic cancer lose the highest percentage of body weight until discharge from the ward in relation to body weight at the time of admission to the ward from the analyzed groups. Weight loss mainly occurs as fat loss (FM).


1964 ◽  
Vol 6 (3) ◽  
pp. 309-319 ◽  
Author(s):  
S. K. Stephenson

1. Body shape and carcass composition have been measured in a dated series of Romney-Southdown cross and Australian Merino sheep foetuses.2. Large differences in shape exist between the two breed groups and these result from growth rate differences in certain components of the bone and muscle tissue.3. Carcass composition at any particular foetal weight, however, is more uniform. In relation to body weight, the Merino has a higher proportion of bone in the body but the proportion of muscle is the same in both breed groups. Nevertheless, the distribution of muscle tissue is changed as there s i a higher proportion of muscle in the hind limb of the Romney-Southdown cross.


2017 ◽  
Vol 6 ◽  
Author(s):  
Iris Mayumi Kawauchi ◽  
Juliana Toloi Jeremias ◽  
Paula Takeara ◽  
Danilo Ferreira de Souza ◽  
Júlio Cesar de Carvalho Balieiro ◽  
...  

AbstractNeutering is a common veterinary recommendation and is often associated with obesity development. Thus, the aim of the present study was to evaluate the effects of two different amounts of protein intake by neutered dogs regarding maintenance energy requirement (MER), body composition, and biochemical and hormonal parameters. A total of fourteen healthy adult dogs were fed either a diet containing 59·7 g protein/1000 kcal (4184 kJ) (P60) or a diet with 94·0 g protein/1000 kcal (4184 kJ) (P94) for 26 weeks after neutering to maintain their body weight prior to neutering. A mixed model was fitted to verify diet, time and diet × time interaction effects on biochemical parameters, serum concentrations of insulin, glucagon, leptin and insulin-like growth factor-1 (IGF-1). MER and the body composition data were evaluated within diets (paired t test) and within times (unpaired t test). A time effect was found for fructosamine, TAG, total lipids and IGF-1 serum concentrations. The diet × time interaction was significant for glucagon (P < 0·05). No differences between diets in the MER within each time were found. However, there was a reduction in the MER of dogs fed the P60 diet 26 weeks after neutering (P = 0·042). The fat body mass of dogs fed the P60 diet increased (P < 0·05) after neutering, even without a body-weight change. Some of the biochemical parameters changed over time, but all remained within the normal range. For the period evaluated in the present study, a diet with 94·0 g of protein/1000 kcal (4184 kJ) metabolisable energy seems to be a beneficial nutritional strategy to maintain the MER and the body composition of dogs after neutering.


1965 ◽  
Vol 43 (2) ◽  
pp. 297-308 ◽  
Author(s):  
J. S. Hayward

The body composition in terms of fat, water, and protein has been determined for 115 deer mice (genus Peromyscus) of six racial stocks. The changes in composition that are characteristic of seasonal extremes and that accompany laboratory acclimation are presented. The composition of the fat-free body exhibits the constancy which has been found in other mammals. Body protein averaged 22.97% and body water 69.71% of the fat-free body weight. Body fat levels are shown to vary considerably among individuals and races. The highest fat levels occurred in the desert-adapted race (P. m. sonoriensis). The importance of considering body composition in comparative studies of metabolic rate is discussed.


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