Study of chronic venous insufficiency in relation with body mass index

Background: Chronic venous insufficiency (CVI) is a condition that occurs due to dysfunctional venous wall and/or valves in the lower limb veins. Some common etiological factors of CVI are obesity, age of more than 50 years, family history of CVI, smoking and pregnancy. The combination of obesity and other genetic and environmental factors creates a higher risk for the development of CVI.Methods: The grade of the venous disease was recorded using the CEAP (anatomical and pathophysiologic criteria). BMI (body mass index) was calculated for each patient and the patients were classified into underweight, normal, overweight and obese categories. Mean, standard deviation, p value and percentage of each stage of venous disease in each group was calculated accordingly and studied.Results: In this study, it was established that a patient with a high BMI (>25 kg/m2) had a higher probability of developing CVI in comparison to a patient with a lower BMI. According to the data, 28.6% of normal weight patients had CVI, 64.3% of overweight patients had CVI and 81.5% of obese patients had CVI.Conclusions: In this study, we concluded that as the BMI increases the probability of development of CVI (C3-C6) also increases. Thus, the presence of CVI should be identified and treated promptly in obese individuals with close follow-up in order to prevent complications.

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The association between body mass index and recovery from post-traumatic stress disorder after the nuclear accident in Fukushima

Scientific Reports ◽

10.1038/s41598-021-84644-5 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Masato Nagai ◽

Tetsuya Ohira ◽

Masaharu Maeda ◽

Seiji Yasumura ◽

Itaru Miura ◽

...

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Post Traumatic Stress Disorder ◽

Traumatic Stress ◽

Stress Disorder ◽

Error Variance ◽

Normal Weight ◽

Post Traumatic Stress ◽

Post Traumatic

AbstractPost-traumatic stress disorder (PTSD) and obesity share common risk factors; however, the effect of obesity on recovery from PTSD has not been assessed. We examined the association between body mass index (BMI) and recovery from PTSD after the Great East Japan Earthquake. We analyzed 4356 men and women with probable PTSD aged ≥ 16 years who were living in evacuation zones owing to the radiation accident in Fukushima, Japan. Recovery from probable PTSD was defined as Post-traumatic Stress Disorder Checklist-specific scores < 44. Using Poisson regression with robust error variance adjusted for confounders, we compared the prevalence ratios (PRs) and 95% confidence intervals (CIs) for this outcome in 2013 and 2014. Compared with point estimates for normal weight (BMI: 18.5–24.9 kg/m2), especially in 2013, those for underweight (BMI: < 18.5 kg/m2) and obesity (BMI: ≥ 30.0 kg/m2) tended to slightly increase and decrease, respectively, for recovery from probable PTSD. The multivariate-adjusted PRs (95% CIs) for underweight and obesity were 1.08 (0.88–1.33) and 0.85 (0.68–1.06), respectively, in 2013 and 1.02 (0.82–1.26) and 0.87 (0.69–1.09), respectively, in 2014. The results of the present study showed that obesity may be a useful predictor for probable PTSD recovery. Obese victims with PTSD would require more intensive support and careful follow-up for recovery.

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Correlation of Body Mass Index with Oncologic Outcomes in Colorectal Cancer Patients: A Large Population-Based Study

Cancers ◽

10.3390/cancers13143592 ◽

2021 ◽

Vol 13 (14) ◽

pp. 3592

Author(s):

Chong-Chi Chiu ◽

Chung-Han Ho ◽

Chao-Ming Hung ◽

Chien-Ming Chao ◽

Chih-Cheng Lai ◽

...

Keyword(s):

Colorectal Cancer ◽

Body Mass Index ◽

Body Weight ◽

Body Mass ◽

Survival Rates ◽

Normal Weight ◽

P Value ◽

Administrative Claims ◽

The Impact

It has been acknowledged that excess body weight increases the risk of colorectal cancer (CRC); however, there is little evidence on the impact of body mass index (BMI) on CRC patients’ long-term oncologic results in Asian populations. We studied the influence of BMI on overall survival (OS), disease-free survival (DFS), and CRC-specific survival rates in CRC patients from the administrative claims datasets of Taiwan using the Kaplan–Meier survival curves and the log-rank test to estimate the statistical differences among BMI groups. Underweight patients (<18.50 kg/m2) presented higher mortality (56.40%) and recurrence (5.34%) rates. Besides this, they had worse OS (aHR:1.61; 95% CI: 1.53–1.70; p-value: < 0.0001) and CRC-specific survival (aHR:1.52; 95% CI: 1.43–1.62; p-value: < 0.0001) rates compared with those of normal weight patients (18.50–24.99 kg/m2). On the contrary, CRC patients belonging to the overweight (25.00–29.99 kg/m2), class I obesity (30.00–34.99 kg/m2), and class II obesity (≥35.00 kg/m2) categories had better OS, DFS, and CRC-specific survival rates in the analysis than the patients in the normal weight category. Overweight patients consistently had the lowest mortality rate after a CRC diagnosis. The associations with being underweight may reflect a reverse causation. CRC patients should maintain a long-term healthy body weight.

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Long-Term Postoperative Total Knee Arthroplasty Flexion Scores in Relation to Body Mass Index

The Journal of Knee Surgery ◽

10.1055/s-0040-1718601 ◽

2020 ◽

Author(s):

Matthew A. Siegel ◽

Michael J. Patetta ◽

Angie M. Fuentes ◽

Armaan S. Haleem ◽

Craig W. Forsthoefel ◽

...

Keyword(s):

Body Mass Index ◽

Total Knee Arthroplasty ◽

Body Mass ◽

Knee Arthroplasty ◽

Statistical Significance ◽

P Value ◽

Preoperative Body Mass Index ◽

Total Knee

AbstractKnee range of motion (ROM) is an important postoperative measure of total knee arthroplasty (TKA). There is conflicting literature whether patients who are obese have worse absolute ROM outcomes than patients who are not obese. This study analyzed whether preoperative body mass index (BMI) influences knee ROM after patients' primary TKA. A retrospective investigation was performed on patients, who underwent primary TKA at an academic institution, by one of three fellowship-trained adult reconstruction surgeons. Patients were stratified according to their preoperative BMI into nonobese (BMI < 30.0 kg/m2) and obese (BMI ≥ 30.0 kg/m2) classifications. Passive ROM was assessed preoperatively as well as postoperatively at patients' most recent follow-up visit that was greater than 2 years. Mann–Whitney U tests were performed to determine statistical significance at p-value <0.05 for ROM outcomes. No statistically significant differences were observed when ROM in the nonobese group was compared with ROM in the obese group both preoperatively (105.73 ± 11.58 vs. 104.14 ± 13.58 degrees, p-value = 0.417) and postoperatively (105.83 ± 14.19 vs. 104.49 ± 13.52 degrees, p-value = 0.777). Mean follow-up time for all patients was 4.49 ± 1.92 years. In conclusion, long-term postoperative ROM outcomes were similar between patients who were nonobese and patients who were obese.

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Long-term effects of GnRH agonist treatment on body mass index in girls with idiopathic central precocious puberty

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2019-0214 ◽

2020 ◽

Vol 33 (1) ◽

pp. 99-105 ◽

Cited By ~ 2

Author(s):

Dogus Vuralli ◽

Zeynep Alev Ozon ◽

Elmas Nazli Gonc ◽

Ayfer Alikasifoglu ◽

Nurgun Kandemir

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Precocious Puberty ◽

Standard Deviation Score ◽

Central Precocious Puberty ◽

Normal Weight ◽

Long Term Effects ◽

Dietary Recommendations ◽

Idiopathic Central Precocious Puberty

AbstractIntroductionStudies evaluating effects of gonadotropin-releasing hormone agonist (GnRHa) on weight and body-mass-index (BMI) in girls with idiopathic central precocious puberty (iCPP) include short-term effects. The aim of this study is to investigate changes in BMI during and 2 years after completion of GnRHa to determine the factors that may impact BMI in girls with iCPP.MethodsMedical files of 138 girls who completed GnRHa were evaluated. All patients had weight and height measurements at the beginning and end of treatment, and 111 patients had anthropometric measurements 2 years after the completion of treatment.ResultsIn the beginning, 82 (59.4%) had normal weight (NW), 42 (30.4%) were overweight (OW), and 14 (10.2%) were obese (OB). Analysis of BMI-standard deviation score (SDS) in the whole group showed an overall increase during GnRHa treatment (0.92 ± 0.74 vs. 1.20 ± 0.51, p < 0.001). Changes in BMI-SDS (ΔBMI-SDS) during GnRHa differed between NW and OW/OB (0.45 ± 0.31 vs. 0.03 ± 0.20, p < 0.001). BMI-SDSs of both groups returned to baseline scores (or initial levels) 2 years after the completion of treatment. Two factors affecting ΔBMI-SDS in multiple linear regression analyses were baseline BMI and Δheight-SDS, both correlated negatively with ΔBMI-SDS.ConclusionsThe present study is one of the studies evaluating BMI change over a long period of time in girls with CPP. Although BMI-SDS increased during GnRHa in NW girls, it was reversible in follow-up after treatment. However, BMI-SDS did not change during and in follow-up in OW/OB girls. Conserving BMI-SDS in OW/OB girls may be related to the fact that weight management programs were recommended for these patients. Dietary recommendations should be provided for children with NW who undergo GnRHa, as is the case for OW patients.

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Association between Acne and Body Mass Index: A Hospital Based Cross Sectional Study

Nepal Journal of Dermatology Venereology & Leprology ◽

10.3126/njdvl.v16i1.19408 ◽

2018 ◽

Vol 16 (1) ◽

pp. 53-56

Author(s):

Saraswoti Neupane ◽

Binamra Basnet ◽

Tara Devi Sharma

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Acne Vulgaris ◽

Cross Sectional Study ◽

Normal Weight ◽

P Value ◽

Cross Sectional ◽

Middle Income ◽

Medical College ◽

Middle Income Countries

Introduction: Acne vulgaris is a common and chronic inflammatory skin disease of pilosebaceous unit. Obesity is one of the biggest problems in western life style but nowadays, the problem is increasing even in low and middle-income countries. Body Mass Index (BMI) is used to accurately measure obesity.Objective: To find out the association between different categories of BMI and severity of acne.Materials and methods: This was a cross sectional prospective study conducted in the outpatient department of Gandaki Medical College from January to July, 2017. All the newly diagnosed patients with acne were included in the study. Height and weight of the patients was recorded and BMI was calculated. BMI was categorized as underweight, normal weight, overweight and obese. Type of lesions were noted and severity of acne was graded from 1 to 4.Statistical analysis was performed using SPSS version 17.0 for windows. One-way Analysis of Variance between groups (ANOVA) test was applied. P value of less than 0.05 was considered significant.Results: There were altogether 249 patients with acne. Age of the patients ranged from 10 to 44 years with mean age of 20.82 ±5.9 years. Most of the patients were in the age group of 11-20 years. Female: male ratio was 1:1.4. Majority of patients (65.5%) had normal BMI. Most of the patients had Grade 2 acne (52.6%). There was no significant association between the BMI and severity of acne (p=0.129).Conclusion: There was no significant association between BMI and severity of acne.

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Obesity, Aspirin, and Risk of Colorectal Cancer in Carriers of Hereditary Colorectal Cancer: A Prospective Investigation in the CAPP2 Study

Journal of Clinical Oncology ◽

10.1200/jco.2014.58.9952 ◽

2015 ◽

Vol 33 (31) ◽

pp. 3591-3597 ◽

Cited By ~ 57

Author(s):

Mohammad Movahedi ◽

D. Timothy Bishop ◽

Finlay Macrae ◽

Jukka-Pekka Mecklin ◽

Gabriela Moeslein ◽

...

Keyword(s):

Colorectal Cancer ◽

Body Mass Index ◽

Body Mass ◽

Reference Group ◽

Significant Risk ◽

Significant Risk Factor ◽

Normal Weight ◽

Obese People ◽

Msh6 Mutation

Purpose In the general population, increased adiposity is a significant risk factor for colorectal cancer (CRC), but whether obesity has similar effects in those with hereditary CRC is uncertain. This prospective study investigated the association between body mass index and cancer risk in patients with Lynch syndrome (LS). Patients and Methods Participants with LS were recruited to the CAPP2 study, in which they were randomly assigned to receive aspirin 600 mg per day or aspirin placebo, plus resistant starch 30 g per day or starch placebo (2 × 2 factorial design). Mean intervention period was 25.0 months, and mean follow-up was 55.7 months. Results During follow-up, 55 of 937 participants developed CRC. For obese participants, CRC risk was 2.41× (95% CI, 1.22 to 4.85) greater than for underweight and normal-weight participants (reference group), and CRC risk increased by 7% for each 1-kg/m2 increase in body mass index. The risk of all LS-related cancers in obese people was 1.77× (95% CI, 1.06 to 2.96; P = .03) greater than for the reference group. In subgroup analysis, obesity was associated with 3.72× (95% CI, 1.41 to 9.81) greater CRC risk in patients with LS with MLH1 mutation, but no excess risk was observed in those with MSH2 or MSH6 mutation (P = .5). The obesity-related excess CRC risk was confined to those randomly assigned to the aspirin placebo group (adjusted hazard ratio, 2.75; 95% CI, 1.12 to 6.79; P = .03). Conclusion Obesity is associated with substantially increased CRC risk in patients with LS, but this risk is abrogated in those taking aspirin. Such patients are likely to benefit from obesity prevention and/or regular aspirin.

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Body Mass Index and Frailty Among Older Mexican Americans: Findings From an 18-year of Follow-up

Innovation in Aging ◽

10.1093/geroni/igab046.2988 ◽

2021 ◽

Vol 5 (Supplement_1) ◽

pp. 820-820

Author(s):

Megan Rutherford ◽

Brian Downer ◽

Chih-Ying Li ◽

Soham Al Snih

Keyword(s):

Body Mass Index ◽

Depressive Symptoms ◽

Body Mass ◽

Mexican Americans ◽

Mexican American ◽

Normal Weight ◽

Healthy Weight ◽

Weight Category ◽

Over Time

Abstract The objective of this study was to examine body mass index (BMI) as predictor of frailty among non-frail Mexican American older adults at baseline. Data are from an 18-year prospective cohort of 1,647 non-institutionalized Mexican American aged ≥ 67 years from the Hispanic Established Population for the Epidemiologic Study of the Elderly (1995/1996-2012/13). BMI (Kg/m2) was grouped according to the National Institutes of Health obesity standards (<18.5=underweight, 18.5–24.9=normal weight, 25.0–29.9=overweight, 30.0–34.9=obesity category I and ≥ 35=obesity category II and extreme obesity). Frailty was defined as meeting three or more of the following: unintentional weight loss of >10 pounds, weakness, self-reported exhaustion, low physical activity, and slow walking speed. Covariates included socio-demographics, comorbidities, cognitive function, depressive symptoms, and limitations in activities of daily living (ADL). General Estimating Equations were performed to estimate the odds ratio (OR) and 95% confidence interval (CI) of frailty as a function of BMI categories. All variables were analyzed as time varying except for gender and education. Participants in the underweight or obesity type II / morbidity obesity category had increased OR of frailty over time than those in the normal weight category (2.68, 95% CI=1.46-4.9 vs.1.55, 95% CI=1.02-2.35, respectively) after controlling for all covariates. Those who reported arthritis, hip fracture, depressive symptoms, or ADL disability had increased odds of frailty over time. This study showed a U-shaped relationship between BMI and frailty over an 18-year period of follow-up which has implications for maintaining a healthy weight to prevent frailty in this population.

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Serum Osteocalcin, P1NP, Alkaline Phosphase, and CrossLaps in Humans.The relationship with body mass index

Revista de Chimie ◽

10.37358/rc.19.5.7179 ◽

2019 ◽

Vol 70 (5) ◽

pp. 1615-1618

Author(s):

Mara Carsote ◽

Smaranda Adelina Preda ◽

Mihaela Mitroi ◽

Adrian Camen ◽

Lucretiu Radu

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Biochemical Markers ◽

Mean Value ◽

Normal Weight ◽

P Value ◽

Biochemical Bone Marker ◽

Vitamin D Levels ◽

Significant Difference ◽

Coefficient Of Regression

This is a clinical study on 56 subjects included in normal weight (NW) group (N=17), overweight (OW) group (N=19) and grade I obese (O) group (N=20), based on BMI (Body Mass Index) values: NW group had a mean BMI of 22.2 � 2.14 kg/sqm, OW group had a BMI of 25.89 � 1.04 kg/sqm, and O group had an average BMI of 32.2 � 2.09 kg/sqm (p-value NW-OW, NW-O, respective OW-O groups was p[0.0005). The 3 groups were similar as age (p-value NW-OW groups = 0.7, between NW- O groups = 0.8, respective between OW - O group = 0.7). The circulating bone formation (osteocalcin, P1NP alkaline phosphatase) and resorption profile (CrossLaps) indicated no statistical significant difference between groups while the coefficient of regression r between each biochemical bone marker and BMI in every BMI group exceeded the value of p]0.05. All the 3 groups had a mean value of 25-hydroxycholecalciferol in deficiency ranges ([ 30 ng/mL, normal recommended values are above 30 ng/mL) without significant differences regarding BMI groups, except for obese group when compare to the other two groups. No secondary hyperparathyroidism was associated in any group despite low vitamin D levels. Based on our observation, bone turnover biochemical markers are not influenced by BMI.

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Differences in the Outcome of Patients with COPD according to Body Mass Index

Journal of Clinical Medicine ◽

10.3390/jcm9030710 ◽

2020 ◽

Vol 9 (3) ◽

pp. 710 ◽

Cited By ~ 2

Author(s):

Zichen Ji ◽

Javier de Miguel-Díez ◽

Christian Reynaldo Castro-Riera ◽

José María Bellón-Cano ◽

Virginia Gallo-González ◽

...

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Hospital Admissions ◽

Obesity Paradox ◽

Chronic Obstructive ◽

P Value ◽

Obstructive Pulmonary Disease ◽

Copd Patients ◽

Critical Unit

Background: In chronic obstructive pulmonary disease (COPD), the “obesity paradox” is a phenomenon without a clear cause. The objective is to analyze the complications of COPD patients according to their body mass index (BMI). Methods: An observational study with a six-year prospective follow-up of 273 COPD patients who attended a spirometry test in 2011. Survival and acute events were analyzed according to the BMI quartiles. Results: A total of 273 patients were included. BMI quartiles were ≤24.23; 24.24–27.69; 27.70–31.25; ≥31.26. During the follow-up, 93 patients died. No differences were found in exacerbations, pneumonia, emergency visits, hospital admissions or income in a critical unit. Survival was lower in the quartile 1 of BMI with respect to each of the 2–4 quartiles (p-value 0.019, 0.013, and 0.004, respectively). Advanced age (hazard ratio, HR 1.06; 95% confidence interval, CI 1.03–1.09), low pulmonary function (HR 0.93; 95% CI 0.86–0.99), exacerbator with chronic bronchitis phenotype (HR 1.76; 95% CI 1.01–3.06), high Charlson (HR 1.32, 95% CI 1.18–1.49), and the quartile 1 of BMI (HR 1.99, 95% CI 1.08–3.69) were identified as risk factors independently associated with mortality. Conclusions: In COPD, low BMI conditions a lower survival, although not for having more acute events.

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Association of body mass index changes from childhood to adulthood with dyslipidemia in adults: Hanzhong adolescent cohort study

Journal of Public Health ◽

10.1093/pubmed/fdaa108 ◽

2020 ◽

Author(s):

Yue-Yuan Liao ◽

Chao Chu ◽

Yang Wang ◽

Wen-Ling Zheng ◽

Qiong Ma ◽

...

Keyword(s):

Body Mass Index ◽

Weight Loss ◽

Body Mass ◽

Rural Areas ◽

Normal Weight ◽

Increased Risk ◽

And Control ◽

Early Weight Loss

Abstract Background Dyslipidemia is a disorder of lipid metabolism and associated with insulin resistance. The relationship between longitudinal body mass index (BMI) changes from childhood to adulthood and long-term dyslipidemia was explored in this study. Methods We assessed the longitudinal relationship between BMI changes since childhood and dyslipidemia among 1738 participants in rural areas of Hanzhong City, Shaanxi. All participants were initially examined between the ages of 6 and 15 years in 1987 and were reexamined in 1995, 2013 and 2017; the total follow-up duration was 30 years. Anthropometric measurements and blood biochemistry indexes were measured. Results We found that gradual progression of normal weight to overweight (OR = 1.65; 95% CI = 1.27, 2.15) or persistent overweight (OR = 2.45; 95% CI = 1.52, 3.96) from childhood to adulthood was associated with an increased risk of dyslipidemia in adulthood. And these risks were largely disappeared if the overweight or obesity during childhood was resolved by adulthood. The higher the BMI in adulthood and the younger the age at which overweight begins, the higher the risk of dyslipidemia. Conclusions Early weight loss and any degree of weight loss from childhood to adulthood can help improve dyslipidemia in adulthood. We further emphasize the importance of weight management and control in public health primary prevention.

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