From traditional to novel treatment of arthritis: a review of recent advances in nanotechnology-based thermal therapy

Nanomedicine ◽  
2021 ◽  
Author(s):  
Hongtao Shang ◽  
Huan Gu ◽  
Nan Zhang
Keyword(s):  
Side Effects ◽  
Molecular Mechanisms ◽  
Near Infrared ◽  
Thermal Therapy ◽  
Infrared Light ◽  
Combined Application ◽  
Novel Treatment ◽  
Thermal Therapies ◽  
Heavy Burden ◽  
Arthritic Joints

Arthritis has been a heavy burden on the economy and society at large. Recently, nanomaterials that can convert near-infrared light into localized heat have demonstrated better targeting to arthritic joints, fewer side effects, ease of combined application with current therapeutics and enhanced efficacy for arthritis treatment. In this review, the authors summarize traditional thermal therapies for arthritis treatment and their molecular mechanisms and discuss the advantages and applications of nanotechnology-based thermal therapies for arthritis treatment. In conclusion, nanotechnology-based thermal therapies are effective alternatives or adjuvant strategies to the current pharmacological treatment of arthritis. Future clinical translation of thermal therapies could benefit from research elucidating their mechanisms and standardizing their parameters to optimize efficacy.

scholarly journals Bioactivity of PEGylated Graphene Oxide Nanoparticles Combined with Near-Infrared Laser Irradiation Studied in Colorectal Carcinoma Cells

Nanomaterials ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 3061
Author(s):  
Natalia Krasteva ◽  
Dessislava Staneva ◽  
Bela Vasileva ◽  
George Miloshev ◽  
Milena Georgieva
Keyword(s):  
Colorectal Cancer ◽  
Graphene Oxide ◽  
Colorectal Carcinoma ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Molecular Mechanisms ◽  
Near Infrared ◽  
Carcinoma Cells ◽  
Infrared Light ◽  
Mitochondrial Activity

Central focus in modern anticancer nanosystems is given to certain types of nanomaterials such as graphene oxide (GO). Its functionalization with polyethylene glycol (PEG) demonstrates high delivery efficiency and controllable release of proteins, bioimaging agents, chemotherapeutics and anticancer drugs. GO–PEG has a good biological safety profile, exhibits high NIR absorbance and capacity in photothermal treatment. To investigate the bioactivity of PEGylated GO NPs in combination with NIR irradiation on colorectal cancer cells we conducted experiments that aim to reveal the molecular mechanisms of action of this nanocarrier, combined with near-infrared light (NIR) on the high invasive Colon26 and the low invasive HT29 colon cancer cell lines. During reaching cancer cells the phototoxicity of GO–PEG is modulated by NIR laser irradiation. We observed that PEGylation of GO nanoparticles has well-pronounced biocompatibility toward colorectal carcinoma cells, besides their different malignant potential and treatment times. This biocompatibility is potentiated when GO–PEG treatment is combined with NIR irradiation, especially for cells cultured and treated for 24 h. The tested bioactivity of GO–PEG in combination with NIR irradiation induced little to no damages in DNA and did not influence the mitochondrial activity. Our findings demonstrate the potential of GO–PEG-based photoactivity as a nanosystem for colorectal cancer treatment.

scholarly journals Lipophilicity of Bacteriochlorin-Based Photosensitizers as a Determinant for PDT Optimization through the Modulation of the Inflammatory Mediators

2019 ◽  
Vol 9 (1) ◽  
pp. 8 ◽  
Author(s):  
Barbara Pucelik ◽  
Luis G. Arnaut ◽  
Janusz M. Dąbrowski
Keyword(s):  
Immune Response ◽  
Molecular Mechanisms ◽  
Near Infrared ◽  
Antitumor Immune Response ◽  
Infrared Light ◽  
Gm Csf ◽  
Hydrophobic Compound ◽  
Tnf Α ◽  
Wide Range

Photodynamic therapy (PDT) augments the host antitumor immune response, but the role of the PDT effect on the tumor microenvironment in dependence on the type of photosensitizer and/or therapeutic protocols has not been clearly elucidated. We employed three bacteriochlorins (F2BOH, F2BMet and Cl2BHep) of different polarity that absorb near-infrared light (NIR) and generated a large amount of reactive oxygen species (ROS) to compare the PDT efficacy after various drug-to-light intervals: 15 min. (V-PDT), 3h (E-PDT) and 72h (C-PDT). We also performed the analysis of the molecular mechanisms of PDT crucial for the generation of the long-lasting antitumor immune response. PDT-induced damage affected the integrity of the host tissue and developed acute (protocol-dependent) local inflammation, which in turn led to the infiltration of neutrophils and macrophages. In order to further confirm this hypothesis, a number of proteins in the plasma of PDT-treated mice were identified. Among a wide range of cytokines (IL-6, IL-10, IL-13, IL-15, TNF-α, GM-CSF), chemokines (KC, MCP-1, MIP1α, MIP1β, MIP2) and growth factors (VEGF) released after PDT, an important role was assigned to IL-6. PDT protocols optimized for studied bacteriochlorins led to a significant increase in the survival rate of BALB/c mice bearing CT26 tumors, but each photosensitizer (PS) was more or less potent, depending on the applied DLI (15 min, 3 h or 72 h). Hydrophilic (F2BOH) and amphiphilic (F2BMet) PSs were equally effective in V-PDT (>80 cure rate). F2BMet was the most efficient in E-PDT (DLI = 3h), leading to a cure of 65 % of the animals. Finally, the most powerful PS in the C-PDT (DLI = 72 h) regimen turned out to be the most hydrophobic compound (Cl2BHep), allowing 100 % of treated animals to be cured at a light dose of only 45 J/cm2.

Cancer Imaging and Thermal Therapy Facilitated by Nanoparticles and Multiphoton Microscopy

2010 ◽  
Author(s):  
Emily S. Day ◽  
Lissett R. Bickford ◽  
Rebekah A. Drezek ◽  
Jennifer L. West
Keyword(s):  
Cancer Cells ◽  
Causes Of Death ◽  
Near Infrared ◽  
Multiphoton Microscopy ◽  
Therapeutic Agents ◽  
Thermal Therapy ◽  
Infrared Light ◽  
Two Photon ◽  
Cancer Management ◽  
Gold Sulfide

Despite use of currently available technologies, cancer remains one of the leading causes of death worldwide. Gold-based nanoparticles that strongly absorb near-infrared light, such as nanoshells and nanorods, have shown potential as both diagnostic and therapeutic agents for cancer management (1–3). In this work we explored the use of gold-gold sulfide nanoparticles (mean diameter = 37 nm) with peak plasmon resonance at 800 nm for combined imaging and therapy of breast cancer. Upon excitation with a pulsed laser, these particles exhibit two-photon induced luminescence which may be used to image cancer cells. In addition, by increasing the power output of the laser, cancer cells can be thermally ablated as the gold-gold sulfide nanoparticles convert the light energy into heat.

scholarly journals The Potential of Visible and Far-Red to Near-Infrared Light in Glaucoma Neuroprotection

2021 ◽  
Vol 11 (13) ◽  
pp. 5872
Author(s):  
Loredana Bergandi ◽  
Francesca Silvagno ◽  
Giulia Grisolia ◽  
Antonio Ponzetto ◽  
Emilio Rapetti ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Molecular Mechanisms ◽  
Near Infrared ◽  
Ganglion Cells ◽  
Nerve Repair ◽  
Treatment Strategies ◽  
Neuronal Cell ◽  
Infrared Light ◽  
Near Infrared Light ◽  
The Impact

Alternative treatment strategies are necessary to reduce the severity of glaucoma, a group of eye conditions that progressively damage the optic nerve and impair vision. The aim of this review is to gain insight into potentially exploitable molecular mechanisms to slow down the death of retinal ganglion cells (RGCs), a fundamental element in the pathophysiology of all forms of glaucoma, and to stimulate adult optic nerve repair. For this purpose, we focus our analysis on both visible and far-red to near-infrared light photobiomodulation (PBM) as phototherapeutic agents, which were recently proposed in RGCs, and on the nerve lamina region neural progenitor cell (ONLR-NPC) niche. Both are suggested as potential strategies in glaucoma neuroprotection. We discuss the impact of beneficial molecular effects of PBM on both mitochondrial derangement and the alteration of ion fluxes that are considered important causes of RGC damage, as well as on the stimulation of progenitor cells. We suggest these are the most promising approaches to prevent excessive neuronal cell loss. We describe the experimental evidence supporting the validity of PBM therapy which, despite being a safe, non-invasive, inexpensive, and easy to administer procedure, has not yet been fully explored in the clinical practice of glaucoma treatment.

scholarly journals Near-Infrared Photoimmunotherapy for Cancers of the Gastrointestinal Tract

Digestion ◽  
2020 ◽  
pp. 1-8
Author(s):  
Tadanobu Nagaya ◽  
Peter L. Choyke ◽  
Hisataka Kobayashi
Keyword(s):  
Side Effects ◽  
Cancer Therapy ◽  
Near Infrared ◽  
Distant Metastases ◽  
Infrared Light ◽  
Cancer Therapies ◽  
Gi Tract ◽  
Preclinical Research ◽  
Excitation Light ◽  
New Treatment

<b><i>Background:</i></b> Cancers of the gastrointestinal (GI) tract are the common leading cause of cancer-related death in the world. Recent advances in cancer therapies such as intensive multidrug chemotherapy and molecular targeted treatment have improved therapeutic efficacy; however, the outcomes are not satisfied. Moreover, these therapies also cause severe side effects. New type of cancer therapies is urgently needed to improve the outcomes and to reduce side effects of GI tract cancers. <b><i>Summary:</i></b> This account is a comprehensive review article on the newly developed, photochemistry-based cancer therapy named as near-infrared photoimmunotherapy (NIR-PIT). NIR-PIT is a highly selective tumor treatment that employs an antibody-photoabsorber conjugate, which is activated by near-infrared light. A world-wide phase 3 clinical trial of NIR-PIT against recurrent head and neck cancer patients is currently underway. NIR-PIT differs from conventional cancer therapies such as surgery, chemotherapy, and radiation in its selectivity for killing cancer cells and cells treated with NIR-PIT leading to immunogenic cell death. Preclinical research in animals with combining cancer-targeting NIR-PIT and other cancer immunotherapies could lead to responses not only in local tumor but also in distant metastases. NIR-PIT also leads to an immediate and dramatic increase in vascular permeability after therapy. From these aspects, NIR-PIT appears to be a promising new form of cancer therapy. NIR-PIT could be readily translated into clinical use for virtually any cancers in the near future provided suitable humanized antibodies are available. Here, we describe the specific advantages and applications of NIR-PIT in the GI tract. <b><i>Key Messages:</i></b> We believe that NIR-PIT with NIR excitation light, which can be delivered via a fiber optic diffuser through endoscopes, is a promising method for a new treatment of GI cancers.

scholarly journals A Comprehensive Review of Natural Products against Liver Fibrosis: Flavonoids, Quinones, Lignans, Phenols, and Acids

2020 ◽  
Vol 2020 ◽  
pp. 1-19
Author(s):  
Xiaoqi Pan ◽  
Xiao Ma ◽  
Yinxiao Jiang ◽  
Jianxia Wen ◽  
Lian Yang ◽  
...  
Keyword(s):  
Natural Products ◽  
Liver Fibrosis ◽  
Molecular Mechanisms ◽  
Stellate Cell ◽  
Combined Application ◽  
Heavy Burden ◽  
Ecm Degradation

Liver fibrosis resulting from continuous long-term hepatic damage represents a heavy burden worldwide. Liver fibrosis is recognized as a complicated pathogenic mechanism with extracellular matrix (ECM) accumulation and hepatic stellate cell (HSC) activation. A series of drugs demonstrate significant antifibrotic activity in vitro and in vivo. No specific agents with ideally clinical efficacy for liver fibrosis treatment have been developed. In this review, we summarized the antifibrotic effects and molecular mechanisms of 29 kinds of common natural products. The mechanism of these compounds is correlated with anti-inflammatory, antiapoptotic, and antifibrotic activities. Moreover, parenchymal hepatic cell survival, HSC deactivation, and ECM degradation by interfering with multiple targets and signaling pathways are also involved in the antifibrotic effects of these compounds. However, there remain two bottlenecks for clinical breakthroughs. The low bioavailability of natural products should be improved, and the combined application of two or more compounds should be investigated for more prominent pharmacological effects. In summary, exploration on natural products against liver fibrosis is becoming increasingly extensive. Therefore, natural products are potential resources for the development of agents to treat liver fibrosis.

scholarly journals Near-infrared light enhanced starvation therapy to effectively promote cell apoptosis and inhibit migration

2021 ◽  
Author(s):  
Yan Huang ◽  
Peiwei Gong ◽  
Mingyue Liu ◽  
Jingyi Peng ◽  
Ruyue Zhang ◽  
...  
Keyword(s):  
Side Effects ◽  
Drug Use ◽  
Glucose Oxidase ◽  
Catalytic Property ◽  
Cell Apoptosis ◽  
Near Infrared ◽  
Infrared Light ◽  
Great Promise ◽  
Near Infrared Light ◽  
Cancer Inhibition

Starvation therapy depended on catalytic property of glucose oxidase (GOx) holds great promise in cancer inhibition because of its non-drug use and negligible side effects. However, inability to fundamentally kill...

scholarly journals Comparison of Four Common Gold Nanoparticles for Photothermal Cancer Therapy: A Review

2020 ◽  
Vol 5 (4) ◽  
pp. 116-129
Author(s):  
Sabrina N. Saiphoo ◽  
Cassidy M. Rose ◽  
Alexander T. Dunn ◽  
Dwij J. Padia ◽  
Muhammad Hasibul Hasan
Keyword(s):  
Gold Nanoparticles ◽  
Side Effects ◽  
Cancer Therapy ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Treatment Options ◽  
Infrared Light ◽  
Gold Nanospheres ◽  
Cancerous Tissue ◽  
Patient Prognosis

Current cancer treatment options, including surgery, chemotherapy and radiation therapy, often cause damage to healthy tissue and reduce a patient's quality of life with well-known side effects, such as pain, infection and nerve damage. Recent research has shown that gold nanoparticles used as photothermal agents in photothermal therapy may pose as an alternative to traditional treatments. This great potential is due to their ability to selectively accumulate in cancerous tissue, efficiently absorb near-infrared light, and kill cancerous tissue without harming surrounding cells. Gold nanoparticles show promise in increasing treatment efficacy and reducing the side effects associated with cancer therapy. While recent studies show the potential of gold nanoparticles, the existing literature is limited in drawing comparisons between studies and practical use for photothermal therapy. This paper reviews notable studies on four common gold nanoparticles used in the therapeutic treatment of cancer: gold nanocages, gold nanospheres, gold nanorods, and gold nanoshells. By comparing key characteristics of the particles’, including their synthesis, toxicity, absorption spectrum, and selective photothermal lethality, gold nanospheres can be recommended for use in photothermal therapy. Although forms of each gold nanoparticle were found to have a low toxicity, gold nanospheres can be rapidly synthesized and appear to exceed in selective photothermal lethality and immature tumour accumulation. Due to these advantages in using gold nanospheres for photothermal therapy, cancer could be treated more effectively and improve patient prognosis.

scholarly journals Preconditioning with Near-Infrared Irradiation to Enhance the Irreversible Electroporation Efficiency in HeLa Cells

2021 ◽  
Vol 11 (18) ◽  
pp. 8504
Author(s):  
Hong Bae Kim ◽  
Seung Jeong ◽  
Ku Youn Baik
Keyword(s):  
Side Effects ◽  
Hela Cells ◽  
Near Infrared ◽  
Irreversible Electroporation ◽  
Temporal Distribution ◽  
Infrared Light ◽  
Dependent Manner ◽  
Cell Plasma ◽  
Induced Changes ◽  
Lower Electric Field

Irreversible electroporation (IRE) has gained attention for ablation owing to fewer side effects and fast recovery. However, a high current from the applied high voltage can cause muscle contraction. Adding cationic molecules has been introduced to lower electric field strengths and enhance IRE outcomes by inducing hyperpolarization across the cell plasma membrane. Near-infrared light (NIR) has recently been reported to induce hyperpolarization across membranes in a mode-dependent manner. In this study, we performed IRE in HeLa cells after exposure to 810 nm NIR irradiation. Preconditioning with NIR of 3 J/cm2 induced changes in membrane potential, resulting in approximately two times enhancement of apoptosis by IRE. The apoptotic signals were governed by the presence of BAX and p53 and were not related to excess oxidative stress. NIR has better spatial and temporal distribution control than chemicals and, therefore, can enhance the spatial selectivity and reduce the side effects of IRE treatment. These results can be used to enhance the clinical outcomes of IRE.

Fluorescent proteins for in vivo imaging, where's the biliverdin?

2020 ◽  
Vol 48 (6) ◽  
pp. 2657-2667
Author(s):  
Felipe Montecinos-Franjola ◽  
John Y. Lin ◽  
Erik A. Rodriguez
Keyword(s):  
Hydrogen Peroxide ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Fluorescent Protein ◽  
Fluorescent Proteins ◽  
Fluorescent Imaging ◽  
Infrared Light ◽  
Red Fluorescent Protein ◽  
Color Palette

Noninvasive fluorescent imaging requires far-red and near-infrared fluorescent proteins for deeper imaging. Near-infrared light penetrates biological tissue with blood vessels due to low absorbance, scattering, and reflection of light and has a greater signal-to-noise due to less autofluorescence. Far-red and near-infrared fluorescent proteins absorb light &gt;600 nm to expand the color palette for imaging multiple biosensors and noninvasive in vivo imaging. The ideal fluorescent proteins are bright, photobleach minimally, express well in the desired cells, do not oligomerize, and generate or incorporate exogenous fluorophores efficiently. Coral-derived red fluorescent proteins require oxygen for fluorophore formation and release two hydrogen peroxide molecules. New fluorescent proteins based on phytochrome and phycobiliproteins use biliverdin IXα as fluorophores, do not require oxygen for maturation to image anaerobic organisms and tumor core, and do not generate hydrogen peroxide. The small Ultra-Red Fluorescent Protein (smURFP) was evolved from a cyanobacterial phycobiliprotein to covalently attach biliverdin as an exogenous fluorophore. The small Ultra-Red Fluorescent Protein is biophysically as bright as the enhanced green fluorescent protein, is exceptionally photostable, used for biosensor development, and visible in living mice. Novel applications of smURFP include in vitro protein diagnostics with attomolar (10−18 M) sensitivity, encapsulation in viral particles, and fluorescent protein nanoparticles. However, the availability of biliverdin limits the fluorescence of biliverdin-attaching fluorescent proteins; hence, extra biliverdin is needed to enhance brightness. New methods for improved biliverdin bioavailability are necessary to develop improved bright far-red and near-infrared fluorescent proteins for noninvasive imaging in vivo.

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