scholarly journals Effects of Sleep Deprivation on Weight Loss and Gut Microbiota Diversity in Obese Patients on a Calorie Restrict Diet

2021 ◽  
Author(s):  
Surong Wen ◽  
Yaojun Ni ◽  
Ziyu Liu ◽  
Xiaoqing Wang ◽  
Jie Zhang ◽  
...  
Keyword(s):  
Weight Loss ◽  
Gut Microbiota ◽  
Sleep Deprivation ◽  
High Throughput Sequencing ◽  
Resistance Index ◽  
The Body ◽  
Obese Patients ◽  
Anthropometric Parameters ◽  
Deprivation Group ◽  
Microbiota Diversity

Abstract Objective: This study aimed to investigate the effects of sleep deprivation (SD) on the weight loss and gut microbiota diversity in obese patients on a calorie restrict diet (CRD). Methods: Twenty obese patients who were divided into two groups: sleep deprivation group(SD group,n=10) and non-sleep deprivation group(NSD group ,n=10). All the patients received CRD for twelve weeks. Measurement of anthropometric parameters, biochemical examinations and gut microbiota detection were done at baseline and the end of week 12. MI Bands were used to monitor the sleep and exercise. Body shape parameters were measured by using the JAWON ioi353. The gut microbiota was examined by PCR in the v3-v5 region of 16S rDNA gene, and high-throughput sequencing was carried out on the Illumina Miseq platform. The operational taxonomic units (OTUs) was used for analysis. Results: 1. CRD improved the body weight (BW) , waist circumference(WC), blood pressure (BP),basal metabolic rate (BMR) ,body fat content(BFC),and Insulin resistance index (HOMA-IR) in all obese patients. 2. In the NSD group, the BW, BFC, VFA, BMR and total cholesterol (TC) reduced significantly when compared with the NSD group after CRD intervention (P<0.05). 3. The Alpha diversity of gut microbiota remained unchanged after the intervention in two groups after CRD intervention. 4. There was a negative correlation between Mollicutes and BMR in the NSD group. Conclusion: The effects of CRD may be weaken by SD in weight loss and the metabolism of blood lipid. Mollicutes bacteria may be related to the weight loss after CRD intervention in obese patients.

scholarly journals Dynamics of adipose tissue changes measured by MRI in obese patients during Reduxin treatment

2012 ◽  
Vol 9 (4) ◽  
pp. 39-43 ◽  
Author(s):  
T I Romantsova ◽  
I V Poluboyarinova ◽  
O V Roik
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Waist Circumference ◽  
Dynamic Assessment ◽  
Randomized Study ◽  
Subcutaneous Fat ◽  
Obese Patients ◽  
Anthropometric Parameters ◽  
Imaging Results ◽  
Clinically Significant

Objective. To study the influence of the drug Reduxine in obese patients on the distribution of adipose tissue measured by MRI. Methods. In an open, prospective, non-randomized study duration of 20 weeks included 31 obese patients aged 20 to 65 years. During the study, the anthropometric parameters and the dynamics of the area of adipose tissue by means of MR imaging. Results. Weight loss in patients averaged 9.0 kg. Clinically significant weight loss reached 23 people (79%). Median reduction in waist circumference was 10 cm. Dynamic assessment of adipose tissue by MRI was performed in 17 patients. Reduxine treatment induced statistically significant decrease of both visceral and subcutaneous fat. Conclusions. According to the results of MRI, the reduction in waist circumference in patients receiving Reduxine occurred by reducing the number of both subcutaneous and visceral fat in the abdominal area.

scholarly journals Diversity in the intestinal microbiota and the influence of delivery, dietary profile and nutritional status

2021 ◽  
Vol 2 (5) ◽  
Author(s):  
Franciele Valduga ◽  
◽  
Malena Rostirola Miri ◽  
Daniela Signori ◽  
Larissa Pereira da Costa ◽  
...  
Keyword(s):  
Nutritional Status ◽  
Gut Microbiota ◽  
School Children ◽  
Alpha Diversity ◽  
Grape Juice ◽  
Anthropometric Parameters ◽  
Culture Methods ◽  
Normal Delivery ◽  
Significant Difference ◽  
Microbiota Diversity

Objective: This research aimed to evaluate the nutritional status and influence on the dietary profile in the gut microbiota, in an attempt to identify possible effects of grape juice consumption among school children aged 6-10. Design: Anthropometric parameters (weight, height, Body Mass Index, waist circumference, triceps, and subscapular skinfold) weremeasured at baseline. A Food Frequency Questionnaire (FFQ) was carried out to evaluate the dietary profile. Feces were analyzed by culture methods and the alpha diversity was determined by the Shannon Index. Participants: 36 volunteer school children aged 6 to 10 years from two different cities in the South of Brazil. Main outcome measure: Gut microbiota diversity according to anthropometric parameters, nutrition profile and delivery patterns. Analysis: For statistical analysis, t or u test and correlation were used through the statistical software SPSS® version 22.0. Results: The volunteers presented a eutrophic nutritional status, but 41.7% in the City 2 were overweight. There was a significant difference in the consumption of polyphenols (p<0.003), microbiotadiversity, breastfeeding, and delivery patterns by city. However, the dietary profile does not include the portions of daily nutrients recommended in both cities. The volunteers from City 1 presented a greater alpha diversity, which may be related to higher micronutrient intake, breastfeeding, and predominant natural/vaginal delivery Conclusion: We observed that the normal delivery and the dietary profile seems to be important factors to the gut microbiota diversity in these children. Keywords: grape juice; dietary profile; gut microbiota.

Weight-loss interventions and gut microbiota changes in overweight and obese patients: a systematic review

2017 ◽  
Vol 18 (8) ◽  
pp. 832-851 ◽  
Author(s):  
F. B. Seganfredo ◽  
C. A. Blume ◽  
M. Moehlecke ◽  
A. Giongo ◽  
D. S. Casagrande ◽  
...  
Keyword(s):  
Systematic Review ◽  
Weight Loss ◽  
Gut Microbiota ◽  
Obese Patients ◽  
Weight Loss Interventions

scholarly journals Impact of a Moderately Hypocaloric Mediterranean Diet on the Gut Microbiota Composition of Italian Obese Patients

2020 ◽  
Author(s):  
Silvia Pisanu ◽  
Vanessa Palmas ◽  
Veronica Madau ◽  
Emanuela Casula ◽  
Andrea Deledda ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Mediterranean Diet ◽  
Illumina Miseq ◽  
Nutritional Intervention ◽  
The Body ◽  
Rrna Gene ◽  
Obese Patients ◽  
Dietary Interventions ◽  
The Impact ◽  
Gut Microbiota Composition

Although it is known that the gut microbiota (GM) can be modulated by diet, the efficacy of specific dietary interventions in determining its composition and diversity in obese patients remains to be ascertained. The present work aims to evaluate the impact of a moderately hypocaloric Mediterranean diet on the GM of obese and overweight patients (OB). The GM of 23 OB patients (F/M= 20/3) was compared before (T0) and after 3 months (T3) of the nutritional intervention (NI). Fecal samples were analyzed by Illumina MiSeq sequencing of the 16S rRNA gene. At baseline, the GM characterization confirmed the typical obesity-associated dysbiosis. After 3 months of NI, patients presented a statistically significant reduction of the body weight and fat mass, along with changes in the relative abundance of many microbial patterns. In fact, we observed an increased abundance in several Bacteroidetes taxa (i.e. Sphingobacteriaceae, Sphingobacterium, Bacteroides spp., Prevotella stercorea) and depletion of many Firmicutes taxa (i.e. Lachnospiraceae members, Ruminococcaceae and Ruminococcus, Veillonellaceae, Catenibacterium, Megamonas). In addition, the phylum Proteobacteria showed an increased abundance, while the genus Sutterella, within the same phylum, decreased after the intervention. Metabolic pathways, predicted by bioinformatic analyses, showed a decrease in membrane transport and cell motility after NI. The present study extends our knowledge of the GM profiles in OB, highlighting the potential benefit of a moderate caloric restriction in counteracting the gut dysbiosis.

scholarly journals Ligustrum robustum Intake, Weight Loss, and Gut Microbiota: An Intervention Trial

2019 ◽  
Vol 2019 ◽  
pp. 1-11
Author(s):  
Tao Zhou ◽  
Jiayi Chen ◽  
Yuhang Chen ◽  
Jiayi Xu ◽  
Sijing Liu ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Gut Microbiota ◽  
Animal Studies ◽  
The Body ◽  
Obese Women ◽  
Obese Female ◽  
Rrna Sequencing ◽  
Chao1 Estimator

Ligustrum robustum (LR) shows antiobesity effects in animal studies. However, little is known about the effect on human. The present study aimed to investigate the effect of LR intake on weight change in obese women and the role of gut microbiota. Thirty overweight and obese female participants (BMI ≥24 kg/m2) were recruited in the current study. The participants drank LR 10g/d for 12 wks. Their body composition and related biomarkers were assessed. Alterations of the gut microbiota were analyzed using 16S rRNA sequencing. The primary outcome was the change in body weight. LR intake resulted in 2.5% weight loss over 12 wks (P<0.01). Change in body fat at 12 wk was -1.77 ± 1.19 kg (P<0.01). In addition, decreased Firmicutes-to-Bacteroidetes ratio (P=0.03), increased richness (the ACE estimator, P<0.01; the Chao1 estimator, P<0.01), and altered representative taxa of the gut microbiota were observed. Bacteroidaceae, Bacteroides, Bacilli, and Lactobacillales were higher while Ruminococcaceae, Enterobacteriaceae, Enterobacteriales, Lachnospiraceae, Clostridia, and Clostridiales were lower at 12 wk. Moreover, LR intervention decreased fasting glucose (P<0.01), serum leptin (P<0.01), and IL8 (P=0.02) and increased HOMA-β (P<0.01). LR intervention moderately decreased the body weight in overweight and obese women and such effect might be due to modulation of gut microbiota.

Gut microbiota composition correlates with changes in body fat content due to weight loss

2015 ◽  
Vol 6 (4) ◽  
pp. 431-439 ◽  
Author(s):  
M. Remely ◽  
I. Tesar ◽  
B. Hippe ◽  
S. Gnauer ◽  
P. Rust ◽  
...  
Keyword(s):  
Weight Loss ◽  
Gut Microbiota ◽  
Weight Reduction ◽  
Dietary Intervention ◽  
Dietary Factors ◽  
The Body ◽  
Microbial Composition ◽  
Bacterial Composition ◽  
Coa Transferase ◽  
Time Point

Genetics, lifestyle, and dietary habits contribute to metabolic syndrome, but also an altered gut microbiota has been identified. Based on this knowledge it is suggested that host bacterial composition tends to change in response to dietary factors and weight loss. The aim of this study was to identify bacteria affecting host metabolism in obesity during weight loss and to correlate them with changes of the body composition obtained from bioelectrical impedance analysis (BIA). We recruited obese individuals receiving a dietary intervention according DACH (German, Austrian, and Swiss Society of Nutrition) reference values and guidelines for ‘prevention and therapy of obesity’ of DAG e.V., DDG, DGE e.V., and DGEM e.V. over three months. Faecal microbiota and BIA measurements were conducted at three time points, before, during, and after the intervention. Gut microbiota was analysed on the basis of 16S rDNA with quantitative real time PCR. Additionally, a food frequency questionnaire with questions to nutritional behaviour, lifestyle, and physical activity was administered before intervention. After weight reduction, obese individuals showed a significant increase of total bacterial abundance. The ratio of Firmicutes/Bacteroidetes significantly decreased during intervention. Lactobacilli significantly increased between the first and the second time point. These differences also correlated with differences in weight percentage. During the intervention period Clostridium cluster IV increased significantly between the second and the third time point. In contrast Clostridium cluster XIVa showed a decreased abundance. The dominant butyrate producer, Faecalibacterium prausnitzii, significantly increased as did the abundance of the butyryl-CoA: acetate CoA-transferase gene. Archaea and Akkermansia were significantly more prevalent after weight reduction. Our results show a clear difference in the gut bacterial composition before and after dietary intervention with a rapid change in gut microbial composition after a few weeks, but also indicate that a major shift requires long term dietary treatment.

scholarly journals Dietary Polysaccharide from Enteromorpha clathrata Attenuates Obesity and Increases the Intestinal Abundance of Butyrate-producing Bacterium, Eubacterium xylanophilum, in Mice Fed a High-Fat Diet

Polymers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 3286
Author(s):  
Jiali Wei ◽  
Yiran Zhao ◽  
Chen Zhou ◽  
Qing Zhao ◽  
Hongqian Zhong ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
High Throughput Sequencing ◽  
Serum Levels ◽  
Bioinformatic Analysis ◽  
The Body ◽  
Therapeutic Effects ◽  
High Fat ◽  
Intestinal Dysbiosis ◽  
Treatment Of Obesity

Previous studies have suggested that polysaccharide from Enteromorpha clathrata (ECP) could be used as a potential prebiotic to treat dysbiosis-associated diseases. However, whether it has any therapeutic effects on obesity has not been investigated. In the present study, we explored the anti-obesity effect of ECP and illustrated that it can significantly reduce the body weight and decrease the serum levels of triacylglycerol and cholesterol in high-fat diet (HFD)-fed mice. As revealed by 16S rRNA high-throughput sequencing and bioinformatic analysis, HFD remarkably changed the composition of the gut microbiota and promoted the growth of opportunistic pathogens such as Mucispirillum, Desulfobacterota and Alphaproteobacteria in obese mice. Interestingly, ECP improved intestinal dysbiosis caused by HFD and reshaped the structure of the gut microbiota in diseased mice by increasing the abundance of butyrate-producing bacterium, Eubacterium xylanophilum, in the gut. Altogether, we demonstrate for the first time an anti-obesity effect of ECP and shed new light into its therapeutic mechanisms from the perspective of gut microbiota. Our study will pave the way for the development of ECP as new prebiotic for the treatment of obesity and its associated disorders.

scholarly journals Association between Gut Microbiota and Infant’s Temperament in the First Year of Life in a Chinese Birth Cohort

2020 ◽  
Vol 8 (5) ◽  
pp. 753
Author(s):  
Ying Wang ◽  
Xiaoli Chen ◽  
Yun Yu ◽  
Yanqun Liu ◽  
Qing Zhang ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Maternal Education ◽  
High Throughput Sequencing ◽  
Critical Role ◽  
First Year ◽  
Significant Difference ◽  
First Year Of Life ◽  
The Relationship ◽  
Microbiota Diversity ◽  
Gut Microbiota Composition

Infant temperament characteristics play a critical role in children’s developmental pathways and can predict adulthood psychopathology. The diversity and composition of the gut microbiota are associated with human temperament in both adults and young children. However, the relationship between the gut microbiota and temperament in 12-month-old infants is rarely studied; this developmental period is when temperament reaches a relatively stable stage. We used high-throughput sequencing methods to explore whether temperament characteristics were associated with gut microbiota diversity and composition. Infants’ fecal samples were collected at 12 months of age for the gut microbiota analysis. Based on the primary caregivers’ reports, infants’ temperaments were measured using the Infant Behavior Questionnaire-revised (IBQ-R). This study included 51 infants, including 20 boys and 31 girls, with a mean age of 12.25 months. Results showed that soothability was positively correlated with maternal education level (β = 0.29, p = 0.043, adjust p = 0.025) and the abundance of Bifidobacterium genera (β = 0.62, p = 0.004, adjust p = 0.002). Conversely, cuddliness was negatively correlated with the abundance of Hungatella genera. There was no significant difference in temperament based on gender. This study demonstrated that gut microbiota composition was associated with temperament in 12-month-old infants. These results point to the importance of gut microbiota balance. Future studies on the mechanisms behind the gut microbiota affecting temperament are warranted.

scholarly journals Diet prescription in obese patients

2005 ◽  
Vol 64 (1) ◽  
Author(s):  
Carlo Lesi ◽  
Ester Giaquinto ◽  
Luca Valeriani ◽  
Luisa Zoni
Keyword(s):  
Diabetes Mellitus ◽  
Cardiovascular Disease ◽  
Body Mass Index ◽  
Weight Loss ◽  
Patient Characteristics ◽  
The Body ◽  
Obese Patients ◽  
Metabolic Complications ◽  
Unbalanced Diet ◽  
Lipid Abnormalities

Diet is a cornerstone in the treatment of obese patients with or without metabolic complications. To optimize outcome, diet treatment should always take into account factors such as the Body Mass Index, the timeframe for reaching the recommended weight loss, comorbidities (e.g. arterial hypertension, diabetes mellitus, renal disease, lipid abnormalities, hyperuricemia) and, finally, individual patient characteristics (e.g. habits, preferences, adherence capacity). Hypocaloric diets need to be adequately balanced in terms of glucides, lipids and proteins, vitamins and minerals. For these reasons the diet prescription for obese patients, particularly those with comorbidities or cardiovascular disease, should be under the guidance of expert nutrition professionals who are aware of the risks of an unbalanced diet.

scholarly journals APPROBATING METHODOLOGY FOR REDUCTION OF BODY FAT WITH CRYOLIPOLYSIS AND CAVITATION

2020 ◽  
Vol 26 (4) ◽  
pp. 3416-3422
Author(s):  
Mariya Gramatikova ◽  
◽  
Stamenka Mitova ◽  
Iliya Kanelov ◽  
◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Fat ◽  
T Test ◽  
The Body ◽  
P Value ◽  
Anthropometric Parameters ◽  
Impedance Analyzer ◽  
Before And After ◽  
Positive Effect

The aim of this study is to develop and approbation methods and algorithms for reducing body fat. Material/Methods: In the research, participants were aged 35-45 years with obesity. Anthropometric parameters were analyzed with an impedance analyzer for bodyweight parameters, a somatotype profile, by the methodology Heath-Carter. Measurements were made before and after 60 days of the apparatus physiotherapy including cryolipolysis and cavitation. Twice a week a cardio training was performed Results: The somatotype of the contingent is Mesomorphic - endomorphic endomorphism is highest (6.63), and mesomorphic (6.36) is higher than ectomorph (1.08). In the second study, the data showed a decrease in the endomorphic index (6,18), having almost equalized values with the mesomorph (6,15), while at the same time the greatest movement was observed in the ectomorphic index, which increased with nearly 30% to 1.38. The research contingent has positively influenced the procedures and its propensity for weight loss has increased. However, the somatotype profile remains a mesomorph-endomorph. From the data on the quality of the body composition, only the BMI (kg/m2), VFA (cm2) and MBF (kg) parameters have statistically significant decreases. The measured parameters before and after the applied procedures, with no statistically reliable changes P-value <0.05 level (Wilcoxon, t-test) observed only in the circumference of the hips. A statistically significant decrease of the results is found in the circumferences of both thighs at the measured heights P-value <0.0 001 level (Wilcoxon, t-test). Conclusion: The approbation methodology for reducing body fat has a positive effect on the contingents and leads to the modeling of the body.

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