Production of p-Anisic Acid by Modified Williamson Etherification Reaction Using Design of Experiments

2010 ◽  
Vol 5 (1) ◽  
Author(s):  
Pankaj J. Gandhi ◽  
Yogen H. Talia ◽  
Z.V.P. Murthy
Keyword(s):  
Design Of Experiments ◽  
Large Scale ◽  
Maximum Yield ◽  
High Yield ◽  
Small Scale ◽  
Scale Production ◽  
Complex Processes ◽  
Small Scale Industry ◽  
Anisic Acid ◽  
Process Factors

Majority of the processes available for manufacturing of p-anisic acid (4-methoxy benzoic acid) are pertaining to large-scale production comprising of heterogeneous and homogeneous catalysis. These are involved with hazardous and highly toxic materials, involving complex processes, which are not suitable for small-scale industries. The present work has been conducted in a small-scale industry laboratory. A modified Williamson etherification reaction has been studied through process validation and design of experiments (DOE). It is observed that the yield is affected by the process factors; such as mole ratio, addition temperature, reaction temperature, time of addition (or dosage rate), and agitator speed. The maximum yield can be derived by setting the time of addition (120 min) and agitator speed (300 rpm). This simple process may serve the purpose of small scale industry to derive this important product through less hazardous and toxic chemicals with high yield.

AGRICULTURAL PRODUCTION OF CA DONG PEOPLE IN RESETTLEMENT AREA OF TRANH RIVER HYDROPOWER NUMBER 2: CURRENT SITUATION AND IMPACT FACTORS

2020 ◽  
Vol 9 (2) ◽  
Author(s):  
Bùi Thị Bích Lan
Keyword(s):  
Social Relations ◽  
Agricultural Production ◽  
Large Scale ◽  
Transition Process ◽  
Impact Factors ◽  
Small Scale ◽  
Scale Production ◽  
Technical Application ◽  
Production Models ◽  
Role Of The State

In Vietnam, the construction of hydropower projects has contributed significantly in the cause of industrialization and modernization of the country. The place where hydropower projects are built is mostly inhabited by ethnic minorities - communities that rely primarily on land, a very important source of livelihood security. In the context of the lack of common productive land in resettlement areas, the orientation for agricultural production is to promote indigenous knowledge combined with increasing scientific and technical application; shifting from small-scale production practices to large-scale commodity production. However, the research results of this article show that many obstacles in the transition process are being posed such as limitations on natural resources, traditional production thinking or the suitability and effectiveness of scientific - technical application models. When agricultural production does not ensure food security, a number of implications for people’s lives are increasingly evident, such as poverty, preserving cultural identity, social relations and resource protection. Since then, it has set the role of the State in researching and building appropriate agricultural production models to exploit local strengths and ensure sustainability.

scholarly journals Fabrication Techniques for Graphene Oxide-Based Molecular Separation Membranes: Towards Industrial Application

Nanomaterials ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 757
Author(s):  
Ohchan Kwon ◽  
Yunkyu Choi ◽  
Eunji Choi ◽  
Minsu Kim ◽  
Yun Chul Woo ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Large Scale ◽  
Spray Coating ◽  
Dip Coating ◽  
Small Scale ◽  
Scale Production ◽  
Separation Membranes ◽  
Current Review ◽  
Slot Die ◽  
Continuous Fabrication

Graphene oxide (GO) has been a prized material for fabricating separation membranes due to its immense potential and unique chemistry. Despite the academic focus on GO, the adoption of GO membranes in industry remains elusive. One of the challenges at hand for commercializing GO membranes lies with large-scale production techniques. Fortunately, emerging studies have acknowledged this issue, where many have aimed to deliver insights into scalable approaches showing potential to be employed in the commercial domain. The current review highlights eight physical methods for GO membrane fabrication. Based on batch-unit or continuous fabrication, we have further classified the techniques into five small-scale (vacuum filtration, pressure-assisted filtration, spin coating, dip coating, drop-casting) and three large-scale (spray coating, bar/doctor blade coating, slot die coating) approaches. The continuous nature of the large-scale approach implies that the GO membranes prepared by this method are less restricted by the equipment’s dimensions but rather the availability of the material, whereas membranes yielded by small-scale methods are predominately limited by the size of the fabrication device. The current review aims to serve as an initial reference to provide a technical overview of preparing GO membranes. We further aim to shift the focus of the audience towards scalable processes and their prospect, which will facilitate the commercialization of GO membranes.

scholarly journals Low-cost Large Scale Vermicompost Unit

2021 ◽  
Vol 2115 (1) ◽  
pp. 012026
Author(s):  
Sonam Solanki ◽  
Gunendra Mahore
Keyword(s):  
Large Scale ◽  
Low Cost ◽  
Small Scale ◽  
Scale Production ◽  
Key Innovation ◽  
Main Challenge ◽  
Long Run ◽  
Large Scale Production ◽  
Term Maintenance

Abstract In the current process of producing vermicompost on a large-scale, the main challenge is to keep the worms alive. This is achieved by maintaining temperature and moisture in their living medium. It is a difficult task to maintain these parameters throughout the process. Currently, this is achieved by building infrastructure but this method requires a large initial investment and long-run maintenance. Also, these methods are limited to small-scale production. For large-scale production, a unit is developed which utilises natural airflow with water and automation. The main aim of this unit is to provide favourable conditions to worms in large-scale production with very low investment and minimum maintenance in long term. The key innovation of this research is that the technology used in the unit should be practical and easy to adopt by small farmers. For long-term maintenance of the technology lesser number of parts are used.

The Scalability of Wet Ball Milling for The Production of Nanosuspensions

2019 ◽  
Vol 7 (2) ◽  
pp. 147-161 ◽  
Author(s):  
Maria L.A.D. Lestari ◽  
Rainer H. Müller ◽  
Jan P. Möschwitzer
Keyword(s):  
Ball Milling ◽  
Large Scale ◽  
Milling Time ◽  
High Energy ◽  
Small Scale ◽  
Particle Sizes ◽  
Scale Production ◽  
Batch Mode ◽  
Pharmaceutical Ingredients ◽  
Large Scale Production

Background: Miniaturization of nanosuspensions preparation is a necessity in order to enable proper formulation screening before nanosizing can be performed on a large scale. Ideally, the information generated at small scale is predictive for large scale production. Objective: This study was aimed to investigate the scalability when producing nanosuspensions starting from a 10 g scale of nanosuspension using low energy wet ball milling up to production scales of 120 g nanosuspension and 2 kg nanosuspension by using a standard high energy wet ball milling operated in batch mode or recirculation mode, respectively. Methods: Two different active pharmaceutical ingredients, i.e. curcumin and hesperetin, have been used in this study. The investigated factors include the milling time, milling speed, and the type of mill. Results: Comparable particle sizes of about 151 nm to 190 nm were obtained for both active pharmaceutical ingredients at the same milling time and milling speed when the drugs were processed at 10 g using low energy wet ball milling or 120 g using high energy wet ball milling in batch mode, respectively. However, an adjustment of the milling speed was needed for the 2 kg scale produced using high energy wet ball milling in recirculation mode to obtain particle sizes comparable to the small scale process. Conclusion: These results confirm in general, the scalability of wet ball milling as well as the suitability of small scale processing in order to correctly identify the most suitable formulations for large scale production using high energy milling.

scholarly journals Solutions for changing production scale in the agricultural sector in Vietnam

2020 ◽  
Vol 175 ◽  
pp. 10008
Author(s):  
Thi Hoai Nguyen ◽  
Duc Luan Nguyen
Keyword(s):  
Labor Productivity ◽  
Agricultural Production ◽  
Large Scale ◽  
Agricultural Sector ◽  
Current Situation ◽  
Small Scale ◽  
Scale Production ◽  
Number Of Solutions ◽  
Production Scale ◽  
Large Scale Production

In this paper, the authors analyze the current situation of agricultural production in Vietnam and affirm that fragmentation is one of the basic causes leading to ineffective potentials and low labor productivity. Based on this, the authors propose a number of solutions to convert small-scale production to large-scale production in order to improve labor productivity and optimally exploit resources in the agricultural sector in Vietnam today.

scholarly journals Large-Scale Production of Human iPSC-Derived Macrophages for Drug Screening

2020 ◽  
Vol 21 (13) ◽  
pp. 4808 ◽  
Author(s):  
Simon Gutbier ◽  
Florian Wanke ◽  
Nadine Dahm ◽  
Anna Rümmelin ◽  
Silke Zimmermann ◽  
...  
Keyword(s):  
Drug Screening ◽  
Large Scale ◽  
Neoplastic Cell ◽  
Leukemic Cells ◽  
High Yield ◽  
Scale Production ◽  
Large Scale Production ◽  
Compound Screening ◽  
Health And Disease ◽  
Induced Pluripotent

Tissue-resident macrophages are key players in inflammatory processes, and their activation and functionality are crucial in health and disease. Numerous diseases are associated with alterations in homeostasis or dysregulation of the innate immune system, including allergic reactions, autoimmune diseases, and cancer. Macrophages are a prime target for drug discovery due to their major regulatory role in health and disease. Currently, the main sources of macrophages used for therapeutic compound screening are primary cells isolated from blood or tissue or immortalized or neoplastic cell lines (e.g., THP-1). Here, we describe an improved method to employ induced pluripotent stem cells (iPSCs) for the high-yield, large-scale production of cells resembling tissue-resident macrophages. For this, iPSC-derived macrophage-like cells are thoroughly characterized to confirm their cell identity and thus their suitability for drug screening purposes. These iPSC-derived macrophages show strong cellular identity with primary macrophages and recapitulate key functional characteristics, including cytokine release, phagocytosis, and chemotaxis. Furthermore, we demonstrate that genetic modifications can be readily introduced at the macrophage-like progenitor stage in order to interrogate drug target-relevant pathways. In summary, this novel method overcomes previous shortcomings with primary and leukemic cells and facilitates large-scale production of genetically modified iPSC-derived macrophages for drug screening applications.

scholarly journals Regeneration Technique of Bamboo Species through Nodal Segments: A Review

2020 ◽  
Vol 8 (1) ◽  
pp. 54-68
Author(s):  
Meena Maiya Suwal ◽  
Janardan Lamichhane ◽  
Dhurva Prasad Gauchan
Keyword(s):  
Large Scale ◽  
Physiological Stress ◽  
Perennial Grass ◽  
Shoot Multiplication ◽  
Nodal Segments ◽  
Individual Species ◽  
Small Scale ◽  
Scale Production ◽  
Bamboo Species

Micropropagation is an alternative technique to propagate at large scale plants to meet global plant demand. Various researchers have worked on the micropropagation technique to regenerate bamboo species by using nodal segments from years. Contamination, browning, necrosis, and acclimatization with physiological stress are the extreme problems of the micropropagation technique. But, many numbers of papers have been published on micropropagation of the bamboo species through nodal segments as explants. The proliferation of the bamboo shoots is dependent on the season of collection, size of explants, the position of explants, diversity of plants, concentration and combination of plant growth regulators, most adequate culture medium, environmental condition of the equipment, handling, and individual species. Bamboo is a monocarpic fast-growing, tall perennial grass and having the high potential to generate economic and social benefits. It helps to maintain land patterns and control soil erosion.  The long life cycle of the bamboo produces a huge amount of seeds but unfortunately, mostly, they are non-viable. So, bamboos are propagated from vegetative by cutting and air layering. However, these methods are only for a small scale and they also tend to destroy large mother plant stocks and difficult to be transported. So, the in vitro propagation technique is useful to obtain large progenies from desired genotypes. Mostly, BAP and TDZ growth hormones are widely used for shoot multiplication and IBA, NAA and IAA are used for root initiation as per developed protocols in tissue culture for large scale production. This review intends to explore an overview of the recent literature reports to summarize the importance of micropropagation by using nodal segments of bamboo species and factors influencing it.

scholarly journals Large-Scale Production of Bioactive Terrein by Aspergillus terreus Strain S020 Isolated from the Saudi Coast of the Red Sea

Biomolecules ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 480 ◽  
Author(s):  
Hani Z. Asfour ◽  
Zuhier A. Awan ◽  
Alaa A. Bagalagel ◽  
Mahmoud A. Elfaky ◽  
Reda F. A. Abdelhameed ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Crude Extract ◽  
Large Scale ◽  
Aspergillus Terreus ◽  
Antimicrobial Activities ◽  
Carcinoma Cells ◽  
Small Scale ◽  
Scale Production ◽  
Fungal Strains

The diversity of symbiotic fungi derived from two marine sponges and sediment collected off Obhur, Jeddah (Saudi Arabia), was investigated in the current study. A total of 23 isolates were purified using a culture-dependent approach. Using the morphological properties combined with internal transcribed spacer-rDNA (ITS-rDNA) sequences, 23 fungal strains (in the majority Penicillium and Aspergillus) were identified from these samples. The biological screening (cytotoxic and antimicrobial activities) of small-scale cultures of these fungi yielded several target fungal strains which produced bioactive secondary metabolites. Amongst these isolates, the crude extract of Aspergillus terreus strain S020, which was cultured in fermentation static broth, 21 L, for 40 days at room temperature on potato dextrose broth, displayed strong antimicrobial activities against Pseudomonas aeruginosa and Staphylococcus aureus and significant antiproliferative effects on human carcinoma cells. Chromatographic separation of the crude extract by silica gel column chromatography indicated that the S020 isolate could produce a series of chemical compounds. Among these, pure crystalline terrein was separated with a high yield of 537.26 ± 23.42 g/kg extract, which represents the highest fermentation production of terrein to date. Its chemical structure was elucidated on the basis of high-resolution electrospray ionization mass spectrometry (HRESIMS) or high-resolution mass spectrometry (HRMS), 1D, and 2D NMR spectroscopic analyses and by comparison with reported data. The compound showed strong cytotoxic activity against colorectal carcinoma cells (HCT-116) and hepatocellular carcinoma cells (HepG2), with IC50 values of 12.13 and 22.53 µM, respectively. Our study highlights the potential of A. terreus strain S020 for the industrial production of bioactive terrein on a large scale and the importance of future investigations of these strains to identify the bioactive leads in these fungal extracts.

scholarly journals Spiked pepper: selection of clones toward cropping on the edaphoclimatic conditions from Belém, Brazil

2010 ◽  
Vol 28 (4) ◽  
pp. 418-423
Author(s):  
José Maria D Gaia ◽  
Milton Guilherme da C Mota ◽  
Carmen Célia C da Conceição ◽  
José Guilherme S Maia
Keyword(s):  
Essential Oil ◽  
Production Systems ◽  
Biological Properties ◽  
Leaf Length ◽  
High Yield ◽  
Small Scale ◽  
Scale Production ◽  
Fresh Matter ◽  
Climate Conditions ◽  
Branch Plant

Spiked pepper presents a high yield of essential oil with useful biological properties for human health and agriculture. In order to evaluate the morphoagronomic variability and, afterwards, to select genotypes for plant breeding and cultivation, thirteen clones were propagated. Thus, spiked pepper cuttings were rooted under greenhouse, transferred to a nursery and, afterwards, planted at the experimental area. The evaluations were carried out in two harvest seasons. The evaluated morphoagronomic traits were number of leaves per branch, leaf length, leaf width, diameter of the oldest branch, plant height, number of orthotropic branches, number of plagiotropic branches, internode length, fresh and dry matter, yield of essential oil and dillapiole content. The analysis of variance and the Scott-Knott test were utilized for data analysis and comparisons among clones and parentals were carried out through genetic and experimental variation coefficients. Fresh matter (first season), number of orthotropic branches and diameter of the the oldest branch (second season) presented variability. The Scott-Knott test detected variability for fresh matter, dillapiole content (first season), diameter of the oldest branch and number of orthotropic branches (second season). The yield of essential oil and the dillapiole content were higher for the clones than for the parentals. In conclusion, the clones showed adaptability to the soil and climate conditions of Belém, Pará State, Brazil; the harvest time influenced the oil yield and the dillapiole content; the variance analysis evidenced uniformity and productivity for the evaluated clones, suggesting they can be recommended for cultivation on small-scale production systems in this location.

scholarly journals Ultra-high Yield On-surface Synthesis and Assembly of Circumcoronene into Chiral Electronic Kagome-honeycomb Lattice

2020 ◽  
Author(s):  
Mykola Telychko ◽  
Guangwu Li ◽  
Pingo Mutombo ◽  
Diego Soler-Polo ◽  
Xinnan Peng ◽  
...  
Keyword(s):  
Density Functional ◽  
Large Scale ◽  
Tight Binding ◽  
Cascade Reactions ◽  
High Yield ◽  
Honeycomb Lattice ◽  
Scale Production ◽  
Methyl Radical ◽  
Synthetic Strategy ◽  
Temperature Scanning

On-surface synthesis has revealed remarkable potential in the fabrication of a plethora of elusive nanographenes with tailored structural, electronic and magnetic properties unattainable by conventional wet-chemistry synthesis. Unfortunately, surface-assisted synthesis often involves multiple-step cascade reactions with competing pathways, leading to the formation of a diversity of products with limited yield, which reduces its feasibility towards the large-scale production for future technological applications. Here, we devise a new on-surface synthetic strategy for the ultra-high yield synthesis of a hexagonal nanographene with six zigzag edges, namely circumcoronene on Cu(111) via surfaceassisted intramolecular dehydrogenation of the rationally-designed precursor molecule, followed by methyl radical-radical coupling and aromatization. An elegant electrostatic interaction between circumcoronene and Cu(111) drives their self-organization into an extended superlattice, as revealed by bond-resolved low-temperature scanning probe microscopy and spectroscopy measurements. Density functional theory and tight-binding calculations reveal that unique hexagonal zigzag topology of circumcoronenes, along with their periodic electrostatic landscape confines two-dimensional (2D) electron gas in Cu(111) surface into chiral electronic Kagome-honeycomb lattice with two emergent electronic flat bands. Our findings open up a new route for the high-yield fabrication of elusive nanographenes with zigzag topologies and their novel 2D superlattices with possible nontrivial electronic properties towards their future technological applications.

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