scholarly journals Declining sperm counts: The impact of covid-19 on testicular function and sperm parameters and overall male reproductive performance

2021 ◽  
Vol 10 (4) ◽  
pp. 85-89
Author(s):  
Panayiotis Michael Zavos
Keyword(s):  
Male Fertility ◽  
Viral Infections ◽  
Sperm Quality ◽  
Sperm Count ◽  
Tobacco Consumption ◽  
Reproductive Organs ◽  
Male Reproductive Success ◽  
Herpes Simplex Viruses ◽  
Human Immunodeficiency Viruses ◽  
The Impact

Male infertility is linked to some viral infections including human papillomavirus (HPV), herpes simplex viruses (HSV) and human immunodeficiency viruses (HIVs). As for acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), its effects on worldwide declines in sperm count and fertility have not been researched thoroughly. With the recent increase of viral infections due to the pandemic, the potential negative impacts that SARS-CoV-2 will have on male reproductive organs and male fertility have raised countless concerns. This review article aims to discuss the possible effects that the SARS-CoV-2 pandemic will have on an already declining male reproductive success while integrating the results of recent studies focusing on similar topics. Furthermore, this article will also mention the future implications that come with a more infertile population. Within the articles studied, it has become apparent that the SARS-CoV-2 pandemic has and will only decrease men’s sperm quality further. These findings became apparent through the study of oxidative stress established through the sperm’s production of reactive oxygen species1 and the COVID-19 virus’ ability to attack human spermatozoa produced in the testes due the expression of the ACE2 gene.2 As for the decline in male fertility prior to the SARS-CoV-2 pandemic, there are many factors to be discussed, some of which include: tobacco consumption, alcoholism, diet, electronics, and higher rates of testicular cancer.3

Effect of new dietary supplement on sperm quality

2012 ◽  
Vol 153 (45) ◽  
pp. 1787-1792 ◽  
Author(s):  
Mária Horváth ◽  
Endre Czeizel
Keyword(s):  
Adverse Effect ◽  
Clinical Trial ◽  
Dietary Supplement ◽  
Male Fertility ◽  
Sperm Quality ◽  
Sperm Count ◽  
Before And After ◽  
The Usa ◽  
New Treatments

Introduction: There is a decline in male fertility thus new treatments are needed. Aims: To test the efficacy of a new dietary supplement developed in the USA and registered as a curing drug in Hungary (OGYI). Methods: In a clinical trial 100 men with low sperm quality (spermium count 5–20 M/ml, good motility 10–40%, and adverse shape 30–50%) were examined. Results: Sperm parameters were measured before and after a 3-month treatment and after another 3-month without treatment. This dietary supplement statistically and clinically significantly improved sperm count and motility. In 74 cases this dietary supplement demonstrated a beneficial effect on sperm quality (more than 10% increase in sperm count, or quality of motility, or shape); in 16 cases the improvement exceeded 30%. No adverse effect could be accounted for this treatment. Conclusions: This new dietary supplement may contribute to the treatment of male infertility. Orv. Hetil., 2012, 153, 1787–1792.

scholarly journals Experimental heatwaves negatively impact sperm quality in the zebra finch

2018 ◽  
Vol 285 (1871) ◽  
pp. 20172547 ◽  
Author(s):  
Laura L. Hurley ◽  
Callum S. McDiarmid ◽  
Christopher R. Friesen ◽  
Simon C. Griffith ◽  
Melissah Rowe
Keyword(s):  
Male Fertility ◽  
Elevated Temperatures ◽  
Sperm Quality ◽  
Recovery Period ◽  
Heat Exposure ◽  
Effect Of Temperature ◽  
Normal Morphology ◽  
Warming World ◽  
The Impact

For sexually reproducing species, functionally competent sperm are critical to reproduction. While high atmospheric temperatures are known to influence the timing of breeding, incubation and reproductive success in birds, the effect of temperature on sperm quality remains largely unexplored. Here, we experimentally investigated the impact of ecologically relevant extreme temperatures on cloacal temperature and sperm morphology and motility in zebra finches Taeniopygia guttata . We periodically sampled males exposed to 30°C or 40°C temperatures daily for 14 consecutive days. Following a 12-day (23°C) recovery period, birds were again exposed to heat, but under the alternate treatment (e.g. birds initially exposed to 40°C were exposed to 30°C). Elevated temperatures led to an increase in cloacal temperature and a reduction in the proportion of sperm with normal morphology; these effects were most notable under 40°C conditions, and were influenced by the duration of heat exposure and prior exposure to high temperature. Our findings highlight the potential role of temperature in determining male fertility in birds, and perhaps also in constraining the timing of avian breeding. Given the increased frequency of heatwaves in a warming world, our results suggest the need for further work on climatic influences on sperm quality and male fertility.

scholarly journals The relationship between diet, energy balance and fertility in men

2020 ◽  
Vol 90 (5-6) ◽  
pp. 514-526 ◽  
Author(s):  
Edyta Suliga ◽  
Stanisław Głuszek
Keyword(s):  
Energy Balance ◽  
Male Fertility ◽  
Sperm Count ◽  
Direct Analysis ◽  
Reproductive Hormones ◽  
Semen Parameters ◽  
The Right ◽  
Meta Analyses ◽  
The Impact ◽  
The Relationship

Abstract. Research conducted in recent years provides more and more evidence that diet can have a significant impact on male fertility. The aim of the study was to analyze the relationship between diet, energy balance and fertility in men. A comprehensive literature search of published studies in various languages, was carried out in electronic databases. The direct analysis included 96 works published between 2008 and 2018, including 12 randomized controlled trials and 23 systematic reviews and meta-analyses. A strong adherence to a healthy dietary pattern is positively correlated with total sperm count, progressive motility and total motile sperm count (all p < 0.05). However, attention is drawn to the fact that foods that are considered “healthy” can sometimes contain a significant amount of pollution, which negatively affect the semen parameters. An adequate intake of antioxidants or their supplementation have been quite effective in the prevention and treatment of male infertility. The improvement of pregnancy rate after antioxidant therapy ranged in various studies from 11% to 41%. An important problem, however, may be choosing the right dose of the supplement or finding an appropriate combination of antioxidants that may be more effective than any single antioxidant. The normalization of men’s body weight is beneficial for the quality of sperm and the concentration of male reproductive hormones. Further, long-term studies require the assessment of the impact of drastic weight loss after bariatric surgery on male fertility.

scholarly journals The Impact of Radiofrequency Waves on Male Infertility: A Systematic Review

2020 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Leili Darvish ◽  
Azadeh Amraee ◽  
Marjan Akhavan Amjadi ◽  
Zahra Atarodi Kashani ◽  
Masoumeh Ghazanfarpour ◽  
...  
Keyword(s):  
Systematic Review ◽  
Male Infertility ◽  
Sperm Quality ◽  
Sperm Count ◽  
Sperm Concentration ◽  
Membrane Integrity ◽  
Semen Parameters ◽  
Cochrane Library ◽  
Negative Effects ◽  
The Impact

Context: As the use of cellphones and other electronic devices increases, concerns about the possible effect of radiofrequency waves on health are growing. Long-term use of the cellphone may have negative effects on sperm quality. Objectives: The purpose of this research was to examine men's infertility due to the effect of radiofrequency waves. Methods: In this systematic review, language restrictions were not considered in searching the databases. Cochrane Library, Google Scholar, PubMed, EMBASE, ProQuest, CINAHL, Science Direct, MEDLINE, and Scopus were used to obtain the data from them. All data were scanned from the year 2000 until 2019. Papers selected for retrieval were evaluated by the Newcastle-Ottawa and CONSORT scales. Results: A total of 14 articles that met the inclusion criteria were ultimately assessed. Motile sperm, sperm vitality and membrane integrity, morphology, volume, total sperm count, sperm concentration, and sperm fertility were found to be influenced by radiofrequency waves. Conclusions: The results showed that RF has detrimental effects on semen parameters and due to an increase in RF wave use currently and its role in male infertility, giving information to men about adverse complications of RF is necessary. Further studies are needed to design the less harmful devices.

scholarly journals A CASE STUDY-INFERTILITY & AYURVEDA

2021 ◽  
Vol 5 (02) ◽  
Author(s):  
Pranali Dandekar
Keyword(s):  
Herpes Simplex ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Viral Infections ◽  
Specific Treatment ◽  
Reproductive Organs ◽  
Previous Pregnancy ◽  
Herpes Simplex Viruses ◽  
Maternal Infections

Ayurveda emphasized on four main essential factors for fertility i.e. Ritu(menstruation),Kshetra(functioning reproductive organs),Ambu(Digestive juices) and Bija(Healthy sperm and ovum) .Abnormality in any one of this factors causes infertility.Infertility is a failure to conceive within one or more years of regular unprotected coitus.Primary infertility denotes who has never conceived and secondary indicates previous pregnancy but failure to conceive subsequently. Secondary Infertilily with recurrent pregnancy loss because of Viral infections like TORCH is a worrisome issue for the reproductive couple.Majority of early missed abortions and spontaneous abortion are seen in current population of country.Toxoplasmosis,cytomegaly virus,rubella and herpes simplex viruses are responsible for manifestation of the maternal infections causing early pregnancy loss.According to Ayurveda recurrent pregnancy loss is specified under Putraghni yonivyapad and specific treatment like Uttarbasti is described for the same. As yoniyapada leads to infertility because of vikrit Vata ,ultimately the treatment of Vata i.e. bastichikitsa is seen very beneficial in the treatment of Infertility.

scholarly journals The Role of Exercise to Reduce the Impact of Diabetes in the Seminal Quality: A Systematic Review

Medicina ◽  
2021 ◽  
Vol 57 (2) ◽  
pp. 159
Author(s):  
Ana Myriam Lavín-Pérez ◽  
Daniel Collado-Mateo ◽  
Santos Villafaina ◽  
Violeta Calle-Guisado
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Physical Exercise ◽  
Exercise Intervention ◽  
Sperm Quality ◽  
Sperm Count ◽  
Group 2 ◽  
Induced Apoptosis ◽  
Meta Analyses ◽  
The Impact

Background and Objectives: One of the most relevant consequences of diabetes mellitus is the temporal or complete infertility which can happen in young individuals. Therefore, the current systematic review aimed to investigate the effects of exercise to reduce the impact of Type 2 Diabetes Mellitus (T2DM) in seminal quality and related parameters. Materials and Methods: A systematic search was conducted in Pubmed and Web of Science databases following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Guidelines (PRISMA). The inclusion criteria were: (1) the study included at least one experimental and one comparison group, (2) the sample of the study was comprised of humans or animals with diabetes mellitus, (3) an intervention based on physical exercise was conducted, and (4) the study reported variables related to the seminal quality. Results: A total of 115 articles were identified. However, only six accomplished the inclusion and exclusion criteria. This systematic review includes a sample size of 260 participants (180 rats and 80 humans). Intervention ranged from 6 to 14 weeks, with 3–6 days per week. All interventions performed endurance training (50–70% VO2max or maximum heart rate). Physical exercise increased sperm count, motility, and morphology, as well as improved testosterone, Luteinizing Hormone (LH), and Follicle Stimulating Hormone (FSH) levels. Moreover, physical exercise intervention reduced the percentages of sperms with negative Tubular Differentiation Index (TDI) and Spermiogenesis Index (SPI), DNA fragmentation, and also ameliorated the diabetes-induced apoptosis and improved sperm apoptosis index. Conclusions: Physical exercise could ameliorate diabetic pathological effects on sperm quality and related parameters that cause infertility or subfertility conditions. However, further homogeneous studies are needed to confirm these findings.

scholarly journals Chronic Inflammation Impairs Male Fertility—A Case-Control Study in Ulcerative Colitis Patients

2021 ◽  
Vol 10 (7) ◽  
pp. 1460
Author(s):  
Artur Wdowiak ◽  
Mariusz Gujski ◽  
Iwona Bojar ◽  
Dorota Raczkiewicz ◽  
Joanna Bartosińska ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Dna Fragmentation ◽  
Male Fertility ◽  
Sperm Quality ◽  
Sperm Count ◽  
Microbial Pathogens ◽  
Semen Parameters ◽  
Control Group ◽  
Study Group ◽  
Healthy Males

Recent evidence indicates that a systemic state of inflammation may exert a negative effect on male fertility. The aim of this study is to evaluate sperm quality parameters in male patients with ulcerative colitis (UC). Between December 2019 and December 2020 semen analyses are performed in 50 patients with UC in clinical remission. The control group consists of 50 healthy volunteers. Total sperm count, sperm count, percentage of morphologically normal spermatozoa, viability, and progressive motility, are significantly lower in the study group than in healthy males (p < 0.001). The DNA fragmentation index (DFI) and oxidation-reduction potential (ORP) are significantly higher in the study group (28.9% and 1.55% on average, respectively) than in healthy males (14.6% and 0.79% on average, respectively). Bacteriospermia is more clearly observed in the study group (p = 0.037), and the most frequent pathogen is Enterococcus faecalis. The DFI and ORP are significantly higher in bacteria carriers, compared to males without microbial pathogens from both the study and control groups (p < 0.001). To conclude, UC patients have worse basic sperm parameters compared to their healthy counterparts. Deterioration of semen parameters, as well as an intensified DNA fragmentation could be a result of oxidative stress intensification.

scholarly journals Effect of Lunasia amara Blanco on Sperm Number, Sperm Motility, and Testicular Histology of Male Rats

2015 ◽  
Vol 4 (2) ◽  
pp. 31
Author(s):  
Muhammad Ja’far Luthfi
Keyword(s):  
Sperm Motility ◽  
Male Fertility ◽  
Sperm Quality ◽  
Sperm Count ◽  
Male Rats ◽  
Quality Analysis ◽  
Sprague Dawley ◽  
Sperm Analysis ◽  
Testicular Histology ◽  
Positive Effect

<p>Sanrego (<em>Lunasia amara</em>), has been used in the folk medicine to increase and/or to treat male fertility. However there is no scientific evidence to confirm the positive effect of the plant on an improvement of male fertility. The objective of this research was to study the effects of the plant (on adult Sprague-Dawley male rats) at the doses of 30 mg/kg, 60 mg/kg, and 90 mg/kg on the sperm count, motility, and testicular histology. Administration were given by force-feeding between 10.00 am and 12.00 pm daily for a period of 42 days followed by sperm quality analysis and testicular histology evaluation. The sperm analysis showed that the sanrego increased the sperm count and sperm motility. The testicular histology also revealed positive effect of the plant on spermatogenesis.   Overall the present study showed the sanrego is potential plant to increase male fertility.</p>

scholarly journals Influence of environmental factors on the qualitative and quantitative parameters of male ejaculate (literature review)

2019 ◽  
Vol 23 (3) ◽  
pp. 530-534
Author(s):  
S.V. Khmil ◽  
O.Yu. Mayorova ◽  
I.V. Dudchuk
Keyword(s):  
Environmental Factors ◽  
Sperm Quality ◽  
Sperm Count ◽  
Sperm Concentration ◽  
Toxic Substances ◽  
Normal Morphology ◽  
Qualitative And Quantitative ◽  
Literary Sources ◽  
The Impact

Today it is important to study the problem of male infertility, as well as to identify the factors of its occurrence. The purpose of the work is to evaluate the overall picture of the quality of ejaculate during the last 50 years and to determine the reasons for such changes. More than 40 literary sources were published for thorough analysis in the period 1984–2018 (the share of new references is 20%). There was a decrease in sperm concentration by 1.5% / year, total sperm count — 1.6% / year, total sperm motility — 0.4% / year, decrease in the percentage of progressive motility sperm by 5.5% / year and with normal morphology 2.2% / year. One of the main reasons for the deterioration of sperm quality is the impact of negative environmental factors — chemical and radioactive contamination, as well as electromagnetic radiation. Among the most toxic substances are the heavy metals, pesticides, bisphenol A, phthalates, polychlorinated biphenyls, dioxin and its derivatives. Thus, over the last 50 years there has been a decline in the qualitative and quantitative indices of ejaculate men worldwide. One of the reasons is the worsening environmental situation.

Microbiota-independent antiviral protection conferred by aminoglycoside antibiotics

2018 ◽  
Author(s):  
Smita Gopinath ◽  
Myoungjoo V. Kim ◽  
Tasfia Rakib ◽  
Patrick W. Wong ◽  
Michael van Zandt ◽  
...  
Keyword(s):  
Influenza A ◽  
Viral Infections ◽  
Antibiotic Use ◽  
Antiviral Effect ◽  
Aminoglycoside Antibiotics ◽  
Host Cells ◽  
Vaginal Mucosa ◽  
Herpes Simplex Viruses ◽  
The Impact

AbstractAntibiotics are widely used to treat infections in humans. However, the impact of antibiotic use on host cells is understudied. We have identified a novel antiviral effect of commonly used aminoglycoside antibiotics. We show that mucosal application of aminoglycosides increased host resistance to a broad range of viral infections including herpes simplex viruses, influenza A virus and Zika virus. Aminoglycoside treatment also reduced viral replication in primary human cells. This antiviral activity was independent of the microbiota as aminoglycoside treatment protected germ-free mice. Microarray analysis uncovered a marked upregulation of transcripts for interferon-stimulated genes (ISGs) following aminoglycoside application. ISG induction was mediated by TLR3, and required TIR-domain-containing adapter-inducing interferon-β (TRIF), signaling adaptor, and interferon regulatory factors 3 (IRF3) and IRF7, transcription factors that promote ISG expression. XCR1+ dendritic cells, which uniquely express TLR3, were recruited to the vaginal mucosa upon aminoglycoside treatment and were required for ISG induction. These results highlight an unexpected ability of aminoglycoside antibiotics to confer broad antiviral resistancein vivo.

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