scholarly journals Determining the Levels of Some Trace Elements and Heavy Metals (Cu, Mn, Mg, Fe, Zn, CO, Pb and CD) in the Cancers of Lip and Oral Cavity

2021 ◽  
Author(s):  
Derya ÇAY DEMİR
Keyword(s):  
Heavy Metals ◽  
Trace Elements ◽  
Oral Cavity ◽  
Human Body ◽  
Oral Cavity Cancer ◽  
Control Group ◽  
Central Research ◽  
Control Groups ◽  
Comparison Results ◽  
Healthy Control

Abstract Aim: The aim of the study is to determine the relationship of some trace elements and heavy metals with lip and oral cavity cancer. Materials And Methods: Blood counts of 21 individuals with lip and oral cavity cancer were compared with those in the control group consisting of 30 volunteer and healthy subjects. Levels of trace elements and heavy metals in the serum (Zn, Cu, Mg, Pb, Mn, Cd, Co and Fe) were determined using Atomic Absorption Spectrophotometer method at YUU Central Research Laboratory (Spectrometer: Thermo Scientific C103500100, China). Findings: In this study, the descriptive statistics and comparison results for Cu, Mn, Mg, Fe, Zn, Co, Pb, Cd were found to be statistically significant (p <0.05). According to these results, Zn, Fe, Mn, Mg and Cu levels which are necessary trace elements for human body were found to be significantly lower in patients than healthy control groups. Cd, Co and Pb levels which are harmful and toxic to human body were found to be significantly higher in patients than healthy control groups (p <0.05). Results: Based on these findings of this first and new study in the literature, it was concluded that, trace elements and heavy metals (Cu, Mn, Mg, Fe, Zn, Co, Pb and Cd) in the lip and oral cavity may affect the etiopathogenesis of the disease.

scholarly journals Selected CDKN2A and MDM2 polymorphisms in oral cavity cancer

2020 ◽  
Author(s):  
Jadwiga Gaździcka ◽  
Karolina Gołąbek ◽  
Joanna Katarzyna Strzelczyk ◽  
Paweł Kiczmer ◽  
Katarzyna Miśkiewicz-Orczyk ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Kinase Inhibitor ◽  
Oral Cavity Cancer ◽  
Clinicopathological Parameters ◽  
Control Group ◽  
Polish Population ◽  
Mdm2 Gene ◽  
Allelic Discrimination ◽  
Cyclin Dependent Kinase Inhibitor ◽  
Human Malignancy

The head and neck squamous cell carcinoma (HNSCC) is an aggressive human malignancy diagnosed in more than 800 000 new cases worldwide, and mostly arises in the oral cavity, oropharynx, larynx, hypopharynx, and nasopharynx. The study presented here aimed to determine a possible association of rs11515 and rs3088440 gene polymorphisms in the CDKN2A gene (cyclin dependent kinase inhibitor 2A), as well as rs769412 and rs937283 in the MDM2 gene (murine double minute 2), with oral cavity cancer in a sample of Polish population; CDKN2A is crucial in regulating the cell cycle while MDM2 is an oncogene involved in regulating cell proliferation and apoptosis. The study included 95 primary tumor samples following surgical resection from patients, and the control group consisted of 100 healthy individuals. DNA samples were genotyped by employing the 5’ nuclease assay for allelic discrimination using TaqMan SNP Genotyping Assays (Applied Biosystems, USA). There was no significant association between any of the polymorphism (rs11515, rs3088440, rs769412 and rs937283) and the oral cavity cancer risk. We found that the AA homozygotes for rs3088440 were significantly more frequent in the control group (OR=0.046, p<0.0001). In addition, the GG genotype of rs769412 was not found in any group. We found no influence of the examined genotypes on clinicopathological parameters, such as T, N and grading values in patients with oral cavity cancer. The results of this study indicate that none of the investigated polymorphisms were associated with the risk of oral cavity cancer in the examined sample of the Polish population.

Rhythm of 24-h Intraocular and Perfusion Pressure in Patients With Ocular Hypertension

2020 ◽  
Author(s):  
Ran Xia ◽  
Na Shu ◽  
Huixian Cui ◽  
JORGE AGUSTÍN TRUJILLO PERDOMO ◽  
Hong Zhang ◽  
...  
Keyword(s):  
Ocular Hypertension ◽  
Perfusion Pressure ◽  
Open Angle Glaucoma ◽  
Healthy Control Group ◽  
Control Group ◽  
Ocular Perfusion Pressure ◽  
Control Groups ◽  
Ocular Perfusion ◽  
Healthy Control ◽  
Maximum Minimum

Abstract AIMThe aim of the present study was to characterize the rhythm of 24-h intraocular pressure (IOP) and ocular perfusion pressure (OPP) in patients with ocular hypertension (OHTN), in order to provide a reference for the clinical diagnosis and treatment of OHTN. METHODSAccording to the diagnostic criteria, 107 patients with OHTN were included, and an age- and sex-matched healthy control group (71 patients) was selected. The IOP and blood pressure (BP) of the OHTN and the healthy control groups were recorded every 2 h over a 24-h period. BP was measured using a digital automatic BP monitor, and IOP was measured using a non-contact tonometer. RESULTSThe maximum, minimum and mean IOP were significantly higher in subjects with OHTN than in the healthy control group (P<0.05), and the maximum, minimum and mean MOPP were significantly lower in the OHTN group than in the healthy control group (P<0.05). The minimum and mean SOPP and DOPP values of the OHTN group were lower than those of the healthy control group (P<0.05), and the IOP, MOPP, SOPP and DOPP diurnal and nocturnal fluctuation values were significantly greater in the OHTN group than in the healthy control group (P<0.05). The peak and trough IOP times of the two groups coincided, which tended to be low during the day and higher at night. The peak and trough MOPP and SOPP times of the two groups also coincided, and were primarily higher during the day and lower at night. The 24-h DOPP in the healthy control group was generally higher during the daytime and lower at night, with peak values between 19:00-23:00 h, and trough values between 3:00-7:00 h. No obvious day-to-night fluctuations were observed in the OHTN group. CONCLUSIONThe OPP of patients with OHTN is lower, and the 24-h OPP fluctuates more than that of healthy control subjects. This may be an important blood flow factor for the progression to primary open angle glaucoma in patients with OHTN.

Diagnostic value of anti-CD74 antibodies in early and late axial spondyloarthritis and its relationship to disease activity

Rheumatology ◽  
2020 ◽  
Vol 60 (1) ◽  
pp. 263-268 ◽  
Author(s):  
Marwa Mahmoud Abdelaziz ◽  
Rania M Gamal ◽  
Nadia M Ismail ◽  
Raghda A Lafy ◽  
Helal F Hetta
Keyword(s):  
Disease Activity ◽  
Axial Spondyloarthritis ◽  
Diagnostic Value ◽  
Inactive Disease ◽  
Control Group ◽  
Igg Antibodies ◽  
Control Groups ◽  
Significant Difference ◽  
Healthy Control

Abstract Objectives This study was designed to evaluate the role of anti-CD74 antibodies in diagnosis of axial spondyloarthritis (axSpA) and their relationship to disease duration and disease activity. Methods Fifty patients with axSpA, 15 patients with RA and 15 healthy subjects were included in the study. Clinical examination and laboratory tests were done. The ESR, CRP level and ASDAS were measured as markers of the disease activity. Quantitative determination of human CD74 IgG antibodies was done. Results The mean age of the patients was 38.22 (S.D.12.20) years. The level of CD74 autoantibodies was significantly higher in axSpA in comparison to control groups. Most patients with positive articular and extra-articular manifestations were positive for CD74 autoantibodies. In patients with inactive disease, 33.3% were positive for CD74 autoantibodies, as were 83% with active disease. High percentages of patients with early and late axSPA were CD74 autoantibody positive. The majority of patients with positive disease activity in early and late axSpA were CD74 autoantibody positive. CD74 autoantibodies had 80% sensitivity vs both control groups with 87% specificity vs the healthy control group and 80% vs the RA control group in the diagnosis of axSpA. Conclusions The frequency of positive anti-CD74 IgG antibodies was as high in patients with early axSpA as in those with late axSpA, with no significant differences. There was a significant difference in the frequency of positive anti-CD74 IgG antibodies between patients with positive and negative disease activity. Based on the sensitivity and specificity of anti-CD74 IgG, this is a promising diagnostic tool to support the clinical diagnosis of axSpA.

scholarly journals Trace elements in scalp hair of leukaemia patients

Nukleonika ◽  
2014 ◽  
Vol 59 (3) ◽  
pp. 111-120 ◽  
Author(s):  
Ali Khuder ◽  
Mohammad Adel Bakir ◽  
Reem Hasan ◽  
Ali Mohammad ◽  
Khozama Habil
Keyword(s):  
Trace Elements ◽  
Scalp Hair ◽  
Principal Component ◽  
Control Group ◽  
Control Groups ◽  
Exact Probability ◽  
Median Rank ◽  
Hair Samples ◽  
Age Factor ◽  
And Control

Abstract The aim of this study was to determine the concentration of Fe, Ni, Cu, Zn and Pb in scalp hair of leukaemia patients and healthy volunteers, using the optimised XRF method. Leukaemia hair samples were classifi ed corresponding to type, growth and age of the participants. The results showed that the studied trace elements (TEs) in both of leukaemia and control groups were positively skewed. In comparison with the control group, lower Fe, Cu, Zn and Pb and higher of Ni medians were found in all studied leukaemia patients. The median rank obtained by Mann-Whitney U-test revealed insignifi cant differences between the leukaemia patients subgroups and the controls. An exact probability (α < 0.05) associated with the U-test showed signifi cant differences between medians in leukaemia patients and controls groups for Pb (lymphatic/control, acute/control), Cu (lymphatic/control, chronic/control), Ni (lymphatic/control, chronic/control) and Fe (chronic/control). Very strong positive and negative correlations (r > 0.70) in the scalp hair of control group were observed between Ni/Fe-Ni, Cu/Fe-Cu, Zn/Fe-Zn, Pb/Fe-Pb, Cu/Ni-Zn/Ni, Cu/Ni-Pb/Ni, Zn/Ni-Pb/Ni, Zn/Fe-Zn/Cu, Pb/Ni-Ni and Ni/Fe-Pb/Ni, whereas only very strong positive ratios in the scalp hair of leukaemia patients group were observed between Ni/Fe-Ni, Cu/Fe-Cu, Zn/Fe-Zn and Pb/Fe-Pb, all correlations were signifi cant at p < 0.05. Other strong and signifi cant correlations were also observed in scalp hair of both groups. Signifi cant differences between grouping of studied TEs in all classifi ed leukaemia groups and controls were found using principal component analysis (PCA). The results of PCA confi rmed that the type and the growth of leukaemia factors were more important in element loading than the age factor.

scholarly journals Bee Pollen – Nutritional and Toxicological Aspects

2019 ◽  
Vol 1 (4) ◽  
pp. 41-47
Author(s):  
Katarína Fatrcová-Šramková ◽  
Janka Nôžková
Keyword(s):  
Heavy Metals ◽  
Trace Elements ◽  
Dietary Supplements ◽  
Human Health ◽  
Dietary Supplement ◽  
Human Body ◽  
Polyphenolic Compounds ◽  
Nutritional Elements ◽  
Enrich Food ◽  
Important Amount

Pollen contains nutritional elements – carbohydrates, proteins, lipids, vitamins, minerals, trace elements. The pollen contains also important amount of polyphenolic compounds, primarily antioxidants. Because the pollen is rich in nutrients, honeybee-collected pollen is recommended as a dietary supplement. The product can be used as dietary supplements to enrich food with valuable nutrients performing important functions in the human body. Pollen is a bee product affected by contaminants of various origins. In addition to important nutrients, it may also contain heavy metals that are harmful to human health. May be contaminated from air and soil by heavy metals and pesticides.

scholarly journals E-SELECTIN AS A BIOMARKER IN FEMALE PATIENTS WITH Β-THALASSEMIA IN AL-NAJAF PROVENCE, IRAQ

2020 ◽  
Vol 28 (29) ◽  
pp. 66-73
Author(s):  
Intisar Razzaq Sharba ◽  
Arshad Noori Al-Dujaili
Keyword(s):  
Inflammatory Process ◽  
Normal Weight ◽  
Control Group ◽  
World Population ◽  
Control Groups ◽  
Healthy Control ◽  
Entire World ◽  
The Relationship ◽  
Weight Groups ◽  
Inflammation Cytokines

E-selectin, as identified (CD62E), is expressed on endothelial cells after stimulation with inflammation cytokines. β-Thalassemia diseases (βT) and early diagnosis are of utmost significance in the entire world population. This study was performed in the Thalassemia Center of the Al-Zahraa Educational Hospital in Al-Najaf Province, Iraq, on sixty-nine with β-thalassemia (54 βT major and 15 βT Intermedia) aged 8-40 years who transfused blood. Compared to 20 healthy volunteers as a control group. In both βT patients and healthy groups were assessed serum E-selectin levels. It was investigated the relationship with RBC, Hb, PCV, WBC, PLT, BMI, splenic status, iron, and ferritin levels. The results revealed a significant (P<0.05) decreased values of HB, RBC, P.C.V, and BMI. In contrast, values of WBC, PLT, Iron, and Ferritin were significantly increased in βT patients as compared to the healthy control groups. A significant (P<0.05) increase in serum E- Selectin level in βT patients (20.55±0.47) ng/ml to compare with the healthy group (9.16±0.50) ng/ml. Furthermore, it was a significant decrease in groups of βT major (19.87±0.42) ng/ml more than in βT intermedia (23±1.42) ng/ml. E-Selectin revealed a significant increase (P<0.05) in progress age and associated with splenectomies and underweight groups compared to splenectomies and the normal weight groups, respectively. Also, E-Selectin levels significantly positively correlated with WBC, PLT value, iron, and Ferritin levels. However, it was no significant with RBC, PCV, Hb. As a conclusion from this study, E- Selectin is an important biomarker in β-thalassemia patients can be identified as the complications associated with iron overload, inflammatory process, and endothelial dysfunction in βT disease.

Sydenham's Chorea; Clinical and Magnetic Resonance Imaging Findings, a Retrospective Observational Study in Children

2019 ◽  
Vol 18 (05) ◽  
pp. 217-222
Author(s):  
Fatma Hanci ◽  
Mustafa Hizal ◽  
Sevim Türay ◽  
Oya Kalaycioğlu ◽  
Nimet Kabakuş
Keyword(s):  
Magnetic Resonance Imaging ◽  
Prefrontal Cortex ◽  
Basal Ganglia ◽  
Globus Pallidus ◽  
Healing Time ◽  
Control Group ◽  
Resonance Imaging ◽  
Control Groups ◽  
Healthy Control ◽  
And Control

AbstractThe purpose of this study was to evaluate the correlation between magnetic resonance imaging (MRI) findings and demographic and clinical characteristics, response to treatment times, and recurrence rates of Sydenham's chorea (SC), the most common of the acquired pediatric choreas. The clinical and radiological findings of 12 patients presenting to the pediatric neurology clinic in the previous 4 years and diagnosed with SC on the basis of the modified Jones criteria were investigated retrospectively from the hospital files. In addition, we measured the maximum prefrontal cortex and basal ganglia (globus pallidus, putamen, and caudate nucleus) thicknesses in the axial plane from patients' cerebral MRIs and compared these values with prefrontal cortex and basal ganglia thicknesses of a healthy control group measured using the same technique. Patient and control groups' cranial and basal ganglia MRIs were found to be normal. However, patients' globus pallidus thicknesses were significantly lower than those of the healthy control group. Additionally, the globus pallidus values of patients with recurrent SC and a prolonged healing time were lower than average. However, we determined no significant difference in terms of prefrontal motor cortex, caudate nucleus, or putamen thicknesses between the patient and control groups. Low globus pallidus thicknesses in patients with SC may indicate atrophy associated with globus pallidus involvement. Further experimental and prospective and long-term studies are needed for a better understanding of the factors affecting the pathophysiology, recurrence, and healing time of SC.

CLEC4E as a New Tumor Marker for Early Diagnosis of GIT Tumors

2021 ◽  
pp. 3167-3172
Author(s):  
Rasha Hasan Jasim ◽  
Hadeer Haider Abdualameer
Keyword(s):  
Early Diagnosis ◽  
Tumor Marker ◽  
Patient Group ◽  
Study Groups ◽  
The Other ◽  
Control Group ◽  
Control Groups ◽  
Healthy Control ◽  
The Relationship ◽  
Sera Samples

During the period from the beginning of December 2018 to the end of May 2019, 108 resident of Babylon were included to participate in the current study, were divided into two main groups: 81 patients with GIT diseases, their age ranged from 12-80 years; and the controls group (27 individuals) with the age 17-71 years old. Furthermore, the patient group was divided into two subgroups, the first involved 51 patients with GIT tumors and the other with non-tumoral diseases of GIT (30 individuals suffered non tumoral GIT illness were enrolled as a pathological control group). CLEC4L, Serotonin were evaluated in the sera samples of the study groups. The current study revealed statistical significant increase in the levels of serotonin while it showed significant decrease in the levels of CLEC4L in the sera testers of patients with malignant GIT tumors when compared to benign GIT tumors, pathological GIT control, and healthy control groups. The present study showed that the relationship between CLEC4E with serotonin became negative. Serotonin showed the (88%) sensitivity among the assessed criteria followed by CLEC4L (76%).

Study on the Subtypes of Dendritic Cells and the Expression of T Cell Co-Stimulating Molecules (CD80, CD86, CD40) on Dendritic Cells and B Cells in the Peripheral Blood of SAA Patients.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 3753-3753
Author(s):  
Zonghong Shao ◽  
Meifeng Tu ◽  
Hong Liu ◽  
Guangsheng He ◽  
Jun Shi ◽  
...  
Keyword(s):  
T Cell ◽  
B Lymphocytes ◽  
Normal Control ◽  
Peripheral Blood ◽  
Active Phase ◽  
Control Group ◽  
Control Groups ◽  
Significant Difference ◽  
Healthy Control ◽  
Cd40 Expression

Abstract Objective To detect the quantities of monocyte-derived dendritic cell precursors (pDC1) and plasmacytoid dendritic cell precursors (pDC2) in peripheral blood mononuclear cells (PBMC) of severe aplastic anemia (SAA) patients before and after immune suppressive therapy (IST), the ratio of their pDC1 to pDC2, and the expression of T-cell co-stimulating molecules (CD80, CD86, CD40) on dentritic cells (DC) and B cells surface in the SAA patients’ peripheral blood. Methods with three-color monoclonal antibody labeling technology, the quantities and ratio of pDC1 and pDC2 in PBMC were detected in 26 patients with SAA at active phase,13 patients with SAA at recovery phase and 15 normal control respectively by FACS. The aforementioned merits of 10 SAA patients were tested before and 2 months after IST by FACS. By FACS, the expression of CD80, CD86 and CD40 on DC and B lymphocytes were detected in 16 patients with SAA and 15 normal controls. Results The percentages of total pDC, pDC1, pDC2 and the ratio of pDC1/pDC2 of controls (healthy people) were(0.72±0.32)%,(0.41±0.18)%,(0.30±0.21)%, 1.58±0.69 respectively, and those of the patients with SAA at active phase were(0.96±0.92)%,(0.67±0.65)%,(0.32±0.30)%,2.70±1.63 respectively. The differences were significant [pDC1 (P<0.05); pDC1/pDC2 ratio (P<0.01)]. The aforementioned merits of recuperating SAA patients decreased to (0.77±0.48)%,(0.43±0.37)%,(0.34±0.34)%,1.78±1.29 respectively, which were not significantly different from those of normal control group. The aforementioned merits of 10 SAA patients were(0.87±0.98)%,(0.35±0.30)%,2.65±1.27 before IST, and(0.24±0.28)%,(0.14±0.14)%,2.16±0.82 after IST, with significant decreases of pDC1 and pDC2 (P<0.05). The percentages of CD80, CD86 and CD40 expression on DC in peripheral blood of healthy control were(1.61±2.37)%,(11.97±12.18)%,(0.56±1.26)% respectively, and those of SAA patients were(9.14±12.89)%,(29.84±9.56)%,(7.04±11.99)% respectively. There was a significant difference of CD86 expression (p<0.05) between SAA patient and normal control groups. The percentages of CD19, CD80, CD86 and CD40 expression on lymphocytes in peripheral blood of healthy control group were (9.38±3.18)%,(2.57±1.51)%,(1.86±1.11)%,(7.34±4.21)% respectively, and those of SAA patients were(11.12±9.02)%,(5.17±2.72)%,(5.98±3.84)%,(8.85±9.95)% respectively. There were significant differences of CD80 and CD86 expressions (P<0.05, P<0.01) between SAA and control groups. The percentages of CD80, CD86 and CD40 expression on B lymphocytes of control were(28.22±12.32)%, 8.04±2.27% and(81.6±22.45)% respectively, and those of SAA patients were(23.06±14.9)%,(20.46±11.1)%,(81.57±21.14)% respectively. There was a significant difference of CD86 expression (p<0.05) between patient and control groups. Conclusion The pDC subtypes were abnormal and the percentage of pDC1 increased in SAA patients, which were associated with the state of this illness. DC and B Lymphocytes in SAA up-regulated the expression of T cell co-stimulating molecules (CD86) that draw the T lymphocyte abnormally activated.

Salivary and Serum Antioxidant and Oxidative Stress Markers in Dental Caries

2018 ◽  
Vol 52 (6) ◽  
pp. 565-569 ◽  
Author(s):  
Fatemeh Ahmadi-Motamayel ◽  
Mohammad Taghi Goodarzi ◽  
Ali Mahdavinezhad ◽  
Zohreh Jamshidi ◽  
Mohammad Darvishi
Keyword(s):  
Oxidative Stress ◽  
Dental Caries ◽  
Oral Disease ◽  
Healthy Control Group ◽  
Oxidative Stress Marker ◽  
Control Group ◽  
Control Groups ◽  
Whole Saliva ◽  
Healthy Control ◽  
And Control

Dental caries is the most common, chronic, noncommunicable, preventable oral disease worldwide. Oxidation may play an important role in dental caries initiation and progression. Antioxidants in body fluids protect cells. The aim of this study was to evaluate salivary and serum total antioxidant capacity (TAC) and malondialdehyde (MDA) levels in dental caries. A total of 118 healthy caries-free and caries-active male and female students participated. Caries was detected clinically. Unstimulated whole-saliva samples and blood samples were obtained. Sialochemical analysis was carried out by spectrophotometric assay. Data were analyzed with the Student t test using STATA 11. Salivary and serum TAC levels in the case and control groups did not show any significant differences. Mean salivary MDA levels in the case and control groups were 0.71 ± 0.1 and 0.35 ± 0.06 nmol/mL, respectively. The results showed significantly higher levels of salivary and serum MDA in the case group compared to the healthy control group. The oxidative stress marker was significantly higher in the caries group compared to the healthy control group. Antioxidants were not significantly different between the two groups. MDA can be produced by dental caries, resulting in a decrease in antioxidant levels, causing disease progression. Further studies are necessary to determine whether MDA is the cause or effect of the disease.

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