scholarly journals Influence of single oral administration of taurine-dextrin associate on concentration of amino acids in rat plasma

2020 ◽  
Vol 22 (2) ◽  
pp. 15-19
Author(s):  
R. D. Ostapiv ◽  
◽  
O. I. Lukashchuk ◽  
V. Ya. Samaryk ◽  
M. I. Nagornyak ◽  
...  
Keyword(s):  
Amino Acids ◽  
Oral Administration ◽  
Blood Plasma ◽  
Rat Plasma ◽  
Group Iv ◽  
Control Group ◽  
Liquid Chromatograph ◽  
The Third ◽  
Single Oral Administration ◽  
Experimental Group

The aim of the study was to test the ability of dextrin particles of different sizes, modified with N-stearylglutamic acid, to increase the transport of taurine into the blood plasma of rats. To achieve this goal, Wistar rats weighing 240–260 g were divided into control and four experimental groups. The control group was administered once perorally with water. The first experimental group was administered perorally with an aqueous solution of taurine at a dose of 100 mg/kg, the second and third ― a solution of taurine-dextrin associate with particle sizes of 60–90 nm and 500–800 nm, in which the dose of taurine was 100 mg/kg. The fourth experimental group (IV) was administered only dextrin. In 30 min, the rats were decapitated, and blood was collected. Blood cells and proteins were precipitated, and samples were derivatized with 1-fluoro-2,4-dinitrobenzene. Free amino acids of plasma were separated on a Dionex Ultimate 3000 liquid chromatograph equipped with a spectrophotometric detector, chromatographic column Luna C18 (2) 250×4.6 mm, elution type was gradient. It was registered that in the first and third experimental groups the content of taurine in the blood plasma of rats was 33.8% higher than in the control. Oral administration of taurine-dextrin associate with 60–90 nm particles increases the taurine content by 62.6% compared to the control and by 21.6% more than in the first and third experimental groups. This indicates efficient transport of taurine by dextrin only with particles of 60–90 nm. Administration of both taurine and taurine-dextrin associate reduced concentrations of glutamine, methionine, lysine, alanine, phenylalanine, and histidine. Moreover, the reason for the decrease in the content of the last two amino acids was not only taurine, but also the transporter itself. With the administration of the transporter the concentration of asparagine was lower than in control, and the content of arginine, on the contrary, higher. In the first experimental group, the concentration of aspartic acid and serine decreased, and in the second ― valine, leucine and tryptophan, in the third ― glutamic acid. The glycine content increased in the second experimental group. Ornithine content in all experimental groups except the third was higher, compared with the control. Thus, modified dextrin with a particle size of 60–90 nm increases the transport of taurine into the blood.

scholarly journals Intensity of growth of calves of Ukrainian black-and-white dairy breed in colostrum and milk periods while feeding them with pyridoxine hydrochloride

2019 ◽  
Vol 21 (90) ◽  
pp. 108-112
Author(s):  
O. V. Yaremko ◽  
R. A. Peleno
Keyword(s):  
Live Weight ◽  
Group Iv ◽  
Scar Formation ◽  
The Body ◽  
Control Group ◽  
Pyridoxine Hydrochloride ◽  
Group V ◽  
The Third ◽  
Daily Increments ◽  
Experimental Group

The effect of pyridoxine hydrochloride on the body mass of animals, absolute and average daily increment, relative growth rate, growth factor of live weight and multiplicity of increase in live weight of calves in the early stages of postnatal ontogenesis were studied. For the experiment, six groups of one-day calves (control and five experimental) were formed, with 5 animals in each, which, in addition to the main diet (MD), fed pyridoxine hydrochloride in different doses, according to the scheme: control group – MD, I experimental group – MD + 1 mg/kg g. m pyridoxine hydrochloride, II – MD + 2 mg/kg g. m of the preparation, ІІІ – MD + 3 mg/kg of w. m., IV – MD + 4 mg/kg g. m and V experimental group – MD + 5 mg/kg g. m pyridoxine hydrochloride. Conditionally, the research was divided into four periods: colostrum – from birth and up to 5 days, until the formation of digestion – from 5 to 21 days, the period of the formation of digestion scar – from 21 to 60 days and the end of the milk period – from 60 to 90 days. It was established that feeding to calves with pyridoxine hydrochloride resulted in an increase in the live weight of 60 days of calves by 5.9% in the second group (P < 0.05), by 8.7% in the third group, by 8.3% in IV and 9.2% in V groups (P < 0.001) and for 90 days it was higher by 9.3%, 9.1%, 9.2% and 9.1% respectively (P < 0.05). The highest average daily increments were in the colostrum period in calves IV and V groups, which were added to the main diet, respectively, 4 and 5 mg/kg b.w. pyridoxine hydrochloride, in the period prior to the formation of digestion scar in calves of group IV, in the period of the formation of digestion scar in calves of the III group and at the end of the milking period in calves of group V. Absolute incresements of calves in the colostrum period and the period prior to the formation of digestion scar were the highest in calves of Group IV and the difference in control was respectively 0.34 and 1.05 kg. During the period of the digestion scar formation and the end of the milk period, the highest absolute increases were in calves of group V, which was added to the main ration of 5 mg/kg b.w. pyridoxine hydrochloride. The highest increase in body weight of calves in colostric period and prior to the operation scar rate was in group IV, the period of digestion scar formation was in the third group and during the completion period of milk in the second group of calves. In colostric period the increase of live weight was higher in calves III, IV and V groups of 5 to 21 days in calves of group IV, from 21 to 60 days in the third group and during the completion period of milk in the second group of calves.

scholarly journals The morphological composition of the blood and the peculiarities of metabolism in gonadectomized cockerels of the Adler silvery breed

2021 ◽  
pp. 18-26
Author(s):  
I. Cheverda ◽  
M. Zakharenko
Keyword(s):  
Uric Acid ◽  
Blood Plasma ◽  
The Body ◽  
Metabolic Parameters ◽  
Clinical State ◽  
Control Group ◽  
The Third ◽  
Morphological Composition ◽  
Physiological Values ◽  
Experimental Group

The article reflects the results of a study of the morphological composition of blood, indicators of metabolism and the content of hormones in the blood plasma of gonadectomized cockerels of the Adler silvery breed. In the experiment, 40 males were used at the age of 6 weeks, of which two groups were formed, a control and an experimental, 20 heads each. It was found that during the preparatory (leveling) period, the clinical state, morphological composition of blood and metabolic parameters in the experimental group of males did not differ from each other and were within the limits of their physiological values. There were also no differences in blood glucose concentration, protein content, triglycerol, cholesterol, uric acid, as well as the activity of alkaline phosphatase, alanine and aspartate aminotransferase in the blood plasma of cockerels in the experimental and control groups during the preparatory period. Gonadectomy of males by surgical intervention at the age of six weeks did not significantly affect the morphology of their blood on the third day, with the exception of ESR, the value of which in birds of the experimental group was 1.9 times higher than in the control. In gonadectomized males, the number of platelets in the blood decreased by 30.7% compared to the control, which indicates a decrease in platelet activity and is probably associated with their participation in blood coagulation processes in the body after gonadectomy. Other indicators of the morphological composition of blood, namely, the number of erythrocytes, leukocytes, lymphocytes, eosinophils and neutrophils in gonadectomized males did not change compared with the control. It was found that the concentration of glucose in the blood, as well as total protein and uric acid in the blood plasma of males who underwent gonadectomy on the third day of the research period were at the level of the values of the control group birds and corresponded to the physiological values of these parameters in clinically healthy birds. On the 125th day of the main period in gonadectomized males, the level of glucose and protein, as well as indicators of lipid metabolism, namely, the concentration of triglycerol and cholesterol in the blood plasma did not change, while the content of uric acid increased by 23.7% compared with the control. It was found that the content of cortisol in the blood plasma of gonadectomized males was 3.2 times lower, and testosterone 10.2 times lower than in the control. So, gonadectomy of cockerels does not affect the morphological composition of the blood, indicators of the metabolic status of the bird, but it helps to reduce the content of cortisol and testosterone in the blood plasma. Key words: roosters, gonadectomy, blood morphology, metabolic parameters, enzyme activity, cortisol, testosterone.

scholarly journals GLOBIGEN JUMP START APPLICATION WITHIN THE PRE-STARTER FEED TO THE POST-WAENING PIGLETS

2021 ◽  
Vol 22 (1) ◽  
pp. 184-190
Author(s):  
T. Y. Prudius ◽  
A. V. Hutsol ◽  
N. V. Hutsol ◽  
O. O. Mysenko
Keyword(s):  
Amino Acids ◽  
Blood Plasma ◽  
African Swine Fever ◽  
Essential Amino Acids ◽  
Feed Additives ◽  
Feed Additive ◽  
Animal Origin ◽  
Control Group ◽  
Negative Effect ◽  
Experimental Group

Balanced addition of essential amino acids, vitamins and minerals, easily digestible proteins, namely proteins of animal origin is an important factor for efficient feeding and pigs performance, that leads to a systematic search for new solutions when using feed additives. They provide digestibility, better absorbtion of protein, vitamins, minerals and other nutrients. Such supplements include blood plasma, meat and bone meal, fish meal and others. Besides fishmeal, other protein groups are dangerous in relation to African swine fever. Furthermore blood plasma additionally to the protein group contains immunoglobulins that can passively affect the immune system of piglets, An alternative to blood plasma is the animal nutrition supplement Globigen Jump Start, which is made from chicken eggs, containing essential and replaceable amino acids with a high percentage of absorption. Another important factor is the presence of specific IgY immuno-globulins, which being ingested have a negative effect on the pathogenic intestinal microflora, namely viruses, bacteria and cryptosporidium. Knowledge of the feed additive Globigen Jump Start effect gave impetus to the study of its effect on the piglets’ performance during the stressful period after weaning. The objective of the work was evaluation of the effect of the Globigen Jump Start fed within the pre-starter feed on the productive characteristics of post-weaning piglets. Based on the obtained research results, the best ones were shown in the experimental group, which was fed compound feed containing Globigen Jump Start in the amount of 2 kg / t of compound feed. It was found that at the end of the experiment, the weight of piglets in the control group was 19.2 kg, and in the experimental group - 21.0 kg, which is 1.8 kg or 9.4% more comparing to the control.

THE EFFECT OF APPLYING DEMONSTRATION METHOD ON STUDENTS’ ACHIEVEMENT IN SPEAKING SKILL AT THE THIRD GRADE OF SMK PAB 3 MEDAN ESTATE

2015 ◽  
Vol 4 (2) ◽  
Author(s):  
Meryanti Napitupulu And Anni Holila Pulungan
Keyword(s):  
High School ◽  
Control Group ◽  
Vocational High School ◽  
Control Groups ◽  
Speaking Test ◽  
The Third ◽  
Speaking Skill ◽  
The Subject ◽  
And Control ◽  
Experimental Group

This study was conducted as an attempt to discover the effect of applying Demonstration Method on students’ achievement in speaking skill. It was an experimental research. The subject was students of Grade XII, Vocational High School (Sekolah Menengah Kejuruan: SMK), which consisted of 79 students. The research was divided into two groups: experimental and control groups. The instrument used to collect the data was speaking test. To obtain the reliability of the test, the writer applied Kuder Richardson 21 formula. The result of the reliability was 0.7, and it was found that the test was reliable. The data were analyzed by using t-test formula. The analysis showed that the scores of the students in the experimental group were significantly higher than the scores of the students in the control group at the level of significant m = 0.05 with the degree of freedom (df) 77, t-observed value 8.9 > t-table value 1.99. The findings indicate that using Demonstration Method significantly affected the students’ achievement in speaking skill. So, English teachers are suggested to use Demonstration Method in order to improve students’ achievement in speaking skill.

scholarly journals The occurrence rate and clinical application of Osteo-line on the femur neck

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Mingchen Zou ◽  
Haotian Wu ◽  
Shuangquan Yao ◽  
Dong Ren ◽  
Song Liu ◽  
...  
Keyword(s):  
Clinical Application ◽  
Visual Inspection ◽  
Occurrence Rate ◽  
Control Group ◽  
Leg Length ◽  
X Ray ◽  
The Third ◽  
Femur Neck ◽  
Medical University ◽  
Experimental Group

Abstract Background This study was done to observe the incidence of Osteo-line on the femur neck and to explore the clinical application of Osteo-line in osteotomy. Methods Eighty-nine adult femur specimens were selected to observe the incidence of Osteo-line on the femur neck. From August 2015 to January 2019, a total of 278 patients who completed unilateral hip arthroplasty at the Third Hospital of Hebei Medical University were retrospectively included. Patients who accepted osteotomy via Osteo-line on the femur neck were defined as the experimental group (n = 139), and patients who accepted osteotomy via traditional method (The femoral distance 1.5 cm above the trochanter was retained for osteotomy by visual inspection.) were defined as the control group (n = 139). According to the postoperative pelvic X-ray, Photoshop was used to evaluate the leg length discrepancy (LLD) by the CFR-T-LT method. Results Among the 89 specimens, the incidence of anterior Osteo-line was 75.28%, and the incidence of posterior Osteo-line was 100%. According to the clinical application results, the incidence of anterior Osteo-line on the femur neck was 80%, and the incidence of posterior Osteo-line was 100%. The Osteo-line was clearer than those on the femoral specimens. Twenty-six cases had LLD greater than 1 cm (9.29%), including 2 cases in the experimental group and 24 cases in the control group. The average postoperative LLD in the experimental group (0.19 ± 0.38 mm) was significantly shorter than in the control group (0.54 ± 0.51 mm)(P = 0.005). Conclusion The incidence of Osteo-line on the femur neck was high, and patients who accepted osteotomy via Osteo-line on the femur neck can achieve shorter postoperative LLD than the control group.

scholarly journals BIOLOGICAL EFFECTS OF SILICON OXIDE NANOPARTICLES ON BROILER CHICKEN

2020 ◽  
Vol 5 (2) ◽  
pp. 63-71
Author(s):  
Vladimir Nikulin ◽  
Aleksandra Mustafina
Keyword(s):  
Red Blood Cells ◽  
Total Protein ◽  
Blood Cells ◽  
Broiler Chickens ◽  
Broiler Chicken ◽  
Silicon Oxide ◽  
The Body ◽  
Control Group ◽  
The Third ◽  
Experimental Group

The aim of the study is to increase the productive qualities of broiler chickens by including ultrafine silicon oxide into main diet. During the experiment, the biological effect of ultrafine silicon oxide on broiler chickens was estab-lished. Use of ultrafine SiO2 particles for poultry feeding contributed to an increase in the number of red blood cells and content of total protein and albumins. By the end of the experiment, the number of red blood cells in birds in-creased by 17.43% (P≤0.001) – in the blood of birds of the first experimental group, 16.51% (P≤0.01) – the second one, 20.80% (P≤0.001) – the third experimental and 21.71% (P≤0.001) – the fourth experimental group, compared with the indicator of the control group. The amount of total protein in blood serum of chickens of the first and the second experimental groups increased by 1.36-1.39 %, in the third and fourth ones there was a significant (P≤0.05) increase by 5.45 and 3.05%, respectively. The blood glucose content of chickens in the experimental groups is higher by 8.04-23.65% compared to this indicator with ones in the control group. During the experiment feed con-sumption per 1 kg gain of live weight decreased: in the first experimental group by 3.00 % in the second by – 0.50 %, the third – 6.00 % the fourth– by 4.50 %, compared to this with the control group. The chicken’s vibrancy of the first the experimental group was higher by 4.77 %, the second – by 6.20 %, the third – by 19.25 % and the fourth– by 11.59% than in the control one. Consequently, when converting the feed energy into the body energy of a broiler chicken, the energy conversion coefficient of the experimental group of poultry is higher than that of the control one by 7.16-21.76 %. Thus, the most optimal dose for further research was determined.

scholarly journals Therapeutic Effect of Oral Administration and External Therapy of Traditional Chinese Medicine on Cervical Tuberculous

2019 ◽  
Vol 3 (3) ◽  
Author(s):  
Guoqiang Yang ◽  
Jin Zhang
Keyword(s):  
Statistical Analysis ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Oral Administration ◽  
Total Effective Rate ◽  
Statistical Significance ◽  
Effective Rate ◽  
Control Group ◽  
Treatment Data ◽  
Experimental Group

Objective: To analyze the clinical effect and value of oral administration and external therapy of traditional Chinese medicine for treatment of cervical tuberculous lymphadenopathy. Methods: A total of 56 patients with cervical tuberculous lymphadenopathy admitted to our hospital from January 1 to January 2018 were recruited. By using double-blind method, the patients were divided into control group (n=28) and experimental group (n=28). Control group comprised of patients with conventional anti-tuberculosis treatment, while the experimental group comprised of patients treated with oral administration and external therapy of traditional Chinese medicine. Total effective rate, incidence of complication and level of T lymphocyte subsets were compared between the two groups of cervical tuberculous lymphadenopathy patients. Results: Post-treatment data of total effective rate, complication rate, CD3+, CD4+, CD8+, CD4+/CD8+ of the experimental group were compared with the control group. P<0.05; statistical analysis showed statistical significance. Post-treatment data of CD3+, CD4+, CD8+, CD4+/CD8+ of both control and experimental groups were compared with pre-treatment data. P<0.05; statistical analysis showed statistical significance. Conclusion: Oral administration and external therapy of traditional Chinese medicine possesses significant effect in treatment of cervical tuberculous lymphadenopathy.

scholarly journals Dynamics of the Antioxidant System and Endogenous Intoxication in Patients Being Treated for Microbial Eczema

2019 ◽  
Vol 26 (4) ◽  
pp. 56-65
Author(s):  
М. M. Tlish ◽  
Е. К. Popandopulo
Keyword(s):  
Molecular Weight ◽  
Blood Plasma ◽  
Antioxidant System ◽  
Catalase Activity ◽  
Reduced Glutathione ◽  
Control Group ◽  
Low Molecular Weight ◽  
Antioxidant Defence ◽  
Endogenous Intoxication ◽  
Experimental Group

Aim. The paper studies the dynamics of the indicators defi ning the antioxidant system (AOS) and endogenous intoxication in patients with microbial eczema (ME) prior to and following treatment.Materials and methods. The experimental group consisted of patients with ME (n=30) and the control group comprising somatically healthy individuals (n=30). In this study, we determined the components of the antioxidant defence system in blood plasma and erythrocyte suspension, as well as assessed endogenous intoxication.Results. The study revealed an imbalance of indicators refl ecting the severity of oxidative stress and endogenous intoxication in patients suffering from ME. Prior to receiving treatment, the experimental group, as compared to the control group, exhibited an increase in catalase activity (CAT) up to 35.93 [32.50; 38.22] mmol / (min • l) (p < 0.001) and glutathione peroxidase (GPx) up to 1194.27 [1069.50; 1375.78] μmol / (min • l) (p < 0.001). In addition, there was a decrease in the activity of superoxide dismutase (SOD) to 13.28 [11.35; 14.10] u/l (p < 0.001), glutathione reductase (GR) to 501.46 [479.77; 542.52] mmol / (min • l) (p < 0.001) and the concentration of reduced glutathione to 1.64 [1.59; 1.78] μmol / ml (p = 0.043). We observed no statistically signifi cant changes in the total antioxidant activity (TAA) of blood plasma (0.59 [0.55;0.62] mg/l; р = 0.375) and the sulphhydryl groups (0.44 [0.41;0.47] ODU; р =0.111). The patients with ME exhibited the syndrome of endogenous intoxication (SEI), accompanied by an increase in the content of medium and low molecular weight molecules in plasma to 12.19 [11.20; 13.37] arb. u. (p < 0.001), with their content in erythrocytes being relatively normal – 15.23 [14.26; 16.44] arb. u. (p = 0.005). Following the treatment, changes in the studied parameters were of a multidirectional character in relation to the control values. An increased level of CAT and GPx (р <0,001), as well as lower values of SOD and GR, continued to be observed (р < 0.001). The TAA in serum (p = 0.308), sulphhydryl groups (p = 0.111) and reduced glutathione (p = 0.107) did not differ signifi cantly from the control values. The treatment did not reverse the SEI: the content of medium and low molecular weight molecules continued to increase in both plasma and erythrocytes, as compared to the control values (p < 0.001 in both cases).Conclusion. The obtained data confi rm the failure of mechanisms underlying antioxidant defence in patients with ME. Despite the attempt of its compensation by increasing the catalase activity, SOD control values were still not reached. An increase in the GPx activity along with a decrease in GR was observed, which could have lead, in turn, to a decrease in the concentration of reduced glutathione. The failure of the antioxidant defence mechanisms is also indicated by an increase in the content of medium and low molecular weight molecules, as well as by the development of the SEI, resulting from the excessive formation of reactive oxygen species and the inability of the antioxidant system to neutralise them.

scholarly journals Individual and combined usage of enzyme preparation and heat-treated cereals in pig fattening

2011 ◽  
Vol 51 (No. 4) ◽  
pp. 157-162
Author(s):  
M. Domaćinović ◽  
Z. Steiner ◽  
Đ. Senčić ◽  
Z. Antunovic ◽  
P. Mijić
Keyword(s):  
Muscle Tissue ◽  
Enzyme Preparation ◽  
Control Group ◽  
Pork Production ◽  
The Third ◽  
Combined Application ◽  
Heat Treated ◽  
Group 3 ◽  
Group 2 ◽  
Experimental Group

In order to reach better production and financial results of pork production different technological ways of pig fattening are researched. The purpose of this paper is to show separate results of polyenzyme application and the results of the use of heat-treated cereals in pig fattening as well as the results of their combined application. Pigs fattened on a diet with polyenzyme preparation and heat-treated cereals, either separately or combined, were characterised by an insignificantly higher growth rate and their feed intake per kilogram of weight gain was low compared to pigs fed standard mixtures (control group). In statistical terms, the relative portion of muscle tissue in pork carcass was significantly lower in experimental group 3 fed the mixture with heat-treated cereals than in the other groups. The absolute portion of muscle tissue in pork carcass was statistically more important in experimental group 2 (45.15 kg) receiving the mixture of enzyme additive and heat-treated cereals, and the least important in experimental group 3 (40.92 kg) fed heat-treated cereals. During pig fattening the income for experimental groups was higher than for the control group because of better production results. Average values covering variable expenses show the increase only in the third experimental group in the second fattening period compared to the control group, but these differences were of no statistical importance. &nbsp;

scholarly journals Simultaneous Determination and Pharmacokinetic Characterization of Glycyrrhizin, Isoliquiritigenin, Liquiritigenin, and Liquiritin in Rat Plasma Following Oral Administration of Glycyrrhizae Radix Extract

Molecules ◽  
2019 ◽  
Vol 24 (9) ◽  
pp. 1816 ◽  
Author(s):  
You Jin Han ◽  
Bitna Kang ◽  
Eun-Ju Yang ◽  
Min-Koo Choi ◽  
Im-Sook Song
Keyword(s):  
Oral Administration ◽  
Analytical Method ◽  
Plasma Concentrations ◽  
Rat Plasma ◽  
Pharmacokinetic Studies ◽  
Elution Time ◽  
Glycyrrhizae Radix ◽  
Single Oral Administration ◽  
Limit Of Quantitation ◽  
Liquid Chromatography Tandem Mass

Glycyrrhizae Radix is widely used as herbal medicine and is effective against inflammation, various cancers, and digestive disorders. We aimed to develop a sensitive and simultaneous analytical method for detecting glycyrrhizin, isoliquiritigenin, liquiritigenin, and liquiritin, the four marker components of Glycyrrhizae Radix extract (GRE), in rat plasma using liquid chromatography-tandem mass spectrometry and to apply this analytical method to pharmacokinetic studies. Retention times for glycyrrhizin, isoliquiritigenin, liquiritigenin, and liquiritin were 7.8 min, 4.1 min, 3.1 min, and 2.0 min, respectively, suggesting that the four analytes were well separated without any interfering peaks around the peak elution time. The lower limit of quantitation was 2 ng/mL for glycyrrhizin and 0.2 ng/mL for isoliquiritigenin, liquiritigenin, and liquiritin; the inter- and intra-day accuracy, precision, and stability were less than 15%. Plasma concentrations of glycyrrhizin, isoliquiritigenin, liquiritigenin, and liquiritin were quantified for 24 h after a single oral administration of 1 g/kg GRE to four rats. Among the four components, plasma concentration of glycyrrhizin was the highest and exhibited a long half-life (23.1 ± 15.5 h). Interestingly, plasma concentrations of isoliquiritigenin and liquiritigenin were restored to the initial concentration at 4–10 h after the GRE administration, as evidenced by liquiritin biotransformation into isoliquiritigenin and liquiritigenin, catalyzed by fecal lysate and gut wall enzymes. In conclusion, our analytical method developed for detecting glycyrrhizin, isoliquiritigenin, liquiritigenin, and liquiritin could be successfully applied to investigate their pharmacokinetic properties in rats and would be useful for conducting further studies on the efficacy, toxicity, and biopharmaceutics of GREs and their marker components.

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