scholarly journals Potensi Tanaman Lokal sebagai Tanaman Obat dalam Menghambat Penyebaran COVID-19

2020 ◽  
Vol 7 (2) ◽  
pp. 112
Author(s):  
Yuli Kusuma Dewi ◽  
Baiq Amelia Riyandari
Keyword(s):  
Immune System ◽  
Allium Sativum ◽  
Virus Disease ◽  
Curcuma Longa ◽  
Zingiber Officinale ◽  
Psidium Guajava ◽  
Corona Virus ◽  
Immune Booster ◽  
Red Ginger ◽  
Prevention Methods

COVID-19 (Corona Virus Disease of 2019) merupakan wabah penyakit yang menginfeksi saluran pernafasan pada manusia. Wabah ini tidak hanya terjadi di Indonesia, melainkan terjadi hampir di seluruh negara di Dunia. COVID-19 ini menjadi wabah yang meresahkan karena penyebarannya terjadi dengan sangat cepat melalui kontak antara manusia dengan manusia dan hingga saat ini belum tersedianya vaksin terhadap virus SARS-CoV-2 yang telah diuji klinis untuk mengatasi penyebaran virus ini. Salah satu upaya untuk mencegah penyebaran COVID-19 adalah meningkatkan sistem kekebalan tubuh (sistem imunitas) melalui asupan makanan yang kaya akan kandungan senyawa antioksidan maupun imun booster. Berdasarkan studi literatur yang telah dilakukan, beberapa tanaman lokal Indonesia diprediksi dapat menjadi kandidat penghambat COVID-19. Tanaman yang memiliki potensi sebagai antiviral yang dapat menghambat COVID-19 antara lain: jahe merah (Zingiber officinale), kunyit (Curcuma longa L.), temulawak (Curcuma xanthorriza Roxb), teh hijau (Camelia sinensis), meniran (Phyllantus niruri L.), salam (Syzygium polyanthum), jambu biji (Psidium guajava), cengkeh (Sygizium aromaticum), dan bawang putih (Allium Sativum). COVID-19 (Corona Virus Disease of 2019) is one of disease infecting human respiratory system. This pandemic spreads out not only in Indonesia, but also in all countries around the world. In nowdays, COVID-19 become a terrible disease because the virus can infect very fast through human to human transmission and there is no clinically published vaccine against the SARS-CoV-2 virus to prevent the transmission. One of prevention methods of COVID-19 is by enhancing immune system. Consuming of some food which contain antioxidant agent or immune booster is known as one of method to enhance the immune system. Based on literature studies, there are some Indonesian local plants predicted as the inhibitor against COVID-19. Those plants which are potential as the antiviral to inhibit COVID-19 including red ginger (Zingiber officinale), turmeric (Curcuma longa L.), temulawak (Curcuma xanthorriza Roxb), green tea (Camelia sinensis), meniran (Phyllantus niruri L.), salam (Syzygium polyanthum), guava (Psidium guajava), clove (Sygizium aromaticum), dan garlic (Allium Sativum).Keywords: COVID-19, SARS-CoV-2, medicinal plants, antiviral

scholarly journals Medicinal Plant by Batak Toba Medicinal plants used by the Batak Toba Tribe in Peadundung Village, North Sumatra, Indonesia

2019 ◽  
Vol 20 (2) ◽  
pp. 510-525 ◽  
Author(s):  
MARINA SILALAHI ◽  
NISYAWATI NISYAWATI ◽  
DINGSE PANDIANGAN
Keyword(s):  
Medicinal Plants ◽  
Curcuma Longa ◽  
Zingiber Officinale ◽  
Single Species ◽  
Psidium Guajava ◽  
Piper Betle ◽  
Structured Interviews ◽  
Medicinal Species ◽  
Eurycoma Longifolia ◽  
North Sumatra

Abstract. Silalahi M, Nisyawati, Pandiangan D. 2019. Medicinal plants used by the Batak Toba Tribe in Peadundung Village, North Sumatra, Indonesia. Biodiversitas 20: 510-525. Research of the medicinal plants by the Toba Batak ethnic has limited, even though the globalization and modernization resulted to degradation of the local knowledge. The objectives of this study were (i) documentation of medicinal plants used in the traditional therapies by the Batak Toba tribe of Peadundung Village, North Sumatra, Indonesia, and (ii) analysing the data by quantitative ethnobotanical tools such as use value (UV), cultural significance index (CSI), relative frequency of citation (RCF) and informant consensus factor (ICF) to determine the cultural importance of medicinal plants in order to develop a tool for their conservation. Semi-structured interviews with 41 identified respondents was the methodology employed for qualitative data collection. A total of 149 medicinal species of plants, belonging to 131 genera and 55 families, were recorded in the study which are used in the treatment of 21 categories of ailments. Plants with the highest UV were Eurycoma longifolia (UV=3.44), Curcuma longa (UV=2.67) and Zingiber officinale (UV=2.60). Eight species, namely Curcuma longa, Eurycoma longifolia, Allium cepa, Psidium guajava, Aleurites moluccanus, Piper betle, Citrus hystrix and Uncaria gambir were found to be having the highest RCF value of 1.00. Eurycoma longifolia (CSI=126), Curcuma longa (CSI=112) and Zingiber officinale (CSI = 105) emerged as the culturally most significant medicinal plants. Thrush and aphrodisiac use categories received the highest ICF of 1.00 each because the informants agreed of using only a single species for each of these categories. Eurycoma longifolia was used as an aphrodisiac whereas Averrhoa carambola was used against thrush. All these important and significant plants suffer the greatest harvesting pressure, hence their conservation should be given priority.

scholarly journals The Utilization of Garlic (Allium sativum Linn) and Red Ginger (Zingiber officinale var rubra) Extract on The Growth of Broiler were Infected by Escherichia coli

2018 ◽  
Vol 5 (3) ◽  
Author(s):  
A W Isma ◽  
M Tafsin ◽  
Y L Henuk ◽  
N D Hanafi ◽  
Hamdan
Keyword(s):  
Escherichia Coli ◽  
Broiler Chickens ◽  
Allium Sativum ◽  
Zingiber Officinale ◽  
Ginger Extract ◽  
Tetracycline Antibiotics ◽  
E Coli ◽  
Randomized Design ◽  
Red Ginger ◽  
Alternative Antibiotic

This study aims to examine the effect of garlic (Allium sativum Linn) and red ginger (Zingiber officinale var rubra) extract on the growth of broiler chickens were infected by Escherichia coli. The design used in this study was a complete randomized design (CRD) with 6 treatments and 3 replications. Treatment consists of P0A = Control without infection; P0B = Control + E. coli infection; P1 = Infection E. coli + tetracycline antibiotics 0.05%; P2 = Infection E. coli + garlic extract (Allium sativum Linn) (1%); P3 = Infection E. coli + red ginger extract (Zingiber officinale var rubra) (1%); P4 = Infection E. coli + garlic (Allium sativum Linn) and red ginger (Zingiber officinale var rubra) extract (1%). The results showed that the effect of garlic and red ginger gave significant influence (P <0,05) to growth of broiler were infected by Escherichia coli. The combination of garlic (Allium sativum Linn) and red ginger (Zingiber officinale var rubra) extract has the highest influence of other activities. It was concluded that giving of garlic and red ginger extract give influence to growth of broiler were infected by Escherichia coli and can be used as alternative antibiotic.

scholarly journals Pelatihan Penerapan Gizi Seimbang Pada Masa Pandemi Covid-19

2021 ◽  
Vol 2 (2) ◽  
pp. 64-68
Author(s):  
Atika Nur Azizah
Keyword(s):  
Immune System ◽  
Virus Disease ◽  
Knowledge And Skills ◽  
Corona Virus ◽  
Implementation Method

The covid-19 pandemic (corona virus disease 2019) causes a decrease in the body's immune system. One of the things that can increase a toddler's immune system is eating a balanced nutritious diet. The purpose of the training on the application of balanced nutrition is to increase knowledge and skills about balanced nutrition. Balanced nutrition is necessary to promote a good immune system. The implementation method is in the form of training with lecture methods, discussions, and the practice of applying balanced nutrition to the management of the Nasyiatul Aisyiyah Rawalo Branch Manager. The result is an increase in knowledge by 60% and an increase in skills in the application of balanced nutrition by 85%.

Plantes médicinales utilisées contre le cancer du sein par la population d’Algérie de l’Est

2021 ◽  
Author(s):  
K. Ounaissia ◽  
R. Bechiri ◽  
M. Snani ◽  
L. Naoun
Keyword(s):  
Nous Avons ◽  
Cancer Du Sein ◽  
Allium Sativum ◽  
Nigella Sativa ◽  
Curcuma Longa ◽  
Zingiber Officinale ◽  
Plantes Médicinales ◽  
Annona Muricata ◽  
Berberis Vulgaris ◽  
Étude Ethnobotanique

Une étude ethnobotanique des plantes médicinales utilisées traditionnellement dans le traitement du cancer du sein a été menée en 2018–2019 auprès des patients du service de radiothérapie, « centre anticancer, CAC », Annaba, Algérie. Cette étude a permis de réunir toutes les informations concernant l’usage des plantes médicinales pratiqué par les malades. L’analyse des résultats, obtenus à partir de fiches questionnaires, a permis de recenser 35 espèces végétales réparties dans 27 familles botaniques, avec une représentation importante des espèces suivantes : Nigella sativa L. (12 citations), Curcuma longa L., Allium sativum L., Berberis vulgaris L., Annona muricata L., Ephedra sp (neuf citations), suivies par le Zingiber officinale Roscoe (huit citations), le reste des espèces ont une fréquence de citation comprise entre une et sept. Nous avons noté aussi que parmi les organes des plantes, le feuillage constitue la partie la plus utilisée, avec un pourcentage de 20 %. Toutes ces informations constituent une ébauche importante pour réaliser des recherches expérimentales ultérieures dans le but de déterminer les principes actifs et leurs mécanismes d’action sur le cancer.

scholarly journals Rethinking on Using of Traditional Indigenous Medicinal Plants for the Management of Covid-19 In India- A Review

2021 ◽  
pp. 53-63
Author(s):  
Halavath Ramesh ◽  
M.F.Valan
Keyword(s):  
Herbal Medicine ◽  
Virus Disease ◽  
Nigella Sativa ◽  
Curcuma Longa ◽  
Cocos Nucifera ◽  
Tinospora Cordifolia ◽  
Virus Family ◽  
Traditional System ◽  
Research Activities ◽  
Corona Virus

Novel corona virus first began in Wuhan, china, in December 2019, and it rapidly expanded globally. Corona virus disease 2019 (COVID-19) is a new infectious disease caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) that belongs to the corona virus family. With no specific and effective antiviral therapy for CoVID-19, new or repurposed antiviral are urgently needed. For traditional medicinal treasure India is well recognized all over the world. There are more than 3000 authorized plants in India that hold prodigious medicinal potential. The traditional systems of medicines viz. Ayurveda, Siddha, Unani, western herbal medicine, traditional Chinese medicine and homeopathy have roots in medicinal herbs. In view of the significant morbidity and mortality associated with this pandemic, many research activities are ongoing globally to explore possible therapeutic regiments or prophylactic agents. Ayurveda the traditional system of Indian medicine can offer prophylactic or therapeutic solutions for COVID-19. Traditional Indian Medicines has lot to offer in the management of COVID-19. Many research documents suggested that ethno pharmacological information on the medicinal plant species used by herbalists against corona virus disease. Herbal medicine are achieving attention because of the extensive therapeutics like potent antiviral, immunomodulatory, anti-inflammatory, and anti-oxidant properties and certain natural compounds might be effective for the treatment of COVID-19 based on general concepts from previous experiments. These articles discusses some herbal agents extracted from various plants, including Cinchona, Curcuma longa, Nigella sativa, Azadirachta indica, Tinospora Cordifolia, Allium sativum, Oxylum indicum, Punicagranatum, Cocos nucifera and some more plants, Herbal medicine, phytochemical which are considered for the treatment of COVID-19. This review will open an area for the development of novel natural herbal formulations as an alternative therapy that can be used for the preparation of immunopotentiator, development of herbal/Ayurvedic antiviral drugs, designing anti-microbial / anti viral materials and prevention and treatment of COVID-19.

scholarly journals Phytobiotic Properties of Garlic, Red Ginger, Turmeric and Kencur in Growing Ducks

2015 ◽  
Vol 17 (1) ◽  
pp. 49 ◽  
Author(s):  
Ismoyowati Ismoyowati ◽  
Diana Indrasanti ◽  
Mochamad Mufti ◽  
Abdoreza Soleimani Farjam
Keyword(s):  
Escherichia Coli ◽  
Allium Sativum ◽  
Zingiber Officinale ◽  
Feed Conversion ◽  
Feeding Trial ◽  
E Coli ◽  
Salmonella Pullorum ◽  
Red Ginger

Abstract. Phytobiotic properties of garlic (Allium sativum), turmeric (Curcuma domestica), red ginger (Zingiber officinale) and kencur (Kaempferia galangal) were studied using standard in vitro antibacterial test and in vivo feeding trial with ducklings. In the in vitro experiment, potency of aqueous extract of these phytobiotic agents were tested against Salmonella pullorum and Escherichia coli. Feeding trial was carried out for 6 week starting at day 28 using ducklings fed diets supplemented with 1% of each of four phytobiotic agents. The highest antibacterial activity against S. pullorum and E. coli was observed with garlic and no additive effect when mixture of phytobiotics was used. Weight gain, fed intake and feed conversion ratio of ducklings were not affected by inclusion of garlic, red ginger and kencur. However, 1% turmeric supplementation significantly reduced growth performance to ducklings. Key words: phytobiotic, antibiotic, duck, medicinal plants Abstrak.  Penelitian karakteristik fitobiotik dari bawang putih (Allium sativum), kunyit (Curcuma domestica), jahe merah (Zingiber officinale) dan kencur (Kaempferia galangal) telah dilakukan secara in vitro melalui uji aktivitas antibakteri dan secara in vivo dengan perlakuan suplemetasi fitobiotik didalam pakan anak itik. Pada percobaan  in vitro, potensi  aktivitas antibakteri dari ektrak  fitobiotik diuji menggunakan Salmonella pullorum and Escherichia coli.  Percobaan suplementasi fitobiotik diberikan masing-masing sebesar 1% didalam pakan anak itik.  Pemberian pakan perlakuan dilakukan selama 6 minggu,  dimulai pada saat anak itik berumur 28 hari.  Hasil penelitian menunjukkan aktivitas antibakteri terhadap S. pullorum dan E. coli paling tinggi adalah ektrak bawang putih dan tidak ada pengaruh yang lebih baik apabila dicampur dengan ektrak fitobiotik lainnya.  Pertambahan bobot badan, konsumsi pakan dan konversi pakan anak itik tidak dipengaruhi oleh penambahan bawang putih, kunyit, jahe merah dan kencur.  Akan tetapi, suplementasi kunyit nyata menurunkan performan pertumbuhan anak itik. Kata kunci: fitobiotik, antibiotik, itik, tanaman obat-obatan.

scholarly journals Molecular Docking Terhadap Senyawa Kurkumin dan Arturmeron pada Tumbuhan Kunyit (Curcuma Longa Linn.) yang Berpotensi Menghambat Virus Corona

2021 ◽  
Vol 9 (2) ◽  
Author(s):  
Tiara C. Pradani ◽  
. Fatimawali ◽  
Aaltje E. Manampiring ◽  
Billy J. Kepel ◽  
Fona D. Budiarso ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Binding Affinity ◽  
In Silico ◽  
Virus Disease ◽  
Curcuma Longa ◽  
Positive Control ◽  
Tropical Plant ◽  
Corona Virus ◽  
Main Protease ◽  
Close Relationship

Abstract: At the end of 2019 the world was shocked by the emergence of a new virus, namely the corona virus (SARS-CoV 2) which is called Corona Virus Disease 2019 or COVID-19. The origin of the emergence of this virus is known to have originated in the city of Wuhan, Hubei Province, China in December 2019.1 Research shows a close relationship with the corona virus that causes Severe Acute Respitatory Syndrome (SARS) which broke out in Hong Kong in 2003, until WHO named it the novel corona virus ( nCoV19). Turmeric (Curcuma longa L.) is a tropical plant that has many benefits and is found in many parts of Indonesia. Turmeric is widely used by the community as a traditional medicine to treat several diseases, such as: anti-inflammatory, antioxidant, hepatoprotective, and others. This study aims to determine the content in several compounds in the turmeric plant that have the potential to inhibit COVID-19 by using the molecular docking method. Using the In Silico method, namely molecular docking with the compounds taken were curcumin and ar-turmerone and the main protease COVID-19 (6LU7). This study obtained the binding affinity of curcumin compounds, namely -7.2 and Ar-turmerone -5.8 compounds against Mpro COVID-19. Remdesivir, which was used as a positive control, had a binding affinity of -7.7. In conclusion, remdesivir got better results compared to curcumin and Ar-turmerone compounds.Keywords: Molecular Docking, Turmeric, COVID-19.  Abstrak: Pada akhir tahun 2019 dunia digemparkan dengan munculnya virus baru yaitu corona virus (SARS-CoV 2) yang disebut dengan Corona Virus Disease 2019 atau COVID-19. Awal mula munculnya virus ini diketahui berasal dari Kota Wuhan, Provinsi Hubei, China pada Desember 2019.1  Penelitian menunjukkan hubungan yang dekat dengan virus corona penyebab Severe Acute Respitatory Syndrome (SARS) yang mewabah di Hongkong pada tahun 2003, hingga WHO menamakannya sebagai novel corona virus (nCoV19). Kunyit (Curcuma longa L.) merupakan salah satu jenis tanaman tropis yang banyak memiliki manfaat dan banyak ditemukan di wilayah Indonesia. Kunyit banyak dimanfaatkan masyarakat sebagai obat tradisional untuk mengobati beberapa penyakit seperti: antiinflamasi, antioksidan, hepatoprotektor, dan lain-lain. Penelitian ini bertujuan untuk mengetahui kandungan dalam beberapa senyawa pada tumbuhan kunyit yang berpotensi menghambat COVID-19 dengan metode molecular docking. Menggunakan metode In Silico yaitu molecular docking dengan senyawa yang diambil adalah kurkumin dan ar-Turmerone dan main protease COVID-19 (6LU7). Penelitian ini didapatkan hasil binding affinity senyawa kurkumin yaitu -7.2 dan senyawa ar-turmeron -5.8 terhadap Mpro COVID-19. Remdesivir yang digunakan sebagai control positif mendapatkan hasil binding affinity yaitu -7.7. Sebagai simpulan, remdesivir mendapat hasil yang lebih baik dibandingkan dengan senyawa kurkumin dan ar-turmeron.Kata Kunci: Molecular Docking, Kunyit, COVID-19.

Immunological response of the respiratory tract in the SARS-CoV-2 infection

Coronaviruses ◽  
2021 ◽  
Vol 02 ◽  
Author(s):  
Sanjiv Singh ◽  
Punita Aggarwal ◽  
Velayutham Ravichandiran
Keyword(s):  
Immune System ◽  
Respiratory Tract ◽  
Viral Infections ◽  
Inflammatory Responses ◽  
Virus Disease ◽  
Adaptive Immune System ◽  
Immunological Response ◽  
Immunological Responses ◽  
Corona Virus ◽  
Maximum Protection

: Severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) is a contagious pathogen responsible for the ongoing corona virus disease 2019 (COVID-19) pandemic. The pathogenesis and immunological response of SARS-CoV-2 infection is poorly understood until now. After a person is infected by SARS-COV-2 immunity is compromised as both innate and adaptive immunity is playing a major role in the same. The host innate immune system forms the first layer of defense for protection from viral infections and initiates activation of the adaptive immune system in order to give maximum protection. In order to protect from tissue damage and diseases, the respiratory tract maintains the balance of T cell, B cell pro- and anti-inflammatory responses. In this review, we discuss the current update in our understanding of the involvement of the immune system in the antiviral defense against SARS-CoV-2. These novel insights at the respiratory tract immunological responses may support the future development of vaccines and immunoregulatory therapy for SARS-CoV-2 infection.

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