scholarly journals THE POTENTIAL EFFECT OF RED DRAGON FRUIT (Hylocereus polyrhizus) PEEL ETHANOL EXTRACT ON ENDOMETRIOSIS PROGRESSIVITY IN ENDOMETRIOSIS MICE

2018 ◽  
Vol 12 (2) ◽  
Author(s):  
Anindya Hapsari ◽  
Yanuar Eka Pujiastutik
Keyword(s):  
Mouse Model ◽  
Ethanol Extract ◽  
Potential Effect ◽  
Positive Control ◽  
Negative Control ◽  
Control Groups ◽  
Fruit Peel ◽  
Treatment Groups ◽  
Dragon Fruit ◽  
Hylocereus Polyrhizus

The aim of this study was to know the effect of red dragon fruit (Hylocereus polyrhizus) peel ethanol extract at dose of 0.25, 0.5, and 1 mg/gbw on endometriosis progressivity, signed by granuloma, on mouse model of endometriosis. Twenty five female mice were used as samples anddivided into 5 groups: 1 positive control, 1 negative control, and 3 treatment groups. Positive control and treatment groups were induced as modelof endometriosis for 14 days. The next 14 days, placebo was given to both control groups, while red dragon fruit peel ethanol extract at dose of0.25, 0.5, and 1 mg/g bw were given to mice in treatment groups as much as 0.2 mL/25 g bw/day orally. Endometriotic lesion was examined.Result showed that there were significantly differences on granuloma among control groups and treatment groups. The conclusion was reddragon fruit peel ethanol extract could inhibit endometriosis progressivity, signed by granuloma, on mouse model of endometriosis.

scholarly journals Analisis Metabolit Sekunder dan Aktivitas Ekstrak Etanol Kulit Buah Salak (Salacca zalacca (Gaertn.) Voss) Terhadap Kadar Glukosa dan Ureum Kreatinin Tikus Putih Jantan (Rattus norvegicus)

KOVALEN ◽  
2021 ◽  
Vol 7 (3) ◽  
pp. 161-168
Author(s):  
Tien Wahyu Handayani ◽  
Agustinus Widodo ◽  
Risna Yanti ◽  
Erdy Prasetyo ◽  
Zulfaidah ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Rattus Norvegicus ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Phytochemical Screening ◽  
Fruit Peel ◽  
Treatment Groups ◽  
White Rats

The snake fruit peel (Salacca zalacca (Gaertn.) Voss) traditionally has several health benefits, one of which is to treat diabetes mellitus. This study aimed to determine the content of secondary metabolites in the ethanolic extract of snake fruit peel and its activity on glucose and urea creatinine levels in male white rats (Rattus norvegicus). Phytochemical screening of extracts was carried out qualitatively and quantitatively using UV-Vis Spectrophotometry. This study is a laboratory experimental study using 30 test animals divided into 6 treatment groups (normal control, negative control, positive control, 70 mg/kg BW, 140 mg/kg BW, and 280 mg/kg BW). The results showed that the ethanol extract of the bark of the salak fruit contained 7.61 %w/w alkaloids, flavonoids 0.041% w/w, tannins 1.18% w/w, and saponins 2% w/w. Ethanol extract of salak fruit peel dose of 140 mg/kg BW affected decreasing blood glucose and urea creatinine levels. The skin of the salak fruit has the potential to be further investigated as an antidiabetic.

UJI EFEK ANALGESIK EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura L.) PADA MENCIT PUTIH JANTAN (Mus musculus) DENGAN INDUKSI NYERI ASAM ASETAT

2017 ◽  
Vol 2 (2) ◽  
pp. 147
Author(s):  
Triswanto Sentat ◽  
Susiyanto Pangestu
Keyword(s):  
Analgesic Effect ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Control Treatment ◽  
Treatment Groups ◽  
Analgesic Effects ◽  
Significant Difference ◽  
Analgesic Dose ◽  
Muntingia Calabura

Kersen leaf (Muntingia calabura L.) contains tannins, flavonoids and polyphenol compounds allegedly have analgesic effect. The objective was to determine the analgesic effect of ethanol extract of kersen leaves and to determine the most effective analgesic dose. This study was an experimental research. Leaves were extracted with ethanol 70% and the analgesic effect test was divided into 5 groups: negative control treatment (distilled water), positive control (mefenamic acid 2.6mg/kg), kersen leaf ethanol extract first dose (100mg/kg), second dose (200mg/kg) and tthird dose (400mg/kg). Giving treatments by oral, after 30 minutes, the mices were given a pain inductor with 0.5% acetic acid by intra peritonial administration. Analgesic power was calculated by counting the number of writhing in mice for 1 hour. The results showed that the ethanol extract of cherry leaf has analgesic effect. From the calculation of the first dose analgesic power (42.9%), second dose (59.4%) and the third dose 69.9%. Statistical test results kruskal wallis value of p=0.011 (p<0.05) showed a significant difference between all analgesic treatment groups. The conclusion of this study is all of the ethanol extract had analgesic effects on male white mice, whereas a dose of 400mg/kg is the most effective analgesic dose.

scholarly journals KULIT BUAH JERUK LIMAU (Citrus amblycarpa (Hassk.) Osche) SEBAGAI ANALGESIK

Jurnal Kimia ◽  
2020 ◽  
pp. 24
Author(s):  
R. A. I. K. Maharani ◽  
N. K. Cahyaningsih ◽  
M. D. Abimanyu ◽  
K. W. Astuti
Keyword(s):  
Body Weight ◽  
Analgesic Activity ◽  
Treatment Options ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Fruit Peel ◽  
Hot Plate ◽  
Inflammatory Drugs ◽  
Negative Controls

Nonsteroidal anti-inflammatory drugs (NSAIDs) are the treatment options for relieving pain. However, long-term use can trigger gastrointestinal bleeding. Therefore, alternative analgesics which have the same therapeutic effect with lower side effects are needed. Limau (Citrus amblycarpa) is an empirical drug for tingling and cramping. The aim of the study is to determine the analgesic activity of ethanol extract of C. amblycarpa fruit peel. The method used in testing analgesic activity is the Hot Plate method. The study was conducted by dividing 30 mice into 6 groups. The group given CMC-Na 1% was used as a negative control, the group given suspension of sodium diclofenac dose of 6.5 mg/kg of body weight was used as a positive control, and the group given suspension of ethanol extract of C. amblycarpa fruit peel with dose variations 100, 300 and 600 mg/kg of body weight. The test animals were placed on top of the Hot Plate with a temperature of 70°C at 30 minutes after giving suspension test and the response time of mice to heat was observed every 30 minutes for 3 hours with cut off time 15 second. Based on the test results, it can be concluded that the administration of ethanol extract of C. amblycarpa fruit peel with 100, 300 and 600 mg/kg of body weight gave analgesic activity on mice compared to the negative controls (CMC-Na 1%).   Keywords: C. amblycarpa, Fruit Peel, Analgesics, Hot Plate 

scholarly journals Evaluation the Effect of Vernonia amygdalina. Del Leaves Ethanol Extract on Blood Sugar and its Synergism with Glibenclamide in Rats

2020 ◽  
Vol 13 (1) ◽  
pp. 26-34
Author(s):  
Igwe K ◽  
Ikpeazu O ◽  
Otuokere I
Keyword(s):  
Blood Glucose ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Vernonia Amygdalina ◽  
Treatment Groups ◽  
Glucose Levels

Antidiabetic activity of Vernonia amygdalina and its possible synergism with glibenclamide was checked. Forty eight rats were used for the research, for hypoglycermic study of V. amygdalina alone, they were grouped into five of six rats each. Group 1 was the negative control and was administered distilled water orally. Groups 2, 3, and 4 were the treatment groups which received 100, 200 and 300 mg/kg body weight of the V. amygdalina extract respectively orally by intubation. Group 5 was the positive control group which received a known antidiabetic drug, glibenclamide. Diabetes was induced with alloxan. For the synergism study, another 18 rats grouped into 3 of six rats each was used. Both groups of glibenclamide only and glibenclamide plus V. amygdalina extract were dosed for 14 days orally by intubation, thereafter were sacrificed and blood collected from heart for analysis. There were 5 replicates grouped by weight throughout the study and both single and synergistic studies had the same controls. Effect of V. amygdalina extract was checked on blood glucose and its possible synergism with glibenclamide. All results in treatment groups were compared with the normal control at statistical confidence of p<0.05. Result shows that V. amygdalina extract reduced blood glucose level in the test groups as dose of extract increased. Combination of V. amygdalina with glibenclamide demonstrated further deduction in blood glucose levels in the treatment rats groups. Therefore addition of V. amygdalina into glibenclamide increased efficacy in the diabetic rats. The interaction between V. amygdalina and glibenclamide in this work was additive and therefore synergistic.

scholarly journals PENGUJIAN EFEKTIVITAS DIURETIK KOMBINASI EKSTRAK ETANOL DAUN AFRIKA (Gymnanthemum amygdalinum Del.) DAN DAUN KELAPA SAWIT (Elaeis guineensis Jacq.) PADA TIKUS JANTAN

2020 ◽  
Vol 3 (1) ◽  
pp. 106-111
Author(s):  
Delisma Simorangkir
Keyword(s):  
Leaf Extract ◽  
Elaeis Guineensis ◽  
Urine Volume ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Treatment Groups ◽  
White Rats ◽  
Group 2 ◽  
Palm Leaf

African Leaf and palm leaf crops have a secondary metabolite content such as alkaloids and flavonoids that are efficacious as diuretics. The purpose of this study is to know the effectiveness of diuretics from the combination  African leaf ethanol extract and palm leaf ethanol extract. Methods used Eksperiemental. The test of diuretic activity is conducted divided into 6 treatment groups. Each group consists of 3 tails of white rats. Group 1 (positive control) administered Furosemide 3.6 mg/kgBB, Group 2 (negative control) was given suspension Na-CMC 0.5%, group 3 without treatment as well as groups of 4.5, and 6 in a row administered a combination of African leaf extract doses and extracts Oil palm leaf ethanol in a row of "50 mg/kgBB + 67, 5mg/kgBB"; "100mg/kgBB + 135 mg/kgBB"; and "200 mg/kgBB + 270 mg/kgBB". Each mouse is then given a 20ml NaCl/kgBB as an oral loading dose. Measured urine volume is recorded every hour for 6 hours after it continues to measure urine volume. The results showed that the combination of African leaf ethanol extract dosage and palm leaf ethanol extract had a diuretic effect if it was compared with negative control. The conclusion of the study was the results of the study showed that the combination of African leaf extract dosage and palm leaf extract is the most effective dose of Group 6 (African leaf extract 200 mg/kgBB + palm leaves 270 mg/kgBB ). Because it produces the highest urine volume of 23.01 ml.

scholarly journals Formulation, Physical Quality Evaluation, and Antioxidant Activity of Body Butter of Ethanol Extract of Dragon Fruit (Hylocereus polyrhizus) Peel

2020 ◽  
Vol 25 (3) ◽  
Author(s):  
Agustina Nila Yuliawati ◽  
Kadek Duwi Cahyadi
Keyword(s):  
Antioxidant Activity ◽  
Quality Evaluation ◽  
Activity Index ◽  
Ethanol Extract ◽  
The Body ◽  
Fruit Peel ◽  
Physical Quality ◽  
Antioxidant Content ◽  
Dragon Fruit ◽  
Hylocereus Polyrhizus

Dragon fruit (Hylocereus polyrhizus) has polyphenols as an antioxidant. It has known that the antioxidant content of dragon fruit peels was more than in the flesh, so it can be used as a source of natural antioxidants to replace synthetic antioxidants. The use of dragon fruit (Hylocereus polyrhizus) peel, especially as topical preparations in the form of body butter, was still rarely done, whereas dragon fruit peel as an antioxidant can be used as an active ingredient of cosmetics. The purpose of this study was to obtain the body butter formula of ethanol extract of dragon fruit (Hylocereus polyrhizus) peel and its physical quality evaluation, to know the antioxidant activity of ethanol extract of dragon fruit (Hylocereus polyrhizus) peel and its body butter. This research was an experimental study with the stages of research consisting of determination of native plants, making ethanol extract of dragon fruit (Hylocereus polyrhizus) peel, ensuring its activity antioxidant, performing body butter formulation procedures, carrying out physical quality evaluation such as organoleptic, homogeneity, pH, spread, protection, and adhesion ability, then antioxidant activity of its body butter. The result of this research showed that the ethanol extract of dragon fruit (Hylocereus polyrhizus) peel has a moderate level of antioxidant (Antioxidant Activity Index / AAI = 0,88). Furthermore, body butter which has contains antioxidant content of ethanol extract of dragon fruit (Hylocereus polyrhizus) peel as much as 0.5% has the best physical quality evaluation during storage and the highest AAI (0,54) among other body butter formulas.

The enhancement of Arg1 and activated ERβ expression in microglia HMC3 by induction of 96% ethanol extract of Marsilea crenata Presl. leaves

2020 ◽  
Vol 30 (6) ◽  
Author(s):  
Burhan Ma’arif ◽  
Mangestuti Agil ◽  
Hening Laswati
Keyword(s):  
Laser Scanning ◽  
Negative Relationship ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Scanning Microscope ◽  
Treatment Groups ◽  
Arginase 1 ◽  
Significant Difference ◽  
Ifn Γ

AbstractBackgroundPhytoestrogens have a high potential to overcome the neuroinflammation caused by estrogen deficiency. Marsilea crenata Presl. is a plant known to contain phytoestrogens. This research aimed to report the activity of a 96% ethanol extract of M. crenata leaves in inducing activation of microglia HMC3 cell to M2 polarity, which has anti-inflammatory characteristics.MethodsThe study was done by culturing microglia HMC3 cell in 24-well microplate and inducing it with IFN-γ for 24 h to activate the cell to M1 polarity, which has proinflammatory characteristics. The 96% ethanol extract was added with various doses of 62.5, 125, and 250 ppm. Genistein, 50 μM, was used as a positive control. The analysis of the immunofluorescence of Arginase-1 (Arg1) and ERβ as markers was done using a convocal laser scanning microscope.ResultsThe result of Arg1 shows a significant difference in Arg1 expression in the microglia HMC3 cell line between the negative control and all treatment groups at p < 0.05, with the best result at 250 ppm, whereas for ERβ, the results show, at doses of 125 and 250 ppm, that the 96% ethanol extract of M. crenata leaves decrease the activated ERβ expression at p < 0.05, with the best result at 250 ppm. The Arg1 and activated ERβ expression have a weak negative relationship with the Pearson correlation test.ConclusionsThe 96% ethanol extract of M. crenata leaves has an antineuroinflammation activity through the induction of Arg1 and activated ERβ expression in microglia HMC3 cell, with the best dose at 250 ppm.

scholarly journals Ekstrak Etanol Kulit Buah Jengkol Menurunkan Kadar Glukosa dan Meningkatkan Hormon Insulin Tikus Diabetes Yang Diinduksi Streptozotocin

2019 ◽  
Vol 20 (1) ◽  
pp. 65
Author(s):  
Desak Made Malini ◽  
Madihah Madihah ◽  
Dita Aprila Khoirunnisa ◽  
Indriani Sasmita ◽  
Nining Ratningsih ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Blood Glucose ◽  
Reference Group ◽  
Ethanol Extract ◽  
Insulin Level ◽  
Positive Control ◽  
Negative Control ◽  
Diabetic Rats ◽  
Female Rats ◽  
Fruit Peel

Diabetes Mellitus (DM) is a disease with metabolism disorder signed by increasing of glucose blood (hyperglicemia), caused by disorder of insulin secretion and or increasing of insulin resistance. Therapy of jengkol’s fruit peel is an alternative treatment for DM. This study aims to determine the effect of ethanol extract of jengkol’s fruit peel to decrease glucose and increase insulin level of Wistar female rats which induced by streptozotocin (STZ). This research used the experimental method of Completely Randomized Design (RAL). Rat were first induced by single intravenous injection of STZ except Negative Control. Furthermore, rats were divided into six groups, namely Negative Control (NC), Positive Control (PC), Reference Group (RG) glibenclamide 10 mg/kg BW, and ethanol extract of jengkol’s fruit peel (EEOJFP) treatment at dose of 385 (P1), 770 (P2), and 1540 (P3) mg/kg BW with four replications each. Treatment was administered orally for 14 days. Data were analyzed by analysis of variance (ANAVA) with 95% confidence level and Duncan Multiple Range Test. The result showed that treatment of EEOJFP with dose of 385, 770 and 1540 mg/ kgBW decreased blood glucose 28.6%;65.4% and 59.1% successively, increased insulin as 54%; 230% and 206%. There was a protective effect of EEOJEF to level of blood glucose and insulin secretion of rat-STZ induced. The conclusion from this research is Ethanol extract of Jengkol’s fruit peel at dose 770 mg/kg BW is an effective dose in decreasing the level of glucose and increasing the level of insulin hormone in STZinduced diabetic rats. 

scholarly journals Tamarindus indica Ameliorates Neural Aluminum Chloride Toxicity in Neonatal Wistar rats

2021 ◽  
Author(s):  
IBE MICHAEL USMAN ◽  
Sunday Abraham Musa ◽  
Ibrahim Abdullahi Iliya ◽  
Eric Osamu Aigbogun ◽  
Keneth Iceland Kasozi ◽  
...  
Keyword(s):  
Positive Control ◽  
Negative Control ◽  
Tamarindus Indica ◽  
Neonatal Rats ◽  
Control Groups ◽  
Treatment Groups ◽  
Copper Zinc ◽  
Group 5 ◽  
Main Components ◽  
Iron And Calcium

Abstract Objective:This was to determine levels of heavy metal expression following Tamarindus indica activity in neonatal rats. Pregnant timed rats were divided into 5 groups (n =4) and neonatal rats were used. Group 1 (negative control), Groups II-V were experimental groups treated with 100 mg/kg of AlCl3 s/c. Group II (positive control), Groups III and IV receiving 400mg/kg and 800mg/kg of Tamarindus indica respectively, and Group 5 receiving 30mg/kg of Vitamin E (comparative control) for 3 weeks. Brain metal; copper, zinc, iron, and calcium (Cu, Zn, Fe, and Ca respectively) quantification was done using atomic absorption spectrophotometer. Results:Tamarindus indica contained 61.6% Oleic Acid, n-Hexadecanoic acid 11.03%, Phenol, 3,5-bis (1,1-dimethyl ethyl)- 8.48 %, and cis-9-Hexadecenal 7.79% as the main components in Tamarindus indica. The differential expression of brain metals in the treatment groups on post gestation day 7 and 21 revealed significantly high mean Zn, Fe, and Cu and lower Ca expression in the positive control compared to the negative control; but significantly lower mean Zn, Fe, and Cu and higher Ca expression was observed in the group treated with 400 and 800mg/kg bw of EATI and comparative control when compared to values observed in positive control.

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