Orchid viruses of natural Ukrainian flora

Virus infection greatly affects to the normal growth and reproductive intensity of orchid species in greenhouses. Peculiarities of ornamental orchid viruses has become known in different countries of the world while there is nothing known about orchid virus infection in natural flora of Europe, for example in Ukraine. After extensive virus detection of natural orchids of Ukraine (Carpathians, Crimea), some viruses infecting these plants in their natural inhabitance were determined.

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USE OF ESSENTIAL FATTY ACIDS AND THEIR ROLE IN THE HUMAN ORGANISM DEVELOPMENT

Knowledge International Journal ◽

10.35120/kij28041219f ◽

2018 ◽

Vol 28 (4) ◽

pp. 1219-1225

Author(s):

Filip Jovanovski ◽

Toni Mitrovski ◽

Viktorija Bezhovska

Keyword(s):

Fatty Acids ◽

Unsaturated Fatty Acids ◽

Essential Fatty Acids ◽

Normal Growth ◽

The Body ◽

Human Nutrition ◽

Human Organism ◽

Working Ability ◽

The World ◽

Growth Development

Food is not just a pleasure in life, it is also an important factor for our health. Human nutrition is a mixture of nutrients, which are the only source of energy needed for survival. Energy-poor diet endangers many life functions, and above all the working ability. In the world, the meaning of the diet is very serious, and hence the demands for a –rational, healthy and safe diet are growing. Human nutrition contains saturated and unsaturated fatty acids. Essential fatty acids (EFAs) must be ingested in everyday diet because the body does not produce it. They are very important for human health. They are present in each cell of the human body and are an important factor for the normal growth, development and functioning of cells, muscles, nerves and organs. They are also used in the production of certain hormones - such as prostaglandins, which are crucial for the performance of certain important processes. The deficit from EFAs is due to a number of health problems, including more serious diseases.

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Atypical Bacterial Infections Explained by a Concomitant Virus Infection

PEDIATRICS ◽

10.1542/peds.76.3.411 ◽

1985 ◽

Vol 76 (3) ◽

pp. 411-414

Author(s):

Ron Dagan ◽

Caroline B. Hall ◽

Marilyn A. Menegus

Keyword(s):

Early Childhood ◽

Virus Infection ◽

Bacterial Infection ◽

Clinical Manifestation ◽

Bacterial Infections ◽

Recent Progress ◽

Clinical Presentation ◽

Virus Detection ◽

Dual Infection ◽

Dual Infections

Because both viral and bacterial infections are common during early childhood, dual infections are not unexpected. However, the clinical manifestation of such combined infections may be, difficult to interpret, and they are often misdiagnosed as "atypical bacterial infection." Five patients with concomitant viral-bacterial infections are described. In all five cases, virus detection enabled the physicians to better understand an otherwise puzzling clinical presentation. In view of the recent progress in rapid viral diagnoses and the potential of antiviral drugs, the possibility of dual infection should be investigated more often.

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Looking into a New Challenge, DKA and Covid-19 A Review on Pediatric DKA Cases during New Coronavirus Pandemic Who is to Blame, the Virus or Health System?

Endocrinology and Disorders ◽

10.31579/2640-1045/102 ◽

2021 ◽

Vol 5 (7) ◽

pp. 01-04

Author(s):

Vida Tajiknia ◽

Maryam Ghandali ◽

Ardavan Ahmadvand ◽

Ali Afrasiabi ◽

Reza Pirdehghan ◽

...

Keyword(s):

Immune System ◽

Virus Infection ◽

Pediatric Patients ◽

Strong Association ◽

Diabetes Type ◽

Diabetes Type 1 ◽

The World ◽

Existing Data

Since the first month of this new pandemic situation, all around the world healthcare system has been facing different challenges and difficulties; patients with chronic diseases such as cancer or diabetes with impaired immune system were at greater risk of infections and complications. It goes without saying that this issue was extremely important among pediatric clinicians dealing with diabetic pediatrics. Diabetes is the number one chronic illness among pediatric patients and the most dangerous and frightened complication of it is Diabetic Ketoacidosis (DKA). Studies have shown a strong association between pandemic and increase in new diabetes type 1 cases and its lethal complication called DKA. Here we are going to take a look at existing data and report about cases with this condition trying to find the missing piece of a big puzzle; what is the role of Covid-19 in causing Diabetes in previously healthy kids and what is the real association between SARS-COV2 virus infection and DKA? We are going to review different studies, possible mechanism, new t1dm cases and old cases, with or without covid infection, DKA cases and its severity.

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Imunocompetent Mice Model for Dengue Virus Infection

The Scientific World JOURNAL ◽

10.1100/2012/525947 ◽

2012 ◽

Vol 2012 ◽

pp. 1-12 ◽

Cited By ~ 11

Author(s):

Denise Gonçalves ◽

Rafael de Queiroz Prado ◽

Eric Almeida Xavier ◽

Natália Cristina de Oliveira ◽

Paulo Marcos da Matta Guedes ◽

...

Keyword(s):

Animal Model ◽

Virus Infection ◽

Dengue Virus ◽

Viral Disease ◽

Mice Model ◽

Rt Pcr ◽

Dengue Virus Infection ◽

Dengue Disease ◽

The Family ◽

The World

Dengue fever is a noncontagious infectious disease caused by dengue virus (DENV). DENV belongs to the familyFlaviviridae, genusFlavivirus, and is classified into four antigenically distinct serotypes: DENV-1, DENV-2, DENV-3, and DENV-4. The number of nations and people affected has increased steadily and today is considered the most widely spread arbovirus (arthropod-borne viral disease) in the world. The absence of an appropriate animal model for studying the disease has hindered the understanding of dengue pathogenesis. In our study, we have found that immunocompetent C57BL/6 mice infected intraperitoneally with DENV-1 presented some signs of dengue disease such as thrombocytopenia, spleen hemorrhage, liver damage, and increase in production of IFNγand TNFαcytokines. Moreover, the animals became viremic and the virus was detected in several organs by real-time RT-PCR. Thus, this animal model could be used to study mechanism of dengue virus infection, to test antiviral drugs, as well as to evaluate candidate vaccines.

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Orf virus infection of human keratinocytes and dermal fibroblasts: limited virus detection and interference with intercellular adhesion molecule‐1 up‐regulation

Experimental Dermatology ◽

10.1111/exd.13861 ◽

2018 ◽

Author(s):

Laura E. Schneider ◽

Martina Protschka ◽

Uwe Müller ◽

Mahmod Muhsen ◽

Thomas Magin ◽

...

Keyword(s):

Virus Infection ◽

Adhesion Molecule ◽

Virus Detection ◽

Human Keratinocytes ◽

Intercellular Adhesion ◽

Dermal Fibroblasts ◽

Orf Virus ◽

Intercellular Adhesion Molecule ◽

Intercellular Adhesion Molecule 1

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THE MONTHLY CHANGING OF THE LOWEST POPULATION DENGUE VIRUS INFECTION IN PATIENT AT SOERYA HOSPITAL SIDOARJO IN 00

Indonesian Journal of Tropical and Infectious Disease ◽

10.20473/ijtid.v2i1.95 ◽

2015 ◽

Vol 2 (1) ◽

pp. 20

Author(s):

Soegeng Soegijanto

Keyword(s):

Global Warming ◽

Virus Infection ◽

Dengue Virus ◽

Urban Area ◽

Dengue Shock Syndrome ◽

Dengue Virus Infection ◽

The World ◽

Important Health ◽

Good Environment ◽

Growing Population

Background: Dengue virus infection is one of the important health problems in Indonesia, although the mortality rate has been decreased but many dengue shock syndrome cases is very difficult to be solving handled. To solve this problem, some factor that influence the prevalence of dengue virus infection should be studied. The Aim of Study: To detect some factor that maintain the higher case of dengue virus infection in patient at the Soerya Hospital Sepanjang, Sidoarjo. Material & Method: Study had been done at Soerya Hospital Sepanjang, Sidoarjo since January 1, 2007 until December 31, 2010. All cases suspected dengue virus infection in patient at soerya hospital were diagnosed based on WHO criteria in 1997 and PCR examination in ITD laboratory. The Result: In 2007, 2008, 2009, the monthly observation showed that decreasing cases of dengue virus infection in patient at Soerya Hospital had been found on September, but in 2010 this event had been found on November. Why this event to be change? It is suggested might be due to global warming in the world and the climate going to influence the environment sanitation. Interaction between agent host and environment becoming increase it might be due to the changing of climate can influence the growing population Aedes Aegyptie and Aedes Albopictus promoting to increase vector for transmit dengue virus infection. It is prominent in sub urban area, with have many peoples don’t aware with the bad environment sanitation. And many peoples showed very dynamic for living until the idea good environment do not be thought. By this condition the monthly population dengue virus infection in patient at hospital are going to maintain higher more than six months than usually. On the year 2007, 2008, 2009 the lowest cases found on September. In 2010, the lowest cases had been found on November. The Conclusion: Global warming, increasing sub urban area which have many peoples don’t aware with the bad environment sanitation and have highly dynamic peoples for getting some money for their life, could influence the higher cases dengue virus infection in patient at hospital more than 6 months.

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The Ability of Zika virus Intravenous Immunoglobulin to Protect From or Enhance Zika Virus Disease

Frontiers in Immunology ◽

10.3389/fimmu.2021.717425 ◽

2021 ◽

Vol 12 ◽

Author(s):

Amelia K. Pinto ◽

Mariah Hassert ◽

Xiaobing Han ◽

Douglas Barker ◽

Trevor Carnelley ◽

...

Keyword(s):

Virus Infection ◽

Polyclonal Antibody ◽

Zika Virus ◽

Virus Disease ◽

Polyclonal Antibodies ◽

Antibody Therapeutics ◽

The World ◽

Flavivirus Infection

The closely related flaviviruses, dengue and Zika, cause significant human disease throughout the world. While cross-reactive antibodies have been demonstrated to have the capacity to potentiate disease or mediate protection during flavivirus infection, the mechanisms responsible for this dichotomy are still poorly understood. To understand how the human polyclonal antibody response can protect against, and potentiate the disease in the context of dengue and Zika virus infection we used intravenous hyperimmunoglobulin (IVIG) preparations in a mouse model of the disease. Three IVIGs (ZIKV-IG, Control-Ig and Gamunex®) were evaluated for their ability to neutralize and/or enhance Zika, dengue 2 and 3 viruses in vitro. The balance between virus neutralization and enhancement provided by the in vitro neutralization data was used to predict the IVIG concentrations which could protect or enhance Zika, and dengue 2 disease in vivo. Using this approach, we were able to define the unique in vivo dynamics of complex polyclonal antibodies, allowing for both enhancement and protection from flavivirus infection. Our results provide a novel understanding of how polyclonal antibodies interact with viruses with implications for the use of polyclonal antibody therapeutics and the development and evaluation of the next generation flavivirus vaccines.

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A Systematic Review on Papers That Study on SNPs That Affect SARS-CoV-2 Infection & COVID-19 Severity

10.21203/rs.3.rs-470358/v1 ◽

2021 ◽

Author(s):

Siyeon Suh ◽

Sol Lee ◽

Ho Gym ◽

Sun Ha Jee ◽

Sanghyuk Yoon ◽

...

Keyword(s):

Systematic Review ◽

Virus Infection ◽

Global Health ◽

Full Text ◽

Clinical Studies ◽

Time History ◽

The World ◽

History Of ◽

Severity Of The Disease

Abstract Background:COVID-19, caused by SARS-CoV-2 has become the most threatening issue to all populations around the world. It is directly and indirectly affecting all of us and thus, is a emergence topic dealt in global health. In order to avoid the infection, various studies have been done and still ongoing. Now having over 141 million cases of COVID19 and causing over 3 million deaths around the world, the tendency of infection and degree severity of the disease shown in different groups of people came up as an issue. Here, we reviewed 21 papers on SNPs related to SARS-CoV-2 infection severity and analyzed the results of them.Methods:The PubMed databases were searched for papers discussing SNPs associated with SARS-CoV-2 infection severity. Clinical studies with human patients and statistically showing relevance of the SNP with virus infection were included. Quality Assessment of all papers were done with Newcastle Ottawa Scale.Results:In the analysis, 21 full-text literatures out of 2956 screened titles and abstracts, including 63496 cases, were included. All were human based clinical studies, some based on certain regions gathered patient data and some based on big databases obtained online. ACE2, TMPRSS2, IFITM3 are the genes mentioned most frequently that are related with SARS-CoV-2 infection. 20 out of 21 studies mentioned one of more of those genes. The relevant genes according to SNPs were also analyzed. rs12252-C, rs143936283, rs2285666, rs41303171, and rs35803318 are the SNPs that were mentioned at least twice in two different studies.Conclusions: We found that ACE2, TMPRSS2, IFITM3 are the major genes that are involved in SARS-CoV-2 infection. The mentioned SNPs were all related to one or more of the above mentioned genes. There were discussions on certain SNPs that increased the infection severity to certain ethinic groups more than the others. However, as there is limited follow up and data due to shortage of time history of the disease, studies may be limited.

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