scholarly journals Association of gene polymorphisms with women urinary incontinence

Open Medicine ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. 1190-1197
Author(s):  
Povilas Aniulis ◽  
Aurelija Podlipskyte ◽  
Alina Smalinskiene ◽  
Rosita Aniuliene ◽  
Mindaugas Jievaltas
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Urinary Incontinence ◽  
Gene Polymorphism ◽  
Adrenergic Receptor ◽  
Gene Polymorphisms ◽  
Serotonin Receptor ◽  
Control Group ◽  
History Of ◽  
And Control

Abstract Aim of study was set to investigate the association of women urinary incontinence (UI) with serotonin receptor HTR2A T102C and beta 3-adrenergic receptor ADRB3 Trp64Arg genes polymorphisms. The study included 110 women with Urge, Stress, and Mixed UI types and the control group – 105 continent women. Both groups have filled in the ICIQ-FLUTS questionnaire and their blood genotyping was performed. Urge UI subgroup was older and had higher body mass index (BMI) in comparison to other UI types and control group. More than half of all women had family history of UI in Stress UI and Mixed UI subgroups. The frequency of HTR2A T102C gene polymorphism’s minor allele C and genotype CC was significantly more expressed in Urge UI subgroup, as compared with control group (C-77.3 vs 58.7%, p = 0.007 and CC-57.6 vs 31.1%, p = 0.015). The ADRB3 Trp64Arg gene polymorphism did not differ between groups. The regression analysis revealed CC genotype (OR = 3.06, 95% CI: 1.11–8.43; p = 0.030) and allele C (OR = 2.53, 95% CI: 1.16–5.53; p = 0.020) were risk factors for development of Urge UI. We conclude that HTR2A T102C gene polymorphism affected the development of Urge UI.

scholarly journals Functional Polymorphisms of Matrix Metalloproteinases 1 and 9 Genes in Women with Spontaneous Preterm Birth

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Nina Pereza ◽  
Ivana Pleša ◽  
Ana Peterlin ◽  
Žiga Jan ◽  
Nataša Tul ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Gene Polymorphisms ◽  
Control Group ◽  
Spontaneous Preterm Birth ◽  
Functional Polymorphisms ◽  
Fetal Birth Weight ◽  
Gestational Age At Delivery ◽  
History Of ◽  
Caucasian Women ◽  
And Control

Objective. The aim of this study was to investigate the association of functionalMMP-1-1607 1G/2G andMMP-9-1562 C/T gene polymorphisms with spontaneous preterm birth (SPTB; preterm birth with intact membranes) in European Caucasian women, as well as the contribution of these polymorphisms to different clinical features of women with SPTB.Methods and Patients. A case-control study was conducted in 113 women with SPTB and 119 women with term delivery (control group). Genotyping ofMMP-1-1607 1G/2G andMMP-9-1562 C/T gene polymorphisms was performed using the combination of polymerase chain reaction and restriction fragment length polymorphism methods.Results. There were no statistically significant differences in the distribution of neither individual nor combinations of genotype and allele frequencies ofMMP-1-1607 1G/2G andMMP-9-1562 C/T polymorphisms between women with SPTB and control women. Additionally, these polymorphisms do not contribute to any of the clinical characteristics of women with SPTB, including positive and negative family history of SPTB, gestational age at delivery, and maternal age at delivery, nor fetal birth weight.Conclusion. We did not find the evidence to support the association ofMMP-1-1607 1G/2G andMMP-9-1562 C/T gene polymorphisms with SPTB in European Caucasian women.

scholarly journals Prognosis of the development of pneumonia in children at the outbreak of respiratory mycoplasmosis

2017 ◽  
Vol 98 (6) ◽  
pp. 921-927 ◽  
Author(s):  
S P Kokoreva ◽  
O A Razuvaev
Keyword(s):  
Risk Factors ◽  
Past History ◽  
Binary Logistic Regression ◽  
Control Group ◽  
Mycoplasma Pneumonia ◽  
Focus Of Infection ◽  
History Of ◽  
Mycoplasmal Pneumonia ◽  
And Control

Aim. To identify risk factors for mycoplasma pneumonia at the outbreak of respiratory mycoplasmosis in the children’s collective using a comprehensive statistical analysis. Methods. 120 children aged 12-15 years from the focus of respiratory mycoplasmosis outbreak were observed. They were divided into two groups: study group - 33 children with mycoplasma pneumonia, and control group - 56 children from the focus of infection, 14 of which during the observation period had no disease simptoms, and 42 children had other forms of respiratory mycoplasmosis. Results. 6 factors influencing the development of mycoplasma pneumonia were identified in children from the focus of respiratory mycoplasmosis outbreak. The correlation analysis was performed and one-dimensional models of the chance of developing pneumonia were constructed by calculating odds ratios. Past history of pneumonia increases the risk for pneumonia by 23.46 times, passive smoking in a child - by 2.77 times. At the same time, emergency prevention with immunotropic drugs reduces the risk for pneumonia by 8.93 times, daily walking - by 3.31 times, walking for more than 2 hours - by 3.83 times, increasing fruit in the diet - by 3.09 times and taking multivitamins - by 2.56 times compared to cases when these measures were not taken. The binary logistic regression was calculated to build a multidimensional research model. The sensitivity of this model was 87.88%, specificity - 91.07%. Conclusion. At the outbreak of respiratory mycoplasmosis the risk factors for the development of mycoplasmal pneumonia are pneumonia in past medical history, smoking in a child’s family; preventive measures are long-term daily exposure to fresh air, emergency prevention with immunotropic, complex multivitamin preparations with trace elements and lactic acid bacteria, dietary intake corrected for fruit intake.

scholarly journals PRIORITY RECOMMENDATIONS FOR SOLVING THE PROBLEM OF CHILDREN OBESITY BASED ON THE RESULTS OF THE RESEARCH

2021 ◽  
Vol 74 (5) ◽  
pp. 1099-1103
Author(s):  
Viktor A. Ohniev ◽  
Kateryna H. Pomohaibo ◽  
Mihail I. Kovtun
Keyword(s):  
Risk Factors ◽  
Medical Care ◽  
Children And Adolescents ◽  
Overweight And Obesity ◽  
Control Group ◽  
Obese Children ◽  
Primary Medical Care ◽  
Children Obesity ◽  
History Of ◽  
And Control

The aim: Of the work was to study and evaluate the risk factors and the level of primary medical care for children with overweight and obesity. Materials and methods: A sociological survey was conducted in main (413 persons) and control group (396 persons) and the copying from the history of the child’s development (f.112/a) of 280 obese children was conducted. Results: It was defined that on the development of excess weight in children and adolescents, biological and social and hygienic factors had a significant impact (η ≥ 3%; p<0,001) and that the level of primary medical care for obese children (proved diagnosis of obesity in the history of the child (f. №.112/а) had only 61,7±2,7% of patients) was insufficient. Conclusions: Identification of comprehensive priority activities for solving problem of children overweight and obesity based on the results of conducted research were done.

scholarly journals Plantar Fasciitis Risk Factorsin Normal Population

2018 ◽  
Vol 15 (2) ◽  
pp. 427-430
Author(s):  
Hadi Ghotbi Joshvaghan ◽  
Farzad Omidi-Kashani
Keyword(s):  
Risk Factors ◽  
Plantar Fasciitis ◽  
Normal Population ◽  
Control Group ◽  
Control Groups ◽  
Orthopedic Surgeon ◽  
History Of ◽  
The Difference ◽  
And Control ◽  
Bony Spur

Conservative treatments results for plantar fasciitis patients are inconsistent and therefore manipulating risk factors could be the best option for this disease. To determine risk factors of plantar fasciitis. In a retrospective study, all patients who had plantar fasciitis were enrolled and were compared to control group on their demographic characteristics. The angle of dorsi-flexion was recorded by examination of orthopedic surgeon, history of pregnancy and time of standing in one day. Plantar curvature was measured by orthopedic surgeon. Female sex percentage was significantly higher in PF group than male sex (p=0.007), but the difference in sex was not significant between PF and control groups (p=0.22). Body mass index (BMI) above 30 was significantly higher in PF group compare to control group (p=0.013). Presence of bony spur was significantly higher in PF group compare to control group (p=0.03). There were significant differences in foot curve degree in patients between PF and control groups (p=0.037). Odds ratio (OR) of plantar fasciitis was 1.65 times in patients with bony spur. History of pregnancy increase OR of plantar fasciitis 1.37 times (OR:1.37; 95% CI:1.20-1.82, p=0.017). Plantar fasciitis is associated with higher BMI, pregnancy, bony spur and foot curve cavus. However, it seems that a predisposing foot structural factor should also be accompanied with these risk factors.

scholarly journals Risk factors of bronchiolitis

2013 ◽  
Vol 53 (1) ◽  
pp. 21
Author(s):  
I Gde Doddy Kurnia Indrawan ◽  
IB Subanada ◽  
Rina Triasih
Keyword(s):  
Risk Factors ◽  
Cigarette Smoke ◽  
Preterm Infants ◽  
Exclusive Breastfeeding ◽  
Statistical Significance ◽  
Control Group ◽  
Case Group ◽  
History Of ◽  
Matched Case ◽  
And Control

Background Bronchiolitis peak incidence is in children aged 2 -6months. History of atopy in parents, non-exclusive breastfeeding,exposure to cigarette smoke, and infants living in crowded areasmay be risk factors for bronchiolitis. Gestational of age at birth isalso influences the mortality oflower respiratory tract infection.Objective To evaluate the following conditions as possiblerisk factors for bronchiolitis: history of atopy, non-exclusivebreastfeeding, preterm infants, exposure to cigarette smoke, and2:: 6 persons residing in the home.Methods A sex-matched case-control study was conductedby collecting data from medical records at Sanglah Hospital,Denpasar. The case group subjects met the diagnostic criteriafor bronchiolitis and were aged 1-24 months. The control groupincluded patients with diagnoses unrelated to the respiratorysystem. Data was analyzed using bivariate (Mc.N emar) andmultivariate methods (logistic regression) with 95% confidenceintervals and statistical significance value of P <0 .05.Results There were 96 subjects in our study, consisted of 48subjects in the case group and 48 in the control group. Thecase and control groups were similar in baseline characteristics.The presence of history of atopy (OR 34.7; 95%CI 3 to 367,P=0.003), non-exclusive breastfeeding (OR 4.3; 95%CI 1.4 to13, P=0.010), exposure to cigarette smoke (OR 3; 95%CI 1 to9.2, P=0.047), and 2:: 6 persons living in the home (OR 7.9;95%CI 2.6 to 24, P<0.0001) were found to be significant riskfactors for bronchiolitis, while the preterm infants seem notsignificant as a risk factor of bronchiolitis (OR3; 95%CI 0.31 to78.99, P=0.625).Conclusion History of atopy, non-exclusive breastfeeding,exposure to cigarette smoke, and 2:: 6 persons living in the homeare found to be risk factors, while preterm infants seem not a riskfactor for bronchiolitis.

scholarly journals Identifying Factors That Contribute to Adolescent Bony Stress Injury in Secondary School Athletes: A Comparative Analysis With a Healthy Athletic Control Group

2019 ◽  
Vol 11 (4) ◽  
pp. 375-379 ◽  
Author(s):  
Eric D. Nussbaum ◽  
Jaynie Bjornaraa ◽  
Charles J. Gatt
Keyword(s):  
High School ◽  
Body Mass Index ◽  
Body Mass ◽  
Weight Training ◽  
Control Group ◽  
Shin Splints ◽  
Dairy Intake ◽  
Significant Difference ◽  
History Of ◽  
And Control

Background:Bony stress injuries (BSIs) are common among adolescents involved in high school sports. A better understanding of factors that contribute to adolescent BSI is needed to target preventative measures.Hypothesis:Individuals who suffer a BSI will demonstrate significant differences in training methods, sleep, diet, and history of injury compared with a healthy, noninjured control group.Study Design:Descriptive epidemiologic study.Methods:Data from the National High School Stress Fracture Registry (NHSSFR), an internet-based adolescent BSI survey, were used to identify variables reported with adolescent (13-18 years of age) BSI. These findings were compared with a survey of 100 (50 males, 50 females) healthy athletic controls to identify significant differences between healthy adolescents and those with BSI.Results:A total of 346 stress fractures were reported in 314 (206 females, 108 males) athletes within the NHSSFR. Comparison with healthy control participants demonstrated multiple significant findings. In particular, body mass index was significantly lower for patients with BSI injury compared with controls ( P < 0.001). Patients slept significantly less than the control group (7.2 vs 7.95 hours; F = 34.41; P < 0.001). Females also slept significantly less hours than males (7.2 vs 7.63 hours; F = 11.02; P < 0.001). Fifty-eight percent of those who reported a BSI did not engage in any weight training. Those with a BSI had significantly higher average stress ratings than control participants (1.67 vs 1.42; P < 0.001), and females also rated their stress levels significantly higher than males (1.8 vs 1.38; P < 0.001). A significant difference between patients with any BSI and control participants existed for history of “shin splints” (Pearson χ2= 28.31; P < 0.001), and females also expressed having shin pain lasting for longer than 4 weeks (Pearson χ2= 8.12; P < 0.001) and more often (Pearson χ2= 5.84; P = 0.02) than males. There was also a significant difference between patients with BSI and control subjects regarding dairy intake (2.25 vs 2.69; F = 6.43; P = 0.01).Conclusion:Findings revealed significant differences between those who reported a BSI relative to healthy athletic adolescents. These differences included body mass index, prior history of shin splints, involvement in weight training, amount of sleep, daily stress, and dairy intake. Preventive measures should be developed to address these areas to reduce the incidence of BSIs in the adolescent population.

Performing high-level sport is strongly associated with urinary incontinence in elite athletes: a comparative study of 372 elite female athletes and 372 controls

2017 ◽  
Vol 52 (24) ◽  
pp. 1586-1590 ◽  
Author(s):  
Alice Carvalhais ◽  
Renato Natal Jorge ◽  
Kari Bø
Keyword(s):  
Risk Factors ◽  
Urinary Incontinence ◽  
Family History ◽  
Potential Risk ◽  
Urinary Infection ◽  
Elite Athletes ◽  
Control Group ◽  
Potential Risk Factors ◽  
History Of ◽  
High Level

ObjectiveTo evaluate the prevalence of urinary incontinence (UI) in female elite athletes compared with controls and to investigate potential risk factors for UI among elite athletes.MethodsThis cross-sectional study included 372 elite athletes (athletes group, AG) and 372 age-matched controls (control group, CG). The median age was low (19 years) and the vast majority were nulliparous. Potential risk factors, including clinical, demographic and sports practice characteristics, were collected by using a questionnaire. The International Consultation on Urinary Incontinence Questionnaire-Urinary Incontinence-Short Form was applied to estimate the prevalence of UI. OR with 95% CIs were used to estimate the association with UI. The final model was adjusted for constipation, family history of UI and history of urinary infection.ResultsThe prevalence of UI was 29.6% and 13.4% in AG and CG, respectively (p<0.001). The following prevalences were obtained: AG: 19.6% and CG: 3.5% (p<0.001) for stress UI, AG: 3.8% and CG: 5.4% (p=0.292) for urgency UI and AG: 5.9% and CG: 0.8% (p<0.001) for mixed UI. After adjustment, performing high-level sport (adjusted (adj) OR=3.31; 95% CI 2.20 to 4.97), family history of UI (adj OR=1.54; 95% CI 1.04 to 2.29), history of urinary infection (adj OR=1.53; 95% CI 1.05 to 2.23) and constipation (adj OR=1.79; 95% CI 1.07 to 2.98) were associated with UI.ConclusionThe prevalence of UI among Portuguese female elite athletes is high and the odds of UI were three times higher than in controls. Also, constipation, family history of UI and history of urinary infections were significantly associated with UI.

scholarly journals Faktor Risiko Kematian Ibu

2013 ◽  
Vol 7 (10) ◽  
pp. 453
Author(s):  
Nurul Aeni
Keyword(s):  
Risk Factors ◽  
Maternal Mortality ◽  
Maternal Mortality Ratio ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
Group Data ◽  
Mortality Ratio ◽  
History Of ◽  
And Control

Angka Kematian Ibu (AKI) di Kabupaten Pati bergerak fluktuatif dan menunjukkan status tertinggi pada tahun 2011 dengan 126 per 100.000 kelahiran hidup. Tujuan penelitian ini adalah menggambarkan kematian ibu di Kabupaten Pati dan menganalisis faktor risiko kematian maternal di Kabupaten Pati Tahun 2011. Penelitian menggunakan pendekatan observasional analitik dengan metode kasus kontrol. Jumlah sampel adalah 24 untuk setiap kelompok kasus dan kelompok kontrol. Analisis data menggunakan uji univariat, bivariat dan multivariat. Hasil dari penelitian adalah tiga penyebab utama kematian ibu di Kabupaten Pati adalah penyakit jantung, preeklamsi/eklamsi, dan perdarahan. Kematian ibu tersebar di 16 kecamatan dari 21 kecamatan yang ada dan sebagian besar kematian terjadi pada masa nifas. Analisis regresi logistik menunjukkan bahwa faktor yang berpengaruh terhadap kematian ibu adalah komplikasi kehamilan (OR = 12,198, nilai p = 0,010), komplikasi persalinan (OR = 9,94, nilai p = 0,020) dan riwayat penyakit (OR = 27,735, nilai p = 0,011). Secara bersama-sama, ketiga variabel tersebut berkontribusi terhadap 64,3% kematian ibu yang terjadi di Kabupaten Pati Tahun 2011.Maternal Mortality Ratio (MMR) of Pati Regency fluctuated and showed the highest state in 2011 with 126 per 100.000 live births. This research aimed to describe maternal mortality cases in Pati Regency and to analyze risk factors of maternal mortality happened in 2011. This research used observational analysis, i.e. cases control study. The number of samples was 24 in each of case group and control group. Data was analyzed with univariate, bivariate, and multivariate. This research resulted that three major causes of maternal mortality were heart disease, preeclampsia/eclampsia, and hemorrhage. Maternal mortality spread on 16 from 21 sub-districts on Pati Regency and the majority of them happened in post delivery period. Logistic regression analysis concluded that risk factors influenced maternal mortality were pregnancy complication (OR = 12.198, p value = 0.010), delivery complication (OR = 9.94, p value = 0.020) and history of illness (OR = 27.735, p value = 0.011). Collectively, those variables contributed to 64.3% of maternal mortality in Pati Regency 2011.

CARDIOVASCULAR RISK FACTORS PECULIARITIES IN MEN UNDER 60 YEARS OLD WITH MYOCARDIAL INFARCTION AND CHRONIC INFLAMMATORY LUNG DISEASES

2020 ◽  
pp. 21-25
Author(s):  
Tupitsyn V.V. ◽  
Bataev Kh.M. ◽  
Men’shikova A.N. ◽  
Godina Z.N.
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Heart Disease ◽  
Cardiovascular Risk ◽  
Digestive System ◽  
Control Group ◽  
Study Group ◽  
Type I ◽  
Internal Organs ◽  
History Of

Relevance. Information about the cardiovascular diseases risk factors (CVD RF) for in men with chronic lung inflam-matory pathology (CLID) is contradictory and requires clarification. Aim. To evaluate the peculiarities of CVD RF in men under 60 years of age with CLID in myocardial infarction (MI) to improve prevention. Material and methods. The study included men aged 19-60 years old with type I myocardial infarction. Patients are divided into two age-comparable groups: I - the study group, with CLID - 142 patients; II - control, without it - 424 patients. A comparative analysis of the frequency of observation of the main and additional cardiovascular risk fac-tors in groups was performed. Results. In patients of the study group, more often than in the control group we observed: hereditary burden of is-chemic heart disease (40.8 and 31.6%, respectively; p = 0.0461) and arterial hypertension (54.2 and 44.6%; p = 0.0461), frequent colds (24.6 and 12.0%; p = 0.0003), a history of extrasystoles (19.7 and 12.7%; p = 0.04); chronic foci of infections of internal organs (75.4 and 29.5%; p˂0.0001), non-ulcer lesions of the digestive system (26.1 and 14.6%; p = 0.007), smoking (95.1 and 66.3%; p˂0.0001), MI in winter (40.8 and 25.9%; p = 0.006). Less commonly were observed: oral cavity infections (9.2 and 23.6%; p˂0.0001); hypodynamia (74.5 and 82.5%; p = 0.0358), over-weight (44.4 and 55.2%; p = 0.0136), a subjective relationship between the worsening of the course of coronary heart disease and the season of the year (43.7 and 55.2%; p = 0.0173) and MI - in the autumn (14.1 and 21.9%; p = 0.006) period. Conclusions. The structure of CVD RF in men under 60 years of age with CLID with MI is characterized by the pre-dominance of smoking, non-ulcer pathology of the digestive system, frequent pro-student diseases, meteorological dependence, a history of cardiac arrhythmias and foci of internal organ infections. It is advisable to use the listed factors when planning preventive measures in such patients.

THE RISK FACTORS OF MOLAR PREGNANCY

2017 ◽  
pp. 53-58
Author(s):  
Lam Huong Le
Keyword(s):  
High Risk ◽  
Gestational Trophoblastic Disease ◽  
Living Standard ◽  
Control Group ◽  
Uterine Perforation ◽  
Molar Pregnancy ◽  
Health It ◽  
Pregnancy Risk ◽  
History Of ◽  
And Control

Objectives: Molar pregnancy is the gestational trophoblastic disease and impact on the women’s health. It has several complications such as toxicity, infection, bleeding. Molar pregnancy also has high risk of choriocarcinoma which can be dead. Aim: To assess the risks of molar pregnancy. Materials and Methods: The case control study included 76 molar pregnancies and 228 pregnancies in control group at Hue Central Hospital. Results: The average age was 32.7 ± 6.7, the miximum age was 17 years old and the maximum was 46 years old. The history of abortion, miscarriage in molar group and control group acounted for 10.5% and 3.9% respectively, with the risk was higher 2.8 times; 95% CI = 1.1-7.7 (p<0.05). The history of molar pregnancy in molar pregnancy group was 9.2% and the molar pregnancy risk was 11.4 times higher than control group (95% CI = 2.3-56.4). The women having ≥ 4 times births accounted for 7.9% in molar group and 2.2% in control group, with the risk was higher 3.8 times, 95% CI= 1.1-12.9 (p<0.05). The molar risk of women < 20 and >40 years old in molar groups had 2.4 times higher than (95% CI = 1.1 to 5.2)h than control group. Low living standard was 7.9% in molar group and 1.3% in the control group with OR= 6.2; 95% CI= 1.5-25.6. Curettage twice accounted for 87.5%, there were 16 case need to curettage three times. There was no case of uterine perforation and infection after curettage. Conclusion: The high risk molar pregnancy women need a better management. Pregnant women should be antenatal cared regularly to dectect early molar pregnancy. It is nessecery to monitor and avoid the dangerous complications occuring during the pregnancy. Key words: Molar pregnancy, pregnancy women

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