Efek hipoglikemik dan hipolipidemik dendeng daging itik curing dengan ekstrak kurkumin kunyit pada Tikus Wistar

Objective: This research aimed to determine hypoglycemic and hypolipidemic effects of cured duck meat jerky with curcumin using male Wistar rats as experimental animals.Methods: This research involved a completely randomized design in oneway pattern with 4 treatments on diabetic (TD) and hyperlipidemic (HD) rats : zero jerky (standard feed, PS), low jerky 0.96 g/head/day (DR), high jerky 1.91g/head/day (DT) and vitamin E 28.80 mg/head/day as control antioxidants (equivalent to 400 IU tocopherol). There were 24 rats divided into 4 treatments for hypoglycemic and hypolipidemia each. The treatment spanned 4 weeks, with hypoglycemic parameters (body weight and blood glucose) observed every week, and hypolipidemic (total cholesterol, triglycerides, HDL, and LDL). Furthermore, an analysis of variance was conducted to determine body weight. When a significant difference was observed, it was continued with Duncan's New Multiples Range Test, while other parameters were analyzed descriptively.Results: The hypoglycemic effect showed a significant difference in body weight where the PS treatment were relatively stable, while DT and vitamin E treatment experienced the highest weight loss. Blood glucose also decreased with the increasing addition of curcumin and vitamin E. Meanwhile, the hyperlipidemic showed a decrease in cholesterol, triglycerides, and LDL, while HDL increased as the concentration of curcumin from jerky increased, the amount of which was equivalent to antioxidant control of vitamin E.Conclusions: The diet of cured duck meat jerky as much as 1.91g/head/day (equivalent to 106.26 g/person/day or 400 IU tocopherol/vitamin E) can lower diabetic blood glucose and improve blood lipid profile.

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Potential Analysis of Lemna sp. Extract as Immunostimulant to Increase Non-Specific Immune Response of Tilapia (Oreochromis niloticus) against Aeromonas hydrophila

Research Journal of Life Science ◽

10.21776/ub.rjls.2021.008.01.6 ◽

2021 ◽

Vol 8 (1) ◽

pp. 40-47

Author(s):

Eric Armando ◽

Ayu Lestiyani ◽

R. Adharyan Islamy

Keyword(s):

Body Weight ◽

Plasma Protein ◽

Lysozyme Activity ◽

Total Plasma ◽

Immune Parameters ◽

Randomized Design ◽

Total Plasma Protein ◽

Significant Difference ◽

And Control ◽

Range Test

Lemna sp. is known to have several bioactive compounds and polysaccharide macromolecules that can function as immunomodulators to affect non-specific immune responses to increase the body's resistance to pathogens. This study aims to determine the potential of catfish eye extract as an immunostimulant by observing non-specific tilapia immune parameters. The extraction method used was 96% ethanol maceration for 2 days with a ratio of 1: 4. The experimental design used a Completely Randomized Design with 5 treatments (doses 0.2, 0.4, 0.6 mg/kg, control + and control -) and 3 replications. The non-specific parameters of immunity observed included total plasma protein (Bradford method), superoxide dismutase and lysozyme activity. The data obtained will be analyzed using ANOVA, if there is a significant difference, it will be further tested with Duncan Multiple. Range Test (DMRT). The results showed that the highest total plasma protein was found in treatment C (giving an extract of 0.3 mg/kg body weight) with an average total plasma protein after 12 days of maintenance of 4.99 g / dL. The extract dose of 0.3 mg/body weight showed a rapid decrease in SOD and increase Lysozyme activity.

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Effects of Vitamin E Supplementation to Metabolic Markers on Diet-Induced Obesity in Mice

Folia Medica ◽

10.3897/folmed.63.e57877 ◽

2021 ◽

Vol 63 (6) ◽

pp. 895-900

Author(s):

Eka Roina Megawati ◽

Lokot Donna Lubis ◽

Febi Yanti Harahap

Keyword(s):

Body Weight ◽

Vitamin E ◽

Blood Sugar ◽

Adiponectin Level ◽

Metabolic Markers ◽

Diet Induced Obesity ◽

Cholesterol Levels ◽

Significant Difference ◽

Obesity In Mice ◽

Vitamin E Supplementation

Introduction: Obesity creates health problems by increasing the risks of chronic diseases such as type 2 diabetes and cardiovascular disorders. Obesity leads to insulin resistance, higher blood glucose and cholesterol levels. Adipose tissues synthesize adiponectin which acts as anti-inflammatory, antidiabetic, and anti-atherogenic agent. Meanwhile, vitamin E is an antioxidant that acts as an anti-inflammation. Aim: The purpose of this study was to analyze the effects of vitamin E supplementation to metabolic markers on diet-induced obesity in mice. Materials and methods: Twenty-four mice (Mus musculus, L) aged four weeks were divided into six groups which were fed different diets and given vitamin E in different dosages or methods. The period of treatment was 18 weeks. The mice body weights were measured every week; blood sugar and cholesterol levels were measured every six weeks, and the adiponectin level measurement was done at week 18. Results: A repeated measures ANOVA showed that body weight and cholesterol level within groups were not significantly different [F(15, 54)=1.417, 0.173 and F(10, 36)=1.391, 0.224 respectively]. The glucose levels were found to be significantly different [F(7.646, 27.526)=2.625, 0.030]. There was no significant difference in the adiponectin levels. Conclusions: Vitamin E supplementation could not prevent the increase of body weight, the elevation of blood sugar and cholesterol levels, and also could not increase adiponectin level.

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ASSOCIATION BETWEEN BLOOD LIPID PROFILE AND BLOOD GLUCOSE LEVELS IN MEN WITH CORONARY HEART DISEASE, METABOLIC SYNDROME, AND TYPE 2 DIABETES MELLITUS

CARDIOVASCULAR THERAPY AND PREVENTION ◽

10.15829/1728-8800-2013-5-29-33 ◽

2013 ◽

Vol 12 (5) ◽

pp. 29-33

Author(s):

S. A. Matveeva

Keyword(s):

Blood Glucose ◽

Lipid Profile ◽

Low Density Lipoprotein ◽

Fasting Blood Glucose ◽

Density Lipoprotein ◽

Blood Lipid ◽

Lipoprotein Cholesterol ◽

Blood Lipid Profile ◽

Glucose Levels ◽

Blood Glucose Levels

Aim.To study the associations between blood lipid profile and blood glucose levels in men with coronary heart disease (CHD), stable effort angina (SEA), metabolic syndrome (MS), and Type 2 diabetes mellitus (DM-2).Material and methods.The study included 82 men (mean age 50,5±0,9 years) with CHD, Functional Class I–III SEA, MS, and DM-2. The following lipid profile parameters were assessed: total cholesterol (TCH), triglycerides (TG), low-density lipoprotein cholesterol (LDL–CH), very low-density lipoprotein cholesterol (VLDL–CH), high-density lipoprotein cholesterol (HDL–CH), atherogenic index (AI), and triglyceride index (TGI), together with fasting blood glucose.Results.There were positive (direct) associations between higher levels (>90th percentile) of lipid profile parameters (TCH, TG, LDL–CH, VLDL– CH, HDL–CH, AI, TGI) and blood glucose, as well as between lower levels (≤10th percentile) of lipid profile parameters (TCH, TG, LDL–CH, VLDL– CH, AI, TGI) and blood glucose. At the same time, there were negative (inverse) associations between lower lipid levels (≤10th percentile of TCH, TG, LDL–CH, VLDL–CH, HDL–CH, AI, TGI) and higher glucose levels (>90th percentile), as well as between higher lipid levels (>90th percentile of TCH, TG, LDL–CH, VLDL–CH, HDL–CH, AI, TGI) and lower glucose levels (≤10th percentile).Conclusion.Dyslipidemia and hyperglycemia demonstrate synergetic proatherogenic effects in patients with CHD, SEA, MS, and DM-2, as suggested by significant heterogeneous (direct and inverse) associations between lipid profile parameters and fasting blood glucose. The results obtained provide an opportunity for the assessment of risk levels, prognosis, and need for pharmacological prevention and treatment in patients with combined cardiovascular pathology.

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Effect of Basil Seed and Chia SeedExtracts on Blood Lipid Profile

10.53350/pjmhs211561368 ◽

2021 ◽

Vol 15 (6) ◽

pp. 1368-1371

Author(s):

S. Munir ◽

S. Khurshid ◽

Q. J. Iqbal ◽

N. Iqbal ◽

Z. Masood

Keyword(s):

Body Weight ◽

Lipid Profile ◽

Plasma Cholesterol ◽

Plasma Lipid ◽

Blood Lipid ◽

Histopathological Analysis ◽

Omega 3 ◽

Blood Lipid Profile ◽

Cholesterol Levels ◽

Maintain Body Weight

Background: Basil and Chia seeds contain higher nutritive values like vitamin, carbohydrates, Omega-3 oil and other dietary fibers. With all these rich dietary benefits these seeds regulate necessary health conditions and maintain body weight. Ocimumbasilicum (Basil) plant have been known to contain properties of weight loss, better digestion and other health benefits. Aim: To check the Basil seed against hyperlipidemia in mice with Chia seeds. Methodology: In this research, the effect of both seeds extract on body weight and plasma lipid profile were estimated in Albino mice after raising their cholesterol levels by high fatty diet. The experiments were performed in different groups like normal control, standard control, hyperlipidemia group and four groups of diet supplemented chia or basil seeds with two different doses. Results: The biochemical analysis revealed that the supplementation of Basil seeds (400mg/kg/day) significantly lowered the levels of total plasma cholesterol, lipoproteins and triacylglycerol. Moreover, histopathological analysis of vital organs like kidneys, heart reported no toxicity. Conclusion: Extracts of Chia and Basil seeds have shown controlling effects over the given parameters in the blood and weights of the animals and these may have potential to control high fat diet-induced hyperlipidemia when taken as dietary supplements. Keywords: Cholesterol, Hyperlipidemia, Ocimumbasilicum, Salvia hispanica

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Daya Hambat Hidrolisis Karbohidrat Oleh Ekstrak Daun Murbei

Jurnal Agripet ◽

10.17969/agripet.v9i2.600 ◽

2009 ◽

Vol 9 (2) ◽

pp. 1-9

Author(s):

S. Syahrir ◽

Komang G Wiryawan ◽

Aminuddin Parakkasi ◽

Winugroho Winugroho ◽

W. Ramdania

Keyword(s):

Body Weight ◽

Blood Glucose ◽

Body Weight Gain ◽

Univariate Analysis ◽

Nutrient Content ◽

Mulberry Leaves ◽

Feed Digestibility ◽

Carbohydrate Hydrolysis ◽

Randomized Design ◽

Hydrolysis Process

Inhibition hydrolysis of carbohydrate by mulberry leaves extractABSTRACT. Mulberry leaves has a great potential as animal feeds because of its high nutrient content, but has deoxynojirimycin (DNJ) active matter. It is potential to inhibit carbohydrate hydrolysis process, come to monosaccharides. The objective of this experiment is to study the inhibiting ability of mulberry leave extract in carbohydrate hydrolysis process. The kinds of carbohydrates were using glucose, maltose, sucrose and starch. This experiment used twenty four of 60 days old male mice (Mus musculus). Diet and water were given ad libitum. Treatment were allocated ina factorial completely randomized design with three replications and two factors containing of completely mulberry leaves extract and variance of carbohydrates. Variable observed were feed consumtion, feed digestibility, body weight gain and blood glucose. The data were analyzed with univariate analysis of variance. The result showed that inclusion of mulberry leaves extract had decrease body weight (P 0,05) and reduce blood glucose (P 0,05).

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The effect of concurrent aerobic-resistance training on thyroid hormones, blood glucose hemostasis, and blood lipid indices in overweight girls with hypothyroidism

Hormone Molecular Biology and Clinical Investigation ◽

10.1515/hmbci-2019-0031 ◽

2019 ◽

Vol 40 (3) ◽

Cited By ~ 1

Author(s):

Sahar Mohammadi Sefat ◽

Ramin Shabani ◽

Marzieh Nazari

Keyword(s):

Blood Glucose ◽

Resistance Training ◽

Blood Sugar ◽

Adolescent Girls ◽

Blood Lipid ◽

T Test ◽

Model Assessment ◽

Fat Percentage ◽

Significant Difference ◽

Experimental Group

Abstract Background The present study aimed to explore the effect of 8 weeks of concurrent aerobic-resistance training on thyroid stimulating hormone (TSH), thyroxine (T4), blood lipid profile, and blood glucose hemostasis in adolescent girls with hypothyroidism. Materials and methods In this clinical trial, 20 adolescent girls with hypothyroidism [age: 12.10 ± 1.94 years; body mass index (BMI): 25.25 ± 2.91 kg/m2] were selected and randomly assigned to experimental and control groups. The experimental group was treated with 8 weeks of concurrent aerobic [60–80% heart rate reserve (HHR)] and resistance (40–65% of 1RM) training. Blood was sampled before and after training. Data were analyzed using a pairwise t-test and an independent t-test (α < 0.05). Results Within-group comparison revealed significant decline of body index, BMI, fat percentage, fasting blood sugar, and homeostatic model assessment (HOMA) in the experimental group (p = 0.002, p = 0.001, p = 0.001, p = 0.03, and p = 0.02, respectively). Also, inter-group comparisons indicated significant differences in weight, BMI, fat percentage and HOMA (p = 0.001). But, no significant difference was observed in the blood sugar index (p > 0.05). Conclusion A short-term period of concurrent aerobic-resistance training may improve blood glucose hemostasis and body composition of adolescent girls with hypothyroidism. However, further research is necessary.

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Profile of Blood Glucose and Insulin after Vitamin C and Vitamin E Supplementation on Active Teenagers

International Journal of Engineering & Technology ◽

10.14419/ijet.v7i4.26.22154 ◽

2018 ◽

Vol 7 (4.26) ◽

pp. 136

Author(s):

Irfiansyah Irwadi ◽

Hayuris Kinandita ◽

Jamaluddin Mahmud ◽

Lilik Herawati

Keyword(s):

Blood Glucose ◽

Vitamin E ◽

Vitamin C ◽

Serum Insulin ◽

Fasting Blood Glucose ◽

Combination Group ◽

Control Group ◽

High Dose ◽

Moderate Dose ◽

Significant Difference

Aim: Antioxidants, such as vitamin C and vitamin E, is widely used as supplements. The aim of this study is to analyze the profile of blood glucose, serum insulin, and HOMA in active teenagers after vitamin C and vitamin E supplementation.Methods: Subjects (14-16 y.o) consisted of 12 boys and 5 girls, divided into 3 groups: control (4 boys, 2 girls), ‘moderate dose’ of vitamin C and vitamin E combination group (5 boys, 1 girls), and ‘high dose’ of vitamin C and vitamin E combination group (3 boys, 2 girls). The treatment was given for 5 days. Vitamin C and vitamin E for ‘moderate dose’ was 500mg; 200IU, and for ‘high dose’ was 1000mg; 400IU. Fasting Blood Glucose (FGB) and 1 hour BG (1hr_BG), fasting serum insulin (FSI) and 1 hour SI (1hr_SI) was collected after treatment. We also calculated the HOMA-IR and HOMA-β.Result: There was no significant difference on FBG, 1hr_BG, FSI, 1hr_SI, HOMA-IR, and HOMA-β (p≥ 0.05). However, mean FBG and 1hr_BG tended to be higher on the treatment groups. The control group had the lowest HOMA-IR and the highest HOMA-β.Conclusions: We suggest that the supplementation of vitamin C and vitamin E in active teenagers is not essential on glucose homeostasis.

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PENGARUH NAA DAN BAP TERHADAP PERTUMBUHAN SUBKULTUR ANGGREK HASIL PERSILANGAN Dendrobium biggibum X Dendrobium liniale

Caraka Tani Journal of Sustainable Agriculture ◽

10.20961/carakatani.v31i1.11938 ◽

2016 ◽

Vol 31 (1) ◽

pp. 33

Author(s):

Sri Hartati ◽

Agus Budiyono ◽

Ongko Cahyono

Keyword(s):

Plant Conservation ◽

Naphthalene Acetic Acid ◽

Randomized Design ◽

Significant Difference ◽

Two Factors ◽

Number Of Leaves ◽

Media Research ◽

Test Level ◽

Range Test

Indonesia has a high diversity of species of orchids. One of them is the Dendrobium orchid. Orchid seeds do not have endosperm should be grown in a medium that has enough nutrients. Orchid propagation in vitro is strongly influenced by the composition of the medium used. Research through experiments aimed at studying the effect of NAA, BAP, NAA and BAP combination of the subculture plantlets growth of hybrids orchid Dendrobium biggibum X liniale in Vacin Went media. Research conducted at the Laboratory of Tissue Culture Center for Plant Conservation Bogor Botanical Gardens. The experimental design used was completely randomized design (CRD) with two factors. The first factor was the concentration of Naphthalene Acetic Acid /NAA ( 0 ppm, 1 ppm, 3 ppm and 5 ppm). The second factor was the type media of Benzyl Amino Purine /BAP ( 0 ppm, 1 ppm, 3 ppm and 5 ppm). Each treatment was replicated eight times. Analysis of the data by F test level 5% and if there is a significant difference continued with Duncan Multiple (Duncan's Multiple Range Test) level of 5%. The result showed that the addition of NAA 3 ppm as much as 4,96 cm and BAP 3 ppm as much as 4,41 cm give a significant effect on the increase of high plantlets and so NAA 3 ppm as much as 5,76 cm effect on roots length , but did not significantly effect the number of leaves and roots.

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Comparative effect of Bambusa vulgaris Schrad. and Gliricidia sepium(Jacq.) charcoal powders on the growth of Parkia biglobosa (Jacq.) Benth seedlings

LAUTECH Journal of Civil and Environmental Studies ◽

10.36108/laujoces/1202.70.0190 ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

B. L Olajiire-Ajayi

Keyword(s):

Growth Parameters ◽

Gliricidia Sepium ◽

Stem Diameter ◽

Parkia Biglobosa ◽

Leaf Production ◽

Randomized Design ◽

Significant Difference ◽

Bambusa Vulgaris ◽

Level Of Significance ◽

Range Test

The high cost of purchasing inorganic fertilizer and its impacts on the soil and the environment remains a major concern in environmental management. Consequently, there is the need to explore other ways to enhance soil fertility. The study investigated the effects of Bambusa vulgaris Schrad. and Gliricidia sepium (Jacq) charcoal powders on the growth of Parkia biglobosa (Jacq). Benth seedlings. The experiment was laid out in a Completely Randomized Design (CRD) with 13 treatments and 9 replicates each. Seeds were sowed directly into polyethene pots while the various treatments were added a week after sowing seeds. Watering was done daily while weeding was done periodically. Growth parameters of seedling height (cm), stem diameter (mm) and leaf count were assessed weekly for 16weeks. Data collected was subjected to Analysis of Variance (ANOVA) at 5% level of significance while the means were separated using Duncan Multiple Range Test (DMRT). The result obtained showed that 15g of Gliricidia sepium charcoal powder + 2kg of topsoil) performed best in height and leaf production with values of 15.85cm and 20.58 respectively.5g of Bambusa vulgaris charcoal powder + 2kg of topsoil) performed best with the value of 0.41mm for stem diameter.2kg of topsoil had the least performance for all parameter assessed. The ANOVA result showed that there was significant difference at P>0.5 among the treatments at 5% level of probability in terms of plant height, stem diameter, leaf production. The study concludes that the addition of charcoalas soil additive enhanced growth of Parkia biglobosa seedling at nursery stage.

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Metabolic impacts of cordycepin on hepatic proteomic expression in streptozotocin-induced type 1 diabetic mice

PLoS ONE ◽

10.1371/journal.pone.0256140 ◽

2021 ◽

Vol 16 (8) ◽

pp. e0256140

Author(s):

Kongphop Parunyakul ◽

Krittika Srisuksai ◽

Sawanya Charoenlappanit ◽

Narumon Phaonakrop ◽

Sittiruk Roytrakul ◽

...

Keyword(s):

Body Weight ◽

Blood Glucose ◽

Signaling Pathway ◽

Tricarboxylic Acid Cycle ◽

Fasting Blood Glucose ◽

Protein Profiling ◽

Diabetic Mice ◽

Final Body Weight ◽

Significant Difference

Type 1 Diabetes mellitus (T1DM) is associated with abnormal liver function, but the exact mechanism is unclear. Cordycepin improves hepatic metabolic pathways leading to recovery from liver damage. We investigated the effects of cordycepin in streptozotocin-induced T1DM mice via the expression of liver proteins. Twenty-four mice were divided into four equal groups: normal (N), normal mice treated with cordycepin (N+COR), diabetic mice (DM), and diabetic mice treated with cordycepin (DM+COR). Mice in each treatment group were intraperitoneally injection of cordycepin at dose 24 mg/kg for 14 consecutive days. Body weight, blood glucose, and the tricarboxylic acid cycle intermediates were measured. Liver tissue protein profiling was performed using shotgun proteomics, while protein function and protein-protein interaction were predicted using PANTHER and STITCH v.5.0 software, respectively. No significant difference was observed in fasting blood glucose levels between DM and DM+COR for all time intervals. However, a significant decrease in final body weight, food intake, and water intake in DM+COR was found. Hepatic oxaloacetate and citrate levels were significantly increased in DM+COR compared to DM. Furthermore, 11 and 36 proteins were only expressed by the N+COR and DM+COR groups, respectively. Three unique proteins in DM+COR, namely, Nfat3, Flcn, and Psma3 were correlated with the production of ATP, AMPK signaling pathway, and ubiquitin proteasome system (UPS), respectively. Interestingly, a protein detected in N+COR and DM+COR (Gli3) was linked with the insulin signaling pathway. In conclusion, cordycepin might help in preventing hepatic metabolism by regulating the expression of energy-related protein and UPS to maintain cell survival. Further work on predicting the performance of metabolic mechanisms regarding the therapeutic applications of cordycepin will be performed in future.

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