scholarly journals Prediction of acute pancreatitis severity via the combined analysis of inflammatory biomarkers and coagulation parameters

2017 ◽  
Vol 25 (3) ◽  
pp. 237-244
Author(s):  
Snezana Tesic Rajkovic ◽  
Biljana Radovanovic Dinic ◽  
Miodrag Djordjevic ◽  
Goran Marjanovic ◽  
Sasa Grgov
Keyword(s):  
Acute Pancreatitis ◽  
Coagulation Factors ◽  
Inflammatory Biomarkers ◽  
Systemic Complications ◽  
Mathematical Formula ◽  
Coagulation Parameters ◽  
Group Iii ◽  
Group I ◽  
Combined Use ◽  
Group B

AbstractIntroduction. Timely assessment of severity of acute pancreatitis is needed to avoid severe systemic complications by making optimal therapeutic approach and correct prognosis of the disease. The aim of the study was to establish the role of several inflammatory biomarkers and coagulation parameters in prediction of AP severity, and also to propose a mathematical formula which allows their combined use for the same purpose. Material and Methods. The prospective study included 70 patients with AP. The patients were divided into groups: mild (group I), moderate (group II) and severe AP (group III). All patients were further classified into two groups: group A (mild AP) and group B (moderate and severe AP). Biochemical markers, inflammatory biomarkers and coagulation factors were tested in all patients. Results. Based on the results of Mann-Whitney,s test, it can be concluded that groups A and B are significant different from each other for CRP (p<0.05). Using the Wald’s stepwise forward method, a prediction model with CRP, PCT, D-dimer1, D-dimer3, fibrinogen1 and fibrinogen3 parameters as predictors of the severity of AP was obtained. The percentage of successful prediction of moderate or severe AP based on this model was 76.9%. The use of ROC analysis with the introduced linear combination from the logistic regression yielded equally good or even better results in the assessment of the severity of AP with the combined use of analyzed parameters. Conclusion. The combined analyses of biohumoral markers and coagulation parameters presented in the form a mathematical formula enabled a more accurate, rapid, rational and clinically available prediction of the severity of AP.

scholarly journals ЗАСТОСУВАННЯ КВІНАПРИЛУ ТА L-АРГІНІНУ З МЕТОЮ КОРЕКЦІЇ ЕНДОТЕЛІАЛЬНОЇ ДИСФУНКЦІЇ У ПАЦІЄНТІВ ІЗ АНКІЛОЗИВНИМ СПОНДИЛОАРТРИТОМ ТА В ПОЄДНАННІ З ГІПЕРТОНІЧНОЮ ХВОРОБОЮ

2018 ◽  
Author(s):  
S. I. Smiian ◽  
B. O. Koshak ◽  
U. S. Slaba
Keyword(s):  
Reactive Hyperemia ◽  
Population Level ◽  
Group Iv ◽  
Group Iii ◽  
Group I ◽  
Combined Use ◽  
Group Ii ◽  
Cv Disease ◽  
And Control ◽  
Concomitant Hypertension

Mortality rate among patients with AS is 2 times higher the population level. It is caused by cardiovascular disease. Now it is clear that the presence of chronic systemic inflammation is an important predictor of cardiovascular (CV) disease due to the development of endothelial dysfunction (ED).The aim of the study – to evaluate the efficacy of correction of ED in patients with AS and arterial hypertension with the use of quinapril and L-arginine aspartate.Materials and Methods. A total of 110 patients with AS were examined with evaluation endothelium-depended vasodilation (EDVD) in response to reactive hyperemia, were chosen patients with EDVD <10 % (n=79), and were divided into 4 groups. Group I included 17 people who received standard therapy. Patients from the group II (n=20) received intravenous infusion of the solution of L-Arginine. Group III included patients with concomitant hypertension and they received quinapril (n=19). Group IV (n=23) consist of patients with hypertension, but their treatment was combination of L-arginine with quinapril.Results and Discussion. It was found that in the group II there was a significant improvement in the endothelium’s function (EDVD (23.2±2.4) % (p=0.0023), and its normalization were in 7 patients. In patients of the third group, who received only quinapril were not found normalization of EDVD in any of the patients. In last group (IV) 7 patients showed normalization of the endothelium, 10 improvements compared with baseline levels, and 6 no changes were observed.Conclusions. L-arginine in the complex therapy of patients with AC can significantly reduce the manifestations of ED in patients without concomitant hypertension. Combined use of quinapril in combination with L-arginine demonstrated improvement of endothelial function and control of blood pressure in patients with hypertension.

Modified Diet Supplementation With Group B Vitamins Changes Antioxidant Defense Activity Of Brain

2018 ◽  
Vol 88 (5-6) ◽  
pp. 291-299 ◽  
Author(s):  
Zuzanna Goluch-Koniuszy ◽  
Radosław Drozd
Keyword(s):  
Brain Tissue ◽  
Antioxidant Status ◽  
Antioxidant Defense ◽  
Iron Concentration ◽  
B Vitamins ◽  
Group Iii ◽  
Group I ◽  
Male Wistar Rats ◽  
Group B ◽  
Modified Diet

Abstract. The research aimed at effect of modified diet and supplementation with synthetic B vitamins on brain antioxidant status evaluation. Forty male Wistar rats were divided into 4 groups (n = 10); group I – fed Basic Diet (BD), groups II-IV – Modified Diet (MD), where wheat flour replaced 83.5 % wheat and sucrose replaced 50 % maize. Groups I-II received only water, while group III (MD + AS) was given an aqueous vitamins solution supplementing deficiency from diet modification (MD + Adequate Supplementation: B1-0.94, B2-0.48, B6-0.5, niacin-1.9 mg); group IV (MD + ES) received a solution in order to supplement deficiency resulting from the change in diet and recommended prophylactic dose of vitamins (MD + Excessive Supplementation: B1-3.1, B2-2.3, B6-2.4, niacin-6.65 mg). The experimental phase lasted 6 weeks. Blood serum was examined, to determine glucose and iron concentration; determination of FRAP in plasma, in brain tissue the activities of GST, GPx, CAT, SOD, SH content, and FRAP. It was found that MD and MD + AS did not influence cereal antioxidant status. In brain tissue, MD + ES group exhibited an increased glycaemia (7.49 mmol×l-1 p = 0.038) and increased activity of antioxidant enzymes activity (GST 0,099 U/mg protein p = 0.005; GPx 0,039 U/mg protein p = 0.007). Brain tissue of rats also exhibited larger content of protein bond SH in comparison to BD, MD and MD + AS groups (SH 414.6 mmol/g wet weight p < 0.001; p < 0.005). These findings suggest that, an excessive supplementation with vitamins B and niacin, in sucrose rich diet, may lead to enhancing activity of cellular antioxidant defense in brain tissue of rats.

Comparison of Repeated Chemical and Microwave Disinfection on Dimensional Accuracy of Gypsum Casts

2021 ◽  
Vol 30 (04) ◽  
pp. 235-242
Author(s):  
Mariya Khalid ◽  
◽  
Mohammad Ali Chughtai ◽  
Sohrab Shaheed ◽  
Syed Nasir Shah
Keyword(s):  
Sample Size ◽  
Sodium Hypochlorite ◽  
Dimensional Accuracy ◽  
Dimensional Change ◽  
Control Group ◽  
Group Iii ◽  
Group I ◽  
Significant Difference ◽  
Group A ◽  
Group B

OBJECTIVE: The aim of this experimental study is to compare the dimensional accuracy of gypsum casts after repeated disinfection in microwave at 900 Watts, 2450 MHz (5 minutes) and immersion in 0.5% Sodium hypochlorite (10 minutes). Disinfecting casts is recommended to prevent cross infection but may cause dimensional changes. During fabrication of prosthesis, a cast may get contaminated several times so there is a need of repeated disinfection. METHODOLOGY: Sample size was 33 (11 in each group), calculated through WHO software for sample size determination by using standard deviation of 0.16 at 95% confidence interval and 80% power of study. Impressions in irreversible hydrocolloid were recorded of an acrylic cast fabricated for this study. The impressions were poured with die stone and were randomly divided into 3 groups; Group I: Microwave disinfection, Group II: Immersion disinfection in 0.5% Sodium hypochlorite, Group III: Control group. For Groups I and II, each cast was disinfected 7 times with 5 minutes interval between two disinfection cycles, after every cycle anteroposterior and mediolateral measurements were recorded using digital Vernier caliper (accuracy upto 0.01 mm). For group III, casts were rinsed with distilled water, dried in open air within temperature range of 28+/-2OC for 10 mins followed by anteroposterior and mediolateral measurements. This procedure was repeated seven times for each cast. RESULTS: Anteroposterior and Mediolateral differences of dimensional change between and within the Group A, B and C was calculated by One Way ANOVA. Inter/intra examiner reliability was taken into consideration at the time of study. Mean dimensional change in the casts were insignificant through six disinfecting cycles. However, in the seventh cycle, a significant difference (p=0.003) was observed in the anteroposterior dimension (0.03% dimensional change for Group A and 1.26 % for Group B whereas, in mediolateral dimension, dimensional change was 0.35% for Group A and 0.59% for Group B (p=0.004). Dimensional change of >0.5% was considered as the cutoff value for casts to be considered as dimensionally accurate. Casts disinfected through immersion disinfection did not produce dimensionally inaccurate casts in anteroposterior dimension after third cycle and in seventh cycle in mediolateral dimension. However, result is significant only in seventh cycle. Microwave disinfection produced dimensionally accurate casts throughout all cycles. CONCLUSION: Microwave disinfected casts remained dimensionally stable compared to immersion disinfection. KEYWORDS: Disinfection, microwave, immersion, dimensional stability, gypsum casts

Plasma Circulating Levels of Soluble P-Selectin and Thrombospondin-1 (TSP1) Are Elevated in Patients with Cancer and a Shortened Activated Partial Thromboplastin Time (APTT) without Clinical Evidence of Thrombosis: An Inexpensive and Simple Test (APTT) To Be Considered for Its Clinical Value.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 4098-4098
Author(s):  
Fabiola E. Del Carpio-Cano ◽  
Diana Zamora-Rangel ◽  
Miguel A. Rosales-Manoatl ◽  
Maria R. Rivas-Gonzalez ◽  
Eduardo Cervera-Ceballos ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coagulation Factors ◽  
Laboratory Measurements ◽  
Clinical Value ◽  
Group Iii ◽  
Patients With Cancer ◽  
Group I ◽  
Group Ii ◽  
Circulating Levels ◽  
D Dimer

Abstract There is evidence of shortening of the APTT in patients afflicted with and without cancer, and cancer is a well known underlying condition associated with hypercoagulability. Increased levels of coagulation factors such as VIII, IX, XI, II, and fibrinogen have been demonstrated as independent risk factors for venous thromboembolism (VTE). However, there is evidence that high levels of circulating factor VIII levels are not the only determinant for a shortened APTT (Blood2004; 104:3631) and likely the same case for the other factors including fibrinogen levels. A shortened APTT in a patient with cancer with no evidence of a thrombotic event could be of clinical value in particular when the cost of measuring individual coagulation factors previously identified as risk factors for VTE would be very high. A lack of understanding of the underlying mechanism leading to a shortened APTT in the absence of VTE limit its clinical use, particularly for the clinical management of the patient presenting at admission with this phenomenon in association with cancer. In this case-control prospective study, we have investigated a potential mechanism associated with a shortened APTT in patients with cancer without evidence of thrombosis. The rationale for this study was a previous observation supporting a functional role of TSP1 in the generation of thrombin on a cell surface (Thrombosis Research2005; 116: 533). The study was comprised of 69 human subjects subdivided in three separate groups, Group I, was constituted by 23 normal human volunteers, Group II included 23 patients without a shortened APTT and cancer, Group III was comprised of 23 patients with cancer with a shortened APTT (see table). Groups I and II were matched with group III by age and gender. In addition patients in Group II were matched with Group III by the type of cancer. Laboratory measurements included APTT, D-Dimer, soluble E, L, and P-Selectins as well as TSP1. Platelet and neutrophil counts were determined by automated methods. Laboratory measurements demonstrating a significant difference in Group III when compared with Group I and II were P-Selectin and TSP1. These results were independent of the platelet count in Group III. However the significant elevated circulating levels in plasma of P-Selectin in Group III are evidence supporting platelet activation. There was a trend for higher levels of D-Dimer in Group III (P &lt; 0.17) when compared with Group II (P&lt; 0.76), in accordance with previous studies reported in the literature. In summary, this prospective study demonstrates a potential association of a shortened APTT in patients with cancer with elevated circulating levels of soluble P-Selectin and TSP1. Our laboratory is currently investigating in more detail this interesting finding as well as the prospective clinical follow up of patients included in Groups II and III. Plasma Determinations Parameter Group I Group II Group III P Value Normal Range APTT: 24.2–35.3 seconds aPTT 29.3±2.7 28.2±2.3 23±1.0 0.01 sP-Selectin 23.2±4 25.4±9 44.0±11 0.001 TSP1 382±39 871±496 1246±295 0.001

Decreased HLA (human leucocyte antigen)-DR expression on peripheral blood monocytes predicts the development of organ failure in patients with acute pancreatitis

2003 ◽  
Vol 105 (4) ◽  
pp. 409-417 ◽  
Author(s):  
Panu MENTULA ◽  
Marja-Leena KYLÄNPÄÄ-BÄCK ◽  
Esko KEMPPAINEN ◽  
Annika TAKALA ◽  
Sten-Erik JANSSON ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Organ Dysfunction ◽  
Immune Suppression ◽  
Human Leucocyte Antigen ◽  
Severe Disease ◽  
Positive Likelihood Ratio ◽  
Group Iii ◽  
Group I ◽  
Hla Dr ◽  
Cellular Marker

Immune suppression plays an important role in the pathogenesis of acute pancreatitis. Monocyte expression of HLA (human leucocyte antigen)-DR, a cellular marker of immune suppression, was determined in relation to the development of organ dysfunction in patients with acute pancreatitis. A total of 310 consecutive patients with acute pancreatitis, admitted to a university hospital within 72 h of pain onset, were studied; 194 (63%) had mild disease (group I), 87 (28%) had severe disease without organ dysfunction (group II), and 29 (9%) had severe disease with organ dysfunction (group III). HLA-DR expression, defined both as the proportion of monocytes that were HLA-DR-positive and as monocyte HLA-DR fluorescence intensity, was determined at admission, using whole-blood flow cytometry. Of the patients in group III, 13 (45%) developed organ dysfunction within 24 h of admission. The proportion of HLA-DR-positive monocytes and monocyte HLA-DR density were both related to the severity of pancreatitis (P<0.001 for linear trend). In predicting organ dysfunction, the sensitivity, specificity and positive-likelihood ratio for the proportion of HLA-DR-positive monocytes were 83% [95% CI (confidence interval) 64–94%], 72% (67–77%) and 3.0 respectively, and for monocyte HLA-DR density the respective values were 69% (49–85%), 84% (79–88%) and 4.3. In conclusion, monocyte HLA-DR expression predicts the development of organ dysfunction that occurs early in patients with acute pancreatitis.

scholarly journals Grouping of Salmonella enterica serotype Montevideo strains by ribotyping and IS200 profiling

2000 ◽  
Vol 124 (3) ◽  
pp. 375-382 ◽  
Author(s):  
D. C. OLD ◽  
S. A. CHISHOLM ◽  
P. B. CRICHTON ◽  
A. TAYLOR
Keyword(s):  
Salmonella Enterica ◽  
Group Iv ◽  
The Other ◽  
Clonal Structure ◽  
Group Iii ◽  
Group I ◽  
Combined Use ◽  
Group Ii ◽  
The Uk

One-hundred and twenty-one isolates of Salmonella enterica serotype Montevideo, representing different biotypes and incidents of infection detected in the UK between 1977 and 1995, were analysed by EcoRI ribotyping, PvuII ribotyping and IS200 fingerprinting. Among the isolates examined, 7 EcoRI ribotypes, 5 PvuII ribotypes and 55 IS200 profile types were recognized and 4 arbitrary groups defined. All 33 isolates of biotype 2d belonged to EcoRI/PvuII ribotype 1/1 and IS200 lineage A and comprised Group I. The other 88 isolates of biotype 10di and its variants were assigned to Groups II–IV. All 27 isolates in Group II were of EcoRI/PvuII ribotype 2/2 and IS200 lineage B. Among the 43 isolates in Group III, 42 of which were of EcoRI/PvuII ribotype 3/3, IS200 analysis identified 38 profiles in lineages C–I. Six EcoRI/PvuII ribotypes and 8 IS200 profiles, mostly in lineages C–E, were recognized among the 18 isolates in Group IV. The combined use of biotyping and ribotyping, and to some extent IS200 profiling, has enhanced our understanding of the clonal structure of serotype Montevideo and provides a basis for further study.

scholarly journals Polymorphonuclear leukocyte dysregulation during the systemic inflammatory response syndrome

Blood ◽  
1994 ◽  
Vol 83 (5) ◽  
pp. 1398-1407 ◽  
Author(s):  
HH Simms ◽  
R D'Amico
Keyword(s):  
Acute Pancreatitis ◽  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Pertussis Toxin ◽  
Whole Blood ◽  
Systemic Inflammatory Response ◽  
Matrix Proteins ◽  
H2o2 Production ◽  
Group Iii ◽  
Group I

Abstract Altered polymorphonuclear leukocyte (PMN) function is thought to contribute to organ dysfunction during the systemic inflammatory response syndrome (SIRS). To test this hypothesis, we evaluated whole blood PMN function adherent to fibronectin or laminin in patients with mild or severe acute pancreatitis as a paradigm for sirs. Whole-blood PMN intracellular H2O2 production, expression of CD32w (Fc gamma R II), CD16 (Fc gamma R III), and phagocytosis were performed using dichlorofluorescein diacetate, fluorescein isothiocyanate-labeled anti- CD32w, CD16, and serum-opsonized fluorescent microspheres. Group I (n x 7) represents normal control individuals; group II (n x 11) represents patients with mild acute pancreatitis. Group III (n x 15) represents critically ill patients with severe acute pancreatitis. Adherence of PMN from groups I and II to matrix proteins resulted in a 5% to 20% increase in each PMN function assayed whereas adherence of PMN from group III to matrix proteins resulted in 50% to 75% increases in each PMN function assayed. Pertussis toxin, pentoxifylline, and dibutyryl cyclic adenosine monophosphate (cAMP) each reduced group I-II H2O2 production and phagocytosis. Pentoxifylline and dibutyryl cAMP but not pertussis toxin reduced group III H2O2 production. Both intracellular H2O2 and phagocytosis assays from group III but not groups I-II showed exaggerated upregulation when exposed to NaF (4 mmol/L). Anti- interleukin-6 reduced the increase in intracellular H2O2 production in group III patients and significantly altered the exaggerated oxidative response to NaF. Longitudinal studies of group III whole-blood PMN showed persistent upregulation of intracellular H2O2 production in those patients whose hospital courses were complicated by multiple system organ failure. These results demonstrate abnormal whole blood PMN function during the systemic inflammatory response syndrome in the presence of fibronectin, or laminin and that this is mediated in part via a pertussis toxin insensitive altered guanosine triphosphate- binding protein.

scholarly journals Ameliorative effect of certolizumab on experimentally induced acute necrotic pancreatitis in rats

2019 ◽  
Vol 65 (2) ◽  
pp. 204-210
Author(s):  
Mehmet Ali Kosekli ◽  
Özkan Herek ◽  
Özlem Ozmen ◽  
Sima Sahinduran
Keyword(s):  
Acute Pancreatitis ◽  
Serum Amylase ◽  
Male Rats ◽  
Control Group ◽  
Group Iii ◽  
Group I ◽  
Necrotic Pancreatitis ◽  
Ameliorative Effect ◽  
Factor Α ◽  
Experimentally Induced

SUMMARY OBJECTIVE: The effects of Certolizumab, a pegylated monoclonal antibody to tumor necrosis factor α, on experimentally induced acute pancreatitis (AP) were examined. METHODS: Thirty-six Wistar Albino male rats were randomly divided into four groups. Group I was the control group and no medication administered to this group. Group II was the Certolizumab group, and 100 ml/kg serum physiologic administered into the biliopancreatic duct and a single dose of 10 μg Certolizumab was simultaneously administered intraperitoneally. Acute pancreatitis was induced with a retrograde injection of 3% Na taurocholate into the common biliopancreatic duct in the study (Group III) and treatment (Groups IV) groups. Rats were sacrificed 72 hours later. Serum amylase, lipase, lactate dehydrogenase activities, along with pancreatic histopathology, were examined. RESULTS: Certolizumab treatment significantly decreased serum amylase, lipase, and LDH levels; histopathologically edema, hemorrhage, parenchymal necrosis, fat necrosis, and infiltration scores; immunohistochemically MDA, MPO, TNF-α and Caspase-3 activity. CONCLUSION: The results support the idea that certolizumab might be beneficial for the severity of AP.

Anti-Emetic Effect of Oculo-Acupuncture on Dogs with Xylazine Induced Vomiting

2007 ◽  
Vol 35 (03) ◽  
pp. 447-453 ◽  
Author(s):  
Jianzhu Liu ◽  
Yoo-Teak Lee ◽  
Sang-Eun Lee ◽  
Jung-Yeon Lee ◽  
Duck-Hwan Kim
Keyword(s):  
The Other ◽  
Control Groups ◽  
Group Iii ◽  
Group I ◽  
Group A ◽  
Body Acupuncture ◽  
Group Ii ◽  
Group B ◽  
Experimental Group ◽  
Needle Acupuncture

The present study was conducted in order to clarify the anti-emetic effect of oculo-acupuncture (OA) on dogs with xylazine-induced vomiting, and also to compare the anti-emetic effect of OA and body acupuncture (AP). Twelve dogs induced to vomit by xylazine were selected from total 29 mongrel dogs in preliminary experiment and were used as subjects in this study. This study was comprised of two experiments. In experiment 1, the anti-emetic effects of OA on dogs were examined in the stomach/spleen region (experimental group I), the zhongjiao region (experimental group II), and the stomach/spleen region plus the zhongjiao region (experimental group III) using 12 dogs induced to vomit for one week interval repeatedly. On the other hand, needle acupuncture (AP) (BL20 + BL21, experimental group A) and OA (stomach/spleen and zhong jiao regions) combined with needle AP (BL20 + BL21) (experimental group B) were examined using 6 vomiting dogs, for one week interval repeatedly in experiment 2. As a result, the vomiting rates of experimental group I (50%, p < 0.05), experimental group II (58.3%) and experimental group III (41.6%, p < 0.01) were lower than that of control (100%), respectively in experiment 1. The vomiting rates of both experimental group A (50%, p < 0.05) and experimental group B (50%, p < 0.05) were lower than that of control (100%) in experiment 2. The starting vomiting time in experimental groups was similar to that of the control groups in experiment 1 and 2. This study demonstrated that OA had anti-emetic effects on dogs with xylazine-induced vomiting and OA in the stomach/spleen region plus the zhongjiao region was the most effective in anti-emesis among the experimental groups. In addition, body AP and OA combined with body AP had a similar anti-emetic effect on dogs with xylazine-induced vomiting.

scholarly journals Increasing efficiency of preterm birth prediction

2021 ◽  
Keyword(s):  
Preterm Birth ◽  
Confidence Interval ◽  
Blood Serum ◽  
Preterm Labor ◽  
Group Iii ◽  
Healthy Pregnancy ◽  
Group I ◽  
Combined Use ◽  
Group Ii ◽  
Plgf Ratio

Abstract. The disturbed placentation in a certain way plays an important role in the pathogenesis of great obstetric syndromes. Therefore, the possibility of using biochemical indicators of the level of placental growth factor (PlGF) and fms-like tyrosine kinase (sFlt-1) for predicting preterm labor is of great interest. The aim of the study was developing criteria for predicting preterm labor based on the combined use of ultrasound cervicometry and the concentration of PlGF and sFlt-1. Materials and methods. A total of 227 pregnant women were examined, 190 of whom had preterm birth. Group I included 48 women whose pregnancy completed at 23 to 27 weeks. In group II, 142 women with prematurity in terms of 28 to 36 weeks were observed. Group III included 37 women with a healthy pregnancy, which completed at 38–41 weeks. All patients involved in the study underwent ultrasound cervicometry on a Voluson 730 (GE Healthcare, USA) at 16 weeks, and also the concentration of PlGF and sFlt-1 in blood serum by electrochemiluminescence immunoassay using a Cobas e411 analyzer was studied (Roche diagnostics, Switzerland). Results. The study revealed a significant (p < 0.001) decrease in the average concentration of PlGF in the blood serum by 65 % associated with an increased level of sFlt-1 by 93% in women with early termination of pregnancy – 23–27 weeks (group I) in relation to women with a healthy pregnancy. In women with preterm birth at 28–36 weeks of gestation (group II), a similar trend of changes was observed: the PlGF level significantly (p = 0.014) decreased on average by 68 % in relation to women with a healthy pregnancy. In women of group I, the value of the sFlt-1 / PlGF ratio exceeded (p < 0.001) the values of patients in group III by 14 times. But an even more pronounced imbalance of angiogenic factors was observed in women of group II – on average 16 times. Two main markers were used to predict premature birth: shortening of the cervix according to ultrasound cervicometry data of less than 30 mm, as well as the sFlt-1/PlGF ratio of more than 50 conv. units. The odds ratio (OR) of preterm birth in the case of using only the length of the cervix was 34,133 (95 % confidence interval – 12.308–94.660). OR in the case of combined use of cervicometry data and angiogenesis variables was 148.750 (95 % confidence interval – 33.243–665.593). Conclusion. Thus, the use of an additional biochemical marker significantly improved the accuracy of preterm labor prediction.

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