scholarly journals Investigation of the Relationship Between Exposure to Preeclampsia and Overweight/Obesity in 2-7 Year Old Children

2020 ◽  
Vol 8 (3) ◽  
pp. 290-296
Author(s):  
Mahshid Ahmadi ◽  
Jila Ganji ◽  
Daniel Zamanfar ◽  
Parisa Ghobadi Golafshani
Keyword(s):  
Gestational Hypertension ◽  
Overweight And Obesity ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
Healthy Children ◽  
Pediatric Endocrinology ◽  
Age Range ◽  
The Relationship ◽  
Obesity In Children

Objectives: Childhood obesity has reached alarming and concerning levels in many countries and poses an urgent and serious challenge to public health. In addition, gestational hypertension contributes to an elevated risk of obesity in children. The present study aimed at determining the relationship between exposure to preeclampsia and overweight/obesity occurrence in children aged 2-7 years old. Materials and Methods: This observational case-control study was designed to assess the relationship between exposure to preeclampsia and overweight/obesity in children aged 2-7 years old. The study population included 205 children within the age range of 2-7 years old referring to Sari Pediatric Endocrinology Clinic as the case group and 209 healthy children who were selected from health centers as the control group and were homogenous in terms of demographic variables. Finally, data were analyzed in SPSS software (version 24), and P value of less than 0.05 was considered statistically significant. Results: The present study was conducted on a total number of 414 children aged 2-7 years old with a mean and standard deviation of 4.41±1.76 years, including 226 females (54.6%) and 188 males (45.4%). The obtained results revealed that gestational hypertension increased the risk of obesity in children significantly (OR=1.88, 95% CI=1.46-2.68). Conclusions: Based on the results of the present research and similar studies, gestational hypertension is associated with overweight and obesity in children.

scholarly journals Relationship of Migraine and Body Mass Index (BMI)

2016 ◽  
Vol 6 (2) ◽  
pp. 80-87
Author(s):  
Mohammed Momenuzzaman Khan ◽  
Md Nazmul Huda ◽  
Manabendra Bhattacharjee ◽  
Md Jalal Uddin ◽  
Mustofa Kamal Uddin Khan
Keyword(s):  
Social Life ◽  
Overweight And Obesity ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
Increased Risk ◽  
Significant Difference ◽  
Associated Symptoms ◽  
Migraine Group ◽  
The Relationship

Background: Migraine is an important cause of headache and headache-related disabilities. It increases loss of working time, causes inability to carry out daily activities and disruption of family and social life. The pathophysiology of migraine is still poorly understood. On the other hand, the prevalence of obesity is constantly increasing worldwide. The consequence of overweight and obesity includes increased risk of diabetes mellitus, dyslipidemia, hypertension, cardiovascular disease and cancer.Objectives: This study was performed to assess the relationship between BMI and migraine by finding out the relationship between migraine frequency and duration in different BMI groups, comparing the socio-demographic variables in migraine and non-migraine patients and to find out the migraine related co-morbidities.Materials and Methods: This observational case-control study was conducted on 100 subjects aged 12–50 years in the Neurology Outpatient Department, Mymensingh Medical College Hospital, Mymensingh in the period of January 2011 to December 2012. Out of total subjects fifty migraine patients were selected as cases and fifty nonmigraineurs as controls. Subjects were then categorized in three groups based on BMI: <23, 23 to 25 and >25. Collected data were compiled and appropriate analyses were done by using computer based software, Statistical Package for Social Sciences (SPSS) version 16.0. For statistical analysis one way ANOVA tests were done for comparing means of quantitative data and Chi-square tests were done for qualitative data. A p value <0.05 was considered statistically significant.Results: In this study, majority (>95%) of the study subjects were between 10 and 35 years of age. Mean age of case group was found 25.55 ± 5.87 and that of control was 25.53 ± 4.22 years. Case group contained 10 (20%) males and 40 (80%) females whereas control group had 14 (28%) males and 36 (72%) females. Number of female cases and controls were higher than that of male. In control group 30 (60%) were unmarried and 20 (40%) were married. There was no significant difference in the financial condition between case and control groups. Students and housewives occupied the largest number of study subjects who were unemployed. Regarding residence, rural and urban patients were equal in case group and in control group 29 (58%) were urban and 21 (42%) rural. Mean duration of headache was 8.9 ± 7.5, 5.8 ± 6.7, 9.6 ± 14.3 years in different BMI groups (<23, 23–25, >25 respectively) in case group and 4.6 ± 5.3, 4.4 ± 3.4, 3.4 ± 1.4 years in control group respectively. There was significant difference in quality of headache. In migrainous group 58.6% in BMI <23, 30% in BMI 23–25, 36.4% in BMI >25 noted their headache as throbbing, in contrast most of the nonmigrainous described them as dull in nature. Mean frequency of headache per month was significantly higher in migraine group compared to non-migraine group (p=0.02). Regarding associated symptoms, nausea, vomiting, photophobia and phonophobia were observed significantly higher in migraine patients in BMI <23 group. Odd ratios (ORs) for vomiting, photophobia and phonophobia with 95% confidence interval (CI) were 23.385 (2.752–97.739), 16.500 (3.060– 88.971) and 13.000 (2.922–57.846) respectively. Smoking was found significantly higher in nonmigrainous group than migraine group in case of BMI <23.Conclusion: From the result of present study it can be concluded that there is statistically no significant relation of BMI with frequency of headache, but some relationship were observed for associated symptoms of migraine with low BMI.J Enam Med Col 2016; 6(2): 80-87

scholarly journals Evaluation of depression and self-esteem in children with monosymptomatic nocturnal enuresis: A controlled trial

2014 ◽  
Vol 86 (3) ◽  
pp. 212 ◽  
Author(s):  
Orhan Koca ◽  
Mehmet Akyüz ◽  
Bilal Karaman ◽  
Zeynep Yesim Özcan ◽  
Metin Öztürk ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Nocturnal Enuresis ◽  
Depression Scale ◽  
Self Esteem ◽  
Control Group ◽  
Case Group ◽  
Healthy Children ◽  
Significant Difference ◽  
Monosymptomatic Nocturnal Enuresis ◽  
Age Range

Objectives: Nocturnal enuresis (NE) is very common and is one of the most common causes for patients to be admitted to urology, pediatrics, child psychiatry and child surgery departments. We aimed to investigate the effect on depression and self-esteem of this disorder that can cause problems on person's social development and human relations. Material and methods: 90 patients who were admitted to our clinic with complaints of nocturnal enuresis were enrolled. Investigations to rule out organic causes were performed in this group of patients. Out of them 38 children and adolescents (age range 8-18 years) with primary monosymptomatic nocturnal enuresis (PMNE) agreed to participate in the study In the same period 46 healthy children and adolescents with a similar age range without bed wetting complaint were included in the study as a control group. The age of the family, educational and socioeconomic level were questioned and Piers-Harris Children's Self-Concept Scale (PHCSCS) and Children's Depression Inventory (CDI) forms were filled out. Results: Mean age of the cases (18 females or 47.4% and 20 males or 52.6%) was 10.76 ± 3.82 years whereas mean age of controls (26 females or 56.5% and 20 males or 43.5%) was 10.89 ± 3.11 years. Depression scale was significantly higher (p = 0.001) in the case group than in the control group (10.42 ± 4.31 vs 7.09 ± 4.35). In both groups there was no statistically significant difference by age and sex in terms of depression scale (p &gt; 0.05). Conclusion: NE is widely seen as in the community and is a source of stresses either for children and for their families. When patients were admitted to physicians for treatment, a multidisciplinary approach should be offered and the necessary psychological support should be provided jointly by child psychiatrists and psychologists.

scholarly journals The correlation between family smoking habits and mosquito coils use with pneumonia incidences in toddlers

2019 ◽  
Vol 2 (2) ◽  
pp. 69-74
Author(s):  
Wiwin Winarsih ◽  
Wiwik Kusumawati ◽  
Anjarwati Anjarwati
Keyword(s):  
Smoking Habits ◽  
Observational Research ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
Chi Square ◽  
Study Approach ◽  
The Family ◽  
The Relationship ◽  
Control Study

The incidences of pneumonia in infants Become the second highest cause mortality before reaching the age of 5 years and a health problem in Indonesia. The family of smoking and smoke from burning mosquito coils are the triggers for air pollution, which can lead to pneumonia in infants. The study aims to analyze the relationship between family smoking habits and the use of mosquito coils with the incidence of pneumonia in under-fives. The method of research applied analytic observational research using a case-control study approach. The number of samples in this study was 87 under-fives in the case group and 87 under-fives in the control group. Sampling was conducted by non-probability sampling. A questionnaire was used as a data collecting instrument. Data analysis used chi-square and multiple logistic regression. The results of this study Showed that there was a relationship between family smoking habits and the use of mosquito coils with the incidence of pneumonia in infants. In addition, there were other variables that had a relationship with the incidence of pneumonia in under-fives namely smoking location (OR = 3,046; 95% CI: 1429-6492, p = 0.003), the number of cigarettes (OR = 7.105 ; 95% CI: 3079-16394, p = 0.000), and length of time with smokers (p = 0.000). On the other hand, the variables of father smoker status and the frequency of using mosquito coils were not related to the incidence of pneumonia in under-fives (p value 0.05). It is concluded that family smoking habits, use of mosquito coils, the location of smoking, and number of cigarettes, and  length of time together with smokers were risk factors associated with the incidence of pneumonia in toddlers

scholarly journals The association between lichen planus and hepatitis C virus infection: A case control study

2021 ◽  
Vol 12 (e) ◽  
pp. e85-e85
Author(s):  
G Rai Subodha Kumar ◽  
Nagesha Parvathi ◽  
RangeGowda Suresh ◽  
Rangaswamy Umadevi ◽  
Nirvanappa Vinay
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Lichen Planus ◽  
Skin Diseases ◽  
Hcv Infection ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
The Relationship

Background: The incidence of Hepatitis C virus (HCV) infection among patients with Lichen planus (LP) varies considerably. There is also lack of data in Indian population. Due to these variation, this study is to assessing the prevalence of HCV infection among patients with CLP in Hassan Karnataka. Methods: 135 clinically diagnosed cases of Lichen planus more than 18 years of age will be included as cases.147 patients having skin diseases other than lichen planus will be included as controls. Details of the patients personal history and family history,medical history and blood transfusion history will be collected. Detection of antibodies against HCV (anti-HCV) by enzyme-linked immunosorbent assay (ELISA). Results: Anti-HCV antibodies were found in 3(2.2%) patients of the case group and 1(0.7%) in control group. P value is 0.274, not statistically significant. Conclusion: Currently, there is no evidence confirming the relationship between HCV infection and CLP in Hassan Karnataka. However, there is a need for further research on larger groups of

scholarly journals Serum Expression of ESM-1, HMWA, and AGEs and Its Relationship with Disease Severity in Patients with Gestational Hypertension

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Yun Yan ◽  
Linlin Luan ◽  
Jieru Xu
Keyword(s):  
Molecular Weight ◽  
Endothelial Cell ◽  
Gestational Hypertension ◽  
Severe Preeclampsia ◽  
Control Group ◽  
Case Group ◽  
High Molecular Weight Adiponectin ◽  
Mild Preeclampsia ◽  
The Relationship ◽  
Group Serum

Objective. The research is to investigate the expression and the relationship between serum endothelial cell-specific molecular molecule-1 (ESM-1), high molecular weight adiponectin (HMWA), and late glycosylation terminal product (AGEs) in patients with gestational hypertension. Methods. 75 patients with pregnant hypertension who were treated in our hospital from June 2019 to June 2020 were selected as the case group, and 70 healthy pregnant women with pregnancy examination at the same period in our hospital were selected as the control group to analyze the changes in serum ESM-1, HMWA, and AGEs levels and the correlation with the degree of illness and their predictive value. Results. Serum ESM-1 and AGEs were significantly higher in the case group than in the control group. Serum HMWA was significantly lower than that in the control group ( P < 0.05 ). The gestational hypertensive serum ESM-1 and AGEs was significantly lower than in patients with mild preeclampsia and severe preeclampsia. Serum HMWA was significantly higher than in patients with mild preeclampsia and severe preeclampsia. Serum ESM-1 and AGEs of mild preeclampsia were significantly lower than in patients with severe preeclampsia. Serum HMWA was significantly higher than in patients with severe preeclampsia ( P < 0.05 ). The result of correlation analysis shows a positive correlation between serum ESM-1 and AGEs ( P < 0.05 ). A negative correlation was observed between HMWA and the degree of illness ( P < 0.05 ). Conclusion. Serum ESM-1, HMWA, and AGEs are abnormally expressed in gestational hypertension, are closely related to the degree of condition, and have important clinical significance for condition control.

scholarly journals The Relationship Between Obsessive-Compulsive Disorders and Childhood Chronic Functional Constipation

2021 ◽  
Author(s):  
Pedram Ataee ◽  
Hadi Badiee ◽  
Soleiman Mohammadzadeh ◽  
Borhan Moradveisi ◽  
Daem Roshani ◽  
...  
Keyword(s):  
Functional Constipation ◽  
Control Group ◽  
Case Group ◽  
Healthy Children ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Significant Difference ◽  
Obsessive Compulsive Disorders ◽  
The Relationship ◽  
Compulsive Disorders

Chronic constipation is one of the most common problems in children. It can cause anxiety and psychological problems in patients and parents. The purpose of this study was to investigate the relationship between obsessive-compulsive disorders (OCD) in children with chronic functional constipation. This is a case-control study performed at the gastroenterology clinic of Besat Hospital Sanandaj for one year. The children aged 7-14-year-old with chronic functional constipation were selected as a case group, and the healthy children were recruited as a control group, who referred for growth control. Then, the Maudsley questionnaire for obsessive-compulsive disorders was completed by a trained assistant. With this questionnaire, the presence or absence of OCD and its type can be determined. Forty-three children were selected as the case group and sixty-seven children as the control group. The mean age of the case and control group was 9.3±1.5 and 8.8±1.6 years, respectively. Based on the results, there was a significant difference between the groups in terms of checking, cleaning, slowness, doubting, and total obsessive score (P˂0.05). Therefore, all five types of obsessive-compulsive disorder in the case group were greater than the control group. Obsessive-compulsive disorders were more common in children with functional constipation, and the total obsessive score in these children than the healthy children was a significant difference.

scholarly journals Hubungan Pengetahuan dan Sikap Terhadap Kejadian Covid-19 pada Masyarakat di Kelurahan Mulyojati Kota Metro

2021 ◽  
Vol 3 (4) ◽  
pp. 517-528
Author(s):  
M. Arifki Zainaro ◽  
Andoko Andoko ◽  
Reka Putri Rahmawati
Keyword(s):  
Correlation Coefficient ◽  
Significant Relationship ◽  
Case Control ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
Knowledge And Attitudes ◽  
Spearman Test ◽  
The Relationship ◽  
Good Attitude

ABSTRACT: THE RELATIONSHIP OF KNOWLEDGE AND ATTITUDE TO THE INCIDENT OF COVID-19 IN THE COMMUNITY OF MULYOJATI VILLAGE METRO CITY 2021 Introduction: The incidence of COVID-19 in Indonesia is still increasing. The factors causing the occurrence of covid-19 are knowledge that is still lacking and attitudes in responding to the prevention of covid-19 which are often ignored by people in Mulyojati Village, Metro City. According to a report from the Indonesian Ministry of Health, there were 2,313,829 confirmed cases (Kementrian Kesehatan RI, 2021). Lampung has 20,808 confirmed cases (Dinas Kesehatan Lampung, 2021). Metro City has a number of confirmed cases of 1,391 cases (Dinas Kesehatan Kota Metro, 2021).Purpose: To find out the relationship between knowledge and attitudes towards the incidence of covid-19 in the community in Mulyojati Village, Metro City.Methods: This study uses a quantitative analytic design using a case control design. The population in this study were 30 people who were positive for COVID-19 and 30 people were negative for COVID-19. The measurement of this study uses a questionnaire that has been tested for validity. Data analysis used frequency distribution test (univariate) and Spearman correlation test (bivariate).Results: Based on the frequency data obtained good knowledge of the case group (60.0%) while the control group (30.0%). Good attitude in the case group (96.7%) while the control group (76.7%). Spearman test results obtained p value .000 (<0.05) and the correlation coefficient is known to be .467. Based on the results of the Spearman test, the p value was .020 (<0.05) and the correlation coefficient was .295.Conclusion: There is a significant relationship between knowledge and the incidence of covid-19 and a moderate correlation. There is a significant relationship between attitude and the incidence of covid-19 and a low correlation. In the Mulyojati sub-district, the case group with good knowledge was higher than the control group, while the good attitude in the case group was higher than the control group. Various efforts must continue to be made, both from the health and non-health sectors, especially increasing knowledge and attitudes to prevent COVID-19. Keywords: Knowledge, Attitude, Covid-19 INTISARI: HUBUNGAN PENGETAHUAN DAN SIKAP TERHADAP KEJADIAN COVID-19 PADA MASYARKAT DI KELURAHAN MULYOJATI KOTA METRO 2021 Pendahuluan: Kejadian covid-19 di Indonesia masih terus bertambah. Faktor penyebab kejadian covid-19 adalah pengetahuan yang masih yang masih kurang dan sikap dalam menanggapi pencegahan covid-19 yang sering diabaikan masyarakat di Kelurahan Mulyojati Kota Metro. Menurut laporan Kementrian Kesehatan RI tercatat 2.313.829 kasus terkonfirmasi (Kementrian kesehatan RI, 2021). Lampung memiliki kasus terkonfirmasi sebanyak 20.808 kasus (Dinas kesehatan Lampung, 2021). Kota Metro memiliki jumlah kasus terkonfirmasi sebanyak 1.391 kasus (Dinas Kesehatan Kota Metro, 2021).Tujuan: Diketahui hubungan pengetahuan dan sikap terhadap kejadian covid-19 pada masyarakat di Kelurahan Mulyojati Kota Metro.Metode: Penelitian ini menggunakan desain analitik kuantitatif dengan menggunakan rancangan case control. Populasi pada penelitian ini adalah 30 orang positif covid-19 dan 30 orang negatif covid-19. Pengukuran penelitian ini menggunakan kuesioner yang sudah di uji validitas. Analisis data menggunakan uji distribusi frekuensi (univariat) dan uji korelasi spearman (bivariate).Hasil: Berdasarkan data frekuensi didapatkan pengetahuan baik kelompok kasus (60.0%) sedangkan kelompok control (30.0%).  Sikap yang baik kelompok kasus (96.7%) sedangkan kelompok control (76.7%). hasil uji spearman didapatkan nilai p value .000 (<0.05) dan diketahui nilai koefisien korelasi .467. Berdasarkan hasil uji spearman didapatkan nilai p value .020 (<0.05) dan diketahui nilai koefisien korelasi .295.Kesimpulan: Ada hubungan yang signifikan antara pengetahuan dengan kejadian covid-19 dan korelasi yang sedang. Ada hubungan yang signifikan antara sikap dengan kejadian covid-19 dan korelasi yang rendah. Dikelurahan mulyojati pada kelompok kasus berpengetahuan baik lebih tinggi dibanding kelompok control sedangkan sikap baik pada kelompok kasus lebih tinggi dibanding kelompok control. Berbagai upaya terus harus dilakukan baik dari sektor kesehatan maupun non-kesehatan terutama meningkatkan pengetahuan dan sikap pencegahan covid-19. Kata kunci: Pengetahuan, Sikap, Covid-19

scholarly journals Evaluating QT dispersion in children with syncope attacks

2018 ◽  
Vol 15 (2) ◽  
pp. 15-20
Author(s):  
Amir Hossein Movahedian ◽  
Ali Mohammad Shakiba ◽  
Mojtaba Sehat ◽  
Maryam Sadat Razavi ◽  
Marzieh Heydarzadeh Arani
Keyword(s):  
Qt Dispersion ◽  
Brain Dysfunction ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
Healthy Children ◽  
Cross Sectional ◽  
Significant Difference ◽  
The Mean ◽  
And Control

Background and Aims: Syncope is due to brain dysfunction and is a common compliant among children. It accounts for almost 3% of all emergency departments (ED) visits. The aim of this study was to evaluate the QT dispersion in children with syncope in Shahid Beheshti Hospital of Kashan in 2014.Methods: This was a descriptive cross-sectional study performed among 50 children with syncope attacks (case group) referred to the Clinic of Shahid Beheshti Hospital in Kashan during 2014 and 50 healthy children (control group) referred to the center for causes such as a cold or developmental examination. ECG was taken and QT, QTd (QT dispersion), QTc (Corrected QT interval) and QTcd (QTmin-QTmax =QT dispersion) intervals were studied. After proper explanation to the parents, data was obtained from the case and control group and was analyzed using Chisquare, Mann-Whitney, Kolmogorov–Smirnov, Levene›s, Kruskal-Wallis statistical tests.Results: Total, there were 100 children in the study, the participants were divided into two groups of case (n=50) and control (n=50). Among the studied children, a total of 46 of them (46%) were boys. The mean age range of children in the case and control groups were 7.73± 2.33 and 8.09± 2.31 years, respectively (P-value 0.440). The mean QTmax, QTcmax, QTd and QTcd in the case group were 348.80 ± 46.93, 464.94±48.71, 47.80±19.72, 68.36±24.59 ms (millisecond) respectively and 305.28 ±35.52, 395.70 ±50.05, 29.68±13.45, and 45.16±24.46 ms respectively in the control group. There was a significant difference in terms of each of the 4 parameters (P <0.001), and the value of indices in the control group was significantly less than that of the patient group.Conclusion: According to the results of the study, the QTd and QTcd values in the children with syncope attacks were higher than those in the control group. Therefore, precise ECG examination in children suspected of syncope attacks can be helpful in confirming the incidence of syncope. Additionally, the recurrence of attacks can also be predicted in children with higher QTd and QTcd values.

Impact of Physical Activity on the Incidence of Vascular Diseases in Adults with Type 2 Diabetes Mellitus

2019 ◽  
Vol 8 ◽  
pp. 1549
Author(s):  
Babak Pezeshki ◽  
Ehsan Bahramali ◽  
Amir Ansari ◽  
Aliasghar Karimi ◽  
Mojtaba Frajam ◽  
...  
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Vascular Function ◽  
Vascular Diseases ◽  
Major Complication ◽  
Control Group ◽  
Case Group ◽  
Vascular Events ◽  
The Relationship

Background: Diabetes mellitus (DM) is a common metabolic disease worldwide and has many complications. The vascular events are the major complication of DM that have an important effect on mortality and disability. The physical activity (PA) enhances the vascular function by several pathways. The aim of this study was to evaluation of the relationship between PA and vascular diseases in patients with DM.Materials and Methods: This research was performed as the case-control study that was extracted from a prospective epidemiological research study in Iran (PERSIAN). The patients with type 2 DM more than six months defined as case group and the non-DM subjects in control group with ratio 1:2, and both groups were matched in the term of age and sex. The MET score was used to evaluate the level of PA and blood glucose, lipid profile, body mass index, overweight, dyslipidemia, glomerular filtration rate, myocardial infarction (MI), unstable angina, and stroke.Results: Overall, 1242 patients with DM were extracted, and 2484 non-diabetic subjects were investigated. In the case group, 355(28.6 %) and 887(71.4%) were men and women, respectively, the and 710 (28.6%) men and 1774(71.4%) women in control group. The mean MET score was 30 and 40.97 in the DM and non-DM groups, respectively (P˂0.001). The frequency of MI, stroke, and cardiac ischemia were 44 (3.5%), 37 (3%), and 267 (21.5%), respectively in DM group, and 54 (2.2%), 43 (1.7%), and 389 (15.7%), respectively in non-DM group.Conclusion: The incidence of vascular events associated with PA level in patients with DM and adherence to regular PA reduce the vascular events and DM complications. [GMJ.2019;inpress:e1549]

scholarly journals Association of interleukin-17A rs2275913 polymorphism with rheumatoid arthritis susceptibility in Sudanese population

2021 ◽  
Vol 9 ◽  
pp. 205031212110202
Author(s):  
Rgda Mohamed Osman ◽  
Mounkaila Noma ◽  
Abdallah Elssir Ahmed ◽  
Hanadi Abdelbagi ◽  
Rihab Ali Omer ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Confidence Interval ◽  
Statistical Tests ◽  
Demographic Data ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
Molecular Technique ◽  
Interleukin 17A ◽  
Significant Difference

Objectives: Rheumatoid arthritis is a chronic inflammatory autoimmune disease. This study aimed to determine the association of interleukin-17A-197G/A polymorphism with rheumatoid arthritis in Sudanese patients. Methods: A case–control study was conducted between March and December 2018. Clinical and demographic data of the study participants were collected and analyzed. Polymerase chain reaction restriction fragment length polymorphism molecular technique was done to investigate interleukin-17A-197G/A polymorphisms. All statistical tests were considered statistically significant when p < 0.05. Results: The study population included 266 participants aged between 1 and 85 years, with an average of 40 years, classified into 85 (31.2%) cases (mean age 48.5 ± 11.3 years), and 181 (68.8%) controls (mean age 35.3 ± 15.9 years). The interleukin-17A homozygote AA genotype was more frequent among the control group compared to the case group; 95 (52.5%) and 7 (8.2%), respectively. The homozygote GG and the heterozygote AG genotypes were proportionally not different among the cases and control groups; 13 (54.2%) and 11 (45.8%), and 65 (46.4%) and 75 (53.6%), respectively. According to the distribution of interleukin-17A genotypes, a statistically significant difference was observed among cases with the interleukin-17A AA and AG genotypes, p values 0.001 and 0.004, respectively. For the association interleukin-17A genotypes and family history a negatively significant association was reported (95% confidence interval, –0.219, p value = 0.001). There was also a negatively significant association of interleukin-17A genotypes and anti-cyclic citrullinated peptide (95% confidence interval, −0.141, p value = 0.002). Conclusion: This study is the first study in Sudan established the association between interleukin-17A-197G/A (rs2275913) polymorphisms and susceptibly to rheumatoid arthritis. These findings appeal for further research in Sudan to investigate the exact role of IL-17A in immunopathology and disease severity among Sudanese rheumatoid arthritis

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