scholarly journals Statistical models for pediatric endocrinology

2021 ◽  
Author(s):  
Andre Madsen
Keyword(s):  
Cross Sectional Study ◽  
Growth Charts ◽  
Clinical Implementation ◽  
Pediatric Endocrinology ◽  
Growth Study ◽  
Cross Sectional ◽  
Reference Framework ◽  
Z Scores ◽  
Reference Curves ◽  
Lms Method

Abstract Background: Modelling references for biomarkers as reference curves enables calculation of patient z-scores that are adjusted for both gender and covariance with age during childhood.Aim: To establish biomarker reference curves using the ‘LMS’ method previously employed for conventional growth charts.Design, Setting and Participants: Cross-sectional study of healthy Norwegian girls (n=647) and boys (n=465) in ages 6 to 16 years were recruited in the Bergen Growth Study (2016). Blood samples were analyzed using state-of-the-art instruments.Results: Reference curves for several biomarkers were established in the ‘LMS’ framework and provided here for clinical implementation. Conclusion: The ‘LMS’ reference framework is already used to create conventional growth charts and may also be applied in clinical biochemistry.

scholarly journals Compliance with the 24-Hour Movement Behavior Guidelines and Associations with Adiposity in European Preschoolers: Results from the ToyBox-Study

2021 ◽  
Vol 18 (14) ◽  
pp. 7499
Author(s):  
Marga Decraene ◽  
Vera Verbestel ◽  
Greet Cardon ◽  
Violeta Iotova ◽  
Berthold Koletzko ◽  
...  
Keyword(s):  
Sleep Duration ◽  
Screen Time ◽  
Total Sample ◽  
Cross Sectional Study ◽  
World Health ◽  
Movement Behavior ◽  
Cross Sectional ◽  
Guideline Compliance ◽  
Z Scores ◽  
Health Organization

In 2019, the World Health Organization (WHO) published 24 h movement behavior guidelines for preschoolers with recommendations for physical activity (PA), screen time (ST), and sleep. The present study investigated the proportion of preschoolers complying with these guidelines (on a total week, weekdays and weekend days), and the associations with adiposity. This cross-sectional study included 2468 preschoolers (mean age: 4.75 years; 41.9% boys) from six European countries. The associations were investigated in the total sample and in girls and boys separately. PA was objectively assessed by step counts/day. Parent-reported questionnaires provided ST and sleep duration data. Generalized estimating equations were used to analyze the association between guideline compliance and adiposity indicators, i.e., body mass index (BMI) z-score and waist to height ratio (WHR). Only 10.1% of the preschoolers complied with the 24 h movement behavior guidelines, 69.2% with the sleep duration guideline, 39.8% with the ST guideline and 32.7% with the PA guideline. No association was found between guideline compliance with all three movement behaviors and adiposity. However, associations were found for isolated weekday screen time (BMI z-scores and WHR: p = 0.04) and weekend day sleep duration (BMI z-scores and WHR: p = 0.03) guideline compliance with both lower adiposity indicators. The latter association for sleep duration was also found in girls separately (BMI z-scores: p = 0.02; WHR: p = 0.03), but not in boys. Longitudinal studies, including intervention studies, are needed to increase preschoolers’ guideline compliance and to gain more insight into the manifestation of adiposity in children and its association with 24 h movement behaviors from a young age onwards.

scholarly journals Waist circumference and waist circumference to height ratios of Kaingáng indigenous adolescents from the State of Rio Grande do Sul, Brazil

2012 ◽  
Vol 28 (11) ◽  
pp. 2053-2062 ◽  
Author(s):  
Teresa Gontijo de Castro ◽  
Laura A. Barufaldi ◽  
Michael Maia Schlüssel ◽  
Wolney Lisboa Conde ◽  
Maurício Soares Leite ◽  
...  
Keyword(s):  
Waist Circumference ◽  
Correlation Coefficients ◽  
Cross Sectional Study ◽  
Rio Grande Do Sul ◽  
Sectional Study ◽  
Cross Sectional ◽  
School Based ◽  
High Prevalence ◽  
Z Scores ◽  
Indigenous Adolescents

The aim of this study was to describe the distribution of waist circumference (WC) and WC to height (WCTH) values among Kaingáng indigenous adolescents in order to estimate the prevalence of high WCTH values and evaluate the correlation between WC and WCTH and body mass index (BMI)-for-age. A total of 1,803 indigenous adolescents were evaluated using a school-based cross-sectional study. WCTH values > 0.5 were considered high. Higher mean WC and WCTH values were observed for girls in all age categories. WCTH values > 0.5 were observed in 25.68% of the overall sample of adolescents. Mean WC and WCTH values were significantly higher for adolescents with BMI/age z-scores > 2 than for those with normal z-scores. The correlation coefficients of WC and WCTH for BMI/age were r = 0.68 and 0.76, respectively, for boys, and r = 0.79 and 0.80, respectively, for girls. This study highlights elevated mean WC and WCTH values and high prevalence of abdominal obesity among Kaingáng indigenous adolescents.

scholarly journals Half-Marathon and Full-Marathon Runners' Hydration Practices and Perceptions

2011 ◽  
Vol 46 (6) ◽  
pp. 581-591 ◽  
Author(s):  
Eric K. O'Neal ◽  
Jonathan E. Wingo ◽  
Mark T. Richardson ◽  
James D. Leeper ◽  
Yasmine H. Neggers ◽  
...  
Keyword(s):  
Total Sample ◽  
Cross Sectional Study ◽  
Hydration Status ◽  
Little Rock ◽  
Cross Sectional ◽  
Marathon Runners ◽  
Adverse Health Effects ◽  
Urine Color ◽  
Expected Performance ◽  
Z Scores

Context: The behaviors and beliefs of recreational runners with regard to hydration maintenance are not well elucidated. Objective: To examine which beverages runners choose to drink and why, negative performance and health experiences related to dehydration, and methods used to assess hydration status. Design: Cross-sectional study. Setting: Marathon registration site. Patients or Other Participants: Men (n = 146) and women (n = 130) (age = 38.3 ± 11.3 years) registered for the 2010 Little Rock Half-Marathon or Full Marathon. Intervention(s): A 23-item questionnaire was administered to runners when they picked up their race timing chips. Main Outcome Measure(s): Runners were separated into tertiles (Low, Mod, High) based on z scores derived from training volume, expected performance, and running experience. We used a 100-mm visual analog scale with anchors of 0 (never) and 100 (always). Total sample responses and comparisons between tertile groups for questionnaire items are presented. Results: The High group (58±31) reported greater consumption of sport beverages in exercise environments than the Low (42 ± 35 mm) and Mod (39 ± 32 mm) groups (P < .05) and perceived sport beverages to be superior to water in meeting hydration needs (P < .05) and improving performance during runs greater than 1 hour (P < .05). Seventy percent of runners experienced 1 or more incidents in which they believed dehydration resulted in a major performance decrement, and 45% perceived dehydration to have resulted in adverse health effects. Twenty percent of runners reported monitoring their hydration status. Urine color was the method most often reported (7%), whereas only 2% reported measuring changes in body weight. Conclusions: Greater attention should be paid to informing runners of valid techniques to monitor hydration status and developing an appropriate individualized hydration strategy.

High urate concentration is associated with elevated blood pressure in schoolchildren

2018 ◽  
Vol 31 (11) ◽  
pp. 1207-1212 ◽  
Author(s):  
Luiza Naujorks Reis ◽  
Cézane Priscila Reuter ◽  
Jane Dagmar Pollo Renner ◽  
Leandro Tibiriçá Burgos ◽  
Silvia Isabel Rech Franke ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Basic Education ◽  
Prevalence Ratio ◽  
Cross Sectional Study ◽  
Blood Collection ◽  
Descriptive Data ◽  
Cross Sectional ◽  
Borderline Hypertension ◽  
Z Scores ◽  
Altered Blood

Abstract Background Studies in adults have shown a relationship between high blood pressure and hyperuricemia, but few studies have investigated this association in children and adolescents. The aim of the present study was to associate urate concentration with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in schoolchildren. Methods This cross-sectional study used a sample of 2335 schoolchildren in basic education between 7 and 17 years old. Blood pressure was classified by percentile according to Brazilian parameters for sex and age, reclassified into two categories: normal and borderline/hypertension. Blood collection to obtain serum for urate concentration analysis was performed after a 12-h fast. Values above 5.5 mg/dL were considered hyperuricemia. Descriptive data were presented in frequency and percentage. Linear regression and Poisson regression (prevalence ratio [PR]) was used to test the association between urate concentration and blood pressure. Results Urate concentration was weakly associated with SBP (β: 0.05; 95% CI: 0.02–0.08) and DBP (β: 0.03; 95% CI: 0.01–0.05) z-scores. Schoolchildren with hyperuricemia had a higher prevalence of high SBP (PR: 1.12; p<0.001) and DBP (PR: 1.08; p<0.001). Conclusions Elevated urate concentration is associated with altered blood pressure in schoolchildren.

scholarly journals Stunting in pre-school and school-age children in the Peruvian highlands and its association with Fasciola infection and demographic factors

2021 ◽  
Vol 15 (6) ◽  
pp. e0009519
Author(s):  
Camille M. Webb ◽  
Maria Luisa Morales ◽  
Martha Lopez ◽  
Benicia Baca-Turpo ◽  
Eulogia Arque ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
School Age Children ◽  
Cross Sectional ◽  
Lower Socioeconomic ◽  
Positive Antibody ◽  
Lost Productivity ◽  
Z Scores ◽  
History Of ◽  
Stool Samples ◽  
Complete Cell

Fascioliasis is a zoonotic trematode infection that is endemic in the highlands of Peru. Chronic fascioliasis can be asymptomatic and remain undiagnosed for years. Chronic malnutrition in children, as manifested by stunting, leads to delayed cognitive development and lost productivity. We hypothesized that fascioliasis is among the factors associated with stunting in children from endemic areas. We conducted a cross-sectional study among children attending pre-school and school in 26 communities in the Anta province in the Cusco region of Peru. We conducted interviews to collect information on demographic, socioeconomic, and medical history. Blood was collected and tested for complete cell count and FAS2 ELISA for Fasciola antibodies. Three stool samples per participant were tested for parasites by Kato-Katz and Lumbreras rapid sedimentation methods. Chronic fascioliasis was determined by the presence of ova in stool. Children’s height, weight, and age were recorded and used to calculate height for age (HAZ) Z scores. Three thousand children participated in the study. Nine percent (264) of children had at least one positive test for Fasciola infection, 6% (164) had chronic fascioliasis, and 3% (102) had only positive antibody tests. The median HAZ was -1.41 (IQR: -2.03 to -0.81) and was similar in males and females. Twenty six percent (776) of children had stunting with HAZ < -2. Children with chronic fascioliasis had a lower median HAZ than children with without Fasciola (-1.54 vs. -1.4, p = 0.014). History of treatment for malnutrition, history of treatment for anemia, having other helminths in stool, lower socioeconomic score, living at a higher elevation, and fewer years of schooling of both parents were associated with a lower HAZ score. In a multiple regression analysis, older age and a lower socioeconomic score were associated with a lower HAZ score. While fascioliasis and other helminths were associated with lower HAZ, they were not independent of the socioeconomic score.

Comparing the validity of continuous metabolic syndrome risk scores for predicting pediatric metabolic syndrome: the CASPIAN-V study

2019 ◽  
Vol 32 (4) ◽  
pp. 383-389 ◽  
Author(s):  
Mehri Khoshhali ◽  
Ramin Heshmat ◽  
Mohammad Esmaeil Motlagh ◽  
Hasan Ziaodini ◽  
Mahdi Hadian ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Principal Component ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Risk Scores ◽  
Cross Sectional ◽  
Z Scores ◽  
Iranian Children

Abstract Background The aim of this study was to compare the validity of various approaches to pediatric continuous metabolic syndrome (cMetS) scores including siMS scores (2 waist/height + fasting blood glucose [FBG]/5.6 + triglycerides [TG]/1.7 + systolic blood pressure [BP]/130 + high-density lipoprotein [HDL]/1.02), Z-scores, principal component analysis (PCA) and confirmatory factor analysis (CFA) for predicting metabolic syndrome (MetS). Methods This nationwide cross-sectional study was conducted on 4200 Iranian children and adolescents aged 7–18 years. The cMetS was computed using data on HDL, cholesterol, TGs, FBG, mean arterial pressure (MAP) and waist circumference (WC). The areas under the receiver operating characteristic curves (AUCs) were used to compare the performances of different cMetS scores. Results Data of 3843 participants (52.4% boys) were available for the current study. The mean (standard deviation [SD]) age was 12.6 (3) and 12.3 (3.1) years for boys and girls, respectively. The differences in AUC values of cMetS scores were significant based on the Delong method. The AUCs (95% confidence interval [CI]) were for Z-scores, 0.94 (0.93, 0.95); first PCA, 0.91 (0.89, 0.93); sum PCA, 0.90 (0.88, 0.92), CFA, 0.79 (0.76, 0.3) and also for siMS scores 1 to 3 as 0.93 (0.91, 0.94), 0.92 (0.90, 0.93), and 0.91 (0.90, 0.93), respectively. Conclusions The results of our study indicated that the validity of all approaches for cMetS scores for predicting MetS was high. Given that the siMS scores are simple and practical, it might be used in clinical and research practice.

scholarly journals Malnutrition is associated with dynamic physical performance

2019 ◽  
Vol 32 (6) ◽  
pp. 1085-1092 ◽  
Author(s):  
Keenan A. Ramsey ◽  
Carel G. M. Meskers ◽  
Marijke C. Trappenburg ◽  
Sjors Verlaan ◽  
Esmee M. Reijnierse ◽  
...  
Keyword(s):  
Physical Performance ◽  
Muscle Power ◽  
Nutritional Assessment ◽  
Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Timed Up And Go ◽  
Cross Sectional ◽  
Static Performance ◽  
Z Scores ◽  
Individual Measure

Abstract Background Malnutrition and poor physical performance are both conditions that increase in prevalence with age; however, their interrelation in a clinically relevant population has not been thoroughly studied. Aims This study aimed to determine the strength of the association between malnutrition and measures of both static and dynamic physical performance in a cohort of geriatric outpatients. Methods This cross-sectional study included 286 older adults (mean age 81.8, SD 7.2 years, and 40.6% male) who were referred to geriatric outpatient mobility clinics. The presence of malnutrition was determined using the Short Nutritional Assessment Questionnaire (SNAQ, cut-off ≥ 2 points). Measures of dynamic physical performance included timed up and go (TUG), 4-m walk test, and chair stand test (CST). Static performance encompassed balance tests and hand grip strength (HGS). Physical performance was standardized into sex-specific Z-scores. The association between malnutrition and each individual measure of physical performance was assessed using linear regression analysis. Results 19.9% of the cohort was identified as malnourished. Malnutrition was most strongly associated with CST and gait speed; less strong but significant associations were found between malnutrition and TUG. There was no significant association between malnutrition and HGS or balance. Discussion Physical performance was associated with malnutrition, specifically, dynamic rather than static measures. This may reflect muscle power being more impacted by nutritional status than muscle strength; however, this needs to be further addressed. Conclusions Malnutrition is associated with dynamic physical performance in geriatric outpatients, which should inform diagnosis and treatment/prevention strategies.

scholarly journals Lung function: population epidemiology and concordance in Australian children aged 11–12 years and their parents

BMJ Open ◽  
2019 ◽  
Vol 9 (Suppl 3) ◽  
pp. 53-62 ◽  
Author(s):  
Liam Welsh ◽  
Gayan Kathriachchige ◽  
Tahmeed Raheem ◽  
Anneke C Grobler ◽  
Melissa Wake ◽  
...  
Keyword(s):  
Lung Function ◽  
Population Sample ◽  
Correlation Coefficients ◽  
Cross Sectional Study ◽  
Forced Expiratory Volume ◽  
International Standards ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Parents And Children ◽  
Z Scores

ObjectivesTo describe the epidemiology of lung function in Australian children aged 11–12 years and their parents, and explore the degree of intergenerational concordance.DesignCross-sectional study (the Child Health CheckPoint) nested in the Longitudinal Study of Australian Children (LSAC).SettingAssessment centres in seven Australian cities and eight regional towns, February 2015 to March 2016. Families unable to attend a clinic appointment were offered a home visit during the same period.Participants1874 families (53% of all eligible) participated in the study. Lung function data were available for 1759 children aged 11–12 years and 1774 parents (1668 biological pairs).Outcome measuresParticipants completed spirometry with measures including forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and mid expiratory flow (MEF), converted to z-scores using Global Lung Initiative equations. Parent–child concordance was assessed using Pearson’s correlation coefficients and multivariable linear regression models. Survey weights and methods accounted for LSAC’s complex sampling, stratification and clustering within postcodes.ResultsAll lung function measures followed approximately normal distributions. Mean (SD) for FEV1, FVC and MEF z-scores in children were 0.33 (1.07), 0.83 (1.14) and −0.48 (1.09), respectively. Mean (SD) in parents were 0.28 (1.10), 0.85 (1.15) and −0.45 (1.10), respectively. Parent FEV1, FVC and MEF were associated with child lung function with significant positive correlation coefficients (0.22, 95% CI 0.17 to 0.26; 0.24, 95% CI 0.20 to 0.29; and 0.24, 95% CI 0.20 to 0.29, respectively).ConclusionsMean lung volumes were larger but with smaller airway size than international standards for both parents and children in this population sample. Modest associations between parent and child lung function highlight the potential for better identification of ‘at risk’ populations. Therefore, these findings may aid the development of health policy that aims to prevent the onset or limit the progression of lung disease.

scholarly journals Factors Related to Stunting among Children Age 6-59 Months in Babakan Madang Sub-District, West Java, Indonesia

2020 ◽  
pp. 454-461
Author(s):  
Sri Yuliastini ◽  
Trini Sudiarti ◽  
Ratu Ayu Dewi Sartika
Keyword(s):  
Exclusive Breastfeeding ◽  
Local Governments ◽  
Complementary Feeding ◽  
Cross Sectional Study ◽  
Bivariate Analysis ◽  
West Java ◽  
Chi Square ◽  
Cross Sectional ◽  
Maternal Characteristics ◽  
Z Scores

Stunting is a category of malnutrition that can cause death for children. In 2018, 30.8% of children under five in Indonesia experienced stunting. This study aimed to determine the factors that are related to stunting in Babakan Madang sub district, West Java, Indonesia. A cross sectional study was carried out among 612 children aged 6–59 months on May–August 2019. Z-scores were calculated using WHO Anthro. The characteristics of the under-fives (sex, age, history of infectious diseases), maternal characteristics (education level, mother’s occupation, income per month, age during pregnancy, parity), and infant feeding practices (colostrum feeding, early initiation of breastfeeding, exclusive breastfeeding, pre-lacteal feeding, timely complementary feeding) were analysed. The results of univariate and bivariate analysis using Chi-square showed that for age over 24 months, nonexclusive breastfeeding and untimely complementary feeding were related to stunting. It is recommended that local governments conduct counselling and make positive approaches to the community emphasizing the importance of exclusive breastfeeding and timely complementary feeding.

scholarly journals Motor development in non-microcephalic infants born to mothers with Zika Virus infection during pregnancy

2020 ◽  
Vol 27 (2) ◽  
pp. 174-179
Author(s):  
Laís Rodrigues Gerzson ◽  
Carla Skilhan de Almeida ◽  
Juliana Herrero da Silva ◽  
Lavinia Schüler-Faccini
Keyword(s):  
Motor Development ◽  
Cross Sectional Study ◽  
Control Group ◽  
Cross Sectional ◽  
Gross Motor ◽  
Gross Motor Development ◽  
Significant Difference ◽  
Z Scores ◽  
And Control ◽  
Normal Head

ABSTRACT This cross-sectional study sought to evaluate motor development in infants exposed to ZIKV born with normal head circumference (HC). Thirty one children, distributed into two groups, participated in the study: 15 whose mothers were infected by ZIKV during pregnancy, born with HC from −1.9 to +2 Z-scores, adjusted for sex and gestational age (exposed group); and 16 randomly selected infants without known prenatal exposure to ZIKV, paired by sex and age (control group). Alberta Infant Motor Scale (AIMS) was used to evaluate gross motor development. We found no significant difference between the exposed and control groups. However, considering that AIMS is a screening test that assesses only the gross motor development and the small size of our sample, infants exposed to ZIKV during pregnancy should be continuously evaluated for different aspects of their development.

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