scholarly journals Prevention of recurrent endometrial pathology

2019 ◽  
pp. 21-26
Author(s):  
A. L. Tikhomirov ◽  
S. I. Sarsania ◽  
K. S. Tuskayev ◽  
T. A. Yudina
Keyword(s):  
Hyaluronic Acid ◽  
Integrated Approach ◽  
Therapy Resistance ◽  
Chronic Endometritis ◽  
High Prevalence ◽  
Endometrial Pathology

Therapy resistance of endometrial pathology is one of the significant issues for gynaecologists facing this problem. The features of chronic endometritis include high prevalence of infertility and recurrent endomentrial process, due to adhesive process in the uterus. This task requires an integrated approach, including the use of modern anti-adhesive barrier containing hyaluronic acid and carboxymethylcellulose.

Etiological structure and diagnosis of abnormal uterine bleeding

GYNECOLOGY ◽  
2018 ◽  
Vol 20 (2) ◽  
pp. 14-17
Author(s):  
G E Chernukha ◽  
I A Ivanov ◽  
Z N Efendieva ◽  
M R Dumanovskaya ◽  
A V Asaturova
Keyword(s):  
Diagnostic Accuracy ◽  
Endometrial Hyperplasia ◽  
Ultrasound Examination ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Histological Diagnosis ◽  
Reproductive Age ◽  
Endometrial Polyps ◽  
Chronic Endometritis ◽  
Endometrial Pathology

Abnormal uterine bleeding (AUB) is one of the most common indications for hysteroscopy. Most of the AUB cases occur due to endometrial or myometrium pathology. Among it, endometrial polyps (EP) and chronic endometritis (CE) prevalent in reproductive age, while endometrial hyperplasia (EH) and EP dominate in perimenopause. It was determined that EP and CE are characterized with menorrhagia and metrorrhagia approximately equally, whereas EH reveals AUB with oligomenorrhoea. Verification of exact endometrial pathology by ultrasound examination is hindered, that results in deviations of ultrasound and histological diagnosis. The usage of ultrasound data and AUB’s characteristics may improve the diagnostic accuracy on preadmission period.

HYPERTENSION – A PUBLIC HEALTH PROBLEM

2019 ◽  
Author(s):  
Adia Pilav ◽  
Emira Tanović-Mikulec ◽  
Suada Branković ◽  
Vedran Đido
Keyword(s):  
Public Health ◽  
High Risk ◽  
Public Health Problem ◽  
Integrated Approach ◽  
Community Level ◽  
Effective Control ◽  
Population Approach ◽  
Hypertension Control ◽  
Adequate Model ◽  
High Prevalence

Aim. The aim of this paper is to present public health importance of hypertension in population as one of the major CVD risk factor as well as a model of integrated approach to hypertension control at community level. Background. In spite of wide knowledge of pathophysiology and epidemiology in development of hypertension, ability to easily diagnose it, availability of efficient medications, hypertension continues to have high prevalence and setting up hypertension controls poses significant public health challenge. High prevalence of hypertension exists in all countries of the world, regardless of socioeconomic status of the country. It is estimated that the number of people with hypertension by 2025 will rise by 15-20%, and the number of sick people will increase up to 1.5 billion people worldwide. Methods. A review of the relevant literature which discusses the importance of defining clear strategies and interventions in the control of hypertension in countries, with particular emphasis on integrated hypertension management that has the greatest impact. Discussion. Effective and efficient hypertension control requires two approaches: population approach and individual approach to high-risk individuals. The balanced combination of population approach and an approach to access high-risk individuals is vital for the effective control of hypertension and cardiovascular diseases. Conclusions. Health systems in every country must be flexible and ready to provide adequate model of integrated approach to hypertension control at community level understanding their own local needs.

Clinical case of recurrent vomiting in a child: diagnostic search from functional gastrointestinal disorders to piloid astrocytoma

2021 ◽  
Vol 19 (1) ◽  
pp. 78-81
Author(s):  
E. N. Voronina ◽  
◽  
D. V. Pechkurov ◽  
A. A. Tyazheva ◽  
E. V. Kozarez ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Nutritional Status ◽  
Clinical Case ◽  
Anxiety Symptom ◽  
Functional Gastrointestinal Disorders ◽  
Integrated Approach ◽  
Gastrointestinal Disorders ◽  
Wide Range ◽  
High Prevalence ◽  
Recurrent Vomiting

The urgency of the problem of recurrent vomiting in children is due not only to the high prevalence of this syndrome, but also to a wide range of reasons for its development. The article presents a clinical case of observation of a child with recurrent vomiting syndrome. It shows the dynamics of the disease, the importance of identifying such «anxiety symptom» as the nutritional status violation. In this case, the cause of vomiting of central genesis was not immediately taken into account, although differential diagnosis presupposes an integrated approach, and doctors' oncological alertness should be constantly preserved even in pediatrics.

scholarly journals Defining Pre-Clinical Psoriatic Arthritis in an Integrated Dermato-Rheumatology Environment

2020 ◽  
Vol 9 (10) ◽  
pp. 3262 ◽  
Author(s):  
Laura Savage ◽  
Ilaria Tinazzi ◽  
Alen Zabotti ◽  
Philip M. Laws ◽  
Miriam Wittmann ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Early Recognition ◽  
Joint Damage ◽  
Integrated Approach ◽  
Musculoskeletal Symptoms ◽  
Early Therapy ◽  
High Prevalence ◽  
Clinical Biomarker ◽  
Inflammatory Changes ◽  
Citrullinated Protein

In excess of three quarters of patients with psoriatic arthritis (PsA) have preceding psoriasis (PsO), which offers a clinical biomarker for the recognition of early PsA. Numerous surveys have shown a remarkably high frequency of clinically occult musculoskeletal symptoms in psoriasis patients. Imaging studies, particularly ultrasound, show a high prevalence of subclinical enthesitis and other inflammatory changes in psoriasis subjects. Since a serum biomarker, such as the case of anti-citrullinated protein antibodies (ACPA) in rheumatoid arthritis, neither exists nor seems biologically plausible at this point, this article explores how integration of rheumatological and dermatological assessment can be facilitated for the early recognition of potential PsA. Given that scalp disease is a PsA predictor, but may be managed in the community, then a particular need to access this group is needed. An integrated approach between rheumatology and dermatology can involve joint clinics, parallel clinics with discussion of relevant cases or virtual contact between specialties. Early therapy evaluation and integrated strategies have considerable implications for minimizing suffering and joint damage in PsA.

State-of-the-Art: Exosomes in Colorectal Cancer

2021 ◽  
Vol 21 ◽  
Author(s):  
Yan Dang ◽  
Shutian Zhang ◽  
Yongjun Wang ◽  
Guiping Zhao ◽  
Chuyan Chen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mortality Rate ◽  
Cancer Cells ◽  
Stromal Cells ◽  
State Of The Art ◽  
Therapy Resistance ◽  
Clinical Applications ◽  
Bioactive Molecules ◽  
High Prevalence ◽  
Cancerous Cells

: Colorectal cancer (CRC) has a high prevalence and mortality rate, globally. To date, the progression mechanisms of CRC are still elusive. Exosomes (~100 nm in diameter) correspond to a subset of extracellular vesicles formed by an array of cancerous cells and stromal cells. These particular nanovesicles carry and transmit bioactive molecules, like proteins, lipids, and genetic materials, which mediate the crosstalk between cancer cells and the microenvironment. Accumulating evidence has shown the decisive functions of exosomes in the development, metastasis, and therapy resistance of CRC. Furthermore, some recent studies have also revealed the abilities of exosomes to function as either biomarkers or therapeutic targets for CRC. This review focuses on the specific mechanisms of exosomes in regulating CRC progression, and summarizes the potential clinical applications of exosomes in the diagnosis and therapy of CRC.

scholarly journals Integrated prevention of obesity and eating disorders: barriers, developments and opportunities

2012 ◽  
Vol 15 (12) ◽  
pp. 2295-2309 ◽  
Author(s):  
David Sánchez-Carracedo ◽  
Dianne Neumark-Sztainer ◽  
Gemma López-Guimerà
Keyword(s):  
Risk Factors ◽  
Eating Disorders ◽  
Anorexia Nervosa ◽  
Eating Disorder ◽  
Bulimia Nervosa ◽  
Broad Spectrum ◽  
Integrated Approach ◽  
Overweight And Obesity ◽  
High Prevalence ◽  
Exciting Development

AbstractObjectiveThe serious consequences of obesity and eating disorders (ED), difficulties encountered in treatment and the high prevalence of these conditions are important reasons to develop efforts aimed at their prevention. The implementation of integrated interventions aimed at preventing risk factors for both obesity and ED constitutes a very exciting development. In the present paper we discuss and review the main reasons for an integrated approach to the spectrum of eating- and weight-related problems, which include anorexia nervosa, bulimia nervosa, anorexic and bulimic behaviours, unhealthy dieting practices, body dissatisfaction, binge-eating disorder, overweight and obesity. Given differences between the fields with regard to current perspectives and objectives, key barriers to an integrated approach to prevention are discussed. In order to show the possibilities of development of this approach, we review the main contributions made to date in the fields of both obesity and ED prevention. In particular, environmental approaches in the prevention of obesity and ED are reviewed, given their potential for preventing a broad spectrum of eating- and weight-related problems. Furthermore, several examples of initiatives that have utilized an integrated approach to prevention are discussed.DesignNarrative review.ConclusionsWe recommend a scenario in which the two fields share knowledge to enhance the difficult work of preventing and treating both ED and obesity.

scholarly journals Diagnosis and treatment of osteoporosis in elderly patients with type 2 diabetes

2020 ◽  
pp. 159-164
Author(s):  
N. V. Brailova ◽  
E. N. Dudinskaya ◽  
L. V. Machekhina ◽  
O. N. Tkacheva
Keyword(s):  
Type 2 Diabetes ◽  
Trabecular Bone Score ◽  
Bone Microarchitecture ◽  
Integrated Approach ◽  
Treatment Of Osteoporosis ◽  
Diabetes Status ◽  
High Prevalence ◽  
Patients With Diabetes ◽  
Selection Of

Osteoporosis, falls and low-energy fractures have a high prevalence in elderly, which is increasing in the presence of diabetes mellitus type 2 (T2DM). Patients with T2DM have a low rate of bone metabolism, a pronounced change in bone microarchitecture. The use of trabecular bone score in evaluating of densitometry and the FRAX scale improves the sensitivity of the methods in patients with diabetes. Integrated approach is required in elderly patient with type 2 diabetes and includes assessment of geriatric status, diabetes status, correction of multiple complications of diabetes, carbohydrate metabolism, vitamin D deficiency, selection of the most effective hypoglycemic and anti-osteoporetic therapy and development of preventive and treatment methods aimed to reduce falls risk and fractures rate.

scholarly journals Analysis of shear wave elastography and elastometry results in the endometrial pathology diagnosis in patients with secondary infertility

2016 ◽  
Vol 97 (3) ◽  
pp. 336-341 ◽  
Author(s):  
V N Diomidova ◽  
O V Zakharova ◽  
T K Spiridonova ◽  
O V Petrova
Keyword(s):  
Shear Wave ◽  
Shear Wave Elastography ◽  
Main Group ◽  
Reproductive Age ◽  
Control Group ◽  
Secondary Infertility ◽  
Chronic Endometritis ◽  
Healthy Women ◽  
Nulliparous Women ◽  
Endometrial Pathology

Aim. To analyze the results of the application and to study the effectiveness of ultrasound shear wave elastography and elastometry in the endometrial pathology diagnosis in secondary infertility.Methods. Multiparameter ultrasound with shear wave elastography and elastometry modes (Shear Wave Elastography) was performed in 146 women of reproductive age (Aixplorer scanner, Supersonic Imagine, France). The main group (N1) included 101 women with secondary infertility: 43 patients with tuberculous lesions of the uterus, 58 - with chronic endometritis without concomitant tuberculosis. The control group (N2) included 45 healthy women: 22 nulliparous women, 23 - parous women. Age of examined women ranged from 24 to 48 years, mean age in N1 group was 34.4±2.6 years, in N2 group - 33.9±2.9 years.Results.. Depending on the nature of the pathology elastographic cards of examined women in the main group differed in color. Elastographic cards of blue-green range of low intensity dominated in patients with chronic endometritis. In patients with tuberculous lesions of the uterus unevenly colored, non-homogeneous, high intensity, from green to yellow and red in color-grade elastographic cards were determined. Endometrial stiffness values in patients with chronic endometritis and in tuberculous lesions of the endometrium (31.7±4.3 and 89.7±5.7 kPa, respectively) were significantly higher than that in healthy women (16.5±1.0 kPa, pConclusion. The presented analysis indicates the feasibility of the shear wave elastography and elastometry application in multiparameter ultrasound study of the uterus and adnexa in the diagnostic algorithm of patients with secondary infertility.

An Integrated Approach to Eating Disorders and Obesity Prevention: What Has the Research Taught Us?

2018 ◽  
pp. 228-244
Author(s):  
Dianne Neumark-Sztainer ◽  
Katie A. Loth
Keyword(s):  
Eating Disorders ◽  
Disordered Eating ◽  
Eating Behaviors ◽  
Integrated Approach ◽  
Health Concern ◽  
Disordered Eating Behaviors ◽  
High Prevalence ◽  
Research Findings ◽  
Shared Risk ◽  
Great Public Health

The broad spectrum of weight-related problems, including obesity, eating disorders, and disordered eating, is of great public health concern for adolescents, given the high prevalence and potentially harmful consequences of these problems. Traditionally the fields of obesity and eating disorders have been separate, but there has been a shift toward integration given conceptual support, empirical findings regarding shared risk factors, and practicalities related to limited time and resources. This article summarizes key research findings providing justification for an integrated approach to the prevention of obesity, eating disorders, and disordered eating behaviors. In addition, opportunities for integration within various settings are described.

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