scholarly journals Literature review: manifestation of skin lesion on COVID-19

2021 ◽  
Vol 7 (2) ◽  
pp. 327
Author(s):  
Yohanes Firmansyah ◽  
Sukmawati Tansil Tan ◽  
Jessica Elizabeth ◽  
Christopher Lauren
Keyword(s):  
Literature Review ◽  
Virus Disease ◽  
Clinical Manifestations ◽  
Maculopapular Rash ◽  
Skin Lesions ◽  
Viral Etiology ◽  
Skin Manifestations ◽  
Common Skin ◽  
Novel Coronavirus ◽  
Early Diagnose

<p>New cases of pneumonia, which spread rapidly and are deadly, have spread throughout the world. This disease is known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or corona virus disease 2019 (COVID-19) with a viral etiology in the form of novel coronavirus 2019 (2019-nCoV). This disease has extensive clinical manifestations starting from the lungs, hematology system, heart, nerves, reproduction, and the skin. The thing to be aware of is that the skin manifestations in the form of atypical lesions are often found in COVID-19. Common skin manifestations on COVID-19 are erythema-edema with vesicles or pustules (pseudo-chilblain), vesicular eruption, maculopapular rash, urticaria, and livedo lesion. This literature review discusses comprehensively what kind of skin lesions can be suspected of being part of a COVID-19 infection. This literature review is useful for increasing the awareness of doctors about COVID-19 infection and may help in early diagnose of COVID-19 infection and prevent further transmission.</p><p><strong> </strong></p>

scholarly journals Headache in patients infected with the novel coronavirus (Covid-19): An integrative literature review

2020 ◽  
pp. 3-6
Author(s):  
Sarah Nilkece Mesquita Araújo Nogueira Bastos ◽  
Diego Afonso Cardoso Macedo de Sousa ◽  
Simone Santos e Silva Melo ◽  
Bárbara Louise Freire Barbosa ◽  
Larisse Giselle Barbosa Cruz ◽  
...  
Keyword(s):  
Literature Review ◽  
Clinical Characteristics ◽  
Literature Search ◽  
Virus Disease ◽  
Clinical Manifestations ◽  
Chinese Patients ◽  
The Novel ◽  
Inclusion Criteria ◽  
Medical Databases ◽  
Novel Coronavirus

Introduction: The disease caused by the new coronavirus was named by the acronym COVID- 19 which means “COrona VIrus Disease”, while “19” refers to the year 2019, when the first cases in Wuhan, China, were identified. Objective: Our objective was to identify the prevalence of headache and to know its clinical characteristics in COVID-19 patients, available in the literature. Methods: Based on a literature search in the major medical databases and using the descriptors “headache and coronavirus”, “headache and 2019-nCoV”, “headache and SARS- CoV-2”, “headache and coronavirus and 2019-nCoV” and “headache and coronavirus and SARS-CoV-2” we include articles published between January 2019 and April 2020. We found 94 articles, but only 13 met the inclusion criteria. Results: In 13 articles analyzed in this review, a total of 3,105 Chinese patients (51.6% men and 48.4% women) had laboratory diagnoses of COVID-19. In 240 (7.7%) patients, headache was an associated symptom of COVID-19, but in only 52 (21.7%) of them there was some information about the characteristics of this headache. Conclusions: COVID-19 patients have several clinical manifestations, including headache that is nonspecific with a prevalence of 7.7%.

scholarly journals Cutaneous manifestations in children with the new coronavirus infection COVID-19

2021 ◽  
Vol 25 (1) ◽  
pp. 16-24
Author(s):  
O. B. Tamrazova ◽  
A. S. Stadnikova ◽  
E. V. Rudikova
Keyword(s):  
Literature Review ◽  
Viral Infection ◽  
Causative Agent ◽  
The Novel ◽  
Cutaneous Manifestations ◽  
Skin Manifestations ◽  
The World ◽  
Coronavirus Infection ◽  
Novel Coronavirus

In late 2019, a new viral infection appeared in China, which spread around the world, causing a pandemic. The causative agent of the new coronavirus infection COVID-19 is the SARS-CoV-2 coronavirus. The review presents modern data on the epidemiology, pathogenesis and course of the novel coronavirus infection COVID-19 in children. Chinese, American and European scientists have described a variety of cutaneous manifestations in children with COVID-19. The article provides a literature review of the cutaneous manifestations of COVID-19 coronavirus infection in children. During our own observation of 301 patients with coronavirus infection COVID-19 caused by SARS-CoV-2 at the Bashlyaevs Children Hospital in Moscow from May 17 to November 16, 2020, it was revealed that 39 (13 %) patients had skin manifestations. The article presents a classification of skin manifestations characteristic of COVID-19. A brief description of each group is given.

scholarly journals Skin manifestation in COVID-19 infection: a thousand appearances (immune response perspective)

2020 ◽  
Vol 6 (6) ◽  
pp. 776
Author(s):  
Yohanes Firmansyah ◽  
Jessica Elizabeth ◽  
Sukmawati Tansil Tan
Keyword(s):  
Clinical Symptoms ◽  
Close Contact ◽  
Clinical Manifestations ◽  
Case Series ◽  
Absolute Lymphocyte Count ◽  
Skin Lesions ◽  
Blood Parameters ◽  
Skin Manifestation ◽  
Skin Manifestations ◽  
Initial Symptoms

<p>The clinical manifestations of COVID-19 infection are still unclear. The spectrum of the disease is very broad, with many target organs; one of them is skin. Various skin manifestations have been observed in COVID-19 patients. However, the observed skin manifestation was not specific. This following case series aims to provide an overview of skin manifestations in COVID-19 to help recognize the initial symptoms of COVID-19 infection. This case series also compares cases with and without skin manifestations. This case series discusses seven cases, which the patient had close contact, who had been diagnosed with confirmed COVID-19 by polymerise chain reaction (PCR) examination. The clinical symptoms were mild, such as fever, cough, sore throat, myalgia, malaise, headache, and skin lesions. There are few differences in in complete blood laboratories. Radiology features within normal limits. All patients were given a treatment regimen according to the Indonesian lung association recommendations and symptomatic drugs. Three of seven cases had skin manifestation, which two of them had a maculopapular lesion, and the other one had urticaria lesions. Subjective symptoms, such as itching and burning sensation, were reported. The majority of lesions were localized on the upper and lower limb. Also, in this following case series, there is a tendency for complete blood parameters, neutrophil-to-lymphocyte ratio (NLR), and absolute lymphocyte count (ALC) to be lower in mild cases of confirmed COVID-19 with skin manifestations. It can be concluded that COVID-19 infection may result in skin manifestation with various clinical presentations. This important manifestation may help in diagnosing and treating COVID-19 and prevent further transmission.</p>

Erythema Pernio-like in four Adolescents in the era of the Coronavirus-2 Infection

2020 ◽  
Vol 15 ◽  
Author(s):  
Luigi Promenzio ◽  
Fabio Arcangeli ◽  
Elisabetta Cortis ◽  
Elisa Sama ◽  
Federico Longhini
Keyword(s):  
Observational Study ◽  
Pediatric Population ◽  
Clinical Manifestations ◽  
Skin Lesions ◽  
Cutaneous Manifestation ◽  
Variable Intensity ◽  
Apical Portion ◽  
Adolescent Population ◽  
Nasal Swabs ◽  
Novel Coronavirus

Background: Although epidemic, novel coronavirus (SARS-CoV-2) infection rarely affects pediatric population. However, in the last months an increasing number of Italian pediatricians has reported the occurrence of erythema pernio-like in children following a flu-like syndrome, after the outbreak of SARS-CoV-2 infection. Objective: To report cutaneous manifestation of SARS-CoV-2 infection in 4 adolescents. Methods: : Observational study reporting 4 adolescents with skin lesions, 2 weeks after the occurrence of a flu-like syndrome. Results: Fourteen days after a flu-like syndrome, adolescents exhibited skin lesions to toes and feet. These lesions were rounded, with blurred limits, with a 5-15 mm diameter, red-violaceous-bluish colored, sometimes resulting in bullous lesions in correspondence of the central or apical portion, which tended to be covered with blackish crusts after evolution. Lesions were also accompanied by pain of variable intensity and evolved within two or three weeks to self-resolution without particular sequelae. In two patients, pharyngeal and nasal swabs were negative for SARS-CoV-2 infection, at the presentation of skin lesions. After 2 months from clinical manifestations, patients were tested positive for SARS-CoV-2 antibodies. Conclusions: In pediatric and adolescent population, the occurrence of an erythema pernio-like after a flu-like syndrome could be associated to SARS-CoV-2 infection.

Dermatological manifestations in novel coronavirus infection COVID-19

2021 ◽  
Author(s):  
А.А. Хрянин ◽  
В.Г. Стуров ◽  
А.П. Надеев ◽  
В.К. Бочарова
Keyword(s):  
Primary Infection ◽  
Skin Lesions ◽  
The Novel ◽  
Skin Manifestations ◽  
Skin Symptoms ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
The Complement System ◽  
Secondary Consequence

Обзор посвящен анализу дерматологических проявлений при новой коронавирусной инфекции COVID-19, информация о которых непрерывно обновляется и дополняется. Однако до сих пор имеющиеся данные не были систематизированы. Цель обзора: проанализировать дерматологические проявления новой коронавирусной инфекции COVID-19. В среднем, у 12,5–20,4% пациентов с подтвержденным COVID-19 развились кожные проявления. Вопрос о том, являются ли кожные симптомы вторичным следствием респираторной инфекции или первичной инфекцией самой кожи, на данный момент остается открытым. Обсуждаются вероятные механизмы развития поражений кожи и роли системы комплемента и гиперкоагуляции крови в патогенезе развития дерматологических проявлений. В обзоре также приводятся клинические примеры вовлечения кожных покровов в инфекционный процесс при COVID-19. Поскольку COVID-19 имеет тенденцию к бессимптомному течению в течение 14 дней после заражения, кожные проявления могут служить индикатором инфекции, способствуя своевременной диагностике. Кроме того, осведомленность врачей о кожных симптомах, связанных с инфекцией COVID-19, имеет решающее значение для предотвращения неправильного диагноза заболевания. Review focuses on the analysis of dermatological manifestations of the novel coronovirus infection COVID-19; this information is continuously updated and supplemented. However, the available data have not been systematized until now. The purpose of this review is to analyze the dermatological manifestations of the novel coronavirus infection COVID-19. On average, 12.5–20.4% of patients with confirmed COVID-19 have developed skin manifestations. Whether the skin symptoms are a secondary consequence of a respiratory infection or a primary infection of the skin itself presently remains still open. Possible mechanisms of skin lesions development are discussed as well as the role of the complement system and blood hypercoagulation in the pathogenesis of the dermatological manifestations. The review also provides clinical examples of skin involvement in the infectious process in COVID-19. Since COVID-19 tends to be asymptomatic within 14 days of infection, so skin manifestations can serve as an indicator of infection, facilitating timely diagnosis. Moreover, physicians’ awareness of skin symptoms associated with COVID-19 is crucial for preventing misdiagnosis of the disease.

scholarly journals Dermatological Manifestation in Coronavirus Disease 2019 Patients in Iraq

2021 ◽  
Vol 9 (B) ◽  
pp. 1085-1091
Author(s):  
Anfal L. Al-Harbawi ◽  
Qasim S. Al Chalabi ◽  
Hala N. Alsalman ◽  
Mohammad S. Saeed
Keyword(s):  
Early Recognition ◽  
Cutaneous Lesion ◽  
Maculopapular Rash ◽  
Skin Lesions ◽  
Cross Sectional Study ◽  
Prodromal Phase ◽  
Cross Sectional ◽  
Cutaneous Manifestations ◽  
High Incidence ◽  
Common Skin

Background: Coronavirus disease-19 (COVID-19) is a growing pandemic around the globe that was initially discovered in Wuhan in December 2019. Despite the relatively high incidence of cutaneous manifestations in COVID-19, their role in early recognition and disease progression has not been fully investigated. Aim of this study: To report the possible incidence of the cutaneous lesion in COVID 19 patients and to describe various cutaneous manifestations and their correlation with other clinical features in Covid-19 positive patients to facilitate diagnosis and prognostications toward this virus. Methods: This research was conducted as a cross-sectional study. Skin lesions photography and their analysis were collected by dermatologists from 18 cities in Iraq between September 2020 to January 2021. The data were processed using statistical package SPSS version 23. Results: A total of 3117 confirmed COVID-19 cases were included in this study. Around 268 patients developed skin lesions with age ranged between 8 to 84 years. Of these skin lesions, 46.2% developed during the illness with minority erupting during the prodromal phase, whilst 38.8% appeared after hospitalization. The most common skin lesion was in the form of urticarial 36.74% followed by herpetic lesions 28.4%, maculopapular rash 11.74% and the remainder being candidiasis, oral thrush, chilblains, and other skin conditions. The most affected area was the torso (46%) followed by limbs, face, fingers, and toes. Conclusion: This study demonstrated the high incidence rate of dermatological lesions in different phases of COVID-19 with urticarial rash being the most frequent clinical pattern.  

scholarly journals Modification of DNMTs Gene Expressions by GST O1 and GST O2 Polymorphism in Chronic Arsenic Exposed People with and without malignancy from West Bengal, India.

2021 ◽  
Author(s):  
Sarmishtha Chanda ◽  
Jayashree Roy ◽  
Aditi Mukhopadhyay ◽  
Tushar Chakraborty ◽  
Debendranath Guha Mazumder
Keyword(s):  
Drinking Water ◽  
Expression Profile ◽  
West Bengal ◽  
Clinical Manifestations ◽  
Skin Lesions ◽  
Cumulative Exposure ◽  
Arsenic Content ◽  
Wild Type ◽  
Skin Manifestations ◽  
Arsenical Skin Lesions

Abstract Background: Chronic Arsenic exposure causes skin manifestations and even cancer. However, the response varies widely among persons despite receiving similar cumulative exposure through their food or drinking water or both. These differentiations in manifestations may be due to polymorphic distribution of arsenic metabolizing genes among exposed people. Method: Polymorphism of GSTO1, GSTO2 and their frequency distribution may modify skin manifestations and development of arsenic induced cancer in exposed persons through food chain. Polymorphic variations of GSTO1 and GSTO2 have been studied on 112 subject including control. They were recruited from one of major arsenic affected district, Nadia of West Bengal, India, having high arsenic content in their food. Exposed subjects were categorized into three groups, i.e, with arsenical skin lesions and with out arsenical skin lesions and arsenic induced cancer. Control subjects were 33 in number. Concentration of arsenic in their urine, hair, drinking water, food, extent of clinical manifestations, GST O1and O2status was determined. DNMT1, 3A, and 3B were studied for their expression profile and analyzed with GSTO1 and O2 polymorphisms. Result: Genetic polymorphism of GSTO1 gene polymorphism is significantly associated with arsenic induced skin scores in skin lesion positive cases and arsenic induced cancer cases and also significant increase is seen in DNMT expression and MDA level in exposed cases with homozygous wild type variants. Total urinary arsenic decreases significantly in wild type GSTO1 genotype, although, GSTO2 polymorphism showed no statistically significant differences in skin manifestations, and DNMTs expression. Frequency of GSTO1 and O2 polymorphic variety showed prevalence of wild type homozygous in arsenic induced cancer cases.Conclusion: GSTO1 polymorphism shows significant association with DNMT expression profile in arsenic exposed people.

scholarly journals Urticaria-like rash in a patient with COVID-19 associated pneumonia of moderate severity: aspects of pathogenesis

2020 ◽  
Vol 23 (2) ◽  
pp. 109-114
Author(s):  
Ekaterina V. Orlova ◽  
L. M. Smirnova ◽  
N. I. Melikova ◽  
K. Yu. Popova
Keyword(s):  
Clinical Case ◽  
Case Reports ◽  
Clinical Manifestations ◽  
Skin Lesions ◽  
Infection Process ◽  
Moderate Severity ◽  
Skin Manifestations ◽  
General Weakness

In mid 2020, the number of new coronavirus (COVID-19) cases has exceeded globally six million. The clinical manifestations of COVID-19 infection are numerous mostly causing damage to the bronchopulmonary system in the form of a dry cough, rhinitis, dyspnea, fever, myalgia, and general weakness. Skin manifestations of COVID-19 are rare and currently include five types of skin lesions occurring during the infection process, which are reliably recorded in only a limited number of case reports and certain analytical publications. This article describes the clinical case of a 28-year-old patient with urticaria-like disseminated rash and confirmed COVID-19-associated pneumonia.

Acute Respiratory Distress Syndrome (ARDS) Caused by the Novel Coronavirus Disease (COVID-19): A Practical Comprehensive Literature Review

2020 ◽  
Author(s):  
Francisco Montenegro ◽  
Luis Unigarro ◽  
Gustavo Paredes ◽  
Tatiana Moya ◽  
Ana Romero ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Literature Review ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Clinical Manifestations ◽  
The Novel ◽  
Comprehensive Literature Review ◽  
Wide Range ◽  
Novel Coronavirus

Introduction: The exponential growth of the SARS-CoV-2 virus transmission during the first months of 2020 has placed substantial pressure on health systems worldwide. The complications derived from the novel coronavirus disease (COVID-19) vary in due to comorbidities, sex and age, with more than 50% of the patients who require some level of intensive care developing acute respiratory distress syndrome (ARDS). Areas covered: Various complications caused by SARS-CoV-2 infection have been identified, the most lethal being the acute respiratory distress syndrome, caused most likely by the presence of severe immune cell response and the concomitant alveolus inflammation. The authors carried out an extensive and comprehensive literature review on SARS-CoV-2 infection, the clinical, pathological and radiological presentation as well as the current treatment strategies. Expert Opinion Elevation of inflammatory biomarkers is a common trend among seriously ill patients. The information available strongly suggests that in COVID-19 patients, their altered immune response, including a massive cytokine storm, is responsible for the further damage evidenced among ARDS patients. The increasingly high number of scientific articles and evidence available can only suggest that the individualization of each case is the norm, not all patients with acute respiratory failure due to COVID-19 meet the Berlin definition and therefore ARDS should be considered as a heterogeneous disease, with a wide range in the expression of its severity and clinical manifestations.

SKIN LESIONS IN CHILDREN WITH COVID-19-ASSOCIATED MULTISYSTEM INFLAMMATORY SYNDROME

2020 ◽  
Vol 99 (6) ◽  
pp. 259-265
Author(s):  
O.B. Tamrazova ◽  
◽  
I.M. Osmanov ◽  
A.S. Stadnikova ◽  
L.N. Mazankova ◽  
...  
Keyword(s):  
Clinical Observation ◽  
Clinical Manifestations ◽  
Chinese American ◽  
Skin Lesions ◽  
Disease Course ◽  
Skin Manifestations ◽  
Mucous Membranes ◽  
Coronavirus Infection ◽  
Inflammatory Syndrome ◽  
First Time

The pandemic of the new coronavirus infection COVID-19, caused by SARS-CoV-2 coronavirus, continues to develop. The first data indicated that children tolerate this infection much easier than adults, the disease course is generally asymptomatic and mild. Chinese, American and European scientists described a variety of skin manifestations in children with COVID-19 coronavirus infection. The article presents literature data on skin manifestations in children, characteristic for COVID-19. In April 2020, the description of a new severe inflammatory syndrome in children associated with SARS-CoV-2, called multisystem inflammation syndrome (MIS), appeared for the first time. The article presents literature data on MIS clinical manifestations and its incidence. The authors describe clinical observation of MIS development in a 7-year-old child with COVID-19 and with lesions of the skin and mucous membranes.

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