Effect of zinc nanoaquacitrate on the biochemical and productive parameters of the organism of rabbits

Zinc is an essential microelement for the organism of animals, and its deficiency reduces the synthesis and degradation of proteins, lipids, carbohydrates and nucleic acids, and also decreases the metabolism of vital microelements. The objective of the study was determining the effect of various amounts of zinc nanoaquacitrate on the biochemical parameters of blood and productivity of the organism of rabbits after weaning on 50th to 86th days of life. Compared with the control group, intake of zinc nanoaquacitrate by the animals of the experimental groups exhibited dose-dependent effect on separate biochemical parameters which characterize the processes of lipid and mineral metabolisms, which manifested in the increase in their content in the blood on the 12th, 24th and 36th days of the experiment. Watering rabbits with zinc citrate in the dose of Zn 0.25 mg/kg after weaning determined its physiological effect on the biochemical parameters of their organism, expressed in the most statistically reliable changes compared with other tested amounts, particularly a higher level of the total protein, increase in the activities of glutathione reductase, alanine aminotransferase, catalase and alkaline phosphatase and decrease in the levels of cholesterol, lipid hydroperoxides, compared with the control, which may indicate the positive effect of the applied additives on certain biochemical parameters of the rabbits’ organism. Additional use of zinc citrate in the dose of 0.50 mg/kg of body weight was manifested in their blood by significant increase in the activities of catalase and glutathione reductase, lower level of lipid hydroperoxides and increase in the organism’s growth parameter by 3.1% in the final period of the study. Watering zinc citrate in the amount of 0.75 mg/kg of body weight provoked probable decrease in the level of cholesterol and triacylglycerols and increases in catalase and glutathione reductase, increase in activity of alanine aminotrasferase and decrease in lipid hydroperoxides, which determined the stimulating effect on the growth of the organism with 8.4% higher total gain of body weight after 36 days of the experiment. From a general perspective, the research indicates that intake of lowest amount of zinc citrate was characterized by the greatest effect on the biochemical blood parameters, whereas the use of greater amounts of organic compound of zinc showed positive effect on the processes of growth and development of the organism of rabbits after weaning. Of practical importance is the study of the effect of watering zinc nanoaquacitrate in the physiologically substantiated amounts on biochemical blood parameters and growth and survivability of the offspring and organism of the mother rabbit in the period of lactation.

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The influence of hypothermia prevention by application of skin moisture absorbent on the value of body temperature, body weight and blood parameters in piglets

Arquivo Brasileiro de Medicina Veterinária e Zootecnia ◽

10.1590/1678-4162-12371 ◽

2021 ◽

Vol 73 (5) ◽

pp. 1058-1066

Author(s):

M. Mirkov ◽

I. Radović ◽

M. Cincović ◽

M. P. Horvatović ◽

S. Dragin

Keyword(s):

Body Weight ◽

Body Temperature ◽

Biochemical Parameters ◽

Blood Parameters ◽

Economic Losses ◽

Control Group ◽

Pig Production ◽

Hematological And Biochemical Parameters ◽

Moisture Absorbent ◽

Skin Moisture

ABSTRACT Reducing the mortality rate is of a great economic importance for pig farming. Therefore, it is necessary to define the conditions in the farrowing unit based on the performance of the piglets, and specific hematological and biochemical parameters. Therefore, the aim of this paper is to examine the importance of using skin moisture absorbent and its influence in preventing hypothermia, which causes great economic losses in pig production. The experiment was set up on a commercial farm in Serbia and included 92 pigs divided into the experimental and control group. Body temperature values, body weight and blood parameters were monitored. The obtained values indicate that there is a significantly positive correlation of body temperature change and body weight values, and body temperature showed a significantly higher increase in the experimental group compared to the control group. The results obtained from hematological and biochemical parameters provide a clearer picture of the metabolic processes in piglets in the farrowing unit and can be used to further improve pig production and as a complement to genetic enhancement.

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The “Mix-Factor” is involved in the regulation of the organism's redox systems in the late stages of ontogenesis and affects the lifespan of animals

Ageing & Longevity ◽

10.47855/jal9020-2021-2-4 ◽

2021 ◽

pp. 24-36

Author(s):

Anatoly Bozhkov ◽

Ievgeniy Ivanov ◽

Elena Klimova ◽

Natalia Kurguzova ◽

Аndrii Bozhkov ◽

...

Keyword(s):

Body Weight ◽

Glutathione Peroxidase ◽

Glutathione Reductase ◽

End Of Life ◽

Survival Curve ◽

Male Rats ◽

Control Group ◽

Lipid Hydroperoxides ◽

Key Words Aging ◽

Late Stages

Abstract: the content of lipid hydroperoxides in the serum and liver mitochondria in animals in the late stages of ontogenesis (12 and 33 months old, Wistar male rats) was investigated. The possible effect of the food additive (“mix factor”) on these parameters in 33 months old animals, if they received this supplement from 22 months age daily throughout life in a dose of 0.05 - 0.06 ml / 100 g of body weight was determined. Moreover, the lifespan of animals was determined if they started taking a mix – factor from 22 months and from 30.5 months age. The influence of the mix – factor on the ability of old animals to perform work was determined in a separate series of experiments. It was shown that from 22 to 33 months the content of lipid hydroperoxides in mitochondria and serum increased by 23% and 41%, respectively. The activity of glutathione peroxidase in the serum, mitochondria and erythrocytes decreased, and the activity of glutathione reductase decreased only in the post-mitochondrial fraction of the liver. At the same time, malate– isocitrate dehydrogenase and 6-phosphate dehydrogenase remained unchanged in 33 months old animals compared with 12 months old animals. If animals from 22 months age received a mix factor with drinking water in a dose of 0.05-0.06 mg / 100 g of body weight every day until the end of life, the content of lipid hydroperoxides and the activity of glutathione peroxidase and glutathione reductase of 33 months old animals did not differ from 12 months old animals. The survival curve in animals receiving the mix factor was shifted to the right from 25 to 28 months of age compared with the survival curve of control animals. If animals began to receive the mix – factor at a very old age (from 30.5 months age) until the end of life, their lifespan was longer than that of the control animals. The last ones lived to 41 months, while the animals of the control group lived to 36 months. At the same time, the mix – factor increased the ability of old animals to do work in the test “running in treadmill”. Key words: aging, redox-system, geroprotectors, lifespan

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RESVERATROL INCLUSION COMPLEX WITH β-CYCLODEXTRIN (RCD): CHARACTERIZATION AND EVALUATION OF TOXICITY IN WISTAR RATS

International Journal of Pharmacy and Pharmaceutical Sciences ◽

10.22159/ijpps.2017v9i1.15399 ◽

2016 ◽

Vol 9 (1) ◽

pp. 27 ◽

Cited By ~ 2

Author(s):

V. S. K. Nishihira ◽

N. J. Mezzomo ◽

M. D. Baldissera ◽

R. A. Vaucher ◽

C. G. Pinto ◽

...

Keyword(s):

Inclusion Complex ◽

Oral Administration ◽

Biochemical Parameters ◽

Wistar Rats ◽

Metabolic Diseases ◽

Hematological Parameters ◽

Density Lipoprotein ◽

Blood Parameters ◽

Control Group ◽

Scanning Calorimetry

Objective: The aim of this study was to characterise the resveratrol inclusion complex with β-cyclodextrin (RCD) and evaluate their toxicity in wistar rats.Methods: The RCD were prepared in ultra-turrax. For characterization of the RCD were used: Fourier transform infra-red Spectroscopy, Nuclear Magnetic Resonance (NMR), Differential Scanning Calorimetry (DSC) and X-ray powder diffraction. The RCD and others 4 treatments were performed by the chronic oral administration in 35 rats during 60 ds. After the treatments they were euthanized and the serum blood were collected to analyzed some hemogram and biochemical parameters including aspartyl aminotransferase (AST); alanine aminotransferase (AST); phosphatase alkaline (ALP); total bilirubin (TB); direct bilirubin (DB); total protein (TP); total cholesterol (TC), triacylglycerol (TAG), very low-density lipoprotein (VLDL), high-density lipoprotein (HDL), calcium, iron and phosphate using fully automated biochemistry analyzer.Results: The characterization results indicated a successful formation of the RCD. All hematological parameters analysed were within the normal values in all the groups. Furthermore, the hemogram and biochemical parameters were significantly (P>0.05) similar to the control group.Conclusion: The daily oral administration during 60 d of RCD are not harmful on blood parameters of Wistar rats. Thus, RCD can be used safely for treatment of some metabolic diseases.

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A 90-Day Oral Toxicity of Hydroethanolic Root Extract of Carissa spinarum in Wistar Rats

Journal of Toxicology ◽

10.1155/2021/5570206 ◽

2021 ◽

Vol 2021 ◽

pp. 1-6

Author(s):

Komlan M. Dossou-Yovo ◽

Aboudoulatif Diallo ◽

Povi Lawson-Evi ◽

Yendubé T. Kantati ◽

Tchin Darré ◽

...

Keyword(s):

Body Weight ◽

Biochemical Parameters ◽

Wistar Rats ◽

Hematological Parameters ◽

Relative Weight ◽

Control Group ◽

Root Extract ◽

Weight Changes ◽

Oral Toxicity ◽

Significant Difference

Background. Herbal medication is a worldwide and ancient practice, mostly in developing countries, where a large part of the population is involved in this practice. Hence, studies must be conducted to evaluate their safety and efficiency to avoid or prevent toxicological risks due to their usage. In Togo, Carissa spinarum is a medicinal plant belonging to Apocynaceae family, used as an aphrodisiac or to heal some ailments including malaria, sickle cell anemia, hypertension, pain, and asthma. Notwithstanding its several ethnomedicinal benefits, just a few toxicological data associated with its chronic use are available. Objective. Therefore, this study aims to assess the toxicity of an ethanolic root extract of Carissa spinarum in Wistar rats. Methods. The 90-day oral toxicity process following OECD TG 408 guidelines is used. Male Wistar rats received Carissa spinarum root hydroethanolic extract at 500 and 1000 mg/kg for 90 days by oral gavage. Body weight changes, hematological and blood biochemical parameters, organ weight changes, malondialdehyde as a lipoperoxidation marker expressed according to tissue proteins, and histopathology of vital organs were assessed. Results. No signs of toxicity or mortality were observed during the 90 days experiment. Hematological parameters have not shown any treatment-related abnormalities. According to biochemical parameters, an increase in the chloride ion level was observed at 1000 mg/kg p < 0.01 . There was no significant difference between the treated groups and the control group concerning the malondialdehyde concentration, body weight, and organ relative weight. No changes in necropsy and histopathology of vital organs associated with extract treatment were observed. Conclusion. The results indicated that an ethanolic root extract of Carissa spinarum does not cause adverse effects, which can lead to Wistar rats’ death after 90-day oral administration at 500 and 1000 mg.

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Performance indicators of broilers fed propolis and bee pollen additive

Poljoprivreda ◽

10.18047/poljo.25.1.10 ◽

2019 ◽

Vol 25 (1) ◽

pp. 69-75 ◽

Cited By ~ 1

Author(s):

Ivana Prakatur ◽

Matija Domaćinović ◽

Božica Lachner ◽

Zvonimir Steiner ◽

Dalida Galović ◽

...

Keyword(s):

Experimental Study ◽

Body Weight ◽

Weight Gain ◽

Performance Indicators ◽

Control Group ◽

Significant Positive Effect ◽

Feed Mixture ◽

Bee Pollen ◽

Positive Effect ◽

Diet Supplementation

The aim of this study was to determine the effect of diet supplementation with propolis and/or bee pollen on the performance indicators of broilers. This experimental study was conducted on 200 Ross 308 broilers equally distributed by sex and divided into five groups. Throughout the whole study the control group of chickens was fed feed mixture. Feed mixture fed to the experimental groups of chickens contained additives (propolis and/or bee pollen, each supplement separately or in combination in a certain proportion). The average values of broilers body weight were significantly higher on 7th (p=0.001), 14th, 21st, 28th, 35th (p<0.001) and 42nd (p=0.002) day of feeding in the experimental groups of broilers compared to the control group. The average values of broilers weight gain were significantly higher on 1st (p<0.001), 2nd (p=0.002), 3rd (p<0.001), 4th (p=0.029) and 5th (p=0.009) week of feeding in the experimental groups of broilers compared to the control group. This study has undoubtedly shown that propolis and bee pollen have significant positive effect on performance indicators of broilers.

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Increased hip circumference in individuals with metabolic syndrome affects serum nesfatin-1 levels

Postgraduate Medical Journal ◽

10.1136/postgradmedj-2019-136887 ◽

2019 ◽

Vol 96 (1140) ◽

pp. 600-605

Author(s):

Tuba Tekin ◽

Betül Çiçek ◽

Nurefşan Konyalıgil ◽

İnayet Güntürk ◽

Cevat Yazıcı ◽

...

Keyword(s):

Metabolic Syndrome ◽

Body Weight ◽

Nutritional Status ◽

Blood Parameters ◽

Control Group ◽

Case Group ◽

Hip Circumference ◽

Anthropometric Indices ◽

The Relationship ◽

Positive Significant Correlation

BackgroundThis case–control study was conducted to investigate the relationship between serum nesfatin-1 levels and nutritional status and blood parameters in patients diagnosed with metabolic syndrome.MethodsThirty patients (case) diagnosed with metabolic syndrome according to National Cholesterol Education Program-Adult Treatment Panel III criteria were included. Thirty healthy subjects (control) matched with patients with metabolic syndrome in terms of age, gender and body mass index were included. Three-day food consumption records were obtained. Anthropometric indices were measured and body composition was determined by bioelectrical impedance method. Biochemical parameters and serum nesfatin-1 levels were measured after 8 hours of fasting.ResultsSerum nesfatin-1 levels were 0.245±0.272 ng/mL in the case group and 0.528±0.987 ng/mL in the control group (p>0.05). There was a positive significant correlation between serum nesfatin-1 levels and body weight, waist and hip circumferences in the case group (p<0.05). Each unit increase in hip circumference measurement affects the levels of nesfatin by 0.014 times. In the control group, there was a positive significant correlation between body weight and serum nesfatin-1 levels (p<0.05). A significant correlation was detected between HbA1c and serum nesfatin-1 levels in the case group (p<0.05). A significant relationship was detected between dietary fibre intake and the serum nesfatin-1 levels in the case group (p<0.05).ConclusionsAnthropometric indices and blood parameters were correlated with serum nesfatin-1 levels in patients with metabolic syndrome. More clinical trials may be performed to establish the relationship between serum nesfatin-1 levels and nutritional status.

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Amisulpride - An Athypical Antipsychotic?

Acta Medica Marisiensis ◽

10.1515/amma-2015-0072 ◽

2015 ◽

Vol 61 (4) ◽

pp. 337-341

Author(s):

Echim George ◽

Sorina Cucuiet ◽

Bianca Osz ◽

Alexandra Grosan ◽

Gal Zsolt ◽

...

Keyword(s):

Body Weight ◽

Blood Glucose ◽

Biochemical Parameters ◽

Low Dose ◽

Body Weight Gain ◽

Control Group ◽

Initial Weight ◽

Glucose Levels ◽

Blood Glucose Concentrations ◽

Different Doses

AbstractAim: the purpose of the present study was to determine the effects of amisulpride at different doses on body weight, glucidic and lipidic metabolism.Material and method: Thirty-six white Wistar rats were treated daily for 9 weeks with amisulpride 1mg/kg and 10mg/kg body weight. Another group received distilled water and served as control group. At the end of the treatment period blood samples were collected and the follow biochemical parameters were determined: serum cholesterol, triglycerides, blood glucose, GOT, GPT. Body weight gain was also assessed weekly.Results: After treatment with amisulpride in doses of 1mg/kg and 10 mg/kg for a period of nine weeks, weight gains were recorded for both groups compared with the initial weight and the control group. Blood glucose concentrations in the group treated with 1 mg amisulpride/kg body weight were significantly increased (p<0.05 vs control group), but in the group treated with 10 mg/kg body weight glucose levels were not statistically significant increased compared to controls. Other biochemical parameters (cholesterol, triglycerides, GOT, GPT) showed no statistically significant differences compared to control group.Conclusions: amisulpride administered over a period of 9 weeks, in doses of 1mg/kg and 10mg/kg showed a slight increase of body weight regardless of gender, increased blood glucose only when was administered in the low dose, and does not affect lipid metabolism, even though decreased cholesterol and triglycerides levels. This results highlight a real benefit of treatment with amisulpride, comparatively with other athypical antipsychotics.

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Effect of Lactococcus lactis vs. Lactobacillus spp. bacteria on chicken body weight, mortality, feed conversion and carcass quality

Annals of Animal Science ◽

10.2478/v10220-012-0046-y ◽

2012 ◽

Vol 12 (4) ◽

pp. 549-559 ◽

Cited By ~ 5

Author(s):

Franciszek Brzóska ◽

Bogdan Śliwiński ◽

Krystyna Stecka

Keyword(s):

Body Weight ◽

Lactobacillus Plantarum ◽

Lactococcus Lactis ◽

Broiler Chickens ◽

Liver Weight ◽

Blood Parameters ◽

Feed Consumption ◽

Control Group ◽

Feed Conversion ◽

Dressing Percentage

AbstractA total of 608 Ross 308 broiler chickens of both sexes were studied to determine the effect of Lactococcus lactis 847 bacteria compared to probiotic bacteria Lactobacillus delbruecki 838 and Lactobacillus plantarum 837 on body weight, feed consumption and conversion, mortality, dressing percentage, postmortem carcass traits, composition of breast muscle tissue, and blood plasma traits. Feeding diets with bacteria to chickens did not increase body weight at 42 days of age or improve feed conversion compared to control chickens. It significantly reduced chicken mortality compared to the control group, from 3.3% to 1.4% (P<0.01). No significant differences were found in feed consumption and conversion. There were no significant differences in the weight of carcasses and their parts. Lactococcus lactis 847 and Lactobacillus plantarum 837 bacteria significantly increased dressing percentage (P<0.05). Lactococcus lactis 847 significantly increased liver weight (P<0.05). No significant differences were observed in carcass fatness, and in the dry matter, protein and fat content of breast muscles. Feeding diet with Lactobacillus plantarum 837 to chickens significantly decreased plasma triglyceride levels, and feeding diet with Lactobacillus delbruecki 838 and Lactobacillus plantarum 837 significantly decreased the level of high-density cholesterol (P<0.05). In conclusion, Lactococcus lactis 847 bacteria in diet significantly reduce losses due to digestive disorders while having no effect on the quantity and proportion of saleable cuts in the carcass, the composition of breast muscles and basic blood parameters.

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Influence of the probiotic preparation “Plantarum” in the diets of pregnant animals on the growth and development of young animals

BIO Web of Conferences ◽

10.1051/bioconf/20213700143 ◽

2021 ◽

Vol 37 ◽

pp. 00143

Author(s):

Irina Funk ◽

Nikolay Vladimirov ◽

Alexander Yashkin ◽

Lyudmila Pautova ◽

Vitaly Gorshkov

Keyword(s):

Body Weight ◽

Growth And Development ◽

The Body ◽

Control Group ◽

Standard Diet ◽

Absolute Increase ◽

Probiotic Preparation ◽

Positive Effect ◽

Experimental Group ◽

Different Doses

The work aims to study the effect of different doses of the experimental probiotic preparation “Plantarum” when fed to pregnant animals on their reproductive qualities, as well as on the growth and development of young animals. To obtain young animals, four groups of goats were formed in the type of the Saanen breed, 20 heads each. In the first (control) group, the animals received a standard diet, in the diet of the animals of the second, third and fourth groups in the second half of pregnancy, the probiotic preparation “Plantarum” was additionally introduced, containing Lactobacillus Plantarum, Propiobacterium freudenreihii, in dosages from 0.4 to 0.8 ml/kg of body weight per day. From the offspring of the goats of the experimental groups, four groups of 12 goats were formed. The highest percentage of preservation (94%) and the highest business output of kids per 100 queens (150%) were observed in the fourth experimental group (0.8 ml). The goats of the second, third and fourth groups exceeded the body weight of their contemporaries from the control group by 3%, 6.3%, and 8.8%. The highest indices of the absolute increase in body weight by age periods were noted in the fourth group of goats. There were no significant differences in body build indices during the experiment between the goats of the control and experimental groups. Thus, the maximum positive effect was observed with the introduction of a probiotic preparation into the diet of pregnant goats at a dose of 0.8 ml/kg of body weight per day.

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Effects of Sweet Potato Leaves, Roselle Calyces and Beetroot on Body Weight, Selected Hematological and Biochemical Parameters in Broiler Chicken

Journal of Biology and Life Science ◽

10.5296/jbls.v10i2.14620 ◽

2019 ◽

Vol 10 (2) ◽

pp. 133

Author(s):

Gaymary George Bakari ◽

Robert Arsen Max ◽

Shedrack Reuben Kitimu ◽

Shaabani Mshamu ◽

Benigni Alfred Temba ◽

...

Keyword(s):

Body Weight ◽

Sweet Potato ◽

Biochemical Parameters ◽

Broiler Chickens ◽

Hemoglobin Concentration ◽

The Other ◽

Control Group ◽

Positive Effects ◽

Hematological And Biochemical Parameters ◽

Sweet Potato Leaves

The study was conducted to assess the effects of sweet potato leaves, roselle calyces and beetroot tubers on body weight, selected hematological and biochemical parameters in broiler chickens. Eighty four (84) broiler chickens aged four weeks were randomly assigned into six groups of 14 chickens each. The first group (G0) remained as untreated control while the other groups were the treated groups which received 25% of ground sweet potato leaves (G1), rosella calyces (G2), beetroot tubers (G3) and their mixtures (G4 and G5) for 28 days. Following inclusion of these different vegetables, blood samples were collected and analyzed for selected hematological and biochemical parameters on day 0, 7, 14, 21 and 28. Results showed that consumption of the three vegetables caused significant decreases (p < 0.05) in body weight, serum glucose and cholesterol. On the other hand, hemoglobin concentration, packed cell volume (PCV) and total white blood cell (WBC) counts were shown to increase significantly (p < 0.05) compared to the control group. It is concluded that the hypoglycemic and hypocholesteremic effects in chickens following consumption of the three vegetables together with their positive effects on PCV and WBC counts are important qualities which can be utilized in the management of conditions such as obesity, diabetes mellitus, hyperlipidemia and cardiovascular diseases (atherosclerosis and coronary disease) in humans. Further studies in other animals are recommended.

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