Influence of cadmium on hematological indicators of carp

2020 ◽  
Vol 1 ◽  
pp. 92-96
Author(s):  
L. Yu. Karpenko ◽  
◽  
P. A. Polistovskaya ◽  
A. I. Enukashvili ◽  
A. B. Balykina ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Red Blood Cells ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Blood Cells ◽  
Power Plants ◽  
Cadmium Acetate ◽  
Control Group ◽  
Erythrocyte Sedimentation ◽  
Short Period

The article is devoted to the assessment of the toxic effects of cadmium acetate on fish. The research topic is relevant, since heavy metals, and especially cadmium, are ones of the most dangerous pollutants for the aquatic environment. After the emission of the already used water by the electricity-power plants into the reservoirs of circulating wa-ter, a sharp increase in the maximum permit-ted concentrations of heavy substances can be observed often, which act on hydrobi-onts for a rather short period of time. That is why, modeling this effect is necessary to study the effects of heavy metals. The aim of the assay was to study the hematological parameters of carp after exposure to various concentrations of cadmium acetate. During the experiment, 5 groups of fish were formed - 1 control group (10 fish), 4 experimental groups - 10 fish each. The experimental groups of fish were exposed in a solution of cadmium acetate (Cd (CH3COO) 2) with concentrations of 0.05 mg / l, 0.5 mg / l, 5 mg / l, 50 mg / l (exceeding the maximum permissible concentration of cadmium for fisheries in 10, 100, 1000 and 10000 times respectively). We have investigated: the erythrocyte sedimentation rate, the number of red blood cells in the blood and the con-centration of hemoglobin in the blood. Dur-ing the study, the authors noted an increase in the erythrocyte sedimentation rate due to the formation of conglomerates of blood cells with plasma proteins, as well as a de-crease in the number of red blood cells due to the toxic effect of cadmium acetate. A decrease in the concentration of hemoglobin in the blood was also observed, probably associated with a decrease in the number of red blood cells due to their lysis. With an increase in the concentration of the metal under study, there is a significant increase in ESR, a decrease in the level of hemoglobin and the number of red blood cells.

Experiments on Rouleau Formation

1973 ◽  
Vol 51 (9) ◽  
pp. 690-699 ◽  
Author(s):  
D. Kernick ◽  
A. W. L. Jay ◽  
S. Rowlands ◽  
L. Skibo
Keyword(s):  
Red Blood Cells ◽  
Erythrocyte Sedimentation Rate ◽  
Linear Function ◽  
Sedimentation Rate ◽  
Blood Cells ◽  
Temperature Dependent ◽  
Experimental Conditions ◽  
Erythrocyte Sedimentation ◽  
Rouleau Formation ◽  
High Erythrocyte Sedimentation Rate

Rouleau formation was measured by an adaptation of an old method used by Ponder (1927, Q. J. Exp. Physiol. 16, 173–194). Blood was depleted of red cells to a low hematocrit. It was stirred under standardized conditions, and after various times, samples were examined by microscope. Mean rouleau length was taken as an index of rouleau formation. The method was used to observe changes of rouleau formation with time and temperature and with variations in erythrocyte sedimentation rate (E.S.R.). Under these experimental conditions, mean rouleau length increases with time up to 40 min. Over a range of hematocrit values between 0 and 4%, rouleau length is a linear function of hematocrit. At higher hematocrits random aggregations based on columnar units are seen. Rouleau formation is temperature dependent and maximum mean rouleau length occurs around 37 °C. Subjects with a high erythrocyte sedimentation rate tend to form long rouleaux. By exchanging red blood cells (R.B.C.) between two ABO Rh compatible patients with greatly differing E.S.R. and mean rouleau length, it was shown that the agent responsible was in the plasma and not on the R.B.C. The results were compared with a theory of aggregation which proved inadequate in some respects.

scholarly journals The Erythrocyte Sedimentation Rate and Its Relation to Cell Shape and Rigidity of Red Blood Cells from Chorea-Acanthocytosis Patients in an Off-Label Treatment with Dasatinib

Biomolecules ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 727
Author(s):  
Antonia Rabe ◽  
Alexander Kihm ◽  
Alexis Darras ◽  
Kevin Peikert ◽  
Greta Simionato ◽  
...  
Keyword(s):  
Mathematical Modeling ◽  
Red Blood Cells ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Blood Cells ◽  
Cell Shape ◽  
Healthy Controls ◽  
Off Label ◽  
Erythrocyte Sedimentation ◽  
Hematology Parameters

Background: Chorea-acanthocytosis (ChAc) is a rare hereditary neurodegenerative disease with deformed red blood cells (RBCs), so-called acanthocytes, as a typical marker of the disease. Erythrocyte sedimentation rate (ESR) was recently proposed as a diagnostic biomarker. To date, there is no treatment option for affected patients, but promising therapy candidates, such as dasatinib, a Lyn-kinase inhibitor, have been identified. Methods: RBCs of two ChAc patients during and after dasatinib treatment were characterized by the ESR, clinical hematology parameters and the 3D shape classification in stasis based on an artificial neural network. Furthermore, mathematical modeling was performed to understand the contribution of cell morphology and cell rigidity to the ESR. Microfluidic measurements were used to compare the RBC rigidity between ChAc patients and healthy controls. Results: The mechano-morphological characterization of RBCs from two ChAc patients in an off-label treatment with dasatinib revealed differences in the ESR and the acanthocyte count during and after the treatment period, which could not directly be related to each other. Clinical hematology parameters were in the normal range. Mathematical modeling indicated that RBC rigidity is more important for delayed ESR than cell shape. Microfluidic experiments confirmed a higher rigidity in the normocytes of ChAc patients compared to healthy controls. Conclusions: The results increase our understanding of the role of acanthocytes and their associated properties in the ESR, but the data are too sparse to answer the question of whether the ESR is a suitable biomarker for treatment success, whereas a correlation between hematological and neuronal phenotype is still subject to verification.

scholarly journals Study of IL-33 and IL-1R4 in Iraqi Rheumatoid Arthritis Female Patient's with and without Dyslipidemia Prone to Atherosclerosis

2019 ◽  
Vol 32 (1) ◽  
pp. 47
Author(s):  
Lara Ali Nazar ◽  
Eiman AA.` Abass
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Factor ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Interleukin 1 ◽  
Control Group ◽  
Control Groups ◽  
Interleukin 33 ◽  
Erythrocyte Sedimentation ◽  
And Control

   This study is planned to find relationship between interleukin-33 (IL-33) with its receptor interleukin-1 receptor 4 (IL-1R4), and assurance IL-33/IL-1R4 proportion as biomarker to atherosclerosisin rheumatoid arthritis (RA) Iraqi females patients with and without dyslipidemia. This study was attempted at Baghdad Teaching Hospital included 60 females patients with RA that were isolated into: 30 patients with dyslipidemia(G2), 30 patients without dyslipidemia(G3) and 30 individual as control group (G1) .Patients were experiencing treatment by methortexiene medication, analyzed by rheumatoid factor(RF) and erythrocyte sedimentation rate( ESR) tests. All patients and control groups age ranged from (30-55) years. The results show an increase in ESR, RF, IL-33, and IL-1R4 levels. In addition to decrease in IL-33/IL-1R4 ratio in the two patients groups when contrasted and control group. The momentum examine inferred that the level of ESR, and  IL-33 in RA Iraqi females  patients with dyslipidemia were higher than that in RA Iraqi females patients without dyslipidemia, while the level of IL-33/IL-1R4 ratio in RA Iraqi females patients with dyslipidemia was lower than that in RA Iraqi females patients without dyslipidemia patients; in this manner the IL-33/IL-1R4 ratio may be used as a biomarker in diagnostic early porn to atherosclerosis in RA females patients with dyslipidemia

scholarly journals Should Ultrasonographic Giant-Cell Arteritis Signs be Detected in Patients with Polymyalgia Rheumatica?

2021 ◽  
Author(s):  
Fazıl Kulaklı ◽  
İlker Fatih Sari ◽  
Erdem Çaylı ◽  
Nurçe Çilesizoğlu Yavuz
Keyword(s):  
Giant Cell Arteritis ◽  
Giant Cell ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Polymyalgia Rheumatica ◽  
Control Group ◽  
Newly Diagnosed ◽  
Erythrocyte Sedimentation ◽  
Experienced Radiologist ◽  
Significant Difference

Assessing the presence of ultrasonographic findings of Giant-Cell Arteritis in Polymyalgia Rheumatica patients using Ultrasonography on the temporal artery. The study contributes to the literature evaluating the unclear relationship between Polymyalgia Rheumatica and Giant-Cell Arteritis. It raises awareness that Ultrasonography can be used instead of biopsy in patients with suspected Giant-Cell Arteritis. Twenty patients were newly diagnosed with Polymyalgia Rheumatica, and 20 participants as a control group were included in the study. While the Polymyalgia Rheumatica group was evaluated at baseline and sixth month, the control group was evaluated only at baseline. Laboratory, clinical and ultrasonographic findings of all participants were assessed. Gray-scale Ultrasonography and colored Doppler Ultrasonography were used to present halo and compression, occlusion, and stenosis in addition to intima-media complex thickness in bilateral temporal arteries and frontal-parietal branches by an experienced radiologist blinded to the subject. No significant difference was found between Polymyalgia Rheumatica and control groups based on demographic features, clinical and ultrasonographic results at baseline and sixth month. Erythrocyte sedimentation rate of Polymyalgia Rheumatica at baseline was statistically higher than the control group. Erythrocyte sedimentation rate values have declined significantly in Polymyalgia Rheumatica patients, but no significant changes were found for clinical or ultrasonographic features during the sixth month. Ultrasonographic findings of Giant-Cell Arteritis are not present in newly diagnosed and six months followed up Polymyalgia Rheumatica patients. Further studies are needed.

Society of Physicians at Kazan University

1927 ◽  
Vol 23 (1) ◽  
pp. 144-145
Keyword(s):  
Comparative Study ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Clinical Picture ◽  
Blood Cells ◽  
White Blood Cells ◽  
Not Given ◽  
Blood Picture ◽  
Erythrocyte Sedimentation

Session 9/Xll 1926. Prof. N. K. Goryaev: To estimate the content of white blood cells by smear (Schtzung). The report will be printed in "Kaz. Med. Jour.". Drs. N. Zakharov, N. Kudryashev and M. Aksyantsev: Experience in comparative study of immunobiological reactions in tbc clinic. Report, to be printed in Kaz. Med. Jour. Prof. P. N. Nikolaev pointed out about the report that it is impossible to perform all reactions studied by the reporters at the patient's bedside and that the doctor should never forget the personality of the patient in his work. Prof. N. K. Goryaev noted that a big drawback of the report was the lack of description of the clinical picture of the cases studied, as well as the fact that in parallel with the reactions studied the blood picture was not given. To study erythrocyte sedimentation rate Prof. Goryaev considers the Linzeamier's methodology inconvenient. In addition, Drs. Mastbaum and Aksyantsev commented on the reports.

scholarly journals EFFECTS OF SHOTI (CURCUMA ZEDOARIA) ON GROWTH PERFORMANCES AND HEMATO-BIOCHEMICAL PARAMETERS OF BROILER CHICKS

2016 ◽  
Vol 14 (1) ◽  
pp. 15-19
Author(s):  
M. J. Alam ◽  
M. S. Islam ◽  
M. M. Rahman ◽  
S. Mazumder ◽  
N. Ahmad
Keyword(s):  
Uric Acid ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Biochemical Parameters ◽  
Erythrocyte Count ◽  
Control Group ◽  
Erythrocyte Sedimentation ◽  
Group A ◽  
Group B ◽  
Group D

The research was conducted to observe the effect of shoti meal on weight gain and some selected hematological values such as total erythrocyte count (TEC), hemoglobin (Hb) and erythrocyte sedimentation rate (ESR) and biochemical parameters such as aspartate transaminase (AST), alanine transaminase (ALT), uric acid and creatinine in broilers. Fresh rhizomes were washed, minced and dried and pulverized in a flour meal. A total of 20 broilers (16 day old) were randomly divided into four equal groups.  Group A was treated as control and groups B, C and D were fed with 5%, 10% and 15% shoti respectively for 22 days. The result showed that body weight of broilers fed 10% shoti meal (group C) was higher than that of other treated groups. After having completed the feeding trial, birds were sacrificed to collect blood samples for hematological and serum biochemical analysis. Total erythrocyte count (TEC) in group D varied significantly (p<0.05) from all other groups. The highest hemoglobin content was recorded in group B and lowest in group A (Control). Significant (p<0.05) differences were observed among the groups compared to control group. The highest erythrocyte sedimentation rate (ESR) was in group B and lowest was in group A (control) and group C (shoti 10%). Serum AST within the treated groups 15% shoti, (Group D) was significantly (p<0.05) higher to that of 5% shoti (Group B), and 10% shoti (group C). The ALT value in group A was significantly higher (p<0.05) than the other groups. Uric acid concentration within the treated groups, group C (10% shoti) showed significantly higher (p< 0.05) than the group B (5% shoti) and group D (15% shoti). Creatinine concentration decreased significantly (P<0.05) in control (group A) to that of others group. Biochemical parameters analyzed in present research is the first report in broilers.

scholarly journals Changes in Erythrocyte Sedimentation Rate, White Blood Cell Count, Liver Enzymes, and Magnesium after Gastric Bypass Surgery

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Hans-Erik Johansson ◽  
Arvo Haenni ◽  
Björn Zethelius
Keyword(s):  
Gastric Bypass ◽  
Blood Cell ◽  
Cell Count ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Liver Enzymes ◽  
Liver Steatosis ◽  
Control Group ◽  
Blood Cell Count ◽  
Erythrocyte Sedimentation

Background. Roux-en-Y gastric bypass (RYGBP) is an established method for treatment of obesity, a condition of chronic inflammation with liver steatosis, characterised by increased erythrocyte sedimentation rate (ESR), white blood cell count (WBC), liver enzymes, and decreased magnesium (Mg). We investigated alterations, if any, in ESR, WBC, alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), and Mg after RYGBP.Methods. 21 morbidly obese nondiabetic patients who underwent RYGBP surgery were evaluated preoperatively (baseline), then 1 year (1st followup) and 3.5 years (2nd followup) after RYGBP and compared to an untreated control group.Results. Body mass index, ESR, WBC, ALT, and GGT were all significantly reduced at 1 year in the RYGBP group (30%, 35%, 20%, 45%, and 57%, resp.) while Mg increased by 6%, compared to control group (P=0.001−0.009).Conclusions. Obese patients treated by RYGBP show sustained reductions in ESR, WBC, ALT, and GGT possibly due to reduced liver steatosis and increased Mg.

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