Prevalence and risk factors of polycystic ovarian syndrome among an ethnically diverse overweight/obese adolescent population

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Jacqueline Maya ◽  
Janet Siegel ◽  
Tina Q. Cheng ◽  
Thaina Rousseau-Pierre
Keyword(s):  
Risk Factors ◽  
Suicidal Ideation ◽  
Acanthosis Nigricans ◽  
Polycystic Ovary ◽  
Significant Risk ◽  
Obese Adolescent ◽  
Obese Adolescents ◽  
Prevalence Of Depression ◽  
Hispanic Patients ◽  
Self Harm

AbstractBackgroundMore remains to be known about polycystic ovary syndrome (PCOS) among overweight/obese adolescents across different ethnicities especially in regards to mental illness as an associated comorbidity.ObjectiveTo determine the prevalence of PCOS among overweight and obese adolescents and to evaluate known risk factors for PCOS in a diverse population.MethodsCharts of patients at an Adolescent Clinic between April 1, 2016 and July 30, 2018 were filtered using: obese, overweight and body mass index (BMI) >85%. Charts were reviewed to identify the presence of PCOS using National Institutes of Health (NIH) criteria, race/ethnicity and known risk factors for PCOS [lipid, BMI, glycated hemoglobin (HA1c), blood pressure (BP)] and mental health conditions associated with PCOS (anxiety/depression and self-harm/suicidal ideation).ResultsPatients with PCOS were more likely to have elevated lipids (19.6% vs. 9.9%, p = 0.05), be obese (67.4% vs. 50.9%, p = 0.03), and have acanthosis nigricans (68.9% vs. 28.2%, p =< 0.001). PCOS was more common among non-Hispanic patients (77.9%) vs. Hispanic patients (57.8%). There was no difference in the prevalence of depression/anxiety (37% vs. 33%, respectively, p = 0.590) or self – harm/suicidal ideation (17% vs. 17%, p = 0.96) in patients with and without PCOS. In a logistic regression model, after adjusting for all demographics and clinical features, ethnicity, acanthosis nigricans and BMI were significant risk factors for PCOS.ConclusionPatients with PCOS are more likely to be obese, hyperlipidemic, have acanthosis nigricans and be of non-Hispanic ethnicity. However, there was no difference in the prevalence of depression/anxiety and self-harm/suicidal ideation among adolescents with or without PCOS.

Suicidal ideation during pregnancy in British Pakistani women

2016 ◽  
Vol 33 (S1) ◽  
pp. s272-s272
Author(s):  
A. Sharif ◽  
M. Husain ◽  
N. Gire ◽  
B. Tomenson ◽  
N. Chaudhry ◽  
...  
Keyword(s):  
Risk Factors ◽  
Social Support ◽  
Suicidal Ideation ◽  
Significant Risk ◽  
Depression Scale ◽  
Major Public Health Problem ◽  
Post Natal Depression ◽  
Self Harm ◽  
Pakistani Women ◽  
Severe Life Events

IntroductionSuicide is a major public health problem and one of the common causes of maternal mortality. Rates of suicide and self-harm are higher in British South Asian women compared to the majority white population. Suicidal Ideation (SI) is a significant risk factor associated with self-harm and suicide.ObjectiveTo explore the prevalence and risk factors of SI in British Pakistani women.AimTo identify risk factors associated with SI, in order to inform future preventive strategies.MethodThis is a secondary analysis of a larger study which looked at depression during pregnancy and infant outcomes. Participants who consented (women aged 18 or over, in their third pregnancy trimester) were initially assessed for maternal depression using the Edinburgh Post-Natal Depression Scale (EPDS), with one of the questions on the EPDS being on SI. Participants who met the study criteria, were further assessed regarding socio-demographic factors, perceived social support, social adversity and isolation.ResultsThe rate of SI in this group of women was 8.1%, with baseline interview results suggesting that women with SI being significantly more likely to be aged 20 or less, have experience of severe life events and being less likely to have social support.ConclusionThis area of research is key to understanding SI in British Pakistani women, to better develop culturally sensitive interventions for use within this group.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Attachment Organization in Suicide Prevention Research

Crisis ◽  
2014 ◽  
Vol 35 (1) ◽  
pp. 60-66 ◽  
Author(s):  
Amanda Venta ◽  
Carla Sharp
Keyword(s):  
Risk Factors ◽  
Suicidal Ideation ◽  
Suicide Attempt ◽  
Interpersonal Relationships ◽  
Suicide Ideation ◽  
Suicide Attempts ◽  
Critical Role ◽  
Self Report ◽  
Future Research ◽  
Self Harm

Background: Identifying risk factors for suicide-related thoughts and behaviors (SRTB) is essential among adolescents in whom SRTB remain a leading cause of death. Although many risk factors have already been identified, influential theories now suggest that the domain of interpersonal relationships may play a critical role in the emergence of SRTB. Because attachment has long been seen as the foundation of interpersonal functioning, we suggest that attachment insecurity warrants attention as a risk factor for SRTB. Aims: This study sought to explore relations between attachment organization and suicidal ideation, suicide attempts, and self-harm in an inpatient adolescent sample, controlling for demographic and psychopathological covariates. Method: We recruited 194 adolescents from an inpatient unit and assigned them to one of four attachment groups (secure, preoccupied, dismissing, or disorganized attachment). Interview and self-report measures were used to create four variables reflecting the presence or absence of suicidal ideation in the last year, single lifetime suicide attempt, multiple lifetime suicide attempts, and lifetime self-harm. Results: Chi-square and regression analyses did not reveal significant relations between attachment organization and SRTB, although findings did confirm previously established relations between psychopathology and SRTB, such that internalizing disorder was associated with increased self-harm, suicide ideation, and suicide attempt and externalizing disorder was associated with increased self-harm. Conclusion: The severity of this sample and methodological differences from previous studies may explain the nonsignificant findings. Nonsignificant findings may indicate that the relation between attachment organization and SRTB is moderated by other factors that should be explored in future research.

scholarly journals Risk Factors for Suicidal Ideation and Self-Harm among Undergraduate Students in a Private University in Ogun State, Nigeria

2021 ◽  
Vol 4 (6) ◽  
pp. 29-42
Author(s):  
Johnson F.A. ◽  
Ogunsanmi L. ◽  
Ayokanmi I.
Keyword(s):  
Risk Factors ◽  
Suicidal Ideation ◽  
Young People ◽  
Significant Relationship ◽  
Suicide Ideation ◽  
Rating Scale ◽  
Intrapersonal Factors ◽  
Factors Influencing ◽  
Point Rating Scale ◽  
Self Harm

Background: Today, the most prevalent and the leading cause of death among young people is suicide. Worldwide, suicide accounts for an estimated 6% of all deaths among young people. The study examined the various risk factors for suicidal ideation and self-harm amongst Babcock University undergraduates. Method: Descriptive survey research design was utilized with a multistage sampling technique to select 398 undergraduates. The instrument for data collection was a semi-structured questionnaire that sought information on the environmental, social, and intrapersonal factors influencing suicide ideation and self-harm. Results were presented via means and percentages for descriptive statistics; correlation and regression were used to determine the associations between suicidal ideation and the risk factors. Ethical clearance was sought from Babcock University Health Research Ethics Committee. Results: The distribution of participants showed that 46.0% (183) were males while 54.0% (215) were females. Environmental factors influencing suicidal ideation were computed and measured on a 21-point rating scale with a mean ± SD of 13.38±3.458. The respondents' mean ± SD for the social factors measured on a 27-point rating scale was 17.15±5.772. Correlation analysis showed that suicide ideation had a statistically significant relationship with gender (p<0.01), parents' spousal relationship (p<0.01), environmental (p<0.01), social (p<0.01), and intrapersonal factors (p<0.01). Self-harm had a significant relationship with parents' relationship (p<0.01), environmental (p<0.01), social (p<0.01) and intrapersonal factors (p<0.01). However, the practice of self-harm was not different across the two genders (p = 0.170). Conclusion: Suicidal behaviors have been seen to be a serious public health concern. The prevention and intervention programs of suicide and self-harm should consider the particular characteristics of adolescent suicide and self-harm. This should include social transmission and recognition of mental health disorders.

Polycystic Ovary Syndrome and Non-Suicidal Self-Injury: A community-based study

2021 ◽  
Author(s):  
Sophie Williams ◽  
Dean Fido ◽  
David Sheffield
Keyword(s):  
Suicidal Ideation ◽  
Polycystic Ovary Syndrome ◽  
Emotion Dysregulation ◽  
Polycystic Ovary ◽  
Indirect Pathway ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Self Injury ◽  
Suicidal Intention ◽  
Self Harm

Polycystic Ovary Syndrome (PCOS) is an endocrine condition that has been associated with atypical emotional regulation strategy use as well as elevated levels of depression, anxiety, self-harm, and suicidal ideation. Despite the existence of clinical screening guidance for this population, there is still little to know understanding of how non-suicidal self-injury and suicidal ideation and intention manifests in women with PCOS, and how this might differ from women without PCOS. Within this cross-sectional investigation, women with and without a diagnosis of PCOS (n = 418) completed validated metrics of emotion dysregulation, rumination, and non-suicidal self-injury, as well as self-reported indices of previous suicidal ideation and future suicidal intention. Group comparisons indicated that women with, relative to those without PCOS reported significantly greater metrics across all variables. Moreover, serial mediation analyses were conducted to test the ideation-to-action framework of suicide in women with PCOS, with the positive relationship between a PCOS diagnosis and future suicidal intention being explained through the indirect pathway of increased emotion dysregulation, recent suicidal ideation, and NSSI. Our findings call to action the need for international screening for suicide intention and self-harm in women with PCOS.

Abstract P023: Risk Factors Associated with Progression of Subclinical Diastolic Dysfunction in a Multiethnic Population

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Lili Zhang ◽  
Jian Shan ◽  
Cynthia Taub
Keyword(s):  
Risk Factors ◽  
Renal Disease ◽  
Diastolic Dysfunction ◽  
Significant Risk ◽  
Left Ventricular ◽  
Cumulative Probability ◽  
Factors Associated ◽  
Hispanic Patients ◽  
Multiethnic Population

Background: Subclinical diastolic dysfunction is defined as echocardiographic evidence of left ventricular diastolic dysfunction and normal ejection fraction (EF) without congestive heart failure (HF) symptoms/diagnosis. Our study, for the first time, sought to examine risk factors associated with progression from subclinical diastolic dysfunction to overt HF in a large multiethnic population. Methods: The study population included patients with asymptomatic diastolic dysfunction and EF ≥ 50% assessed by transthoracic echocardiogram between 2003 and 2008 at Montefiore Medical Center, Bronx, NY. Patients with preexisting HF, valvular heart disease or atrial fibrillation prior were excluded. The end point was the development of HF by September 1, 2013. Multivariable adjusted Cox proportional hazards models, determined by stepwise selection method, were performed to examine risk factors associated with the development of HF. All analyses were also performed with adjustment and stratification of race. Results: A total of 7,879 patients, with 21% European Americans (EA), 36% African Americans (AA), 31% Hispanics, and 12% others or unknown, were included in the analysis. Mean follow up time was 6.3 years. Mean age of the cohort was 68±12, with 63% women. The overall cumulative probability of development of HF was 17% (19% in EA, 17% in AA, 19% in Hispanic patients) during the follow up period. In multivariable Cox proportional hazard regression analysis, renal disease (hazard ratio (HR)=1.6, 95% confidence interval (CI) 1.3-2.0, P<0.001) and hemoglobin levels (HR=0.9, 95% CI 0.9-1.0, P=0.001) were significantly associated with the development of HF in overall population. In stratification analysis, age (P=0.012) and hypertension (P=0.007) were independent risk factors for HF in Hispanic patients, but not in EA and AA. Conclusions: In a large multiethnic population with subclinical diastolic dysfunction, renal disease and hemoglobin levels were independently associated with development of HF in overall population.. Age and hypertension were significant risk factors for HF only in Hispanic patients. These results may have important implications in preventing the development of HF from subclinical stage.

scholarly journals Assessment on Occurrences of Depression and Anxiety and Associated Risk Factors in the Infertile Chinese Men

2017 ◽  
Vol 11 (3) ◽  
pp. 767-774 ◽  
Author(s):  
Bin Yang ◽  
Jianchao Zhang ◽  
Yuxia Qi ◽  
Pu Wang ◽  
Ronghuan Jiang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Psychological Symptoms ◽  
Short Form ◽  
Significant Risk ◽  
Anxiety Symptoms ◽  
Reproductive Age ◽  
Depression And Anxiety ◽  
Male Population ◽  
Chinese Men ◽  
Prevalence Of Depression

The prevalence of depression and anxiety in the Chinese male population with infertility is still uncertain. The prevalence of depression, anxiety, and a combination of both psychological symptoms was 20.8%, 7.8%, and 15.4%, respectively in 771 infertile Chinese men in the current study by the Mental Health Inventory–5 and the State–Trait Anxiety Inventory–Short Form questionnaires. Differences in demographics (age, education, and income) had no noticeable impact on the development of psychological symptoms. Clinical factors such as concomitant disorders (varicocele, epididymal cyst, and erectile dysfunction) were identified as risk factors associated with depressive symptoms ( OR = 1.47; 95% CI [1.14, 1.90]; p < .001) and both depressive and anxiety symptoms ( OR = 1.56; 95% CI [1.17, 2.08]; p < .001). An infertility duration over 2 years was associated with a high risk of anxiety symptoms ( OR = 3.94; 95% CI [1.20, 12.93], p < .02). Other clinical conditions such as type of treatment and quality of sperm were not significant risk factors for psychological symptoms. This study provides evidence that Chinese men of reproductive age who suffer from infertility are vulnerable to psychological distress.

scholarly journals Risk factors for suicidal ideation and suicide attempt among medical students: A meta-analysis

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0261785
Author(s):  
Chanhee Seo ◽  
Christina Di Carlo ◽  
Selina Xiangxu Dong ◽  
Karine Fournier ◽  
Kay-Anne Haykal
Keyword(s):  
Risk Factors ◽  
Mental Illness ◽  
Risk Factor ◽  
Medical Students ◽  
Suicidal Ideation ◽  
Suicide Attempt ◽  
Meta Analysis ◽  
Significant Risk ◽  
Individual Risk ◽  
Factors Associated

Background Medical training poses significant challenge to medical student wellbeing. With the alarming trend of trainee burnout, mental illness, and suicide, previous studies have reported potential risk factors associated with suicidal behaviours among medical students. The objective of this study is to provide a systematic overview of risk factors for suicidal ideation (SI) and suicide attempt (SA) among medical students and summarize the overall risk associated with each risk factor using a meta-analytic approach. Methods Systemic search of six electronic databases including MEDLINE, Embase, Education Source, Scopus, PsycInfo, and CINAHL was performed from database inception to March 19, 2021. Studies reporting original quantitative or epidemiological data on risk factors associated with SI and SA among undergraduate medical students were included. When two or more studies reported outcome on the same risk factor, a random-effects inverse variance meta-analysis was performed to estimate the overall effect size. Results Of 4,053 articles identified, 25 studies were included. Twenty-two studies reported outcomes on SI risk factors only, and three studies on both SI and SA risk factors. Meta-analysis was performed on 25 SI risk factors and 4 SA risk factors. Poor mental health outcomes including depression (OR 6.87; 95% CI [4.80–9.82] for SI; OR 9.34 [4.18–20.90] for SA), burnout (OR 6.29 [2.05–19.30] for SI), comorbid mental illness (OR 5.08 [2.81–9.18] for SI), and stress (OR 3.72 [1.39–9.94] for SI) presented the strongest risk for SI and SA among medical students. Conversely, smoking cigarette (OR 1.92 [0.94–3.92]), family history of mental illness (OR 1.79 [0.86–3.74]) and suicidal behaviour (OR 1.38 [0.80–2.39]) were not significant risk factors for SI, while stress (OR 3.25 [0.59–17.90]), female (OR 3.20 [0.95–10.81]), and alcohol use (OR 1.41 [0.64–3.09]) were not significant risk factors for SA among medical students. Conclusions Medical students face a number of personal, environmental, and academic challenges that may put them at risk for SI and SA. Additional research on individual risk factors is needed to construct effective suicide prevention programs in medical school.

scholarly journals HYPERPLASTIC PROCESSES OF ENDOMETRIUM IN WOMEN OF PERIMENOPAUSAL AGE: CLINICAL ASPECTS OF THE PROBLEM

2017 ◽  
Vol 4 (4) ◽  
pp. 201-207
Author(s):  
Dmitry V. Baburin ◽  
A. L Unanyan ◽  
I. S Sidorova ◽  
E. A Kudrina ◽  
A. I Ishchenko
Keyword(s):  
Risk Factors ◽  
Mathematical Model ◽  
Logistic Regression ◽  
Endometrial Cancer ◽  
Malignant Transformation ◽  
Polycystic Ovary ◽  
Treatment Plan ◽  
Significant Risk ◽  
Binary Logistic Regression ◽  
Clinical Aspects

The aim of the study is to identify the most significant clinical and anamnestic risk factors for the onset and progression of endometrial hyperplastic processes and the development of malignant transformation of endometrium in women of perimenopausal age, with taking into account their importance on the basis of statistical analysis. Methods. Based on Spearman’s correlation analysis and determination the degree of dependence of the development of endometrial cancer (from 0 to 1) on clinical-anamnestic and diagnostic risk factors (risk ratio (RR) in groups), there were obtained coefficients for a mathematical model allowing with the use of the binary logistic regression method predict the risk of the appearance of endometrial cancer. Results. The most clinically and statistically significant risk factors for the progression of the pathological process of the endometrium, having a high RR (greater than 1) and a confidence interval of 95% (p < 0.05), are (in the order of significance): recurrence of the endometrial hyperplastic process, obesity, the pronounced blood flow in Ultrasound with color Doppler mapping, polycystic ovary syndrome, abnormal ovarian formations, infertility (primary and secondary), type 2 diabetes mellitus, combined uterine pathology (myoma and/or adenomyosis), hereditary predisposition to cancer development, hypertension, age of 50 years and older. Conclusion. The tactics of the management and treatment of patients with hyperplastic endometrial processes should be based on the detection of the degree of the risk of the progression of pathological processes and the development of the malignant transformation of the endometrium. The study of the individual prognosis of endometrial cancer in patients with hyperplastic endometrial processes currently is becoming increasingly important due to the need to construct a rational treatment plan of the management and performing the follow-up dispensary observation on the basis of a scientifically justified forecast. Results obtained during our work allowed us identify statistically significant risk factors for the development of endometrial cancer. There were obtained coefficients for the creation a reliable mathematical model. With the use of the method of binary logistic regression, it is possible to calculate the risk of developing cancer and choose an effective management tactic for patients with hyperplastic endometrial processes at the perimenopausal age.

scholarly journals Is Fatty Liver Associated With Depression? A Meta-Analysis and Systematic Review on the Prevalence, Risk Factors, and Outcomes of Depression and Non-alcoholic Fatty Liver Disease

2021 ◽  
Vol 8 ◽  
Author(s):  
Jieling Xiao ◽  
Lincoln Kai En Lim ◽  
Cheng Han Ng ◽  
Darren Jun Hao Tan ◽  
Wen Hui Lim ◽  
...  
Keyword(s):  
Risk Factors ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Meta Analysis ◽  
Significant Risk ◽  
Alcoholic Fatty Liver ◽  
Pooled Prevalence ◽  
Prevalence Of Depression ◽  
History Of ◽  
Alcoholic Fatty Liver Disease

Background and Aims: Both non-alcoholic fatty liver disease (NAFLD) and depression have a high global prevalence which is projected to increase further. While studies exploring the association have been done, there are conflicting data. This study aims to assess the prevalence and association between depression and NAFLD.Methods: Medline and Embase were searched from inception to March 3, 2020. Meta-analysis of proportions using the generalized linear mix model was conducted to analyze the pooled prevalence of depression in NAFLD patients. Risk factors for depression in NAFLD patients were evaluated in conventional pairwise meta-analysis.Results: Ten studies involving 2,041,752 NAFLD patients were included. Pooled prevalence of depression was 18.21% (CI: 11.12–28.38%) in patients with NAFLD and 40.68% (CI: 25.11–58.37%) in patients with non-alcoholic steatohepatitis (NASH). NAFLD resulted in significantly higher risk of development of depression (OR: 1.29, CI: 1.02–1.64, p = 0.03). NASH patients had a significantly higher risk of depression compared with NAFLD patients (RR: 2.83, CI: 2.41–3.32, p &lt; 0.001). Diabetes, body mass index (BMI), female sex, smoking, and history of pulmonary disease were significant risk factors for depression in NAFLD patients.Conclusion: This study demonstrated a high prevalence of depression in NAFLD patients and a significant association between both conditions. Furthermore, patients with NASH had a significantly higher risk of depression compared with those with NAFLD. Diabetes, BMI, history of lung disease or smoking, and female gender were significant risk factors. Further studies investigating the pathophysiological mechanism underlying depression and NAFLD are needed.

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